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Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector.

Giel-Moloney M, Esteban M, Oakes BH, Vaine M, Asbach B, Wagner R, Mize GJ, Spies AG, McElrath J, Perreau M, Roger T, Ives A, Calandra T, Weiss D, Perdiguero B, Kibler KV, Jacobs B, Ding S, Tomaras GD, Montefiori DC, Ferrari G, Yates NL, Roederer M, Kao SF, Foulds KE, Mayer BT, Bennett C, Gottardo R, Parrington M, Tartaglia J, Phogat S, Pantaleo G, Kleanthous H, Pugachev KV.

Sci Rep. 2019 Dec 27;9(1):20005. doi: 10.1038/s41598-019-56550-4.


Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.

Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, Clancy CJ, Wingard JR, Lockhart SR, Groll AH, Sorrell TC, Bassetti M, Akan H, Alexander BD, Andes D, Azoulay E, Bialek R, Bradsher RW, Bretagne S, Calandra T, Caliendo AM, Castagnola E, Cruciani M, Cuenca-Estrella M, Decker CF, Desai SR, Fisher B, Harrison T, Heussel CP, Jensen HE, Kibbler CC, Kontoyiannis DP, Kullberg BJ, Lagrou K, Lamoth F, Lehrnbecher T, Loeffler J, Lortholary O, Maertens J, Marchetti O, Marr KA, Masur H, Meis JF, Morrisey CO, Nucci M, Ostrosky-Zeichner L, Pagano L, Patterson TF, Perfect JR, Racil Z, Roilides E, Ruhnke M, Prokop CS, Shoham S, Slavin MA, Stevens DA, Thompson GR, Vazquez JA, Viscoli C, Walsh TJ, Warris A, Wheat LJ, White PL, Zaoutis TE, Pappas PG.

Clin Infect Dis. 2019 Dec 5. pii: ciz1008. doi: 10.1093/cid/ciz1008. [Epub ahead of print]


Early Antimicrobial Therapy for Sepsis: Does Each Hour Really Count?

Guery B, Calandra T.

Semin Respir Crit Care Med. 2019 Aug;40(4):447-453. doi: 10.1055/s-0039-1694970. Epub 2019 Oct 4.


Understanding and Enhancing Sepsis Survivorship. Priorities for Research and Practice.

Prescott HC, Iwashyna TJ, Blackwood B, Calandra T, Chlan LL, Choong K, Connolly B, Dark P, Ferrucci L, Finfer S, Girard TD, Hodgson C, Hopkins RO, Hough CL, Jackson JC, Machado FR, Marshall JC, Misak C, Needham DM, Panigrahi P, Reinhart K, Yende S, Zafonte R, Rowan KM, Angus DC.

Am J Respir Crit Care Med. 2019 Oct 15;200(8):972-981. doi: 10.1164/rccm.201812-2383CP.


La personnalisation : une approche ancrée dans les gènes de l’infectiologie.

Bochud PY, Kaiser L, Calandra T.

Rev Med Suisse. 2019 Apr 10;15(646):763-764. French. No abstract available.


Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project.

Bassetti M, Scudeller L, Giacobbe DR, Lamoth F, Righi E, Zuccaro V, Grecchi C, Rebuffi C, Akova M, Alastruey-Izquierdo A, Arikan-Akdagli S, Azoulay E, Blot SI, Cornely OA, Lass-Flörl C, Koehler P, Cuenca-Estrella M, de Lange DW, De Rosa FG, De Waele JJ, Dimopoulos G, Garnacho-Montero J, Hoenigl M, Kanj SS, Maertens J, Martin-Loeches I, Muñoz P, Kullberg BJ, Agvald-Ohman C, Poulakou G, Rello J, Sanguinetti M, Taccone FS, Timsit JF, Torres A, Vazquez JA, Calandra T; from the Study Group for Infections in Critically Ill Patients (ESGCIP) and the Fungal Infection Study Group (EFISG) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID); European Society of Intensive Care Medicine (ESICM); European Confederation of Medical Mycology (ECMM); Mycoses Study Group Education and Research Consortium (MSGERC).

