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Items: 45


Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice.

Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O'Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA.

Alzheimers Res Ther. 2020 Jan 13;12(1):12. doi: 10.1186/s13195-019-0579-8.


Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer's-like transgenic mice.

Liu B, Hinshaw RG, Le KX, Park MA, Wang S, Belanger AP, Dubey S, Frost JL, Shi Q, Holton P, Trojanczyk L, Reiser V, Jones PA, Trigg W, Di Carli MF, Lorello P, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA.

Sci Rep. 2019 Aug 20;9(1):12118. doi: 10.1038/s41598-019-48615-1.


Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways.

Albayram O, MacIver B, Mathai J, Verstegen A, Baxley S, Qiu C, Bell C, Caldarone BJ, Zhou XZ, Lu KP, Zeidel M.

Sci Rep. 2019 Jun 14;9(1):8646. doi: 10.1038/s41598-019-45234-8.


β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR.

Science. 2017 Sep 1;357(6354):891-898. doi: 10.1126/science.aaf3934.


Disruption of the ATP/adenosine balance in CD39-/- mice is associated with handling-induced seizures.

Lanser AJ, Rezende RM, Rubino S, Lorello PJ, Donnelly DJ, Xu H, Lau LA, Dulla CG, Caldarone BJ, Robson SC, Weiner HL.

Immunology. 2017 Dec;152(4):589-601. doi: 10.1111/imm.12798. Epub 2017 Aug 25.


Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.

Zhang G, Cheng J, McCorvy JD, Lorello PJ, Caldarone BJ, Roth BL, Kozikowski AP.

J Med Chem. 2017 Jul 27;60(14):6273-6288. doi: 10.1021/acs.jmedchem.7b00584. Epub 2017 Jul 18.


Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.

Shi Q, Chowdhury S, Ma R, Le KX, Hong S, Caldarone BJ, Stevens B, Lemere CA.

Sci Transl Med. 2017 May 31;9(392). pii: eaaf6295. doi: 10.1126/scitranslmed.aaf6295.


σ1 receptor ligands control a switch between passive and active threat responses.

Rennekamp AJ, Huang XP, Wang Y, Patel S, Lorello PJ, Cade L, Gonzales AP, Yeh JR, Caldarone BJ, Roth BL, Kokel D, Peterson RT.

Nat Chem Biol. 2016 Jul;12(7):552-8. doi: 10.1038/nchembio.2089. Epub 2016 May 30.


Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.

Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D.

Nat Chem Biol. 2016 Jul;12(7):559-66. doi: 10.1038/nchembio.2097. Epub 2016 May 30.


Synthesis and Behavioral Studies of Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part III.

Onajole OK, Vallerini GP, Eaton JB, Lukas RJ, Brunner D, Caldarone BJ, Kozikowski AP.

ACS Chem Neurosci. 2016 Jun 15;7(6):811-22. doi: 10.1021/acschemneuro.6b00050. Epub 2016 Apr 21.


An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice.

Frost JL, Liu B, Rahfeld JU, Kleinschmidt M, O'Nuallain B, Le KX, Lues I, Caldarone BJ, Schilling S, Demuth HU, Lemere CA.

Neurobiol Aging. 2015 Dec;36(12):3187-3199. doi: 10.1016/j.neurobiolaging.2015.08.021. Epub 2015 Aug 31.


Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline.

Shi Q, Colodner KJ, Matousek SB, Merry K, Hong S, Kenison JE, Frost JL, Le KX, Li S, Dodart JC, Caldarone BJ, Stevens B, Lemere CA.

J Neurosci. 2015 Sep 23;35(38):13029-42. doi: 10.1523/JNEUROSCI.1698-15.2015.


Tau immunization: a cautionary tale?

Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM.

Neurobiol Aging. 2015 Mar;36(3):1316-32. doi: 10.1016/j.neurobiolaging.2014.11.022. Epub 2014 Dec 30.


Rodent models of treatment-resistant depression.

Caldarone BJ, Zachariou V, King SL.

