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Items: 41


DNA methylation dynamic of bone marrow hematopoietic stem cells after allogeneic transplantation.

Trino S, Zoppoli P, Carella AM, Laurenzana I, Weisz A, Memoli D, Calice G, La Rocca F, Simeon V, Savino L, Del Vecchio L, Musto P, Caivano A, De Luca L.

Stem Cell Res Ther. 2019 May 20;10(1):138. doi: 10.1186/s13287-019-1245-6.


An update on extracellular vesicles in multiple myeloma: a focus on their role in cell-to-cell cross-talk and as potential liquid biopsy biomarkers.

De Luca L, Laurenzana I, Trino S, Lamorte D, Caivano A, Musto P.

Expert Rev Mol Diagn. 2019 Mar;19(3):249-258. doi: 10.1080/14737159.2019.1583103. Epub 2019 Feb 26.


Future in the Past: Azorella glabra Wedd. as a Source of New Natural Compounds with Antiproliferative and Cytotoxic Activity on Multiple Myeloma Cells.

Lamorte D, Faraone I, Laurenzana I, Milella L, Trino S, De Luca L, Del Vecchio L, Armentano MF, Sinisgalli C, Chiummiento L, Russo D, Bisaccia F, Musto P, Caivano A.

Int J Mol Sci. 2018 Oct 26;19(11). pii: E3348. doi: 10.3390/ijms19113348.


Use of a low-cost telecytopathology method for remote assessment of thyroid FNAs.

Costa C, Pastorello RG, Mendonça A, Tamaro C, Morais C, Barbosa B, Ribeiro KB, Caivano A, Saieg MA.

Cancer Cytopathol. 2018 Sep;126(9):767-772. doi: 10.1002/cncy.22026. Epub 2018 Sep 19.


Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies.

Laurenzana I, Lamorte D, Trino S, De Luca L, Ambrosino C, Zoppoli P, Ruggieri V, Del Vecchio L, Musto P, Caivano A, Falco G.

Stem Cells Int. 2018 May 27;2018:9863194. doi: 10.1155/2018/9863194. eCollection 2018. Review.


Magnetic Resonance Imaging of Atherosclerotic Plaque at Clinically Relevant Field Strengths (1T) by Targeting the Integrin α4β1.

Woodside DG, Tanifum EA, Ghaghada KB, Biediger RJ, Caivano AR, Starosolski ZA, Khounlo S, Bhayana S, Abbasi S, Craft JW Jr, Maxwell DS, Patel C, Stupin IV, Bakthavatsalam D, Market RV, Willerson JT, Dixon RAF, Vanderslice P, Annapragada AV.

Sci Rep. 2018 Feb 27;8(1):3733. doi: 10.1038/s41598-018-21893-x.


MicroRNAs as New Biomarkers for Diagnosis and Prognosis, and as Potential Therapeutic Targets in Acute Myeloid Leukemia.

Trino S, Lamorte D, Caivano A, Laurenzana I, Tagliaferri D, Falco G, Del Vecchio L, Musto P, De Luca L.

Int J Mol Sci. 2018 Feb 3;19(2). pii: E460. doi: 10.3390/ijms19020460. Review.


EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells.

La Rocca F, Airoldi I, Di Carlo E, Marotta P, Falco G, Simeon V, Laurenzana I, Trino S, De Luca L, Todoerti K, Villani O, Lackmann M, D'Auria F, Frassoni F, Neri A, Del Vecchio L, Musto P, Cilloni D, Caivano A.

Cell Oncol (Dordr). 2017 Oct;40(5):483-496. doi: 10.1007/s13402-017-0338-4. Epub 2017 Jul 18.


Do we need to distinguish exosomes from microvesicles in hematological malignancies?

Caivano A, Del Vecchio L, Musto P.

Leukemia. 2017 Sep;31(9):2009-2010. doi: 10.1038/leu.2017.205. Epub 2017 Jun 28. No abstract available.


Extracellular Vesicles in Hematological Malignancies: From Biology to Therapy.

Caivano A, La Rocca F, Laurenzana I, Trino S, De Luca L, Lamorte D, Del Vecchio L, Musto P.

Int J Mol Sci. 2017 Jun 2;18(6). pii: E1183. doi: 10.3390/ijms18061183. Review.


Knockdown of miR-128a induces Lin28a expression and reverts myeloid differentiation blockage in acute myeloid leukemia.

De Luca L, Trino S, Laurenzana I, Tagliaferri D, Falco G, Grieco V, Bianchino G, Nozza F, Campia V, D'Alessio F, La Rocca F, Caivano A, Villani O, Cilloni D, Musto P, Del Vecchio L.

