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Items: 1 to 50 of 244

1.

Antibody responses to crucial functional epitopes as a novel approach to assess immunogenicity of vaccine adjuvants.

Awasthi S, Hook LM, Swaminathan G, Cairns TM, Brooks B, Smith JS, Ditto NT, Gindy ME, Bett AJ, Espeseth AS, Cohen GH, Friedman HM.

Vaccine. 2019 Jun 27;37(29):3770-3778. doi: 10.1016/j.vaccine.2019.05.068. Epub 2019 May 29.

2.

Surface plasmon resonance (SPR) reveals direct binding of HSV glycoproteins gH/gL to gD and locates a gH/gL binding site on gD.

Cairns TM, Ditto NT, Atanasiu D, Lou H, Brooks BD, Saw WT, Eisenberg RJ, Cohen GH.

J Virol. 2019 May 15. pii: JVI.00289-19. doi: 10.1128/JVI.00289-19. [Epub ahead of print]

PMID:
31092568
3.

Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories.

Cairns TC, Zheng X, Zheng P, Sun J, Meyer V.

Biotechnol Biofuels. 2019 Apr 2;12:77. doi: 10.1186/s13068-019-1400-4. eCollection 2019. Review.

4.

Will the FAbry STabilization indEX make its way to everyday clinical practice?

Cairns T, Wanner C.

Clin Kidney J. 2019 Feb;12(1):61-64. doi: 10.1093/ckj/sfy126. Epub 2018 Dec 24.

5.

A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis.

Pepper RJ, McAdoo SP, Moran SM, Kelly D, Scott J, Hamour S, Burns A, Griffith M, Galliford J, Levy JB, Cairns TD, Gopaluni S, Jones RB, Jayne D, Little MA, Pusey CD, Salama AD.

Rheumatology (Oxford). 2019 Feb 1;58(2):373. doi: 10.1093/rheumatology/kez001. No abstract available.

PMID:
30690635
6.

Glomerular membrane attack complex is not a reliable marker of ongoing C5 activation in lupus nephritis.

Wilson HR, Medjeral-Thomas NR, Gilmore AC, Trivedi P, Seyb K, Farzaneh-Far R, Gunnarsson I, Zickert A, Cairns TD, Lightstone L, Cook HT, Pickering MC.

Kidney Int. 2019 Mar;95(3):655-665. doi: 10.1016/j.kint.2018.09.027. Epub 2019 Jan 14.

7.

Molecular Assessment of C4d-Positive Renal Transplant Biopsies Without Evidence of Rejection.

Dominy KM, Willicombe M, Al Johani T, Beckwith H, Goodall D, Brookes P, Cook HT, Cairns T, McLean A, Roufosse C.

Kidney Int Rep. 2018 Sep 18;4(1):148-158. doi: 10.1016/j.ekir.2018.09.005. eCollection 2019 Jan.

8.

Hot topics in Fabry disease.

Cairns T, Müntze J, Gernert J, Spingler L, Nordbeck P, Wanner C.

Postgrad Med J. 2018 Dec;94(1118):709-713. doi: 10.1136/postgradmedj-2018-136056. Epub 2018 Dec 17. Review.

PMID:
30559317
9.

Oral Chaperone Therapy Migalastat for Treating Fabry Disease: Enzymatic Response and Serum Biomarker Changes After 1 Year.

Müntze J, Gensler D, Maniuc O, Liu D, Cairns T, Oder D, Hu K, Lorenz K, Frantz S, Wanner C, Nordbeck P.

Clin Pharmacol Ther. 2019 May;105(5):1224-1233. doi: 10.1002/cpt.1321. Epub 2019 Jan 13.

PMID:
30506669
10.

Updating genome annotation for the microbial cell factory Aspergillus niger using gene co-expression networks.

Schäpe P, Kwon MJ, Baumann B, Gutschmann B, Jung S, Lenz S, Nitsche B, Paege N, Schütze T, Cairns TC, Meyer V.

Nucleic Acids Res. 2019 Jan 25;47(2):559-569. doi: 10.1093/nar/gky1183.

11.

Using Antibodies and Mutants To Localize the Presumptive gH/gL Binding Site on Herpes Simplex Virus gD.

Atanasiu D, Saw WT, Lazear E, Whitbeck JC, Cairns TM, Lou H, Eisenberg RJ, Cohen GH.

J Virol. 2018 Nov 27;92(24). pii: e01694-18. doi: 10.1128/JVI.01694-18. Print 2018 Dec 15.

12.

A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis.