Eur J Pharmacol. 2015 Apr 15;753:51-65. doi: 10.1016/j.ejphar.2014.10.063. Epub 2014 Nov 21. Review.


Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands.

Onajole OK, Eaton JB, Lukas RJ, Brunner D, Thiede L, Caldarone BJ, Kozikowski AP.

ACS Med Chem Lett. 2014 Sep 29;5(11):1196-201. doi: 10.1021/ml500129k. eCollection 2014 Nov 13.


Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.

Yu LF, Zhang HK, Caldarone BJ, Eaton JB, Lukas RJ, Kozikowski AP.

J Med Chem. 2014 Oct 23;57(20):8204-23. doi: 10.1021/jm401937a. Epub 2014 Jul 2. Review.


Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models.

Stratinaki M, Varidaki A, Mitsi V, Ghose S, Magida J, Dias C, Russo SJ, Vialou V, Caldarone BJ, Tamminga CA, Nestler EJ, Zachariou V.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8254-9. doi: 10.1073/pnas.1214696110. Epub 2013 Apr 29. Erratum in: Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11660.


Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380.

Caldarone BJ, Wang D, Paterson NE, Manzano M, Fedolak A, Cavino K, Kwan M, Hanania T, Chellappan SK, Kozikowski AP, Olivier B, Picciotto MR, Ghavami A.

Psychopharmacology (Berl). 2011 Sep;217(2):199-210. doi: 10.1007/s00213-011-2271-y. Epub 2011 Apr 13.


The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties.

Caldarone BJ, Paterson NE, Zhou J, Brunner D, Kozikowski AP, Westphal KG, Korte-Bouws GA, Prins J, Korte SM, Olivier B, Ghavami A.

J Pharmacol Exp Ther. 2010 Dec;335(3):762-70. doi: 10.1124/jpet.110.174011. Epub 2010 Sep 23.


RGS9-2: probing an intracellular modulator of behavior as a drug target.

Traynor JR, Terzi D, Caldarone BJ, Zachariou V.

Trends Pharmacol Sci. 2009 Mar;30(3):105-11. doi: 10.1016/ Epub 2009 Feb 9.


Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice.

Caldarone BJ, King SL, Picciotto MR.

Neurosci Lett. 2008 Jul 11;439(2):187-91. doi: 10.1016/j.neulet.2008.05.023. Epub 2008 May 13.


Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats.

Lynch WJ, Kiraly DD, Caldarone BJ, Picciotto MR, Taylor JR.

Psychopharmacology (Berl). 2007 Apr;191(2):263-71. Epub 2006 Dec 16.


The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice.

Rabenstein RL, Caldarone BJ, Picciotto MR.

Psychopharmacology (Berl). 2006 Dec;189(3):395-401. Epub 2006 Oct 3.


The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo.

Miwa JM, Stevens TR, King SL, Caldarone BJ, Ibanez-Tallon I, Xiao C, Fitzsimonds RM, Pavlides C, Lester HA, Picciotto MR, Heintz N.

Neuron. 2006 Sep 7;51(5):587-600.


Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein.

Rabenstein RL, Addy NA, Caldarone BJ, Asaka Y, Gruenbaum LM, Peters LL, Gilligan DM, Fitzsimonds RM, Picciotto MR.

J Neurosci. 2005 Feb 23;25(8):2138-45. Erratum in: J Neurosci. 2005 Apr 6;25(14):1 p following 3627.


High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation.

Caldarone BJ, Harrist A, Cleary MA, Beech RD, King SL, Picciotto MR.

Biol Psychiatry. 2004 Nov 1;56(9):657-64.


Alteration of hippocampal cell proliferation in mice lacking the beta 2 subunit of the neuronal nicotinic acetylcholine receptor.

Harrist A, Beech RD, King SL, Zanardi A, Cleary MA, Caldarone BJ, Eisch A, Zoli M, Picciotto MR.

Synapse. 2004 Dec 15;54(4):200-6.


Health correlates of recreational gambling in older adults.

