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Items: 1 to 50 of 197

1.

Phytochemicals as Novel Therapeutic Strategies for NLRP3 Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases.

Pellegrini C, Fornai M, Antonioli L, Blandizzi C, Calderone V.

Int J Mol Sci. 2019 Jun 13;20(12). pii: E2876. doi: 10.3390/ijms20122876. Review.

2.

A Nutraceutical Strategy to Slowing Down the Progression of Cone Death in an Animal Model of Retinitis Pigmentosa.

Piano I, D'Antongiovanni V, Testai L, Calderone V, Gargini C.

Front Neurosci. 2019 May 17;13:461. doi: 10.3389/fnins.2019.00461. eCollection 2019.

3.

Vascular Effects of H2S-Donors: Fluorimetric Detection of H2S Generation and Ion Channel Activation in Human Aortic Smooth Muscle Cells.

Martelli A, Citi V, Calderone V.

Methods Mol Biol. 2019;2007:79-87. doi: 10.1007/978-1-4939-9528-8_6.

PMID:
31148107
4.

Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle.

Vellecco V, Martelli A, Bibli IS, Vallifuoco M, Manzo OL, Panza E, Citi V, Calderone V, de Dominicis G, Cozzolino C, Basso EM, Mariniello M, Fleming I, Mancini A, Bucci M, Cirino G.

Br J Pharmacol. 2019 May 3. doi: 10.1111/bph.14700. [Epub ahead of print]

PMID:
31051045
5.

In-house high-energy-remote SAD phasing using the magic triangle: how to tackle the P1 low symmetry using multiple orientations of the same crystal of human IBA57 to increase the multiplicity.

Gourdoupis S, Nasta V, Ciofi-Baffoni S, Banci L, Calderone V.

Acta Crystallogr D Struct Biol. 2019 Mar 1;75(Pt 3):317-324. doi: 10.1107/S2059798319000214. Epub 2019 Feb 28.

PMID:
30950402
6.

Memantine prodrug as a new agent for Alzheimer's Disease.

Sestito S, Daniele S, Pietrobono D, Citi V, Bellusci L, Chiellini G, Calderone V, Martini C, Rapposelli S.

Sci Rep. 2019 Mar 15;9(1):4612. doi: 10.1038/s41598-019-40925-8.

7.

Erucin exhibits vasorelaxing effects and antihypertensive activity by H2 S-releasing properties.

Martelli A, Piragine E, Citi V, Testai L, Pagnotta E, Ugolini L, Lazzeri L, Di Cesare Mannelli L, Manzo OL, Bucci M, Ghelardini C, Breschi MC, Calderone V.

Br J Pharmacol. 2019 Mar 2. doi: 10.1111/bph.14645. [Epub ahead of print]

PMID:
30825379
8.

Anti-metastatic Properties of Naproxen-HBTA in a Murine Model of Cutaneous Melanoma.

Ercolano G, De Cicco P, Frecentese F, Saccone I, Corvino A, Giordano F, Magli E, Fiorino F, Severino B, Calderone V, Citi V, Cirino G, Ianaro A.

Front Pharmacol. 2019 Feb 8;10:66. doi: 10.3389/fphar.2019.00066. eCollection 2019. Erratum in: Front Pharmacol. 2019 Feb 26;10:213.

9.

Reviewing the Crystal Structure of S100Z and Other Members of the S100 Family: Implications in Calcium-Regulated Quaternary Structure.

Calderone V, Fragai M, Luchinat C.

Methods Mol Biol. 2019;1929:487-499. doi: 10.1007/978-1-4939-9030-6_30.

PMID:
30710292
10.

Anticancer properties of erucin, an H2 S-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1).

Citi V, Piragine E, Pagnotta E, Ugolini L, Di Cesare Mannelli L, Testai L, Ghelardini C, Lazzeri L, Calderone V, Martelli A.

