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Items: 1 to 50 of 57

1.

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.

Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.

EMBO Mol Med. 2019 Apr;11(4). pii: e9976. doi: 10.15252/emmm.201809976.

2.

The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma.

Sun X, Vaghjiani V, Jayasekara WSN, Cain JE, St John JC.

Clin Epigenetics. 2018 Dec 17;10(1):157. doi: 10.1186/s13148-018-0590-0.

3.

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing.

Lim CH, Sun Q, Ratti K, Lee SH, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus MV, Cain JE, Wang DH, Watkins DN, Millar S, Taketo MM, Myung P, Cotsarelis G, Ito M.

Nat Commun. 2018 Nov 21;9(1):4903. doi: 10.1038/s41467-018-07142-9.

4.

Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer.

Leong TL, Gayevskiy V, Steinfort DP, De Massy MR, Gonzalez-Rajal A, Marini KD, Stone E, Chin V, Havryk A, Plit M, Irving LB, Jennings BR, McCloy RA, Jayasekara WSN, Alamgeer M, Boolell V, Field A, Russell PA, Kumar B, Gough DJ, Szczepny A, Ganju V, Rossello FJ, Cain JE, Papenfuss AT, Asselin-Labat ML, Cowley MJ, Watkins DN.

Oncogene. 2019 Mar;38(10):1661-1675. doi: 10.1038/s41388-018-0536-1. Epub 2018 Oct 22.

5.

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy.

Marini KD, Croucher DR, McCloy RA, Vaghjiani V, Gonzalez-Rajal A, Hastings JF, Chin V, Szczepny A, Kostyrko K, Marquez C, Jayasekara WSN, Alamgeer M, Boolell V, Han JZR, Waugh T, Lee HC, Oakes SR, Kumar B, Harrison CA, Hedger MP, Lorensuhewa N, Kita B, Barrow R, Robinson BW, de Kretser DM, Wu J, Ganju V, Sweet-Cordero EA, Burgess A, Martelotto LG, Rossello FJ, Cain JE, Watkins DN.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaat3504. doi: 10.1126/scitranslmed.aat3504.

PMID:
30045976
6.

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.

Szczepny A, Carey K, McKenzie L, Jayasekara WSN, Rossello F, Gonzalez-Rajal A, McCaw AS, Popovski D, Wang D, Sadler AJ, Mahar A, Russell PA, Wright G, McCloy RA, Garama DJ, Gough DJ, Baylin SB, Burgess A, Cain JE, Watkins DN.

Oncogene. 2018 Apr;37(14):1939-1948. doi: 10.1038/s41388-017-0022-1. Epub 2018 Jan 25.

7.

Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.

Sheybani-Deloui S, Chi L, Staite MV, Cain JE, Nieman BJ, Henkelman RM, Wainwright BJ, Potter SS, Bagli DJ, Lorenzo AJ, Rosenblum ND.

J Am Soc Nephrol. 2018 Feb;29(2):532-544. doi: 10.1681/ASN.2017050482. Epub 2017 Nov 6.

8.

Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses.

Pépin G, Nejad C, Ferrand J, Thomas BJ, Stunden HJ, Sanij E, Foo CH, Stewart CR, Cain JE, Bardin PG, Williams BRG, Gantier MP.

MBio. 2017 Oct 3;8(5). pii: e01611-17. doi: 10.1128/mBio.01611-17.

9.

Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo.

Akladios B, Mendoza Reinoso V, Cain JE, Wang T, Lambie DL, Watkins DN, Beverdam A.

PLoS One. 2017 Aug 18;12(8):e0183178. doi: 10.1371/journal.pone.0183178. eCollection 2017.

10.

Modulation of Mitochondrial DNA Copy Number to Induce Hepatocytic Differentiation of Human Amniotic Epithelial Cells.

Vaghjiani V, Cain JE, Lee W, Vaithilingam V, Tuch BE, St John JC.

Stem Cells Dev. 2017 Oct 15;26(20):1505-1519. doi: 10.1089/scd.2017.0041. Epub 2017 Sep 5.

PMID:
28756741
11.

Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes.