Desai RA, Maciejewski PK, Dausey DJ, Caldarone BJ, Potenza MN.

Am J Psychiatry. 2004 Sep;161(9):1672-9. Erratum in: Am J Psychiatry. 2004 Nov;161(11):2150.


The conditioning of dyspneic suffocation fear. Effects of carbon dioxide concentration on behavioral freezing and analgesia.

Mongeluzi DL, Rosellini RA, Ley R, Caldarone BJ, Stock HS.

Behav Modif. 2003 Oct;27(5):620-36.


Sex differences in response to oral amitriptyline in three animal models of depression in C57BL/6J mice.

Caldarone BJ, Karthigeyan K, Harrist A, Hunsberger JG, Wittmack E, King SL, Jatlow P, Picciotto MR.

Psychopharmacology (Berl). 2003 Oct;170(1):94-101. Epub 2003 Jul 15.


Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior.

King SL, Marks MJ, Grady SR, Caldarone BJ, Koren AO, Mukhin AG, Collins AC, Picciotto MR.

J Neurosci. 2003 May 1;23(9):3837-43.


Effect of nicotine and nicotinic receptors on anxiety and depression.

Picciotto MR, Brunzell DH, Caldarone BJ.

Neuroreport. 2002 Jul 2;13(9):1097-106. Review.


Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications.

Picciotto MR, Caldarone BJ, Brunzell DH, Zachariou V, Stevens TR, King SL.

Pharmacol Ther. 2001 Nov-Dec;92(2-3):89-108. Review.


Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice.

Di Paolo G, Sankaranarayanan S, Wenk MR, Daniell L, Perucco E, Caldarone BJ, Flavell R, Picciotto MR, Ryan TA, Cremona O, De Camilli P.

Neuron. 2002 Feb 28;33(5):789-804.


Nicotine receptor inactivation decreases sensitivity to cocaine.

Zachariou V, Caldarone BJ, Weathers-Lowin A, George TP, Elsworth JD, Roth RH, Changeux JP, Picciotto MR.

Neuropsychopharmacology. 2001 May;24(5):576-89.


Habituation of activity in an open field: A survey of inbred strains and F1 hybrids.

Bolivar VJ, Caldarone BJ, Reilly AA, Flaherty L.

Behav Genet. 2000 Jul;30(4):285-93.


Gender differences in learned helplessness behavior are influenced by genetic background.

Caldarone BJ, George TP, Zachariou V, Picciotto MR.

Pharmacol Biochem Behav. 2000 Aug;66(4):811-7.


Nicotinic receptors in the brain. Links between molecular biology and behavior.

Picciotto MR, Caldarone BJ, King SL, Zachariou V.

Neuropsychopharmacology. 2000 May;22(5):451-65. Review.


Enhancement of morphine analgesia in rats following removal from contextual conditioned fear cues.

Caldarone BJ, Abrahamsen GC, Stock HS, Mongeluzi DL, Rossellini RA.

Prog Neuropsychopharmacol Biol Psychiatry. 1997 Aug;21(6):981-95.


Pavlovian aversive context conditioning using carbon dioxide as the unconditional stimulus.

Mongeluzi DL, Rosellini RA, Caldarone BJ, Stock HS, Abrahamsen GC.

J Exp Psychol Anim Behav Process. 1996 Jul;22(3):244-57.


Conditioned fear exacerbates acute morphine dependence.

Abrahamsen GC, Caldarone BJ, Stock HS, Schutz AD, Rosellini RA.

Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):407-13.


Modulation of hypoalgesia by morphine and number of shock trials: covariation of a measure of context fear and hypoalgesia.

Rosellini RA, Abrahamsen GC, Stock HS, Caldarone BJ.

Physiol Behav. 1994 Jul;56(1):183-8.


Learned helplessness inducing foot shock can exacerbate morphine responsiveness.

Abrahamsen GC, Stock HS, Caldarone BJ, Rosellini RA.

Physiol Behav. 1993 Aug;54(2):289-94.


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