Phytother Res. 2019 Mar;33(3):845-855. doi: 10.1002/ptr.6278. Epub 2019 Jan 10.

PMID:
30632211
11.

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities.

Fortunato S, Lenzi C, Granchi C, Citi V, Martelli A, Calderone V, Di Pietro S, Signore G, Di Bussolo V, Minutolo F.

Bioconjug Chem. 2019 Mar 20;30(3):614-620. doi: 10.1021/acs.bioconjchem.8b00808. Epub 2019 Jan 16.

PMID:
30609890
12.

Metal centers in biomolecular solid-state NMR.

Malanho Silva J, Cerofolini L, Giuntini S, Calderone V, Geraldes CFGC, Macedo AL, Parigi G, Fragai M, Ravera E, Luchinat C.

J Struct Biol. 2019 Apr 1;206(1):99-109. doi: 10.1016/j.jsb.2018.11.013. Epub 2018 Nov 28.

PMID:
30502494
13.

Efficacy of isothiocyanate-based compounds on different forms of persistent pain.

Lucarini E, Micheli L, Martelli A, Testai L, Calderone V, Ghelardini C, Di Cesare Mannelli L.

J Pain Res. 2018 Nov 19;11:2905-2913. doi: 10.2147/JPR.S161882. eCollection 2018.

14.

Non-crystallographic symmetry in proteins: Jahn-Teller-like and Butterfly-like effects?

Silva JM, Giuntini S, Cerofolini L, Geraldes CFGC, Macedo AL, Ravera E, Fragai M, Luchinat C, Calderone V.

J Biol Inorg Chem. 2019 Feb;24(1):91-101. doi: 10.1007/s00775-018-1630-0. Epub 2018 Nov 23.

PMID:
30470900
15.

Characterization of PEGylated Asparaginase: New Opportunities from NMR Analysis of Large PEGylated Therapeutics.

Cerofolini L, Giuntini S, Carlon A, Ravera E, Calderone V, Fragai M, Parigi G, Luchinat C.

Chemistry. 2019 Feb 6;25(8):1984-1991. doi: 10.1002/chem.201804488. Epub 2019 Jan 9.

PMID:
30462348
16.

Interaction of Half Oxa-/Half cis-Platin Complex with Human Superoxide Dismutase and Induced Reduction of Neurotoxicity.

Cantini F, Calderone V, Di Cesare Mannelli L, Korsak M, Gonnelli L, Francesconi O, Ghelardini C, Banci L, Nativi C.

ACS Med Chem Lett. 2018 Oct 1;9(11):1094-1098. doi: 10.1021/acsmedchemlett.8b00199. eCollection 2018 Nov 8.

PMID:
30429951
17.

Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates.

Cuffaro D, Camodeca C, D'Andrea F, Piragine E, Testai L, Calderone V, Orlandini E, Nuti E, Rossello A.

Bioorg Med Chem. 2018 Dec 1;26(22):5804-5815. doi: 10.1016/j.bmc.2018.10.024. Epub 2018 Oct 26.

PMID:
30429099
18.

IBA57 Recruits ISCA2 to Form a [2Fe-2S] Cluster-Mediated Complex.

Gourdoupis S, Nasta V, Calderone V, Ciofi-Baffoni S, Banci L.

J Am Chem Soc. 2018 Oct 31;140(43):14401-14412. doi: 10.1021/jacs.8b09061. Epub 2018 Oct 17.

PMID:
30269484
19.

Antioxidant and Antisenescence Effects of Bergamot Juice.

Da Pozzo E, De Leo M, Faraone I, Milella L, Cavallini C, Piragine E, Testai L, Calderone V, Pistelli L, Braca A, Martini C.

Oxid Med Cell Longev. 2018 Jul 12;2018:9395804. doi: 10.1155/2018/9395804. eCollection 2018.

20.

Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H2 S release in vivo.

Lucarini E, Micheli L, Trallori E, Citi V, Martelli A, Testai L, De Nicola GR, Iori R, Calderone V, Ghelardini C, Di Cesare Mannelli L.

