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Items: 16


Long-Acting IL-33 Mobilizes High-Quality Hematopoietic Stem and Progenitor Cells More Efficiently Than Granulocyte Colony-Stimulating Factor or AMD3100.

Alt C, Yuan S, Wu F, Stankovich B, Calaoagan J, Schopies S, Wu JY, Shen J, Schneider D, Zhu Y, Zhao XY, Lippow SM, Bauzon M.

Biol Blood Marrow Transplant. 2019 Aug;25(8):1475-1485. doi: 10.1016/j.bbmt.2019.05.030. Epub 2019 Jun 1.


5'-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors.

Laderoute KR, Calaoagan JM, Chao WR, Dinh D, Denko N, Duellman S, Kalra J, Liu X, Papandreou I, Sambucetti L, Boros LG.

J Biol Chem. 2014 Aug 15;289(33):22850-64. doi: 10.1074/jbc.M114.576371. Epub 2014 Jul 3.


The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity.

Machrouhi F, Ouhamou N, Laderoute K, Calaoagan J, Bukhtiyarova M, Ehrlich PJ, Klon AE.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. doi: 10.1016/j.bmcl.2010.09.088. Epub 2010 Sep 19.


5'-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat.

Jang T, Calaoagan JM, Kwon E, Samuelsson S, Recht L, Laderoute KR.

Int J Cancer. 2011 May 1;128(9):2230-9. doi: 10.1002/ijc.25558.


A novel steroidal inhibitor of estrogen-related receptor alpha (ERR alpha).

Duellman SJ, Calaoagan JM, Sato BG, Fine R, Klebansky B, Chao WR, Hobbs P, Collins N, Sambucetti L, Laderoute KR.

Biochem Pharmacol. 2010 Sep 15;80(6):819-26. doi: 10.1016/j.bcp.2010.05.024. Epub 2010 May 31.


SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK).

Laderoute KR, Calaoagan JM, Madrid PB, Klon AE, Ehrlich PJ.

Cancer Biol Ther. 2010 Jul 1;10(1):68-76. Epub 2010 Jul 26.


A novel peroxisome proliferator-activated receptor delta antagonist, SR13904, has anti-proliferative activity in human cancer cells.

Zaveri NT, Sato BG, Jiang F, Calaoagan J, Laderoute KR, Murphy BJ.

Cancer Biol Ther. 2009 Jul;8(13):1252-61. Epub 2009 Jul 7.


5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments.

Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J, Foretz M, Viollet B.

Mol Cell Biol. 2006 Jul;26(14):5336-47.


Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun.

Laderoute KR, Calaoagan JM, Knapp M, Johnson RS.

Mol Cell Biol. 2004 May;24(10):4128-37.


The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent.

Laderoute KR, Calaoagan JM, Gustafson-Brown C, Knapp AM, Li GC, Mendonca HL, Ryan HE, Wang Z, Johnson RS.

Mol Cell Biol. 2002 Apr;22(8):2515-23.


c-jun cooperates with SV40 T-antigen to sustain MMP-2 expression in immortalized cells.

Laderoute KR, Calaoagan JM, Knapp AM, Mendonca HL, Johnson RS.

Biochem Biophys Res Commun. 2001 Jun 29;284(5):1134-9.


Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor.

Laderoute KR, Alarcon RM, Brody MD, Calaoagan JM, Chen EY, Knapp AM, Yun Z, Denko NC, Giaccia AJ.

Clin Cancer Res. 2000 Jul;6(7):2941-50.


The redox-sensitive human antioxidant responsive element induces gene expression under low oxygen conditions.

Waleh NS, Calaoagan J, Murphy BJ, Knapp AM, Sutherland RM, Laderoute KR.

Carcinogenesis. 1998 Aug;19(8):1333-7.


Early responses of SiHa human squamous carcinoma cells to hypoxic signals.

Laderoute K, Calaoagan J, Mendonca H, Ausserer W, Chen E, Giaccia A, Sutherland R.

Int J Oncol. 1996 May;8(5):875-82.


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