Pepper RJ, McAdoo SP, Moran SM, Kelly D, Scott J, Hamour S, Burns A, Griffith M, Galliford J, Levy JB, Cairns TD, Gopaluni S, Jones RB, Jayne D, Little MA, Pusey CD, Salama AD.

Rheumatology (Oxford). 2019 Feb 1;58(2):260-268. doi: 10.1093/rheumatology/key288.

PMID:
30239910
13.

Comprehensive Improvement of Sample Preparation Methodologies Facilitates Dynamic Metabolomics of Aspergillus niger.

Zheng X, Yu J, Cairns TC, Zhang L, Zhang Z, Zhang Q, Zheng P, Sun J, Ma Y.

Biotechnol J. 2019 Mar;14(3):e1800315. doi: 10.1002/biot.201800315. Epub 2018 Sep 20.

PMID:
30144348
14.

Conditional Expression of the Small GTPase ArfA Impacts Secretion, Morphology, Growth, and Actin Ring Position in Aspergillus niger.

Fiedler MRM, Cairns TC, Koch O, Kubisch C, Meyer V.

Front Microbiol. 2018 May 8;9:878. doi: 10.3389/fmicb.2018.00878. eCollection 2018.

15.

How a fungus shapes biotechnology: 100 years of Aspergillus niger research.

Cairns TC, Nai C, Meyer V.

Fungal Biol Biotechnol. 2018 May 24;5:13. doi: 10.1186/s40694-018-0054-5. eCollection 2018. Review.

16.

Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs.

Hook LM, Cairns TM, Awasthi S, Brooks BD, Ditto NT, Eisenberg RJ, Cohen GH, Friedman HM.

PLoS Pathog. 2018 May 23;14(5):e1007095. doi: 10.1371/journal.ppat.1007095. eCollection 2018 May.

17.

5S rRNA Promoter for Guide RNA Expression Enabled Highly Efficient CRISPR/Cas9 Genome Editing in Aspergillus niger.

Zheng X, Zheng P, Zhang K, Cairns TC, Meyer V, Sun J, Ma Y.

ACS Synth Biol. 2018 Apr 30. doi: 10.1021/acssynbio.7b00456. [Epub ahead of print]

PMID:
29687998
18.

Long-term follow-up of a combined rituximab and cyclophosphamide regimen in renal anti-neutrophil cytoplasm antibody-associated vasculitis.

McAdoo SP, Medjeral-Thomas N, Gopaluni S, Tanna A, Mansfield N, Galliford J, Griffith M, Levy J, Cairns TD, Jayne D, Salama AD, Pusey CD.

Nephrol Dial Transplant. 2018 May 1;33(5):899. doi: 10.1093/ndt/gfy075. No abstract available.

PMID:
29617842
19.

Ofatumumab for B cell depletion in patients with systemic lupus erythematosus who are allergic to rituximab.

Masoud S, McAdoo SP, Bedi R, Cairns TD, Lightstone L.

Rheumatology (Oxford). 2018 Mar 19. doi: 10.1093/rheumatology/key042. [Epub ahead of print]

20.

Long-term follow-up of a combined rituximab and cyclophosphamide regimen in renal anti-neutrophil cytoplasm antibody-associated vasculitis.

McAdoo SP, Medjeral-Thomas N, Gopaluni S, Tanna A, Mansfield N, Galliford J, Griffith M, Levy J, Cairns TD, Jayne D, Salama AD, Pusey CD.

Nephrol Dial Transplant. 2019 Jan 1;34(1):63-73. doi: 10.1093/ndt/gfx378.

21.

Hydroxycloroquine blood concentration in lupus nephritis: a determinant of disease outcome?

Cunha C, Alexander S, Ashby D, Lee J, Chusney G, Cairns TD, Lightstone L.

Nephrol Dial Transplant. 2018 Sep 1;33(9):1604-1610. doi: 10.1093/ndt/gfx318.

22.

A silver bullet in a golden age of functional genomics: the impact of Agrobacterium-mediated transformation of fungi.

Idnurm A, Bailey AM, Cairns TC, Elliott CE, Foster GD, Ianiri G, Jeon J.

Fungal Biol Biotechnol. 2017 Sep 26;4:6. doi: 10.1186/s40694-017-0035-0. eCollection 2017. Review.

23.

Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper.

Meyer V, Andersen MR, Brakhage AA, Braus GH, Caddick MX, Cairns TC, de Vries RP, Haarmann T, Hansen K, Hertz-Fowler C, Krappmann S, Mortensen UH, Peñalva MA, Ram AFJ, Head RM.

Fungal Biol Biotechnol. 2016 Aug 31;3:6. doi: 10.1186/s40694-016-0024-8. eCollection 2016.

24.
25.