Phytother Res. 2018 Nov;32(11):2226-2234. doi: 10.1002/ptr.6159. Epub 2018 Aug 2.

PMID:
30069944
21.

Phosphorylation of AKT and ERK1/2 and mutations of PIK3CA and PTEN are predictive of breast cancer cell sensitivity to everolimus in vitro.

Citi V, Del Re M, Martelli A, Calderone V, Breschi MC, Danesi R.

Cancer Chemother Pharmacol. 2018 Apr;81(4):745-754. doi: 10.1007/s00280-018-3543-6. Epub 2018 Feb 23.

PMID:
29476223
22.

Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity.

Mitidieri E, Tramontano T, Gurgone D, Citi V, Calderone V, Brancaleone V, Katsouda A, Nagahara N, Papapetropoulos A, Cirino G, d'Emmanuele di Villa Bianca R, Sorrentino R.

Nitric Oxide. 2018 May 1;75:53-59. doi: 10.1016/j.niox.2018.02.003. Epub 2018 Feb 13.

PMID:
29452248
23.

The Role of Hydrogen Sulfide and H2S-donors in Myocardial Protection Against Ischemia/Reperfusion Injury.

Citi V, Piragine E, Testai L, Breschi MC, Calderone V, Martelli A.

Curr Med Chem. 2018;25(34):4380-4401. doi: 10.2174/0929867325666180212120504. Review.

PMID:
29436990
24.

1,2,4-Thiadiazolidin-3,5-diones as novel hydrogen sulfide donors.

Severino B, Corvino A, Fiorino F, Luciano P, Frecentese F, Magli E, Saccone I, Di Vaio P, Citi V, Calderone V, Servillo L, Casale R, Cirino G, Vellecco V, Bucci M, Perissutti E, Santagada V, Caliendo G.

Eur J Med Chem. 2018 Jan 1;143:1677-1686. doi: 10.1016/j.ejmech.2017.10.068. Epub 2017 Nov 11.

PMID:
29133036
25.

Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).

Fragai M, Comito G, Di Cesare Mannelli L, Gualdani R, Calderone V, Louka A, Richichi B, Francesconi O, Angeli A, Nocentini A, Gratteri P, Chiarugi P, Ghelardini C, Tadini-Buoninsegni F, Supuran CT, Nativi C.

J Med Chem. 2017 Nov 9;60(21):9003-9011. doi: 10.1021/acs.jmedchem.7b01237. Epub 2017 Oct 27.

PMID:
29048889
26.

The Renal Outer Medullary Potassium Channel (ROMK): An Intriguing Pharmacological Target for an Innovative Class of Diuretic Drugs.

Calderone V, Martelli A, Piragine E, Citi V, Testai L, Breschi MC.

Curr Med Chem. 2018;25(23):2627-2636. doi: 10.2174/0929867324666171012120937. Review.

PMID:
29022503
27.

Pathophysiological Role of Mitochondrial Potassium Channels and their Modulation by Drugs.

Citi V, Calderone V, Martelli A, Breschi MC, Testai L.

Curr Med Chem. 2018;25(23):2661-2674. doi: 10.2174/0929867324666171012115300. Review.

PMID:
29022502
28.

Mitochondriotropic and Cardioprotective Effects of Triphenylphosphonium-Conjugated Derivatives of the Diterpenoid Isosteviol.

Testai L, Strobykina I, Semenov VV, Semenova M, Pozzo ED, Martelli A, Citi V, Martini C, Breschi MC, Kataev VE, Calderone V.

Int J Mol Sci. 2017 Sep 26;18(10). pii: E2060. doi: 10.3390/ijms18102060.

29.

A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions.

Rapposelli S, Gambari L, Digiacomo M, Citi V, Lisignoli G, Manferdini C, Calderone V, Grassi F.

