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Items: 1 to 50 of 52

1.

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.

Amelio I, Mancini M, Petrova V, Cairns RA, Vikhreva P, Nicolai S, Marini A, Antonov AA, Le Quesne J, Baena Acevedo JD, Dudek K, Sozzi G, Pastorino U, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10869-E10878. doi: 10.1073/pnas.1808314115. Epub 2018 Oct 31.

2.

Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas.

Lemonnier F, Poullot E, Dupuy A, Couronné L, Martin N, Scourzic L, Fataccioli V, Bruneau J, Cairns RA, Mak TW, Bernard OA, de Leval L, Gaulard P.

Haematologica. 2018 Mar;103(3):e115-e118. doi: 10.3324/haematol.2017.167973. Epub 2017 Dec 14. No abstract available.

3.

Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.

Leung E, Cairns RA, Chaudary N, Vellanki RN, Kalliomaki T, Moriyama EH, Mujcic H, Wilson BC, Wouters BG, Hill R, Milosevic M.

BMC Cancer. 2017 Jun 15;17(1):418. doi: 10.1186/s12885-017-3402-6.

4.

Fire and water: Tumor cell adaptation to metabolic conditions.

Cairns RA, Mak TW.

Exp Cell Res. 2017 Jul 15;356(2):204-208. doi: 10.1016/j.yexcr.2017.04.029. Epub 2017 Apr 27. Review.

PMID:
28457987
5.

IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization.

Ye J, Gu Y, Zhang F, Zhao Y, Yuan Y, Hao Z, Sheng Y, Li WY, Wakeham A, Cairns RA, Mak TW.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):292-297. doi: 10.1073/pnas.1618605114. Epub 2016 Dec 23.

6.

S-2HG is an immunometabolite that shapes the T-cell response.

Cairns RA, Mak TW.

Cell Death Differ. 2017 Feb;24(2):195-196. doi: 10.1038/cdd.2016.149. Epub 2016 Dec 23. No abstract available.

7.

The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.

Lemonnier F, Cairns RA, Inoue S, Li WY, Dupuy A, Broutin S, Martin N, Fataccioli V, Pelletier R, Wakeham A, Snow BE, de Leval L, Pujals A, Haioun C, Paci A, Tobin ER, Narayanaswamy R, Yen K, Jin S, Gaulard P, Mak TW.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15084-15089. doi: 10.1073/pnas.1617929114. Epub 2016 Dec 12.

8.

An Alternative Sugar Fuels AML.

Cairns RA, Mak TW.

Cancer Cell. 2016 Nov 14;30(5):660-662. doi: 10.1016/j.ccell.2016.10.015.

9.

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW.

Cancer Cell. 2016 Aug 8;30(2):337-348. doi: 10.1016/j.ccell.2016.05.018. Epub 2016 Jul 14.

10.

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.

Agnihotri S, Golbourn B, Huang X, Remke M, Younger S, Cairns RA, Chalil A, Smith CA, Krumholtz SL, Mackenzie D, Rakopoulos P, Ramaswamy V, Taccone MS, Mischel PS, Fuller GN, Hawkins C, Stanford WL, Taylor MD, Zadeh G, Rutka JT.

Cancer Res. 2016 Aug 15;76(16):4708-19. doi: 10.1158/0008-5472.CAN-15-3079. Epub 2016 Jun 20.

11.

Lung Cancer Resets the Liver's Metabolic Clock.

Cairns RA, Mak TW.

Cell Metab. 2016 May 10;23(5):767-9. doi: 10.1016/j.cmet.2016.04.028.

12.

Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.

Hao Z, Cairns RA, Inoue S, Li WY, Sheng Y, Lemonnier F, Wakeham A, Snow BE, Dominguez-Brauer C, Ye J, Larsen DM, Straley KS, Tobin ER, Narayanaswamy R, Gaulard P, Mak TW.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1387-92. doi: 10.1073/pnas.1525354113. Epub 2016 Jan 19.

13.

ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.

Jin S, Chen J, Chen L, Histen G, Lin Z, Gross S, Hixon J, Chen Y, Kung C, Chen Y, Fu Y, Lu Y, Lin H, Cai X, Yang H, Cairns RA, Dorsch M, Su SM, Biller S, Mak TW, Cang Y.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9088-93. doi: 10.1073/pnas.1510757112. Epub 2015 Jul 6.

14.

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW.

Cell Death Differ. 2015 Nov;22(11):1837-45. doi: 10.1038/cdd.2015.38. Epub 2015 Apr 17.

15.

Drivers of the Warburg phenotype.

Cairns RA.

Cancer J. 2015 Mar-Apr;21(2):56-61. doi: 10.1097/PPO.0000000000000106. Review.

PMID:
25815844
16.