Cell Death Dis. 2017 Jun 1;8(6):e2849. doi: 10.1038/cddis.2017.253.


Mesenchymal Stem Cell Derived Extracellular Vesicles: A Role in Hematopoietic Transplantation?

De Luca L, Trino S, Laurenzana I, Lamorte D, Caivano A, Del Vecchio L, Musto P.

Int J Mol Sci. 2017 May 9;18(5). pii: E1022. doi: 10.3390/ijms18051022. Review.


Epha3 acts as proangiogenic factor in multiple myeloma.

Caivano A, La Rocca F, Laurenzana I, Annese T, Tamma R, Famigliari U, Simeon V, Trino S, De Luca L, Villani O, Berardi S, Basile A, Vacca A, Saglio G, Del Vecchio L, Musto P, Cilloni D.

Oncotarget. 2017 May 23;8(21):34298-34309. doi: 10.18632/oncotarget.16100.


P53-MDM2 Pathway: Evidences for A New Targeted Therapeutic Approach in B-Acute Lymphoblastic Leukemia.

Trino S, De Luca L, Laurenzana I, Caivano A, Del Vecchio L, Martinelli G, Musto P.

Front Pharmacol. 2016 Dec 16;7:491. doi: 10.3389/fphar.2016.00491. eCollection 2016. Review.


A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies.

Laurenzana I, Caivano A, La Rocca F, Trino S, De Luca L, D'Alessio F, Schenone S, Falco G, Botta M, Del Vecchio L, Musto P.

Front Pharmacol. 2016 Nov 7;7:416. eCollection 2016.


MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report.

Caivano A, La Rocca F, Simeon V, Girasole M, Dinarelli S, Laurenzana I, De Stradis A, De Luca L, Trino S, Traficante A, D'Arena G, Mansueto G, Villani O, Pietrantuono G, Laurenti L, Del Vecchio L, Musto P.

Cell Oncol (Dordr). 2017 Feb;40(1):97-103. doi: 10.1007/s13402-016-0300-x. Epub 2016 Oct 19.


Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia.

De Luca L, D'Arena G, Simeon V, Trino S, Laurenzana I, Caivano A, La Rocca F, Villani O, Mansueto G, Deaglio S, Innocenti I, Laurenti L, Molica S, Pietrantuono G, De Stradis A, Del Vecchio L, Musto P.

Leuk Lymphoma. 2017 Jun;58(6):1424-1432. doi: 10.1080/10428194.2016.1243790. Epub 2016 Oct 14.


A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia.

Laurenzana I, Caivano A, Trino S, De Luca L, La Rocca F, Simeon V, Tintori C, D'Alessio F, Teramo A, Zambello R, Traficante A, Maietti M, Semenzato G, Schenone S, Botta M, Musto P, Del Vecchio L.

Oncotarget. 2016 Oct 4;7(40):65171-65184. doi: 10.18632/oncotarget.11496.


MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: a new insight in transplantation.

De Luca L, Trino S, Laurenzana I, Simeon V, Calice G, Raimondo S, Podestà M, Santodirocco M, Di Mauro L, La Rocca F, Caivano A, Morano A, Frassoni F, Cilloni D, Del Vecchio L, Musto P.

Oncotarget. 2016 Feb 9;7(6):6676-92. doi: 10.18632/oncotarget.6791.


Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine.

Simeon V, Todoerti K, La Rocca F, Caivano A, Trino S, Lionetti M, Agnelli L, De Luca L, Laurenzana I, Neri A, Musto P.

Int J Mol Sci. 2015 Jul 30;16(8):17514-34. doi: 10.3390/ijms160817514. Review.


Inverse regulation of bridging integrator 1 and BCR-ABL1 in chronic myeloid leukemia.

Trino S, De Luca L, Simeon V, Laurenzana I, Morano A, Caivano A, La Rocca F, Pietrantuono G, Bianchino G, Grieco V, Signorino E, Fragasso A, Bochicchio MT, Venturi C, Rosti G, Martinelli G, Del Vecchio L, Cilloni D, Musto P.

Tumour Biol. 2016 Jan;37(1):217-25. doi: 10.1007/s13277-015-3772-9. Epub 2015 Jul 21.


High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders.

Caivano A, Laurenzana I, De Luca L, La Rocca F, Simeon V, Trino S, D'Auria F, Traficante A, Maietti M, Izzo T, D'Arena G, Mansueto G, Pietrantuono G, Laurenti L, Musto P, Del Vecchio L.