Mycoses. 2019 Apr;62(4):310-319. doi: 10.1111/myc.12869. Epub 2019 Jan 22.


Rational approach in the management of Pseudomonas aeruginosa infections.

Bassetti M, Vena A, Russo A, Croxatto A, Calandra T, Guery B.

Curr Opin Infect Dis. 2018 Dec;31(6):578-586. doi: 10.1097/QCO.0000000000000505. Review.


Antibiotics for Sepsis-Finding the Equilibrium.

Klompas M, Calandra T, Singer M.

JAMA. 2018 Oct 9;320(14):1433-1434. doi: 10.1001/jama.2018.12179. No abstract available.


Let's add invasive aspergillosis to the list of influenza complications.

Lamoth F, Calandra T.

Lancet Respir Med. 2018 Oct;6(10):733-735. doi: 10.1016/S2213-2600(18)30332-1. Epub 2018 Jul 31. No abstract available.


IRF5 Is a Key Regulator of Macrophage Response to Lipopolysaccharide in Newborns.

Schneider A, Weier M, Herderschee J, Perreau M, Calandra T, Roger T, Giannoni E.

Front Immunol. 2018 Jul 11;9:1597. doi: 10.3389/fimmu.2018.01597. eCollection 2018.


Prognostic value of quickSOFA as a predictor of 28-day mortality among febrile adult patients presenting to emergency departments in Dar es Salaam, Tanzania.

Boillat-Blanco N, Mbarack Z, Samaka J, Mlaganile T, Mamin A, Genton B, Kaiser L, Calandra T, D'Acremont V.

PLoS One. 2018 Jun 14;13(6):e0197982. doi: 10.1371/journal.pone.0197982. eCollection 2018.


Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy.

Brunel AS, Wójtowicz A, Lamoth F, Spertini O, Neofytos D, Calandra T, Marchetti O, Bochud PY.

Haematologica. 2018 Nov;103(11):e527-e530. doi: 10.3324/haematol.2018.195453. Epub 2018 Jun 7. No abstract available.


Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases.

Rello J, van Engelen TSR, Alp E, Calandra T, Cattoir V, Kern WV, Netea MG, Nseir S, Opal SM, van de Veerdonk FL, Wilcox MH, Wiersinga WJ.

Clin Microbiol Infect. 2018 Dec;24(12):1264-1272. doi: 10.1016/j.cmi.2018.03.011. Epub 2018 Mar 24.


Re: "Comparison of antipseudomonal betalactams for febrile neutropenia empiric therapy: systematic review and network metaanalysis" by Horita et al.

Averbuch D, Orasch C, Mikulska M, Livermore DM, Viscoli C, Gyssens IC, Kern WV, Klyasova G, Marchetti O, Engelhard D, Akova M, Calandra T, Cordonnier C; ECIL4 antibacterial group, a joint venture of EBMT, EORTC, ICHS, ESGICH/ESCMID and ELN.

Clin Microbiol Infect. 2018 Jun;24(6):662-663. doi: 10.1016/j.cmi.2018.01.012. Epub 2018 Feb 2. No abstract available.


Fluconazole non-susceptible breakthrough candidemia after prolonged low-dose prophylaxis: a prospective FUNGINOS study.

Orasch C, Mertz D, Garbino J, van Delden C, Emonet S, Schrenzel J, Zimmerli S, Damonti L, Mühlethaler K, Imhof A, Ruef C, Fehr J, Zbinden R, Boggian K, Bruderer T, Flückiger U, Conen A, Khanna N, Frei R, Bregenzer T, Lamoth F, Erard V, Bochud PY, Calandra T, Bille J, Marchetti O; Fungal Infection Network of Switzerland (FUNGINOS).

J Infect. 2018 May;76(5):489-495. doi: 10.1016/j.jinf.2017.12.018. Epub 2018 Jan 31.


Changes in the epidemiological landscape of invasive candidiasis.

Lamoth F, Lockhart SR, Berkow EL, Calandra T.

J Antimicrob Chemother. 2018 Jan 1;73(suppl_1):i4-i13. doi: 10.1093/jac/dkx444. Review.


Low sensitivity of qSOFA, SIRS criteria and sepsis definition to identify infected patients at risk of complication in the prehospital setting and at the emergency department triage.