Fleuren EDG, Vlenterie M, van der Graaf WTA, Hillebrandt-Roeffen MHS, Blackburn J, Ma X, Chan H, Magias MC, van Erp A, van Houdt L, Cebeci SAS, van de Ven A, Flucke UE, Heyer EE, Thomas DM, Lord CJ, Marini KD, Vaghjiani V, Mercer TR, Cain JE, Wu J, Versleijen-Jonkers YMH, Daly RJ.

Cancer Res. 2017 Aug 15;77(16):4279-4292. doi: 10.1158/0008-5472.CAN-16-2550. Epub 2017 Jun 20.

12.

The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer.

Szczepny A, Rogers S, Jayasekara WSN, Park K, McCloy RA, Cochrane CR, Ganju V, Cooper WA, Sage J, Peacock CD, Cain JE, Burgess A, Watkins DN.

Oncogene. 2017 Sep 28;36(39):5544-5550. doi: 10.1038/onc.2017.173. Epub 2017 Jun 5.

13.

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis.

Lee WT, Cain JE, Cuddihy A, Johnson J, Dickinson A, Yeung KY, Kumar B, Johns TG, Watkins DN, Spencer A, St John JC.

Cell Death Discov. 2016 Apr 4;2:16016. doi: 10.1038/cddiscovery.2016.16. eCollection 2016.

14.

Cross-frequency coherence and pulse propagation in a turbulent atmosphere.

Ostashev VE, Wilson DK, Collier SL, Cain JE, Cheinet S.

J Acoust Soc Am. 2016 Jul;140(1):678. doi: 10.1121/1.4959003.

PMID:
27475189
15.

Activating Transcription Factor 3 Expression as a Marker of Response to the Histone Deacetylase Inhibitor Pracinostat.

Sooraj D, Xu D, Cain JE, Gold DP, Williams BR.

Mol Cancer Ther. 2016 Jul;15(7):1726-39. doi: 10.1158/1535-7163.MCT-15-0890. Epub 2016 Apr 25.

16.

Cre-dependent DNA recombination activates a STING-dependent innate immune response.

Pépin G, Ferrand J, Höning K, Jayasekara WS, Cain JE, Behlke MA, Gough DJ, G Williams BR, Hornung V, Gantier MP.

Nucleic Acids Res. 2016 Jun 20;44(11):5356-64. doi: 10.1093/nar/gkw405. Epub 2016 May 10.

17.

Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors.

Muscat A, Popovski D, Jayasekara WS, Rossello FJ, Ferguson M, Marini KD, Alamgeer M, Algar EM, Downie P, Watkins DN, Cain JE, Ashley DM.

Clin Cancer Res. 2016 Jul 15;22(14):3560-70. doi: 10.1158/1078-0432.CCR-15-2260. Epub 2016 Feb 26.

18.

The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase.

Deane JA, Ong YR, Cain JE, Jayasekara WS, Tiwari A, Carlone DL, Watkins DN, Breault DT, Gargett CE.

Mol Hum Reprod. 2016 Apr;22(4):272-84. doi: 10.1093/molehr/gav076. Epub 2016 Jan 5.

19.

Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor.

Blake J, Hu D, Cain JE, Rosenblum ND.

Hum Mol Genet. 2016 Feb 1;25(3):437-47. doi: 10.1093/hmg/ddv483. Epub 2015 Nov 24.

20.

Hedgehog Signaling in the Maintenance of Cancer Stem Cells.

Cochrane CR, Szczepny A, Watkins DN, Cain JE.

Cancers (Basel). 2015 Aug 11;7(3):1554-85. doi: 10.3390/cancers7030851. Review.

21.

Genomic characterisation of small cell lung cancer patient-derived xenografts generated from endobronchial ultrasound-guided transbronchial needle aspiration specimens.

Leong TL, Marini KD, Rossello FJ, Jayasekara SN, Russell PA, Prodanovic Z, Kumar B, Ganju V, Alamgeer M, Irving LB, Steinfort DP, Peacock CD, Cain JE, Szczepny A, Watkins DN.

PLoS One. 2014 Sep 5;9(9):e106862. doi: 10.1371/journal.pone.0106862. eCollection 2014.

22.

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling.

Barakat B, Yu L, Lo C, Vu D, De Luca E, Cain JE, Martelotto LG, Dedhar S, Sadler AJ, Wang D, Watkins DN, Hannigan GE.