Sci Rep. 2017 Sep 20;7(1):11940. doi: 10.1038/s41598-017-11608-z.

30.

Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects.

Barresi E, Nesi G, Citi V, Piragine E, Piano I, Taliani S, Da Settimo F, Rapposelli S, Testai L, Breschi MC, Gargini C, Calderone V, Martelli A.

J Med Chem. 2017 Sep 14;60(17):7512-7523. doi: 10.1021/acs.jmedchem.7b00888. Epub 2017 Aug 25.

PMID:
28799763
31.

Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease.

Testai L, Calderone V.

Nutrients. 2017 May 16;9(5). pii: E502. doi: 10.3390/nu9050502. Review.

32.

Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels.

Di Cesare Mannelli L, Lucarini E, Micheli L, Mosca I, Ambrosino P, Soldovieri MV, Martelli A, Testai L, Taglialatela M, Calderone V, Ghelardini C.

Neuropharmacology. 2017 Jul 15;121:49-59. doi: 10.1016/j.neuropharm.2017.04.029. Epub 2017 Apr 19.

PMID:
28431970
33.

Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.

Slobodin B, Han R, Calderone V, Vrielink JAFO, Loayza-Puch F, Elkon R, Agami R.

Cell. 2017 Apr 6;169(2):326-337.e12. doi: 10.1016/j.cell.2017.03.031.

34.

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage.

Da Pozzo E, Costa B, Cavallini C, Testai L, Martelli A, Calderone V, Martini C.

Oxid Med Cell Longev. 2017;2017:9536148. doi: 10.1155/2017/9536148. Epub 2017 Mar 12.

35.

The Citrus Flavanone Naringenin Produces Cardioprotective Effects in Hearts from 1 Year Old Rat, through Activation of mitoBK Channels.

Testai L, Da Pozzo E, Piano I, Pistelli L, Gargini C, Breschi MC, Braca A, Martini C, Martelli A, Calderone V.

Front Pharmacol. 2017 Feb 27;8:71. doi: 10.3389/fphar.2017.00071. eCollection 2017.

36.

The Hydrogen Sulfide Releasing Molecule Acetyl Deacylasadisulfide Inhibits Metastatic Melanoma.

De Cicco P, Panza E, Armogida C, Ercolano G, Taglialatela-Scafati O, Shokoohinia Y, Camerlingo R, Pirozzi G, Calderone V, Cirino G, Ianaro A.

Front Pharmacol. 2017 Feb 27;8:65. doi: 10.3389/fphar.2017.00065. eCollection 2017.

37.

Solving the crystal structure of human calcium-free S100Z: the siege and conquer of one of the last S100 family strongholds.

Calderone V, Fragai M, Gallo G, Luchinat C.

J Biol Inorg Chem. 2017 Jun;22(4):519-526. doi: 10.1007/s00775-017-1437-4. Epub 2017 Jan 10.

PMID:
28074300
38.

The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress.

Testai L, Marino A, Piano I, Brancaleone V, Tomita K, Di Cesare Mannelli L, Martelli A, Citi V, Breschi MC, Levi R, Gargini C, Bucci M, Cirino G, Ghelardini C, Calderone V.

Pharmacol Res. 2016 Nov;113(Pt A):290-299. doi: 10.1016/j.phrs.2016.09.006. Epub 2016 Sep 9.

PMID:
27616550
39.

The novel H2 S donor 4-carboxy-phenyl isothiocyanate inhibits mast cell degranulation and renin release by decreasing intracellular calcium.

Marino A, Martelli A, Citi V, Fu M, Wang R, Calderone V, Levi R.

Br J Pharmacol. 2016 Nov;173(22):3222-3234. doi: 10.1111/bph.13583. Epub 2016 Oct 4.

40.

Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta.

Testai L, Chericoni S, Martelli A, Flamini G, Breschi MC, Calderone V.

J Pharm Pharmacol. 2016 Sep;68(9):1177-83. doi: 10.1111/jphp.12585. Epub 2016 Jun 23.