Tusgul S, Carron PN, Yersin B, Calandra T, Dami F.

Scand J Trauma Resusc Emerg Med. 2017 Nov 3;25(1):108. doi: 10.1186/s13049-017-0449-y.


Fluoroquinolone prophylaxis in haematological cancer patients with neutropenia: ECIL critical appraisal of previous guidelines.

Mikulska M, Averbuch D, Tissot F, Cordonnier C, Akova M, Calandra T, Ceppi M, Bruzzi P, Viscoli C; European Conference on Infections in Leukemia (ECIL).

J Infect. 2018 Jan;76(1):20-37. doi: 10.1016/j.jinf.2017.10.009. Epub 2017 Oct 25.


Early diagnosis of invasive mould infections and disease.

Lamoth F, Calandra T.

J Antimicrob Chemother. 2017 Mar 1;72(suppl_1):i19-i28. doi: 10.1093/jac/dkx030. Review.


Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination.

Choteau L, Vancraeyneste H, Le Roy D, Dubuquoy L, Romani L, Jouault T, Poulain D, Sendid B, Calandra T, Roger T, Jawhara S.

Gut Pathog. 2017 Feb 15;9:9. doi: 10.1186/s13099-017-0158-0. eCollection 2017.


Intensive care medicine research agenda on invasive fungal infection in critically ill patients.

Bassetti M, Garnacho-Montero J, Calandra T, Kullberg B, Dimopoulos G, Azoulay E, Chakrabarti A, Kett D, Leon C, Ostrosky-Zeichner L, Sanguinetti M, Timsit JF, Richardson MD, Shorr A, Cornely OA.

Intensive Care Med. 2017 Sep;43(9):1225-1238. doi: 10.1007/s00134-017-4731-2. Epub 2017 Mar 2. Review.


Plasma Levels of Macrophage Migration Inhibitory Factor and d-Dopachrome Tautomerase Show a Highly Specific Profile in Early Life.

Roger T, Schlapbach LJ, Schneider A, Weier M, Wellmann S, Marquis P, Vermijlen D, Sweep FC, Leng L, Bucala R, Calandra T, Giannoni E.

Front Immunol. 2017 Jan 25;8:26. doi: 10.3389/fimmu.2017.00026. eCollection 2017.


[Macrophage migration inhibitory factor (MIF), a regulator of neonatal innate immune response].

Giannoni É, Schneider A, Calandra T, Roger T.

Med Sci (Paris). 2016 Dec;32(12):1062-1064. doi: 10.1051/medsci/20163212006. Epub 2017 Jan 3. French. No abstract available.


Macrophage Migration Inhibitory Factor (MIF): A Glucocorticoid Counter-Regulator within the Immune System.

Calandra T, Bucala R.

Crit Rev Immunol. 2017;37(2-6):359-370. doi: 10.1615/CritRevImmunol.v37.i2-6.90. Review.


ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients.

Tissot F, Agrawal S, Pagano L, Petrikkos G, Groll AH, Skiada A, Lass-Flörl C, Calandra T, Viscoli C, Herbrecht R.

Haematologica. 2017 Mar;102(3):433-444. doi: 10.3324/haematol.2016.152900. Epub 2016 Dec 23.


Study of Early Elevated Gas6 Plasma Level as a Predictor of Mortality in a Prospective Cohort of Patients with Sepsis.

Stalder G, Que YA, Calzavarini S, Burnier L, Kosinski C, Ballabeni P, Roger T, Calandra T, Duchosal MA, Liaudet L, Eggimann P, Angelillo-Scherrer A.

PLoS One. 2016 Oct 27;11(10):e0163542. doi: 10.1371/journal.pone.0163542. eCollection 2016.


Infectiologie et micro- biologie: entre complexité et santé publique.

Kaiser L, Calandra T.

Rev Med Suisse. 2016 Apr 13;12(514):723-4. French. No abstract available.


Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy.

Calandra T, Roberts JA, Antonelli M, Bassetti M, Vincent JL.

Crit Care. 2016 May 27;20(1):125. doi: 10.1186/s13054-016-1313-6. Review.


