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Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation.

Holmes AC, Zagnoli-Vieira G, Caldecott KW, Semler BL.

Viruses. 2020 Jan 31;12(2). pii: E166. doi: 10.3390/v12020166.


Homozygous pathogenic variant in BRAT1 associated with nonprogressive cerebellar ataxia.

Mahjoub A, Cihlarova Z, Tétreault M, MacNeil L, Sondheimer N, Caldecott KW, Hanzlikova H, Yoon G; Care4Rare Canada Consortium.

Neurol Genet. 2019 Sep 4;5(5):e359. doi: 10.1212/NXG.0000000000000359. eCollection 2019 Oct.


XRCC1 protein; Form and function.

Caldecott KW.

DNA Repair (Amst). 2019 Sep;81:102664. doi: 10.1016/j.dnarep.2019.102664. Epub 2019 Jul 8. Review.


Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

Canela A, Maman Y, Huang SN, Wutz G, Tang W, Zagnoli-Vieira G, Callen E, Wong N, Day A, Peters JM, Caldecott KW, Pommier Y, Nussenzweig A.

Mol Cell. 2019 Jul 25;75(2):252-266.e8. doi: 10.1016/j.molcel.2019.04.030. Epub 2019 Jun 12.


Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux.

Komulainen E, Pennicott L, Le Grand D, Caldecott KW.

ACS Chem Biol. 2019 Jun 21;14(6):1110-1114. doi: 10.1021/acschembio.9b00144. Epub 2019 May 16.


Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ.

Kalasova I, Hanzlikova H, Gupta N, Li Y, Altmüller J, Reynolds JJ, Stewart GS, Wollnik B, Yigit G, Caldecott KW.

Neurol Genet. 2019 Mar 25;5(2):e320. doi: 10.1212/NXG.0000000000000320. eCollection 2019 Apr.


Perspectives on PARPs in S Phase.

Hanzlikova H, Caldecott KW.

Trends Genet. 2019 Jun;35(6):412-422. doi: 10.1016/j.tig.2019.03.008. Epub 2019 Apr 26. Review.


FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress.

Martinez-Macias MI, Moore DA, Green RL, Gomez-Herreros F, Naumann M, Hermann A, Van Damme P, Hafezparast M, Caldecott KW.

Life Sci Alliance. 2019 Feb 26;2(2). pii: e201800222. doi: 10.26508/lsa.201800222. Print 2019 Apr.


Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1.

Polo LM, Xu Y, Hornyak P, Garces F, Zeng Z, Hailstone R, Matthews SJ, Caldecott KW, Oliver AW, Pearl LH.

Cell Rep. 2019 Jan 15;26(3):573-581.e5. doi: 10.1016/j.celrep.2018.12.082.


Confirming TDP2 mutation in spinocerebellar ataxia autosomal recessive 23 (SCAR23).

Zagnoli-Vieira G, Bruni F, Thompson K, He L, Walker S, de Brouwer APM, Taylor RW, Niyazov D, Caldecott KW.

Neurol Genet. 2018 Aug 1;4(4):e262. doi: 10.1212/NXG.0000000000000262. eCollection 2018 Aug. Erratum in: Neurol Genet. 2018 Sep 19;4(5):e277. Taylor, Robert [corrected to Taylor, Robert W].


The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication.

Hanzlikova H, Kalasova I, Demin AA, Pennicott LE, Cihlarova Z, Caldecott KW.

Mol Cell. 2018 Jul 19;71(2):319-331.e3. doi: 10.1016/j.molcel.2018.06.004. Epub 2018 Jul 5.


Nonsyndromic cerebellar ataxias associated with disorders of DNA single-strand break repair.

Yoon G, Caldecott KW.

Handb Clin Neurol. 2018;155:105-115. doi: 10.1016/B978-0-444-64189-2.00007-X. Review.


TDP2, TOP2, and SUMO: what is ZATT about?

Zagnoli-Vieira G, Caldecott KW.

Cell Res. 2017 Dec;27(12):1405-1406. doi: 10.1038/cr.2017.147. Epub 2017 Nov 21.


Acylpeptide hydrolase is a component of the cellular response to DNA damage.

Zeng Z, Rulten SL, Breslin C, Zlatanou A, Coulthard V, Caldecott KW.

DNA Repair (Amst). 2017 Oct;58:52-61. doi: 10.1016/j.dnarep.2017.08.008. Epub 2017 Aug 24.


The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.

Breslin C, Mani RS, Fanta M, Hoch N, Weinfeld M, Caldecott KW.

