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Items: 22

1.

Novel Inhaled Pan-JAK Inhibitor, LAS194046, Reduces Allergen-Induced Airway Inflammation, Late Asthmatic Response, and pSTAT Activation in Brown Norway Rats.

Calbet M, Ramis I, Calama E, Carreño C, Paris S, Maldonado M, Orellana A, Calaf E, Pauta M, De Alba J, Bach J, Miralpeix M.

J Pharmacol Exp Ther. 2019 Aug;370(2):137-147. doi: 10.1124/jpet.119.256263. Epub 2019 May 13.

PMID:
31085698
2.

In vitro anti-inflammatory effects of AZD8999, a novel bifunctional muscarinic acetylcholine receptor antagonist /β2-adrenoceptor agonist (MABA) compound in neutrophils from COPD patients.

Milara J, Contreras S, de Diego A, Calbet M, Aparici M, Morcillo E, Miralpeix M, Cortijo J.

PLoS One. 2019 Jan 4;14(1):e0210188. doi: 10.1371/journal.pone.0210188. eCollection 2019.

3.

Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases.

Erra M, Taltavull J, Bernal FJ, Caturla JF, Carrascal M, Pagès L, Mir M, Espinosa S, Gràcia J, Domínguez M, Sabaté M, Paris S, Maldonado M, Hernández B, Bravo M, Calama E, Miralpeix M, Lehner MD, Calbet M.

J Med Chem. 2018 Nov 8;61(21):9551-9567. doi: 10.1021/acs.jmedchem.8b00873. Epub 2018 Oct 29.

PMID:
30351000
4.

PI3K, p38 and JAK/STAT signalling in bronchial tissue from patients with asthma following allergen challenge.

Southworth T, Mason S, Bell A, Ramis I, Calbet M, Domenech A, Prats N, Miralpeix M, Singh D.

Biomark Res. 2018 Apr 11;6:14. doi: 10.1186/s40364-018-0128-9. eCollection 2018.

5.

Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy.

Calbet M, Andrés M, Armengol C, Bravo M, Eichhorn P, López R, García-González V, Roberts R, Miralpeix M.

Pharmacol Res. 2016 Sep;111:208-216. doi: 10.1016/j.phrs.2016.06.014. Epub 2016 Jun 16.

PMID:
27317944
6.

Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists.

Buil MA, Calbet M, Castillo M, Castro J, Esteve C, Ferrer M, Forns P, González J, López S, Roberts RS, Sevilla S, Vidal B, Vidal L, Vilaseca P.

Eur J Med Chem. 2016 May 4;113:102-33. doi: 10.1016/j.ejmech.2016.02.023. Epub 2016 Feb 11.

PMID:
26922232
7.

Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: the role of a hydrogen-bond acceptor in long receptor residence times.

Alonso JA, Andrés M, Bravo M, Buil MA, Calbet M, Castro J, Eastwood PR, Esteve C, Ferrer M, Forns P, Gómez E, González J, Lozoya E, Mir M, Moreno I, Petit S, Roberts RS, Sevilla S, Vidal B, Vidal L, Vilaseca P.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5127-33. doi: 10.1016/j.bmcl.2014.08.028. Epub 2014 Aug 19.

PMID:
25437506
8.

Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: lead optimization.

Alonso JA, Andrés M, Bravo M, Calbet M, Eastwood PR, Eichhorn P, Esteve C, Ferrer M, Gómez E, González J, Mir M, Moreno I, Petit S, Roberts RS, Sevilla S, Vidal B, Vidal L, Vilaseca P, Zanuy M.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5123-6. doi: 10.1016/j.bmcl.2014.08.029. Epub 2014 Aug 19.

PMID:
25437505
9.

Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists I.

Alonso JA, Andrés M, Bravo M, Buil MA, Calbet M, Castro J, Eastwood PR, Eichhorn P, Esteve C, Gómez E, González J, Mir M, Petit S, Roberts RS, Vidal B, Vidal L, Vilaseca P, Zanuy M.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5118-22. doi: 10.1016/j.bmcl.2014.09.005. Epub 2014 Oct 15.

PMID:
25437504
10.

Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonists.

Andrés M, Buil MA, Calbet M, Casado O, Castro J, Eastwood PR, Eichhorn P, Ferrer M, Forns P, Moreno I, Petit S, Roberts RS.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5111-7. doi: 10.1016/j.bmcl.2014.08.026. Epub 2014 Aug 18.

