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Items: 35


NIH funding longevity by gender.

Hechtman LA, Moore NP, Schulkey CE, Miklos AC, Calcagno AM, Aragon R, Greenberg JH.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):7943-7948. doi: 10.1073/pnas.1800615115. Epub 2018 Jul 16.


A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy.

Gillet JP, Andersen JB, Madigan JP, Varma S, Bagni RK, Powell K, Burgan WE, Wu CP, Calcagno AM, Ambudkar SV, Thorgeirsson SS, Gottesman MM.

Mol Pharmacol. 2016 Feb;89(2):263-72. doi: 10.1124/mol.115.101360. Epub 2015 Dec 14.


Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma.

Gillet JP, Calcagno AM, Varma S, Davidson B, Bunkholt Elstrand M, Ganapathi R, Kamat AA, Sood AK, Ambudkar SV, Seiden MV, Rueda BR, Gottesman MM.

Clin Cancer Res. 2012 Jun 1;18(11):3197-206. doi: 10.1158/1078-0432.CCR-12-0056. Epub 2012 Apr 5.


Evolution of drug resistance in cancer: the emergence of unique mechanisms and novel techniques.

Calcagno AM.

Mol Pharm. 2011 Dec 5;8(6):1993. doi: 10.1021/mp200531m. No abstract available.


Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.

Gillet JP, Calcagno AM, Varma S, Marino M, Green LJ, Vora MI, Patel C, Orina JN, Eliseeva TA, Singal V, Padmanabhan R, Davidson B, Ganapathi R, Sood AK, Rueda BR, Ambudkar SV, Gottesman MM.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18708-13. doi: 10.1073/pnas.1111840108. Epub 2011 Nov 8.


Clinical relevance of multidrug resistance gene expression in ovarian serous carcinoma effusions.

Gillet JP, Wang J, Calcagno AM, Green LJ, Varma S, Bunkholt Elstrand M, Trope CG, Ambudkar SV, Davidson B, Gottesman MM.

Mol Pharm. 2011 Dec 5;8(6):2080-8. doi: 10.1021/mp200240a. Epub 2011 Jul 15.


Enhancement of drug absorption through the blood-brain barrier and inhibition of intercellular tight junction resealing by E-cadherin peptides.

Kiptoo P, Sinaga E, Calcagno AM, Zhao H, Kobayashi N, Tambunan US, Siahaan TJ.

Mol Pharm. 2011 Feb 7;8(1):239-49. doi: 10.1021/mp100293m. Epub 2010 Dec 17.


Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics.

Calcagno AM, Salcido CD, Gillet JP, Wu CP, Fostel JM, Mumau MD, Gottesman MM, Varticovski L, Ambudkar SV.

J Natl Cancer Inst. 2010 Nov 3;102(21):1637-52. doi: 10.1093/jnci/djq361. Epub 2010 Oct 8.


Analysis of expression of drug resistance-linked ABC transporters in cancer cells by quantitative RT-PCR.

Calcagno AM, Ambudkar SV.

Methods Mol Biol. 2010;637:121-32. doi: 10.1007/978-1-60761-700-6_6.


Molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells.

Calcagno AM, Ambudkar SV.

Methods Mol Biol. 2010;596:77-93. doi: 10.1007/978-1-60761-416-6_5.


Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database.

Orina JN, Calcagno AM, Wu CP, Varma S, Shih J, Lin M, Eichler G, Weinstein JN, Pommier Y, Ambudkar SV, Gottesman MM, Gillet JP.

Mol Cancer Ther. 2009 Jul;8(7):2057-66. doi: 10.1158/1535-7163.MCT-09-0256. Epub 2009 Jul 7.


Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies.

Wu CP, Calcagno AM, Ambudkar SV.

Curr Mol Pharmacol. 2008 Jun;1(2):93-105. Review.


Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.

Calcagno AM, Fostel JM, To KK, Salcido CD, Martin SE, Chewning KJ, Wu CP, Varticovski L, Bates SE, Caplen NJ, Ambudkar SV.

Br J Cancer. 2008 May 6;98(9):1515-24. doi: 10.1038/sj.bjc.6604334. Epub 2008 Apr 1.


Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics.

Wright MH, Calcagno AM, Salcido CD, Carlson MD, Ambudkar SV, Varticovski L.

Breast Cancer Res. 2008;10(1):R10. doi: 10.1186/bcr1855. Epub 2008 Feb 1.


Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter.

Wu CP, Shukla S, Calcagno AM, Hall MD, Gottesman MM, Ambudkar SV.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3287-96.


ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions.

Calcagno AM, Kim IW, Wu CP, Shukla S, Ambudkar SV.

Curr Drug Deliv. 2007 Oct;4(4):324-33. Review.


A "silent" polymorphism in the MDR1 gene changes substrate specificity.

Kimchi-Sarfaty C, Oh JM, Kim IW, Sauna ZE, Calcagno AM, Ambudkar SV, Gottesman MM.

Science. 2007 Jan 26;315(5811):525-8. Epub 2006 Dec 21. Erratum in: Science. 2011 oCT 7;334(6052):39. Science. 2007 Nov 30;318(5855):1382-3.


Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor.

Seamon JA, Rugg CA, Emanuel S, Calcagno AM, Ambudkar SV, Middleton SA, Butler J, Borowski V, Greenberger LM.

Mol Cancer Ther. 2006 Oct;5(10):2459-67.


Comparison of drug transporter levels in normal colon, colon cancer, and Caco-2 cells: impact on drug disposition and discovery.

Calcagno AM, Ludwig JA, Fostel JM, Gottesman MM, Ambudkar SV.

Mol Pharm. 2006 Jan-Feb;3(1):87-93.


Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

Wu CP, Calcagno AM, Hladky SB, Ambudkar SV, Barrand MA.

FEBS J. 2005 Sep;272(18):4725-40.


Candida glabrata Ste11 is involved in adaptation to hypertonic stress, maintenance of wild-type levels of filamentation and plays a role in virulence.

Calcagno AM, Bignell E, Rogers TR, Jones MD, Mühlschlegel FA, Haynes K.

Med Mycol. 2005 Jun;43(4):355-64.


Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.

Bignell E, Negrete-Urtasun S, Calcagno AM, Arst HN Jr, Rogers T, Haynes K.

Infect Immun. 2005 Aug;73(8):5204-7.


Modulation of cell adhesion molecules in various epithelial cell lines after treatment with PP2.

Calcagno AM, Fostel JM, Orchekowski RP, Alston JT, Mattes WB, Siahaan TJ, Ware JA.

Mol Pharm. 2005 May-Jun;2(3):170-84.


The Aspergillus pH-responsive transcription factor PacC regulates virulence.

Bignell E, Negrete-Urtasun S, Calcagno AM, Haynes K, Arst HN Jr, Rogers T.

Mol Microbiol. 2005 Feb;55(4):1072-84.


Effects of an E-cadherin-derived peptide on the gene expression of Caco-2 cells.

Calcagno AM, Fostel JM, Reyner EL, Sinaga E, Alston JT, Mattes WB, Siahaan TJ, Ware JA.

Pharm Res. 2004 Nov;21(11):2085-94.


Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence.

Kamran M, Calcagno AM, Findon H, Bignell E, Jones MD, Warn P, Hopkins P, Denning DW, Butler G, Rogers T, Mühlschlegel FA, Haynes K.

Eukaryot Cell. 2004 Apr;3(2):546-52.


Cloning and expression analysis of the ornithine decarboxylase gene (PbrODC) of the pathogenic fungus Paracoccidioides brasiliensis.

Niño-Vega GA, Sorais F, Calcagno AM, Ruiz-Herrera J, Martínez-Espinoza AD, San-Blas G.

Yeast. 2004 Feb;21(3):211-8.


Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation.

Calcagno AM, Bignell E, Warn P, Jones MD, Denning DW, Mühlschlegel FA, Rogers TR, Haynes K.

Mol Microbiol. 2003 Nov;50(4):1309-18.


N-cadherin involvement in the heterotypic adherence of malignant T-cells to epithelia.

Makagiansar IT, Yusuf-Makagiansar H, Ikesue A, Calcagno AM, Murray JS, Siahaan TJ.

Mol Cell Biochem. 2002 Apr;233(1-2):1-8.


RFLP analysis reveals marked geographical isolation between strains of Paracoccidioides brasiliensis.

Niño-Vega GA, Calcagno AM, San-Blas G, San-Blas F, Gooday GW, Gow NA.

Med Mycol. 2000 Dec;38(6):437-41.


Lysis of Paracoccidioides brasiliensis by Zygosporium geminatum.

San-Blas G, Moreno B, Calcagno AM, San-Blas F.

Med Mycol. 1998 Apr;36(2):75-9.


Geographic discrimination of Paracoccidioides brasiliensis strains by randomly amplified polymorphic DNA analysis.

Calcagno AM, Niño-Vega G, San-Blas F, San-Blas G.

J Clin Microbiol. 1998 Jun;36(6):1733-6.


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