J Biol Chem. 2017 Sep 29;292(39):16024-16031. doi: 10.1074/jbc.M117.806638. Epub 2017 Aug 16.


TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.

Gómez-Herreros F, Zagnoli-Vieira G, Ntai I, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A, Caldecott KW.

Nat Commun. 2017 Aug 10;8(1):233. doi: 10.1038/s41467-017-00307-y.


XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.

Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GM, McKinnon PJ, Wang ZQ, Wagner JD; Care4Rare Canada Consortium, Yoon G, Caldecott KW.

Nature. 2017 Jan 5;541(7635):87-91. doi: 10.1038/nature20790. Epub 2016 Dec 21.


Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin.

Hanzlikova H, Gittens W, Krejcikova K, Zeng Z, Caldecott KW.

Nucleic Acids Res. 2017 Mar 17;45(5):2546-2557. doi: 10.1093/nar/gkw1246.


The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models.

Oplustil O'Connor L, Rulten SL, Cranston AN, Odedra R, Brown H, Jaspers JE, Jones L, Knights C, Evers B, Ting A, Bradbury RH, Pajic M, Rottenberg S, Jonkers J, Rudge D, Martin NM, Caldecott KW, Lau A, O'Connor MJ.

Cancer Res. 2016 Oct 15;76(20):6084-6094. Epub 2016 Aug 22.


PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).

Grundy GJ, Polo LM, Zeng Z, Rulten SL, Hoch NC, Paomephan P, Xu Y, Sweet SM, Thorne AW, Oliver AW, Matthews SJ, Pearl LH, Caldecott KW.

Nat Commun. 2016 Aug 17;7:12404. doi: 10.1038/ncomms12404.


Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW.

Biochem J. 2016 Jul 1;473(13):1869-79. doi: 10.1042/BCJ20160180. Epub 2016 Apr 20.


The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.

Grundy GJ, Rulten SL, Arribas-Bosacoma R, Davidson K, Kozik Z, Oliver AW, Pearl LH, Caldecott KW.

Nat Commun. 2016 Apr 11;7:11242. doi: 10.1038/ncomms11242.


Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections.

Maciejewski S, Nguyen JH, Gómez-Herreros F, Cortés-Ledesma F, Caldecott KW, Semler BL.

mBio. 2015 Dec 29;7(1):e01931-15. doi: 10.1128/mBio.01931-15.


Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains.

Cherry AL, Nott TJ, Kelly G, Rulten SL, Caldecott KW, Smerdon SJ.

DNA Repair (Amst). 2015 Nov;35:116-25. doi: 10.1016/j.dnarep.2015.10.002. Epub 2015 Oct 23.


The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function.

Breslin C, Hornyak P, Ridley A, Rulten SL, Hanzlikova H, Oliver AW, Caldecott KW.

Nucleic Acids Res. 2015 Aug 18;43(14):6934-44. doi: 10.1093/nar/gkv623. Epub 2015 Jun 29.


Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?

Cui X, McAllister R, Boregowda R, Sohn JA, Cortes Ledesma F, Caldecott KW, Seeger C, Hu J.

PLoS One. 2015 Jun 16;10(6):e0128401. doi: 10.1371/journal.pone.0128401. eCollection 2015.


Identification and Functional Characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3.

Dai X, Rulten SL, You C, Caldecott KW, Wang Y.

J Proteome Res. 2015 Jun 5;14(6):2575-82. doi: 10.1021/acs.jproteome.5b00126. Epub 2015 Apr 27.


The Yin and Yang of DAXX regulation.

Caldecott KW.

Cell Cycle. 2015;14(3):295-6. doi: 10.1080/15384101.2015.1006552. No abstract available.


DNA single-strand break repair.

Caldecott KW.

Exp Cell Res. 2014 Nov 15;329(1):2-8. doi: 10.1016/j.yexcr.2014.08.027. Epub 2014 Aug 28. Review. No abstract available.


Protein ADP-ribosylation and the cellular response to DNA strand breaks.

Caldecott KW.

DNA Repair (Amst). 2014 Jul;19:108-13. doi: 10.1016/j.dnarep.2014.03.021. Epub 2014 Apr 20. Review.


One ring to bring them all--the role of Ku in mammalian non-homologous end joining.

Grundy GJ, Moulding HA, Caldecott KW, Rulten SL.

DNA Repair (Amst). 2014 May;17:30-8. doi: 10.1016/j.dnarep.2014.02.019. Epub 2014 Mar 26. Review.


TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.

Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, de Vries BB, Caldecott KW.

Nat Genet. 2014 May;46(5):516-21. doi: 10.1038/ng.2929. Epub 2014 Mar 23.