Mutant IDH is sufficient to initiate enchondromatosis in mice.

Hirata M, Sasaki M, Cairns RA, Inoue S, Puviindran V, Li WY, Snow BE, Jones LD, Wei Q, Sato S, Tang YJ, Nadesan P, Rockel J, Whetstone H, Poon R, Weng A, Gross S, Straley K, Gliser C, Xu Y, Wunder J, Mak TW, Alman BA.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2829-34. doi: 10.1073/pnas.1424400112. Epub 2015 Feb 17.

17.

Backward wave cyclotron-maser emission in the auroral magnetosphere.

Speirs DC, Bingham R, Cairns RA, Vorgul I, Kellett BJ, Phelps AD, Ronald K.

Phys Rev Lett. 2014 Oct 10;113(15):155002. Epub 2014 Oct 7.

18.

Early atlantoaxial subluxation in enthesitis-related arthritis.

Enazi AA, Morishita K, Cairns RA, Tucker L, Cabral D, Petty R, Guzman J.

J Rheumatol. 2014 Jun;41(6):1190-1. doi: 10.3899/jrheum.131206. No abstract available.

PMID:
24882848
19.

Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities.

Cairns RA, Mak TW.

Cancer Discov. 2013 Jul;3(7):730-41. doi: 10.1158/2159-8290.CD-13-0083. Epub 2013 Jun 24. Review.

20.

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.

Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW.

Genes Dev. 2012 Sep 15;26(18):2038-49. doi: 10.1101/gad.198200.112. Epub 2012 Aug 27.

21.

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters.

Lemonnier F, Couronné L, Parrens M, Jaïs JP, Travert M, Lamant L, Tournillac O, Rousset T, Fabiani B, Cairns RA, Mak T, Bastard C, Bernard OA, de Leval L, Gaulard P.

Blood. 2012 Aug 16;120(7):1466-9. doi: 10.1182/blood-2012-02-408542. Epub 2012 Jul 3.

22.

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma.

Cairns RA, Iqbal J, Lemonnier F, Kucuk C, de Leval L, Jais JP, Parrens M, Martin A, Xerri L, Brousset P, Chan LC, Chan WC, Gaulard P, Mak TW.

Blood. 2012 Feb 23;119(8):1901-3. doi: 10.1182/blood-2011-11-391748. Epub 2012 Jan 3.

23.

Cancer cell metabolism.

Cairns RA, Harris I, McCracken S, Mak TW.

Cold Spring Harb Symp Quant Biol. 2011;76:299-311. doi: 10.1101/sqb.2011.76.012856. Epub 2011 Dec 12. Review.

PMID:
22156302
24.

Childhood osseous sarcoidosis presenting with headache and lytic skull lesions.

Alqanatish JT, Houghton KM, Cairns RA.

J Clin Rheumatol. 2011 Dec;17(8):455. doi: 10.1097/RHU.0b013e31823b15ca. No abstract available.

PMID:
22126806
25.

IDH mutation status in prostate cancer.

Ghiam AF, Cairns RA, Thoms J, Dal Pra A, Ahmed O, Meng A, Mak TW, Bristow RG.

Oncogene. 2012 Aug 16;31(33):3826. doi: 10.1038/onc.2011.546. Epub 2011 Nov 28. No abstract available.

PMID:
22120718
26.

Production of picosecond, kilojoule, and petawatt laser pulses via Raman amplification of nanosecond pulses.

Trines RM, Fiúza F, Bingham R, Fonseca RA, Silva LO, Cairns RA, Norreys PA.

Phys Rev Lett. 2011 Sep 2;107(10):105002. Epub 2011 Aug 31.

PMID:
21981507
27.

Regulation of cancer cell metabolism.

Cairns RA, Harris IS, Mak TW.

Nat Rev Cancer. 2011 Feb;11(2):85-95. doi: 10.1038/nrc2981. Review.

PMID:
21258394
28.

Infrapatellar bursitis in children with juvenile idiopathic arthritis: a case series.

Alqanatish JT, Petty RE, Houghton KM, Guzman J, Tucker LB, Cabral DA, Cairns RA.

Clin Rheumatol. 2011 Feb;30(2):263-7. doi: 10.1007/s10067-010-1620-2. Epub 2010 Nov 19.

PMID:
21088860
29.

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.

Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG, Sasaki M, Jin S, Schenkein DP, Su SM, Dang L, Fantin VR, Mak TW.

J Exp Med. 2010 Feb 15;207(2):339-44. doi: 10.1084/jem.20092506. Epub 2010 Feb 8.

30.

Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104.

Cairns RA, Bennewith KL, Graves EE, Giaccia AJ, Chang DT, Denko NC.

Clin Cancer Res. 2009 Dec 1;15(23):7170-4. doi: 10.1158/1078-0432.CCR-09-1676. Epub 2009 Nov 17.