Advances in antibiotic therapy in the critically ill.

Vincent JL, Bassetti M, François B, Karam G, Chastre J, Torres A, Roberts JA, Taccone FS, Rello J, Calandra T, De Backer D, Welte T, Antonelli M.

Crit Care. 2016 May 17;20(1):133. doi: 10.1186/s13054-016-1285-6. Review.


Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis.

Savva A, Brouwer MC, Roger T, Valls Serón M, Le Roy D, Ferwerda B, van der Ende A, Bochud PY, van de Beek D, Calandra T.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3597-602. doi: 10.1073/pnas.1520727113. Epub 2016 Mar 14.


High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates.

Roger T, Schneider A, Weier M, Sweep FC, Le Roy D, Bernhagen J, Calandra T, Giannoni E.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E997-1005. doi: 10.1073/pnas.1514018113. Epub 2016 Feb 8.


Novel strategies for targeting innate immune responses to influenza.

Shirey KA, Lai W, Patel MC, Pletneva LM, Pang C, Kurt-Jones E, Lipsky M, Roger T, Calandra T, Tracey KJ, Al-Abed Y, Bowie AG, Fasano A, Dinarello CA, Gusovsky F, Blanco JC, Vogel SN.

Mucosal Immunol. 2016 Sep;9(5):1173-82. doi: 10.1038/mi.2015.141. Epub 2016 Jan 27.


Plant Immune Responses: Aphids Strike Back.

Reymond P, Calandra T.

Curr Biol. 2015 Jul 20;25(14):R604-6. doi: 10.1016/j.cub.2015.05.051.


[Infectious diseases and Koch's postulates: turning the page].

Kaiser L, Calandra T.

Rev Med Suisse. 2015 Apr 15;11(470):847-8. French. No abstract available.


Sepsis: a roadmap for future research.

Cohen J, Vincent JL, Adhikari NK, Machado FR, Angus DC, Calandra T, Jaton K, Giulieri S, Delaloye J, Opal S, Tracey K, van der Poll T, Pelfrene E.

Lancet Infect Dis. 2015 May;15(5):581-614. doi: 10.1016/S1473-3099(15)70112-X. Epub 2015 Apr 19. Review. Erratum in: Lancet Infect Dis. 2015 Aug;15(8):875.


Emerging single-cell technologies in immunology.

Herderschee J, Fenwick C, Pantaleo G, Roger T, Calandra T.

J Leukoc Biol. 2015 Jul;98(1):23-32. doi: 10.1189/jlb.6RU0115-020R. Epub 2015 Apr 23. Review.


Interleukin-1- and type I interferon-dependent enhanced immunogenicity of an NYVAC-HIV-1 Env-Gag-Pol-Nef vaccine vector with dual deletions of type I and type II interferon-binding proteins.

Delaloye J, Filali-Mouhim A, Cameron MJ, Haddad EK, Harari A, Goulet JP, Gomez CE, Perdiguero B, Esteban M, Pantaleo G, Roger T, Sékaly RP, Calandra T.

J Virol. 2015 Apr;89(7):3819-32. doi: 10.1128/JVI.03061-14. Epub 2015 Jan 21.


Virological and immunological characterization of novel NYVAC-based HIV/AIDS vaccine candidates expressing clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as virus-like particles.

Perdiguero B, Gómez CE, Cepeda V, Sánchez-Sampedro L, García-Arriaza J, Mejías-Pérez E, Jiménez V, Sánchez C, Sorzano CÓ, Oliveros JC, Delaloye J, Roger T, Calandra T, Asbach B, Wagner R, Kibler KV, Jacobs BL, Pantaleo G, Esteban M.

J Virol. 2015 Jan 15;89(2):970-88. doi: 10.1128/JVI.02469-14. Epub 2014 Oct 29.


A revival for immunoglobulin therapy in septic shock?

Textoris J, Calandra T, Pène F.

Intensive Care Med. 2014 Dec;40(12):1957-9. doi: 10.1007/s00134-014-3506-2. Epub 2014 Oct 30. No abstract available.


Resistance of Candida spp. to antifungal drugs in the ICU: where are we now?