Tumour Biol. 2015 Dec;36(12):9739-52. doi: 10.1007/s13277-015-3741-3. Epub 2015 Jul 9.


Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.

Mori M, Cau Y, Vignaroli G, Laurenzana I, Caivano A, Vullo D, Supuran CT, Botta M.

ACS Chem Biol. 2015 Sep 18;10(9):1964-9. doi: 10.1021/acschembio.5b00337. Epub 2015 Jul 1.


Lenalidomide differently modulates CD20 antigen surface expression on chronic lymphocytic leukemia B-cells.

D'Arena G, Ruggieri V, D'Auria F, La Rocca F, Simeon V, Statuto T, Caivano A, Telesca D, Del Vecchio L, Musto P.

Leuk Lymphoma. 2015;56(8):2458-9. doi: 10.3109/10428194.2014.999329. Epub 2015 Jan 29. No abstract available.


A HGF/cMET autocrine loop is operative in multiple myeloma bone marrow endothelial cells and may represent a novel therapeutic target.

Ferrucci A, Moschetta M, Frassanito MA, Berardi S, Catacchio I, Ria R, Racanelli V, Caivano A, Solimando AG, Vergara D, Maffia M, Latorre D, Rizzello A, Zito A, Ditonno P, Maiorano E, Ribatti D, Vacca A.

Clin Cancer Res. 2014 Nov 15;20(22):5796-807. doi: 10.1158/1078-0432.CCR-14-0847. Epub 2014 Sep 11.


HIF-1α of bone marrow endothelial cells implies relapse and drug resistance in patients with multiple myeloma and may act as a therapeutic target.

Ria R, Catacchio I, Berardi S, De Luisi A, Caivano A, Piccoli C, Ruggieri V, Frassanito MA, Ribatti D, Nico B, Annese T, Ruggieri S, Guarini A, Minoia C, Ditonno P, Angelucci E, Derudas D, Moschetta M, Dammacco F, Vacca A.

Clin Cancer Res. 2014 Feb 15;20(4):847-58. doi: 10.1158/1078-0432.CCR-13-1950. Epub 2013 Dec 2.


Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion.

Vanderslice P, Biediger RJ, Woodside DG, Brown WS, Khounlo S, Warier ND, Gundlach CW 4th, Caivano AR, Bornmann WG, Maxwell DS, McIntyre BW, Willerson JT, Dixon RA.

J Biol Chem. 2013 Jul 5;288(27):19414-28. doi: 10.1074/jbc.M113.479634. Epub 2013 May 23.


Integrin α2β1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cells.

Haidari M, Zhang W, Caivano A, Chen Z, Ganjehei L, Mortazavi A, Stroud C, Woodside DG, Willerson JT, Dixon RA.

J Biol Chem. 2012 Sep 21;287(39):32981-92. Epub 2012 Jul 25.


Design and characterization of a peptide mimotope of the HIV-1 gp120 bridging sheet.

Schiavone M, Fiume G, Caivano A, de Laurentiis A, Falcone C, Masci FF, Iaccino E, Mimmi S, Palmieri C, Pisano A, Pontoriero M, Rossi A, Scialdone A, Vecchio E, Andreozzi C, Trovato M, Rafay J, Ferko B, Montefiori D, Lombardi A, Morsica G, Poli G, Quinto I, Pavone V, de Berardinis P, Scala G.

Int J Mol Sci. 2012;13(5):5674-99. doi: 10.3390/ijms13055674. Epub 2012 May 10.


Co-immunization with multimeric scaffolds and DNA rapidly induces potent autologous HIV-1 neutralizing antibodies and CD8+ T cells.

Jaworski JP, Krebs SJ, Trovato M, Kovarik DN, Brower Z, Sutton WF, Waagmeester G, Sartorius R, D'Apice L, Caivano A, Doria-Rose NA, Malherbe D, Montefiori DC, Barnett S, De Berardinis P, Haigwood NL.

PLoS One. 2012;7(2):e31464. doi: 10.1371/journal.pone.0031464. Epub 2012 Feb 16.


Four proteins governing overangiogenic endothelial cell phenotype in patients with multiple myeloma are plausible therapeutic targets.

Berardi S, Caivano A, Ria R, Nico B, Savino R, Terracciano R, De Tullio G, Ferrucci A, De Luisi A, Moschetta M, Mangialardi G, Catacchio I, Basile A, Guarini A, Zito A, Ditonno P, Musto P, Dammacco F, Ribatti D, Vacca A.

