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Diabetic Neuropathy: New Insights to Early Diagnosis and Treatments.

Yorek M, Malik RA, Calcutt NA, Vinik A, Yagihashi S.

J Diabetes Res. 2018 Dec 10;2018:5378439. doi: 10.1155/2018/5378439. eCollection 2018. No abstract available.


Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes.

Aghanoori MR, Smith DR, Shariati-Ievari S, Ajisebutu A, Nguyen A, Desmond F, Jesus CHA, Zhou X, Calcutt NA, Aliani M, Fernyhough P.

Mol Metab. 2019 Feb;20:149-165. doi: 10.1016/j.molmet.2018.11.008. Epub 2018 Nov 28.


Internode length is reduced during myelination and remyelination by neurofilament medium phosphorylation in motor axons.

Villalón E, Barry DM, Byers N, Frizzi K, Jones MR, Landayan DS, Dale JM, Downer NL, Calcutt NA, Garcia ML.

Exp Neurol. 2018 Aug;306:158-168. doi: 10.1016/j.expneurol.2018.05.009. Epub 2018 May 14.


The H-Reflex as a Biomarker for Spinal Disinhibition in Painful Diabetic Neuropathy.

Lee-Kubli C, Marshall AG, Malik RA, Calcutt NA.

Curr Diab Rep. 2018 Jan 23;18(1):1. doi: 10.1007/s11892-018-0969-5. Review.


A novel curcumin derivative for the treatment of diabetic neuropathy.

Daugherty DJ, Marquez A, Calcutt NA, Schubert D.

Neuropharmacology. 2018 Feb;129:26-35. doi: 10.1016/j.neuropharm.2017.11.007. Epub 2017 Nov 6.


Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats.

Aghanoori MR, Smith DR, Roy Chowdhury S, Sabbir MG, Calcutt NA, Fernyhough P.

Exp Neurol. 2017 Nov;297:148-157. doi: 10.1016/j.expneurol.2017.08.005. Epub 2017 Aug 10.


Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy.

Marshall AG, Lee-Kubli C, Azmi S, Zhang M, Ferdousi M, Mixcoatl-Zecuatl T, Petropoulos IN, Ponirakis G, Fineman MS, Fadavi H, Frizzi K, Tavakoli M, Jeziorska M, Jolivalt CG, Boulton AJM, Efron N, Calcutt NA, Malik RA.

Diabetes. 2017 May;66(5):1380-1390. doi: 10.2337/db16-1181. Epub 2017 Feb 15.


Schwann cell interactions with axons and microvessels in diabetic neuropathy.

Gonçalves NP, Vægter CB, Andersen H, Østergaard L, Calcutt NA, Jensen TS.

Nat Rev Neurol. 2017 Mar;13(3):135-147. doi: 10.1038/nrneurol.2016.201. Epub 2017 Jan 30. Review.


Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy.

Calcutt NA, Smith DR, Frizzi K, Sabbir MG, Chowdhury SK, Mixcoatl-Zecuatl T, Saleh A, Muttalib N, Van der Ploeg R, Ochoa J, Gopaul A, Tessler L, Wess J, Jolivalt CG, Fernyhough P.

J Clin Invest. 2017 Feb 1;127(2):608-622. doi: 10.1172/JCI88321. Epub 2017 Jan 17.


Differential effects of myostatin deficiency on motor and sensory axons.

Jones MR, Villalón E, Northcutt AJ, Calcutt NA, Garcia ML.

Muscle Nerve. 2017 Dec;56(6):E100-E107. doi: 10.1002/mus.25570. Epub 2017 Apr 11.


Peripheral Neuropathy in Mouse Models of Diabetes.

Jolivalt CG, Frizzi KE, Guernsey L, Marquez A, Ochoa J, Rodriguez M, Calcutt NA.

Curr Protoc Mouse Biol. 2016 Sep 1;6(3):223-55. doi: 10.1002/cpmo.11. Review.