Positive antineutrophil cytoplasmic antibody serology in patients with lupus nephritis is associated with distinct histopathologic features on renal biopsy.

Turner-Stokes T, Wilson HR, Morreale M, Nunes A, Cairns T, Cook HT, Pusey CD, Tarzi RM, Lightstone L.

Kidney Int. 2017 Nov;92(5):1223-1231. doi: 10.1016/j.kint.2017.04.029. Epub 2017 Jul 24.

26.

Artefactual ST elevation with Mindray monitors.

Cairns T, de Courcy J.

Anaesthesia. 2017 Jun;72(6):789. doi: 10.1111/anae.13847. No abstract available.

27.

Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging.

Cairns TM, Ditto NT, Lou H, Brooks BD, Atanasiu D, Eisenberg RJ, Cohen GH.

PLoS Pathog. 2017 Jun 14;13(6):e1006430. doi: 10.1371/journal.ppat.1006430. eCollection 2017 Jun.

28.

Long-term outcome in biopsy-proven acute interstitial nephritis treated with steroids.

Prendecki M, Tanna A, Salama AD, Tam FW, Cairns T, Taube D, Cook HT, Ashby D, Duncan ND, Pusey CD.

Clin Kidney J. 2017 Apr;10(2):233-239. doi: 10.1093/ckj/sfw116. Epub 2016 Dec 24.

29.

Mycophenolate mofetil therapy in immunoglobulin A nephropathy: histological changes after treatment.

Beckwith H, Medjeral-Thomas N, Galliford J, Griffith M, Levy J, Lightstone L, Palmer A, Roufosse C, Pusey C, Cook HT, Cairns T.

Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i123-i128. doi: 10.1093/ndt/gfw326.

30.

Altered expression of signalling lymphocyte activation molecule receptors in T-cells from lupus nephritis patients-a potential biomarker of disease activity.

Stratigou V, Doyle AF, Carlucci F, Stephens L, Foschi V, Castelli M, McKenna N, Cook HT, Lightstone L, Cairns TD, Pickering MC, Botto M.

Rheumatology (Oxford). 2017 Jul 1;56(7):1206-1216. doi: 10.1093/rheumatology/kex078.

31.

Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs.

Persson J, Zhang Y, Olafsdottir TA, Thörn K, Cairns TM, Wegmann F, Sattentau QJ, Eisenberg RJ, Cohen GH, Harandi AM.

Front Immunol. 2016 Dec 26;7:640. doi: 10.3389/fimmu.2016.00640. eCollection 2016.

32.

Secondary metabolite arsenal of an opportunistic pathogenic fungus.

Bignell E, Cairns TC, Throckmorton K, Nierman WC, Keller NP.

Philos Trans R Soc Lond B Biol Sci. 2016 Dec 5;371(1709). pii: 20160023. doi: 10.1098/rstb.2016.0023.

33.

Highly active promoters and native secretion signals for protein production during extremely low growth rates in Aspergillus niger.

Wanka F, Arentshorst M, Cairns TC, Jørgensen T, Ram AF, Meyer V.

Microb Cell Fact. 2016 Aug 20;15(1):145. doi: 10.1186/s12934-016-0543-2.

34.
35.

The natural history of immunoglobulin M nephropathy in adults.

Connor TM, Aiello V, Griffith M, Cairns T, Roufosse CA, Cook HT, Pusey CD.

Nephrol Dial Transplant. 2017 May 1;32(5):823-829. doi: 10.1093/ndt/gfw063.

36.

Ofatumumab for B cell depletion therapy in ANCA-associated vasculitis: a single-centre case series.

McAdoo SP, Bedi R, Tarzi R, Griffith M, Pusey CD, Cairns TD.

Rheumatology (Oxford). 2016 Aug;55(8):1437-42. doi: 10.1093/rheumatology/kew199. Epub 2016 Apr 19.

37.

Tubuloreticular Inclusions in Renal Allografts Associate with Viral Infections and Donor-Specific Antibodies.

Willicombe M, Moss J, Moran L, Brookes P, Santos-Nunez E, McLean AG, Cairns T, Taube D, Cook TH, Roufosse C.

J Am Soc Nephrol. 2016 Jul;27(7):2188-95. doi: 10.1681/ASN.2015050478. Epub 2015 Nov 27.

38.

Tet-on, or Tet-off, that is the question: Advanced conditional gene expression in Aspergillus.

Wanka F, Cairns T, Boecker S, Berens C, Happel A, Zheng X, Sun J, Krappmann S, Meyer V.

Fungal Genet Biol. 2016 Apr;89:72-83. doi: 10.1016/j.fgb.2015.11.003. Epub 2015 Nov 10.

PMID:
26555930
39.