Maubon D, Garnaud C, Calandra T, Sanglard D, Cornet M.

Intensive Care Med. 2014 Sep;40(9):1241-55. doi: 10.1007/s00134-014-3404-7. Epub 2014 Aug 5. Review.


Mandatory infectious diseases consultation for MRSA bacteremia is associated with reduced mortality.

Tissot F, Calandra T, Prod'hom G, Taffe P, Zanetti G, Greub G, Senn L.

J Infect. 2014 Sep;69(3):226-34. doi: 10.1016/j.jinf.2014.05.004. Epub 2014 May 15.


[Infectious disease in Switzerland: we want to continue to play in the League of Champions!].

Calandra T.

Rev Med Suisse. 2014 Apr 23;10(427):899-900. French. No abstract available.


Polymorphisms in tumor necrosis factor-α increase susceptibility to intra-abdominal Candida infection in high-risk surgical ICU patients*.

Wójtowicz A, Tissot F, Lamoth F, Orasch C, Eggimann P, Siegemund M, Zimmerli S, Flueckiger UM, Bille J, Calandra T, Marchetti O, Bochud PY; Fungal Infection Network of Switzerland (FUNGINOS).

Crit Care Med. 2014 Apr;42(4):e304-8. doi: 10.1097/CCM.0000000000000208.


What's new in antimicrobial use and resistance in critically ill patients?

Bassetti M, Nicolau DP, Calandra T.

Intensive Care Med. 2014 Mar;40(3):422-6. doi: 10.1007/s00134-013-3190-7. Epub 2013 Dec 18. No abstract available.


Candida species distribution and antifungal susceptibility testing according to European Committee on Antimicrobial Susceptibility Testing and new vs. old Clinical and Laboratory Standards Institute clinical breakpoints: a 6-year prospective candidaemia survey from the fungal infection network of Switzerland.

Orasch C, Marchetti O, Garbino J, Schrenzel J, Zimmerli S, Mühlethaler K, Pfyffer G, Ruef C, Fehr J, Zbinden R, Calandra T, Bille J; FUNGINOS.

Clin Microbiol Infect. 2014 Jul;20(7):698-705. doi: 10.1111/1469-0691.12440. Epub 2013 Dec 12.


Invasive candidiasis as a cause of sepsis in the critically ill patient.

Delaloye J, Calandra T.

Virulence. 2014 Jan 1;5(1):161-9. doi: 10.4161/viru.26187. Epub 2013 Aug 27. Review.


Deletion of the vaccinia virus gene A46R, encoding for an inhibitor of TLR signalling, is an effective approach to enhance the immunogenicity in mice of the HIV/AIDS vaccine candidate NYVAC-C.

Perdiguero B, Gómez CE, Di Pilato M, Sorzano CO, Delaloye J, Roger T, Calandra T, Pantaleo G, Esteban M.

PLoS One. 2013 Sep 17;8(9):e74831. doi: 10.1371/journal.pone.0074831. eCollection 2013.


Matrix-assisted laser desorption ionization time-of-flight mass spectrometry and PCR-based rapid diagnosis of Staphylococcus aureus bacteraemia.

Clerc O, Prod'hom G, Senn L, Jaton K, Zanetti G, Calandra T, Greub G.

Clin Microbiol Infect. 2014 Apr;20(4):355-60. doi: 10.1111/1469-0691.12329. Epub 2013 Aug 28.


β-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis.

Tissot F, Lamoth F, Hauser PM, Orasch C, Flückiger U, Siegemund M, Zimmerli S, Calandra T, Bille J, Eggimann P, Marchetti O; Fungal Infection Network of Switzerland (FUNGINOS).

Am J Respir Crit Care Med. 2013 Nov 1;188(9):1100-9. doi: 10.1164/rccm.201211-2069OC.


IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction.

Bibert S, Roger T, Calandra T, Bochud M, Cerny A, Semmo N, Duong FH, Gerlach T, Malinverni R, Moradpour D, Negro F, Müllhaupt B, Bochud PY; Swiss Hepatitis C Cohort Study.

J Exp Med. 2013 Jun 3;210(6):1109-16. doi: 10.1084/jem.20130012. Epub 2013 May 27.

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