31.

Dust-acoustic shock waves due to strong correlation among arbitrarily charged dust.

Mamun AA, Cairns RA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2009 May;79(5 Pt 2):055401. Epub 2009 May 21.

PMID:
19518514
32.

Cystic bone lesions in a boy with Darier disease: a magnetic resonance imaging assessment.

Ramien ML, Prendiville JS, Brown KL, Cairns RA.

J Am Acad Dermatol. 2009 Jun;60(6):1062-6. doi: 10.1016/j.jaad.2008.10.049.

PMID:
19467380
33.

Cyclotron maser radiation from an inhomogeneous plasma.

Cairns RA, Vorgul I, Bingham R.

Phys Rev Lett. 2008 Nov 21;101(21):215003. Epub 2008 Nov 20.

PMID:
19113419
34.

Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy.

Cairns RA, Papandreou I, Sutphin PD, Denko NC.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9445-50. Epub 2007 May 15.

35.

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC.

Cell Metab. 2006 Mar;3(3):187-97.

36.

Efficiency and energy spread in laser-wakefield acceleration.

Reitsma AJ, Cairns RA, Bingham R, Jaroszynski DA.

Phys Rev Lett. 2005 Mar 4;94(8):085004. Epub 2005 Mar 4.

PMID:
15783901
37.

A fluorescent orthotopic model of metastatic cervical carcinoma.

Cairns RA, Hill RP.

Clin Exp Metastasis. 2004;21(3):275-81.

PMID:
15387378
38.
39.

Molecular mechanisms of tumor invasion and metastasis: an integrated view.

Cairns RA, Khokha R, Hill RP.

Curr Mol Med. 2003 Nov;3(7):659-71. Review.

PMID:
14601640
40.

Role of parallel flow in the improved mode on the STOR-M tokamak.

Sen S, Xiao C, Hirose A, Cairns RA.

Phys Rev Lett. 2002 May 6;88(18):185001. Epub 2002 Apr 17.

PMID:
12005688
41.

Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors.

Cairns RA, Kalliomaki T, Hill RP.

Cancer Res. 2001 Dec 15;61(24):8903-8.

42.

Knee magnetic resonance imaging in childhood chronic monarthritis.

Ramsey SE, Cairns RA, Cabral DA, Malleson PN, Bray HJ, Petty RE.

J Rheumatol. 1999 Oct;26(10):2238-43.

PMID:
10529147
43.

Congenital-infantile fibrosarcoma: magnetic resonance imaging findings.

Lee MJ, Cairns RA, Munk PL, Poon PY.

Can Assoc Radiol J. 1996 Apr;47(2):121-5. Review.

PMID:
8612084
44.

Osteosarcoma in a 19-month-old girl.

Graham NJ, Cairns RA, Anderson RA.

Can Assoc Radiol J. 1996 Feb;47(1):33-5.

PMID:
8548467
45.

An unusual case of mixed sclerosing bone dystrophy presenting with morning stiffness and joint swelling in childhood: a case report.

Foeldvari I, Cairns RA, Petty RE, Cabral DA.

Clin Exp Rheumatol. 1995 Jul-Aug;13(4):525-8. Review.

PMID:
7586791
46.

Obstructive lung disease in children after allogeneic bone marrow transplantation: evaluation with high-resolution CT.

Sargent MA, Cairns RA, Murdoch MJ, Nadel HR, Wensley D, Schultz KR.

AJR Am J Roentgenol. 1995 Mar;164(3):693-6.

PMID:
7863896
47.

Atlantoaxial subluxation in children with seronegative enthesopathy and arthropathy syndrome: 2 case reports and a review of the literature.

Foster HE, Cairns RA, Burnell RH, Malleson PN, Roberton DM, Tredwell SJ, Petty RE, Cabral DA.

J Rheumatol. 1995 Mar;22(3):548-51.

PMID:
7783079
48.

Pediatric case of the day. Hypogenetic lung syndrome (scimitar syndrome) with right-sided congenital diaphragmatic hernia.

Cairns RA, Culham JA, Stringer DA, Murphy JJ.

Radiographics. 1995 Mar;15(2):496-9. No abstract available.

PMID:
7761655
49.

Pediatric case of the day. Congenital fibrosarcoma (CFS).

Fink AM, Stringer DA, Cairns RA, Nadel HR, Magee JF.

Radiographics. 1995 Jan;15(1):243-6. No abstract available.

PMID:
7899610
50.

Comparison of stimulable phosphor technology and conventional screen-film technology in pediatric scoliosis.

Stringer DA, Cairns RA, Poskitt KJ, Bray H, Milner R, Kennedy B.

Pediatr Radiol. 1994;24(1):1-5.

PMID:
8008484

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