Oncogene. 2012 May 3;31(18):2258-69. doi: 10.1038/onc.2011.412. Epub 2011 Oct 3.


Synthesis and evaluation of an anti-MLC1 × anti-CD90 bispecific antibody for targeting and retaining bone-marrow-derived multipotent stromal cells in infarcted myocardium.

Gundlach CW 4th, Caivano A, Cabreira-Hansen Mda G, Gahremanpour A, Brown WS, Zheng Y, McIntyre BW, Willerson JT, Dixon RA, Perin EC, Woodside DG.

Bioconjug Chem. 2011 Aug 17;22(8):1706-14. doi: 10.1021/bc200309h. Epub 2011 Aug 2.


Vaccination with filamentous bacteriophages targeting DEC-205 induces DC maturation and potent anti-tumor T-cell responses in the absence of adjuvants.

Sartorius R, Bettua C, D'Apice L, Caivano A, Trovato M, Russo D, Zanoni I, Granucci F, Mascolo D, Barba P, Del Pozzo G, De Berardinis P.

Eur J Immunol. 2011 Sep;41(9):2573-84. doi: 10.1002/eji.201141526. Epub 2011 Aug 18.


Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma.

De Luisi A, Ferrucci A, Coluccia AM, Ria R, Moschetta M, de Luca E, Pieroni L, Maffia M, Urbani A, Di Pietro G, Guarini A, Ranieri G, Ditonno P, Berardi S, Caivano A, Basile A, Cascavilla N, Capalbo S, Quarta G, Dammacco F, Ribatti D, Vacca A.

Clin Cancer Res. 2011 Apr 1;17(7):1935-46. doi: 10.1158/1078-0432.CCR-10-2381. Epub 2011 Feb 9.


A multimeric immunogen for the induction of immune memory to beta-amyloid.

Mantile F, Basile C, Cicatiello V, De Falco D, Caivano A, De Berardinis P, Prisco A.

Immunol Cell Biol. 2011 Jul;89(5):604-9. doi: 10.1038/icb.2010.134. Epub 2010 Nov 23.


HIV-1 Gag p17 presented as virus-like particles on the E2 scaffold from Geobacillus stearothermophilus induces sustained humoral and cellular immune responses in the absence of IFNγ production by CD4+ T cells.

Caivano A, Doria-Rose NA, Buelow B, Sartorius R, Trovato M, D'Apice L, Domingo GJ, Sutton WF, Haigwood NL, De Berardinis P.

Virology. 2010 Nov 25;407(2):296-305. doi: 10.1016/j.virol.2010.08.026. Epub 2010 Sep 20.


Potent in vivo suppression of inflammation by selectively targeting the high affinity conformation of integrin α4β1.

Vanderslice P, Woodside DG, Caivano AR, Decker ER, Munsch CL, Sherwood SJ, Lejeune WS, Miyamoto YJ, McIntyre BW, Tilton RG, Dixon RA.

Biochem Biophys Res Commun. 2010 Oct 1;400(4):619-24. doi: 10.1016/j.bbrc.2010.08.114. Epub 2010 Aug 31.


Comparative analysis of new innovative vaccine formulations based on the use of procaryotic display systems.

D'Apice L, Sartorius R, Caivano A, Mascolo D, Del Pozzo G, Di Mase DS, Ricca E, Li Pira G, Manca F, Malanga D, De Palma R, De Berardinis P.

Vaccine. 2007 Mar 1;25(11):1993-2000. Epub 2006 Dec 5.


Use of fusion proteins and procaryotic display systems for delivery of HIV-1 antigens: development of novel vaccines for HIV-1 infection.

De Berardinis P, Sartorius R, Caivano A, Mascolo D, Domingo GJ, Del Pozzo G, Gaubin M, Perham RN, Piatier-Tonneau D, Guardiola J.

Curr HIV Res. 2003 Oct;1(4):441-6.


Induction of specific T-helper and cytolytic responses to epitopes displayed on a virus-like protein scaffold derived from the pyruvate dehydrogenase multienzyme complex.

Domingo GJ, Caivano A, Sartorius R, Barba P, Bäckström M, Piatier-Tonneau D, Guardiola J, De Berardinis P, Perham RN.

Vaccine. 2003 Mar 28;21(13-14):1502-9.


Design of cassette vectors permitting cloning of all types of human TCR variable alpha and beta regions.

Caivano A, D'Apice L, Tiberio C, Prisco A, Acuto O, Guardiola J, De Berardinis P.

J Immunol Methods. 2001 Sep 1;255(1-2):125-34.


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