EMBO Rep. 2013 Sep;14(9):837-44. doi: 10.1038/embor.2013.110. Epub 2013 Jul 23. Erratum in: EMBO Rep. 2013 Oct;14(10):945. Martellotto, Luciano G [corrected to Martelotto, Luciano G].

23.

Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells.

Cain JE, McCaw A, Jayasekara WS, Rossello FJ, Marini KD, Irving AT, Kansara M, Thomas DM, Ashley DM, Watkins DN.

Sarcoma. 2013;2013:608964. doi: 10.1155/2013/608964. Epub 2013 Feb 28.

24.

Deletions in 16q24.2 are associated with autism spectrum disorder, intellectual disability and congenital renal malformation.

Handrigan GR, Chitayat D, Lionel AC, Pinsk M, Vaags AK, Marshall CR, Dyack S, Escobar LF, Fernandez BA, Stegman JC, Rosenfeld JA, Shaffer LG, Goodenberger M, Hodge JC, Cain JE, Babul-Hirji R, Stavropoulos DJ, Yiu V, Scherer SW, Rosenblum ND.

J Med Genet. 2013 Mar;50(3):163-73. doi: 10.1136/jmedgenet-2012-101288. Epub 2013 Jan 18. Erratum in: J Med Genet. 2013 Apr;50(4):270.

PMID:
23335808
25.

Visualizing renal primary cilia.

Deane JA, Verghese E, Martelotto LG, Cain JE, Galtseva A, Rosenblum ND, Watkins DN, Ricardo SD.

Nephrology (Carlton). 2013 Mar;18(3):161-8. doi: 10.1111/nep.12022. Review.

PMID:
23240784
26.

Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma.

Kelleher FC, Cain JE, Healy JM, Watkins DN, Thomas DM.

Pharmacol Ther. 2012 Nov;136(2):153-68. doi: 10.1016/j.pharmthera.2012.08.004. Epub 2012 Aug 11. Review.

PMID:
22906929
27.

β-catenin causes renal dysplasia via upregulation of Tgfβ2 and Dkk1.

Bridgewater D, Di Giovanni V, Cain JE, Cox B, Jakobson M, Sainio K, Rosenblum ND.

J Am Soc Nephrol. 2011 Apr;22(4):718-31. doi: 10.1681/ASN.2010050562. Epub 2011 Mar 24.

28.

GLI3 repressor controls functional development of the mouse ureter.

Cain JE, Islam E, Haxho F, Blake J, Rosenblum ND.

J Clin Invest. 2011 Mar;121(3):1199-206. doi: 10.1172/JCI45523. Epub 2011 Feb 21.

29.

Control of mammalian kidney development by the Hedgehog signaling pathway.

Cain JE, Rosenblum ND.

Pediatr Nephrol. 2011 Sep;26(9):1365-71. doi: 10.1007/s00467-010-1704-x. Epub 2010 Dec 15. Review.

PMID:
21161287
30.

Genetics of renal hypoplasia: insights into the mechanisms controlling nephron endowment.

Cain JE, Di Giovanni V, Smeeton J, Rosenblum ND.

Pediatr Res. 2010 Aug;68(2):91-8. doi: 10.1203/00006450-201011001-00175. Review.

PMID:
20421843
31.

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.

Cain JE, Islam E, Haxho F, Chen L, Bridgewater D, Nieuwenhuis E, Hui CC, Rosenblum ND.

PLoS One. 2009 Oct 7;4(10):e7313. doi: 10.1371/journal.pone.0007313.

32.

Bone morphogenetic protein signaling in the developing kidney: present and future.

Cain JE, Hartwig S, Bertram JF, Rosenblum ND.

Differentiation. 2008 Oct;76(8):831-42. doi: 10.1111/j.1432-0436.2008.00265.x. Epub 2008 Mar 7. Review.

PMID:
18331343
33.

Ureteric branching morphogenesis in BMP4 heterozygous mutant mice.

Cain JE, Bertram JF.

J Anat. 2006 Dec;209(6):745-55.

34.

Polymorphisms in the prostate-specific antigen gene promoter do not predict serum prostate-specific antigen levels in African-American men.

Beebe-Dimmer JL, Lange LA, Cain JE, Lewis RC, Ray AM, Sarma AV, Lange EM, Cooney KA.

Prostate Cancer Prostatic Dis. 2006;9(1):50-5.

PMID:
16247489
35.