Molecular biology. Ribose--an internal threat to DNA.

Caldecott KW.

Science. 2014 Jan 17;343(6168):260-1. doi: 10.1126/science.1248234. No abstract available.


PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.

Rulten SL, Rotheray A, Green RL, Grundy GJ, Moore DA, Gómez-Herreros F, Hafezparast M, Caldecott KW.

Nucleic Acids Res. 2014 Jan;42(1):307-14. doi: 10.1093/nar/gkt835. Epub 2013 Sep 18.


DNA strand break repair and neurodegeneration.

Rulten SL, Caldecott KW.

DNA Repair (Amst). 2013 Aug;12(8):558-67. doi: 10.1016/j.dnarep.2013.04.008. Epub 2013 May 24. Review.


TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.

Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, Vermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F.

PLoS Genet. 2013;9(3):e1003226. doi: 10.1371/journal.pgen.1003226. Epub 2013 Mar 7.


Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose.

Caldecott KW.

Nat Struct Mol Biol. 2012 Dec;19(12):1212-3. doi: 10.1038/nsmb.2455. No abstract available.


APLF promotes the assembly and activity of non-homologous end joining protein complexes.

Grundy GJ, Rulten SL, Zeng Z, Arribas-Bosacoma R, Iles N, Manley K, Oliver A, Caldecott KW.

EMBO J. 2013 Jan 9;32(1):112-25. doi: 10.1038/emboj.2012.304. Epub 2012 Nov 23.


TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF.

Nucleic Acids Res. 2012 Sep 1;40(17):8371-80. Epub 2012 Jun 26.


Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair.

Reynolds JJ, Walker AK, Gilmore EC, Walsh CA, Caldecott KW.

Nucleic Acids Res. 2012 Aug;40(14):6608-19. doi: 10.1093/nar/gks318. Epub 2012 Apr 15.


3rd International Genome Dynamics in Neuroscience Conference: "DNA repair and neurological disease".

Caldecott KW, Bohr VA, McKinnon PJ.

Mech Ageing Dev. 2011 Aug;132(8-9):353-4. doi: 10.1016/j.mad.2011.07.006. Epub 2011 Jul 26. No abstract available.


PARP-3 and APLF function together to accelerate nonhomologous end-joining.

Rulten SL, Fisher AE, Robert I, Zuma MC, Rouleau M, Ju L, Poirier G, Reina-San-Martin B, Caldecott KW.

Mol Cell. 2011 Jan 7;41(1):33-45. doi: 10.1016/j.molcel.2010.12.006.


TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.

Zeng Z, Cortés-Ledesma F, El Khamisy SF, Caldecott KW.

J Biol Chem. 2011 Jan 7;286(1):403-9. doi: 10.1074/jbc.M110.181016. Epub 2010 Oct 28.


Mutations in PNKP cause microcephaly, seizures and defects in DNA repair.

Shen J, Gilmore EC, Marshall CA, Haddadin M, Reynolds JJ, Eyaid W, Bodell A, Barry B, Gleason D, Allen K, Ganesh VS, Chang BS, Grix A, Hill RS, Topcu M, Caldecott KW, Barkovich AJ, Walsh CA.

Nat Genet. 2010 Mar;42(3):245-9. doi: 10.1038/ng.526. Epub 2010 Jan 31.


A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.

Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K, Caldecott KW.

Nature. 2009 Oct 1;461(7264):674-8. doi: 10.1038/nature08444.


Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90.

Dungey FA, Caldecott KW, Chalmers AJ.

Mol Cancer Ther. 2009 Aug;8(8):2243-54. doi: 10.1158/1535-7163.MCT-09-0201. Epub 2009 Aug 11.


The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1.

Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW, McKinnon PJ.

Nat Neurosci. 2009 Aug;12(8):973-80. doi: 10.1038/nn.2375. Epub 2009 Jul 26.


DNA 3'-phosphatase activity is critical for rapid global rates of single-strand break repair following oxidative stress.

Breslin C, Caldecott KW.

Mol Cell Biol. 2009 Sep;29(17):4653-62. doi: 10.1128/MCB.00677-09. Epub 2009 Jun 22.


Short-patch single-strand break repair in ataxia oculomotor apraxia-1.

Reynolds JJ, El-Khamisy SF, Caldecott KW.

Biochem Soc Trans. 2009 Jun;37(Pt 3):577-81. doi: 10.1042/BST0370577. Review.


Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin.

El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ, Caldecott KW.

DNA Repair (Amst). 2009 Jun 4;8(6):760-6. doi: 10.1016/j.dnarep.2009.02.002. Epub 2009 Mar 19.

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