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Items: 6


The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans.

Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GS.

Sci Transl Med. 2019 Apr 24;11(489). pii: eaav0120. doi: 10.1126/scitranslmed.aav0120.


Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.

Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS.

Sci Transl Med. 2015 Dec 23;7(319):319ra205. doi: 10.1126/scitranslmed.aac6336. Epub 2015 Dec 23.


METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

Yang L, Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GS.

Science. 2015 Jul 31;349(6247):500-6. doi: 10.1126/science.aaa0079.


Turning off the inflammatory, but not the metabolic, flames.

Calay ES, Hotamisligil GS.

Nat Med. 2013 Mar;19(3):265-7. doi: 10.1038/nm.3114. No abstract available.


Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis.

ten Freyhaus H, Calay ES, Yalcin A, Vallerie SN, Yang L, Calay ZZ, Saatcioglu F, Hotamisligil GS.

Cell Metab. 2012 Jul 3;16(1):81-9. doi: 10.1016/j.cmet.2012.05.009. Epub 2012 Jun 14.


Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

Yang L, Li P, Fu S, Calay ES, Hotamisligil GS.

Cell Metab. 2010 Jun 9;11(6):467-78. doi: 10.1016/j.cmet.2010.04.005.

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