New and Improved Techniques for the Study of Pathogenic Fungi.

Cairns TC, Studholme DJ, Talbot NJ, Haynes K.

Trends Microbiol. 2016 Jan;24(1):35-50. doi: 10.1016/j.tim.2015.09.008. Epub 2015 Nov 5. Review.

PMID:
26549580
40.

Eculizumab as rescue therapy in severe resistant lupus nephritis.

Pickering MC, Ismajli M, Condon MB, McKenna N, Hall AE, Lightstone L, Terence Cook H, Cairns TD.

Rheumatology (Oxford). 2015 Dec;54(12):2286-8. doi: 10.1093/rheumatology/kev307. Epub 2015 Aug 27. No abstract available.

41.

Patient-Specific Neutralizing Antibody Responses to Herpes Simplex Virus Are Attributed to Epitopes on gD, gB, or Both and Can Be Type Specific.

Cairns TM, Huang ZY, Gallagher JR, Lin Y, Lou H, Whitbeck JC, Wald A, Cohen GH, Eisenberg RJ.

J Virol. 2015 Sep;89(18):9213-31. doi: 10.1128/JVI.01213-15. Epub 2015 Jun 24.

42.

A suite of Gateway® compatible ternary expression vectors for functional analysis in Zymoseptoria tritici.

Sidhu YS, Chaudhari YK, Usher J, Cairns TC, Csukai M, Haynes K.

Fungal Genet Biol. 2015 Jun;79:180-5. doi: 10.1016/j.fgb.2015.03.021.

PMID:
26092805
43.

Construction and high-throughput phenotypic screening ofZymoseptoria tritici over-expression strains.

Cairns TC, Sidhu YS, Chaudhari YK, Talbot NJ, Studholme DJ, Haynes K.

Fungal Genet Biol. 2015 Jun;79:110-7. doi: 10.1016/j.fgb.2015.04.013.

44.

Exploitation of sulfonylurea resistance marker and non-homologous end joining mutants for functional analysis in Zymoseptoria tritici.

Sidhu YS, Cairns TC, Chaudhari YK, Usher J, Talbot NJ, Studholme DJ, Csukai M, Haynes K.

Fungal Genet Biol. 2015 Jun;79:102-9. doi: 10.1016/j.fgb.2015.04.015.

45.

Correction: The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis.

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.

PLoS Pathog. 2015 Jun 18;11(6):e1004943. doi: 10.1371/journal.ppat.1004943. eCollection 2015 Jun. No abstract available.

46.

Necrotizing and crescentic glomerulonephritis presenting with preserved renal function in patients with underlying multisystem autoimmune disease: a retrospective case series.

McAdoo SP, Tanna A, Randone O, Tam FW, Tarzi RM, Levy JB, Griffith M, Lightstone L, Cook HT, Cairns T, Pusey CD.

Rheumatology (Oxford). 2015 Jun;54(6):1025-32. doi: 10.1093/rheumatology/keu445. Epub 2014 Nov 26.

47.

A modified recombineering protocol for the genetic manipulation of gene clusters in Aspergillus fumigatus.

Alcazar-Fuoli L, Cairns T, Lopez JF, Zonja B, Pérez S, Barceló D, Igarashi Y, Bowyer P, Bignell E.

PLoS One. 2014 Nov 5;9(11):e111875. doi: 10.1371/journal.pone.0111875. eCollection 2014.

48.

The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis.

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.

PLoS Pathog. 2014 Oct 16;10(10):e1004413. doi: 10.1371/journal.ppat.1004413. eCollection 2014 Oct. Erratum in: PLoS Pathog. 2015 Apr;11(4):e1004802. PLoS Pathog. 2015 Jun 18;11(6):e1004943.

49.

Dissection of the antibody response against herpes simplex virus glycoproteins in naturally infected humans.

Cairns TM, Huang ZY, Whitbeck JC, Ponce de Leon M, Lou H, Wald A, Krummenacher C, Eisenberg RJ, Cohen GH.

J Virol. 2014 Nov;88(21):12612-22. doi: 10.1128/JVI.01930-14. Epub 2014 Aug 20.

50.

Long-term outcome of anti-neutrophil cytoplasm antibody-associated glomerulonephritis: evaluation of the international histological classification and other prognostic factors.

Tanna A, Guarino L, Tam FW, Rodriquez-Cubillo B, Levy JB, Cairns TD, Griffith M, Tarzi RM, Caplin B, Salama AD, Cook T, Pusey CD.

Nephrol Dial Transplant. 2015 Jul;30(7):1185-92. doi: 10.1093/ndt/gfu237. Epub 2014 Jul 12.

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