New Directions in Diabetic Neuropathy: Evolution or Extinction?

Fernyhough P, Calcutt NA.

Int Rev Neurobiol. 2016;127:229-34. doi: 10.1016/bs.irn.2016.03.009. Epub 2016 Apr 5. No abstract available.


An Introduction to the History and Controversies of the Pathogenesis of Diabetic Neuropathy.

Fernyhough P, Calcutt NA.

Int Rev Neurobiol. 2016;127:115-20. doi: 10.1016/bs.irn.2016.03.012. Epub 2016 Apr 6. No abstract available.


An Introduction to the History and Controversies of Animal Models of Diabetic Neuropathy.

Calcutt NA, Fernyhough P.

Int Rev Neurobiol. 2016;127:45-52. doi: 10.1016/bs.irn.2016.03.011. Epub 2016 Apr 6. No abstract available.


A Brief Introduction to the History and Controversies of Clinical Trials in Diabetic Neuropathy.

Calcutt NA, Fernyhough P.

Int Rev Neurobiol. 2016;127:3-8. doi: 10.1016/bs.irn.2016.03.014. Epub 2016 Apr 6. No abstract available.


The α5 subunit containing GABAA receptors contribute to chronic pain.

Bravo-Hernández M, Corleto JA, Barragán-Iglesias P, González-Ramírez R, Pineda-Farias JB, Felix R, Calcutt NA, Delgado-Lezama R, Marsala M, Granados-Soto V.

Pain. 2016 Mar;157(3):613-26. doi: 10.1097/j.pain.0000000000000410.


Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation.

Rocca CJ, Kreymerman A, Ur SN, Frizzi KE, Naphade S, Lau A, Tran T, Calcutt NA, Goldberg JL, Cherqui S.

Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7214-23. doi: 10.1167/iovs.15-17107.


Efficacy of a long-acting C-peptide analogue against peripheral neuropathy in streptozotocin-diabetic mice.

Jolivalt CG, Rodriguez M, Wahren J, Calcutt NA.

Diabetes Obes Metab. 2015 Aug;17(8):781-8. doi: 10.1111/dom.12477. Epub 2015 May 20.


Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery.

Hollis ER 2nd, Ishiko N, Pessian M, Tolentino K, Lee-Kubli CA, Calcutt NA, Zou Y.

Nat Commun. 2015 Jan 19;6:6079. doi: 10.1038/ncomms7079.


A novel and robust conditioning lesion induced by ethidium bromide.

Hollis ER 2nd, Ishiko N, Tolentino K, Doherty E, Rodriguez MJ, Calcutt NA, Zou Y.

Exp Neurol. 2015 Mar;265:30-9. doi: 10.1016/j.expneurol.2014.12.004. Epub 2014 Dec 23.


Painful neuropathy: Mechanisms.

Lee-Kubli CA, Calcutt NA.

Handb Clin Neurol. 2014;126:533-57. doi: 10.1016/B978-0-444-53480-4.00034-5. Review.


Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab).

Biessels GJ, Bril V, Calcutt NA, Cameron NE, Cotter MA, Dobrowsky R, Feldman EL, Fernyhough P, Jakobsen J, Malik RA, Mizisin AP, Oates PJ, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt RE, Tesfaye S, Veves A, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D, Zochodne DW.

J Peripher Nerv Syst. 2014 Jun;19(2):77-87. doi: 10.1111/jns5.12072. Review.


Ciliary neurotrophic factor reverses aberrant mitochondrial bioenergetics through the JAK/STAT pathway in cultured sensory neurons derived from streptozotocin-induced diabetic rodents.

Chowdhury SR, Saleh A, Akude E, Smith DR, Morrow D, Tessler L, Calcutt NA, Fernyhough P.

Cell Mol Neurobiol. 2014 Jul;34(5):643-9. doi: 10.1007/s10571-014-0054-9. Epub 2014 Mar 30.


Animal models of diabetes-induced neuropathic pain.