PMID:
25437503
11.

2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists.

Andrés M, Bravo M, Buil MA, Calbet M, Castillo M, Castro J, Eichhorn P, Ferrer M, Lehner MD, Moreno I, Roberts RS, Sevilla S.

Eur J Med Chem. 2014 Jan;71:168-84. doi: 10.1016/j.ejmech.2013.10.072. Epub 2013 Nov 9.

PMID:
24292338
12.

2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists.

Andrés M, Bravo M, Buil MA, Calbet M, Castro J, Domènech T, Eichhorn P, Ferrer M, Gómez E, Lehner MD, Moreno I, Roberts RS, Sevilla S.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3349-53. doi: 10.1016/j.bmcl.2013.03.093. Epub 2013 Apr 2.

PMID:
23601708
13.

The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice.

Tarrasón G, Aulí M, Mustafa S, Dolgachev V, Domènech MT, Prats N, Domínguez M, López R, Aguilar N, Calbet M, Pont M, Milligan G, Kunkel SL, Godessart N.

Int Immunopharmacol. 2011 Nov;11(11):1773-9. doi: 10.1016/j.intimp.2011.07.004. Epub 2011 Jul 26.

PMID:
21798372
14.

What is your diagnosis? Diaphragmatic hernia.

Liste F, Alvarez-Clau AM, Carrillo JM, Gil L, Calbet MA, Balastegui MT, Monteagudo S.

J Am Vet Med Assoc. 2011 Mar 1;238(5):569-70. doi: 10.2460/javma.238.5.569. No abstract available.

PMID:
21355795
15.

Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.

Vidal B, Nueda A, Esteve C, Domenech T, Benito S, Reinoso RF, Pont M, Calbet M, López R, Cadavid MI, Loza MI, Cárdenas A, Godessart N, Beleta J, Warrellow G, Ryder H.

J Med Chem. 2007 May 31;50(11):2732-6. Epub 2007 May 1.

PMID:
17469811
16.

Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning.

Tallent MK, Fabre V, Qiu C, Calbet M, Lamp T, Baratta MV, Suzuki C, Levy CL, Siggins GR, Henriksen SJ, Criado JR, Roberts A, de Lecea L.

Mol Cell Neurosci. 2005 Nov;30(3):465-75. Epub 2005 Sep 22.

PMID:
16182561
17.

Distribution of CNT2 and ENT1 transcripts in rat brain: selective decrease of CNT2 mRNA in the cerebral cortex of sleep-deprived rats.

Guillén-Gómez E, Calbet M, Casado J, de Lecea L, Soriano E, Pastor-Anglada M, Burgaya F.

J Neurochem. 2004 Aug;90(4):883-93.

18.

A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain.

García-Frigola C, Burgaya F, Calbet M, López-Domènech G, de Lecea L, Soriano E.

Brain Res Mol Brain Res. 2004 Mar 30;122(2):133-50.

PMID:
15010206
19.

Mouse Tspan-5, a member of the tetraspanin superfamily, is highly expressed in brain cortical structures.

García-Frigola C, Burgaya F, Calbet M, de Lecea L, Soriano E.

Neuroreport. 2000 Sep 28;11(14):3181-5.

PMID:
11043545
20.

Developmental regulation of two isoforms of Ca(2+)/calmodulin-dependent protein kinase I beta in rat brain.

Løseth OP, de Lecea L, Calbet M, Danielson PE, Gautvik V, Høvring PI, Walaas SI, Gautvik KM.

Brain Res. 2000 Jun 30;869(1-2):137-45.

PMID:
10865068
21.

Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate.

Calbet M, Guadaño-Ferraz A, Spier AD, Maj M, Sutcliffe JG, Przewłocki R, de Lecea L.

Brain Res Mol Brain Res. 1999 Sep 8;72(1):55-64.

PMID:
10521599
22.

Structural and compositional determinants of cortistatin activity.

Criado JR, Li H, Jiang X, Spina M, Huitrón-Reséndiz S, Liapakis G, Calbet M, Siehler S, Henriksen SJ, Koob G, Hoyer D, Sutcliffe JG, Goodman M, de Lecea L.

J Neurosci Res. 1999 Jun 15;56(6):611-9.

PMID:
10374816

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