PMID:
27334686
41.

A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis.

Consalvi S, Poce G, Ragno R, Sabatino M, La Motta C, Sartini S, Calderone V, Martelli A, Ghelardini C, Di Cesare Mannelli L, Biava M.

ChemMedChem. 2016 Aug 19;11(16):1804-11. doi: 10.1002/cmdc.201600086. Epub 2016 May 27.

PMID:
27229194
42.

D-Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase.

Brancaleone V, Esposito I, Gargiulo A, Vellecco V, Asimakopoulou A, Citi V, Calderone V, Gobbetti T, Perretti M, Papapetropoulos A, Bucci M, Cirino G.

Br J Pharmacol. 2016 May;173(9):1556-65. doi: 10.1111/bph.13459. Epub 2016 Mar 23.

43.

Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection.

Testai L, Barrese V, Soldovieri MV, Ambrosino P, Martelli A, Vinciguerra I, Miceli F, Greenwood IA, Curtis MJ, Breschi MC, Sisalli MJ, Scorziello A, Canduela MJ, Grandes P, Calderone V, Taglialatela M.

Cardiovasc Res. 2016 May 1;110(1):40-50. doi: 10.1093/cvr/cvv281. Epub 2015 Dec 29.

PMID:
26718475
44.

Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease.

Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R.

Gastroenterology. 2016 Apr;150(4):982-97.e30. doi: 10.1053/j.gastro.2015.11.038. Epub 2015 Nov 26.

PMID:
26627607
45.

Using hydrogen sulfide to design and develop drugs.

Calderone V, Martelli A, Testai L, Citi V, Breschi MC.

Expert Opin Drug Discov. 2016;11(2):163-75. doi: 10.1517/17460441.2016.1122590. Epub 2015 Dec 19. Review.

PMID:
26593865
46.

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme.

Sestito S, Nesi G, Daniele S, Martelli A, Digiacomo M, Borghini A, Pietra D, Calderone V, Lapucci A, Falasca M, Parrella P, Notarangelo A, Breschi MC, Macchia M, Martini C, Rapposelli S.

Eur J Med Chem. 2015 Nov 13;105:274-88. doi: 10.1016/j.ejmech.2015.10.020. Epub 2015 Oct 22.

PMID:
26498573
47.

Cystathionine β-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia.

Vellecco V, Mancini A, Ianaro A, Calderone V, Attanasio C, Cantalupo A, Andria B, Savoia G, Panza E, Di Martino A, Cirino G, Bucci M.

Clin Sci (Lond). 2016 Jan;130(1):35-44. doi: 10.1042/CS20150521. Epub 2015 Oct 12.

PMID:
26460077
48.

Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation.

Roviezzo F, Bertolino A, Sorrentino R, Terlizzi M, Matteis M, Calderone V, Mattera V, Martelli A, Spaziano G, Pinto A, D'Agostino B, Cirino G.

Pharmacol Res. 2015 Oct;100:85-92. doi: 10.1016/j.phrs.2015.07.032. Epub 2015 Aug 1.

PMID:
26241177
49.

Inhibitors of the renal outer medullary potassium channel: a patent review.

Martelli A, Testai L, Breschi MC, Calderone V.

Expert Opin Ther Pat. 2015;25(9):1035-51. doi: 10.1517/13543776.2015.1050792. Epub 2015 May 26. Review.

PMID:
26004420
50.

Different patterns of H2S/NO activity and cross-talk in the control of the coronary vascular bed under normotensive or hypertensive conditions.

Testai L, D'Antongiovanni V, Piano I, Martelli A, Citi V, Duranti E, Virdis A, Blandizzi C, Gargini C, Breschi MC, Calderone V.

Nitric Oxide. 2015 May 1;47:25-33. doi: 10.1016/j.niox.2015.03.003. Epub 2015 Mar 17.

PMID:
25795591

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