Exogenous BMP-4 amplifies asymmetric ureteric branching in the developing mouse kidney in vitro.

Cain JE, Nion T, Jeulin D, Bertram JF.

Kidney Int. 2005 Feb;67(2):420-31.

36.

A randomized prospective study of posterolateral lumbar fusion. Outcomes with and without pedicle screw instrumentation.

France JC, Yaszemski MJ, Lauerman WC, Cain JE, Glover JM, Lawson KJ, Coe JD, Topper SM.

Spine (Phila Pa 1976). 1999 Mar 15;24(6):553-60.

PMID:
10101819
37.

Isthmic Spondylolisthesis in the Adult.

Lauerman WC, Cain JE.

J Am Acad Orthop Surg. 1996 Jul;4(4):201-208.

PMID:
10795055
38.

Buyouts & ventures. Selling ... or selling out.

Meyer H, Hudson T, Cain JE, Carr SL, Zacharias D.

Hosp Health Netw. 1996 Jun 5;70(11):21-4, 26, 28 passim.

PMID:
8640253
39.

The morbidity of heparin therapy after development of pulmonary embolus in patients undergoing thoracolumbar or lumbar spinal fusion.

Cain JE Jr, Major MR, Lauerman WC, West JL, Wood KB, Fueredi GA.

Spine (Phila Pa 1976). 1995 Jul 15;20(14):1600-3.

PMID:
7570175
40.

The influence of anulotomy selection on disc competence. A radiographic, biomechanical, and histologic analysis.

Ethier DB, Cain JE, Yaszemski MJ, Glover JM, Klucznik RP, Pyka RE, Lauerman WC.

Spine (Phila Pa 1976). 1994 Sep 15;19(18):2071-6.

PMID:
7825048
41.
42.

Muscle flap closure for salvage of complex back wounds.

Klink BK, Thurman RT, Wittpenn GP, Lauerman WC, Cain JE.

Spine (Phila Pa 1976). 1994 Jul 1;19(13):1467-70.

PMID:
7939976
43.

Management of retroperitoneal chylous leakage.

DeHart MM, Lauerman WC, Conely AH, Roettger RH, West JL, Cain JE.

Spine (Phila Pa 1976). 1994 Mar 15;19(6):716-8.

PMID:
8009338
44.

Pathomechanical analysis of thoracolumbar burst fracture reduction. A calf spine model.

Cain JE Jr, DeJong JT, Dinenberg AS, Stefko RM, Platenburg RC, Lauerman WC.

Spine (Phila Pa 1976). 1993 Sep 15;18(12):1647-54.

PMID:
8235845
45.

Vertebrodiatasis experimental lengthening of the juvenile goat spine.

Stefko RM, Cain JE Jr, Lauerman WC 2nd, Brann C, Platenburg RC, Pyka R.

Spine (Phila Pa 1976). 1993 Sep 15;18(12):1616-20.

PMID:
8235840
46.

Spine injuries in combat troops--Panama, 1989.

Parsons TW 3rd, Lauerman WC, Ethier DB, Gormley W, Cain JE, Elias Z, Coe J.

Mil Med. 1993 Jul;158(7):501-2.

PMID:
8351057
47.

Posterior sacroiliac fixation using a sacral pedicle targeting device: an anatomical study.

Miller MD, Cain JE, Lauerman WC, Littlefield WG, Platenberg RC, Wilson MR.

J Orthop Trauma. 1993;7(6):514-20.

PMID:
8308603
48.

Age-related disk degeneration: preliminary report of a naturally occurring baboon model.

Lauerman WC, Platenberg RC, Cain JE, Deeney VF.

J Spinal Disord. 1992 Jun;5(2):170-4.

PMID:
1606375
49.

The histomorphologic sequence of dural repair. Observations in the canine model.

Cain JE Jr, Lauerman WC, Rosenthal HG, Broom MJ, Jacobs RR.

Spine (Phila Pa 1976). 1991 Aug;16(8 Suppl):S319-23.

PMID:
1785079
50.

Quantification of leakage pressures after durotomy repairs in the canine.

Cain JE Jr, Rosenthal HG, Broom MJ, Jauch EC, Borek DA, Jacobs RR.

Spine (Phila Pa 1976). 1990 Sep;15(9):969-70.

PMID:
2259990

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