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Items: 21


A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation.

Bilsland AE, Liu Y, Turnbull A, Sumpton D, Stevenson K, Cairney CJ, Boyd SM, Roffey J, Jenkinson D, Keith WN.

Neoplasia. 2019 Sep;21(9):893-907. doi: 10.1016/j.neo.2019.07.008. Epub 2019 Aug 8.


SIAXI: Placebo-controlled, randomized, double-blind study of incobotulinumtoxinA for sialorrhea.

Jost WH, Friedman A, Michel O, Oehlwein C, Slawek J, Bogucki A, Ochudlo S, Banach M, Pagan F, Flatau-Baqué B, Csikós J, Cairney CJ, Blitzer A.

Neurology. 2019 Apr 23;92(17):e1982-e1991. doi: 10.1212/WNL.0000000000007368. Epub 2019 Mar 27.


A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds.

Cairney CJ, Godwin LS, Bilsland AE, Burns S, Stevenson KH, McGarry L, Revie J, Moore JD, Wiggins CM, Collinson RS, Mudd C, Tsonou E, Sadaie M, Bennett DC, Narita M, Torrance CJ, Keith WN.

PLoS Genet. 2017 Aug 14;13(8):e1006942. doi: 10.1371/journal.pgen.1006942. eCollection 2017 Aug.


Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland.

Wilson GJ, Hewit KD, Pallas KJ, Cairney CJ, Lee KM, Hansell CA, Stein T, Graham GJ.

Development. 2017 Jan 1;144(1):74-82. doi: 10.1242/dev.139733. Epub 2016 Nov 25.


Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.

Bilsland AE, Pugliese A, Liu Y, Revie J, Burns S, McCormick C, Cairney CJ, Bower J, Drysdale M, Narita M, Sadaie M, Keith WN.

Neoplasia. 2015 Sep;17(9):704-715. doi: 10.1016/j.neo.2015.08.009.


Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.

Sadaie M, Dillon C, Narita M, Young AR, Cairney CJ, Godwin LS, Torrance CJ, Bennett DC, Keith WN, Narita M.

Mol Biol Cell. 2015 Sep 1;26(17):2971-85. doi: 10.1091/mbc.E15-01-0003. Epub 2015 Jul 1. Erratum in: Mol Biol Cell. 2015 Oct 1;26(19):3556. Narita, Masashi [Corrected to Narita, Masako].


Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.

Iglesias JM, Cairney CJ, Ferrier RK, McDonald L, Soady K, Kendrick H, Pringle MA, Morgan RO, Martin F, Smalley MJ, Blyth K, Stein T.

PLoS One. 2015 Mar 24;10(3):e0119718. doi: 10.1371/journal.pone.0119718. eCollection 2015.


Isolation, culture, and transfection of melanocytes.

Godwin LS, Castle JT, Kohli JS, Goff PS, Cairney CJ, Keith WN, Sviderskaya EV, Bennett DC.

Curr Protoc Cell Biol. 2014 Jun 3;63:1.8.1-20. doi: 10.1002/0471143030.cb0108s63. Review.


Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.

Bilsland AE, Stevenson K, Liu Y, Hoare S, Cairney CJ, Roffey J, Keith WN.

PLoS Comput Biol. 2014 Feb 13;10(2):e1003448. doi: 10.1371/journal.pcbi.1003448. eCollection 2014 Feb.


A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion, and engraftment to bone marrow in NOD/SCID mice.

Mohanty ST, Cairney CJ, Chantry AD, Madan S, Fernandes JA, Howe SJ, Moore HD, Thompson MJ, Chen B, Thrasher A, Keith WN, Bellantuono I.

Stem Cells. 2012 Jun;30(6):1134-43. doi: 10.1002/stem.1065.


Cancer cell senescence: a new frontier in drug development.

Cairney CJ, Bilsland AE, Evans TR, Roffey J, Bennett DC, Narita M, Torrance CJ, Keith WN.

Drug Discov Today. 2012 Mar;17(5-6):269-76. doi: 10.1016/j.drudis.2012.01.019. Epub 2012 Jan 31. Review.


Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.

Bilsland AE, Cairney CJ, Keith WN.

J Cell Mol Med. 2011 Feb;15(2):179-86. doi: 10.1111/j.1582-4934.2010.01253.x. Review.


TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.

Lafferty-Whyte K, Bilsland A, Hoare SF, Burns S, Zaffaroni N, Cairney CJ, Keith WN.

Neoplasia. 2010 May;12(5):405-14.


A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.

Lafferty-Whyte K, Cairney CJ, Will MB, Serakinci N, Daidone MG, Zaffaroni N, Bilsland A, Keith WN.

Oncogene. 2009 Oct 29;28(43):3765-74. doi: 10.1038/onc.2009.238. Epub 2009 Aug 17.


A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging.

Cairney CJ, Sanguinetti G, Ranghini E, Chantry AD, Nostro MC, Bhattacharyya A, Svendsen CN, Keith WN, Bellantuono I.

Biochim Biophys Acta. 2009 Apr;1792(4):353-63. doi: 10.1016/j.bbadis.2009.01.015. Epub 2009 Feb 6.


Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms.

Lafferty-Whyte K, Cairney CJ, Jamieson NB, Oien KA, Keith WN.

Biochim Biophys Acta. 2009 Apr;1792(4):341-52. doi: 10.1016/j.bbadis.2009.02.003. Epub 2009 Feb 12. Review.


The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma.

Sitaram RT, Cairney CJ, Grabowski P, Keith WN, Hallberg B, Ljungberg B, Roos G.

Int J Cancer. 2009 Aug 15;125(4):783-90. doi: 10.1002/ijc.24335.


High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma.

Cairney CJ, Hoare SF, Daidone MG, Zaffaroni N, Keith WN.

Br J Cancer. 2008 Apr 22;98(8):1467-74. doi: 10.1038/sj.bjc.6604328. Epub 2008 Apr 15.


Telomerase redefined: integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity.

Cairney CJ, Keith WN.

Biochimie. 2008 Jan;90(1):13-23. Epub 2007 Aug 6. Review.


Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart.

Serakinci N, Christensen R, Graakjaer J, Cairney CJ, Keith WN, Alsner J, Saretzki G, Kolvraa S.

Exp Cell Res. 2007 Mar 10;313(5):1056-67. Epub 2007 Jan 8.


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