Lee-Kubli CA, Mixcoatl-Zecuatl T, Jolivalt CG, Calcutt NA.

Curr Top Behav Neurosci. 2014;20:147-70. doi: 10.1007/7854_2014_280.


Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling.

Hedstrom KL, Murtie JC, Albers K, Calcutt NA, Corfas G.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2325-30. doi: 10.1073/pnas.1308889111. Epub 2014 Jan 21.


Location, location, location?: is the pain of diabetic neuropathy generated by hyperactive sensory neurons?

Calcutt NA.

Diabetes. 2013 Nov;62(11):3658-60. doi: 10.2337/db13-1158. No abstract available.


Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type-1 diabetic rodents and the effects of topical insulin.

Chen DK, Frizzi KE, Guernsey LS, Ladt K, Mizisin AP, Calcutt NA.

J Peripher Nerv Syst. 2013 Dec;18(4):306-15. doi: 10.1111/jns5.12044.


Altered rate-dependent depression of the spinal H-reflex as an indicator of spinal disinhibition in models of neuropathic pain.

Lee-Kubli CA, Calcutt NA.

Pain. 2014 Feb;155(2):250-60. doi: 10.1016/j.pain.2013.10.001. Epub 2013 Oct 5.


Guaifenesin derivatives promote neurite outgrowth and protect diabetic mice from neuropathy.

Hadimani MB, Purohit MK, Vanampally C, Van der Ploeg R, Arballo V, Morrow D, Frizzi KE, Calcutt NA, Fernyhough P, Kotra LP.

J Med Chem. 2013 Jun 27;56(12):5071-8. doi: 10.1021/jm400401y. Epub 2013 Jun 13.


Ciliary neurotrophic factor activates NF-κB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents.

Saleh A, Roy Chowdhury SK, Smith DR, Balakrishnan S, Tessler L, Martens C, Morrow D, Schartner E, Frizzi KE, Calcutt NA, Fernyhough P.

Neuropharmacology. 2013 Feb;65:65-73. doi: 10.1016/j.neuropharm.2012.09.015. Epub 2012 Sep 26.


Hypertension-induced peripheral neuropathy and the combined effects of hypertension and diabetes on nerve structure and function in rats.

Gregory JA, Jolivalt CG, Goor J, Mizisin AP, Calcutt NA.

Acta Neuropathol. 2012 Oct;124(4):561-73. doi: 10.1007/s00401-012-1012-6. Epub 2012 Jul 13.


Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes.

Roy Chowdhury SK, Smith DR, Saleh A, Schapansky J, Marquez A, Gomes S, Akude E, Morrow D, Calcutt NA, Fernyhough P.

Brain. 2012 Jun;135(Pt 6):1751-66. doi: 10.1093/brain/aws097. Epub 2012 May 4.


Expansion of neurofilament medium C terminus increases axonal diameter independent of increases in conduction velocity or myelin thickness.

Barry DM, Stevenson W, Bober BG, Wiese PJ, Dale JM, Barry GS, Byers NS, Strope JD, Chang R, Schulz DJ, Shah S, Calcutt NA, Gebremichael Y, Garcia ML.

J Neurosci. 2012 May 2;32(18):6209-19. doi: 10.1523/JNEUROSCI.0647-12.2012.


Similar pattern of peripheral neuropathy in mouse models of type 1 diabetes and Alzheimer's disease.

Jolivalt CG, Calcutt NA, Masliah E.

Neuroscience. 2012 Jan 27;202:405-12. doi: 10.1016/j.neuroscience.2011.11.032. Epub 2011 Dec 9.


Considerations for quantification of lipids in nerve tissue using matrix-assisted laser desorption/ionization mass spectrometric imaging.

Landgraf RR, Garrett TJ, Conaway MC, Calcutt NA, Stacpoole PW, Yost RA.

Rapid Commun Mass Spectrom. 2011 Oct 30;25(20):3178-84. doi: 10.1002/rcm.5189.


GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice.

Jolivalt CG, Fineman M, Deacon CF, Carr RD, Calcutt NA.

Diabetes Obes Metab. 2011 Nov;13(11):990-1000. doi: 10.1111/j.1463-1326.2011.01431.x.


Muscle pathology without severe nerve pathology in a new mouse model of Charcot-Marie-Tooth disease type 2E.

Shen H, Barry DM, Dale JM, Garcia VB, Calcutt NA, Garcia ML.

Hum Mol Genet. 2011 Jul 1;20(13):2535-48. doi: 10.1093/hmg/ddr152. Epub 2011 Apr 14.


Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.

Li W, James MO, McKenzie SC, Calcutt NA, Liu C, Stacpoole PW.

J Pharmacol Exp Ther. 2011 Jan;336(1):87-94. doi: 10.1124/jpet.110.173195. Epub 2010 Sep 30.


Tolerating diabetes: an alternative therapeutic approach for diabetic neuropathy.

Calcutt NA.

ASN Neuro. 2010 Sep 9;2(4):e00042. doi: 10.1042/AN20100026. Review.


Diet-induced obesity in Sprague-Dawley rats causes microvascular and neural dysfunction.

Davidson EP, Coppey LJ, Calcutt NA, Oltman CL, Yorek MA.

Diabetes Metab Res Rev. 2010 May;26(4):306-18. doi: 10.1002/dmrr.1088.


The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy.

Davidson E, Coppey L, Lu B, Arballo V, Calcutt NA, Gerard C, Yorek M.

Exp Diabetes Res. 2009;2009:431980. doi: 10.1155/2009/431980. Epub 2010 Feb 3.


Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment.

Chowdhury SK, Zherebitskaya E, Smith DR, Akude E, Chattopadhyay S, Jolivalt CG, Calcutt NA, Fernyhough P.

Diabetes. 2010 Apr;59(4):1082-91. doi: 10.2337/db09-1299. Epub 2010 Jan 26.


Abnormal calcium homeostasis in peripheral neuropathies.

Fernyhough P, Calcutt NA.

Cell Calcium. 2010 Feb;47(2):130-9. doi: 10.1016/j.ceca.2009.11.008. Epub 2009 Dec 24. Review.


Peripheral neuropathy in rats exposed to dichloroacetate.

Calcutt NA, Lopez VL, Bautista AD, Mizisin LM, Torres BR, Shroads AL, Mizisin AP, Stacpoole PW.

J Neuropathol Exp Neurol. 2009 Sep;68(9):985-93. doi: 10.1097/NEN.0b013e3181b40217.


Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats.

Malisza KL, Jones C, Gruwel ML, Foreman D, Fernyhough P, Calcutt NA.

J Magn Reson Imaging. 2009 Aug;30(2):271-6. doi: 10.1002/jmri.21856.


Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials.

Calcutt NA, Cooper ME, Kern TS, Schmidt AM.

Nat Rev Drug Discov. 2009 May;8(5):417-29. doi: 10.1038/nrd2476. Review.


B vitamins alleviate indices of neuropathic pain in diabetic rats.

Jolivalt CG, Mizisin LM, Nelson A, Cunha JM, Ramos KM, Bonke D, Calcutt NA.

Eur J Pharmacol. 2009 Jun 10;612(1-3):41-7. doi: 10.1016/j.ejphar.2009.04.028. Epub 2009 Apr 23.


Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth.

Garcia ML, Rao MV, Fujimoto J, Garcia VB, Shah SB, Crum J, Gotow T, Uchiyama Y, Ellisman M, Calcutt NA, Cleveland DW.

J Neurosci. 2009 Feb 4;29(5):1277-84. doi: 10.1523/JNEUROSCI.3765-08.2009.


Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters.

Jolivalt CG, Lee CA, Ramos KM, Calcutt NA.

Pain. 2008 Nov 15;140(1):48-57. doi: 10.1016/j.pain.2008.07.005. Epub 2008 Aug 27.

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