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Items: 1 to 50 of 72

1.

What can we learn from cases of internal mammary artery damage in coronary artery bypass graft?

Chen M, Huang FJ, Wu Q, Zou YX, Zhu EJ, Zhang JW, Zhou Y, Yu JB, Cai KQ, Han B.

Chin Med J (Engl). 2019 Feb 5;132(3):377-378. doi: 10.1097/CM9.0000000000000023. No abstract available.

PMID:
30624252
2.

Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers.

Capo-Chichi CD, Cai KQ, Xu XX.

Biomark Res. 2018 Oct 30;6:30. doi: 10.1186/s40364-018-0144-9. eCollection 2018.

3.

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.

Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N.

Cell Rep. 2018 Oct 30;25(5):1384. doi: 10.1016/j.celrep.2018.10.009. No abstract available.

4.

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.

Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N.

Cell Rep. 2018 Sep 25;24(13):3513-3527.e7. doi: 10.1016/j.celrep.2018.08.086. Erratum in: Cell Rep. 2018 Oct 30;25(5):1384.

5.

Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas.

Sementino E, Menges CW, Kadariya Y, Peri S, Xu J, Liu Z, Wilkes RG, Cai KQ, Rauscher FJ 3rd, Klein-Szanto AJ, Testa JR.

J Cell Physiol. 2018 Nov;233(11):8952-8961. doi: 10.1002/jcp.26830. Epub 2018 Jun 15.

PMID:
29904909
6.

Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine.

Tang B, Lee HO, An SS, Cai KQ, Kruger WD.

Cancer Res. 2018 Aug 1;78(15):4386-4395. doi: 10.1158/0008-5472.CAN-18-0814. Epub 2018 May 29.

PMID:
29844120
7.

NEDD9 promotes oncogenic signaling, a stem/mesenchymal gene signature, and aggressive ovarian cancer growth in mice.

Gabbasov R, Xiao F, Howe CG, Bickel LE, O'Brien SW, Benrubi D, Do TV, Zhou Y, Nicolas E, Cai KQ, Litwin S, Seo S, Golemis EA, Connolly DC.

Oncogene. 2018 Aug;37(35):4854-4870. doi: 10.1038/s41388-018-0296-y. Epub 2018 May 18.

8.

A Nonpyroptotic IFN-γ-Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo.

Ingram JP, Tursi S, Zhang T, Guo W, Yin C, A Wynosky-Dolfi M, van der Heijden J, Cai KQ, Yamamoto M, Finlay BB, Brodsky IE, Grivennikov SI, Tükel Ç, Balachandran S.

J Immunol. 2018 May 15;200(10):3626-3634. doi: 10.4049/jimmunol.1701386. Epub 2018 Apr 13.

PMID:
29654208
9.

Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment.

Wagner J, Kline CL, Zhou L, Campbell KS, MacFarlane AW, Olszanski AJ, Cai KQ, Hensley HH, Ross EA, Ralff MD, Zloza A, Chesson CB, Newman JH, Kaufman H, Bertino J, Stein M, El-Deiry WS.

J Clin Invest. 2018 Jun 1;128(6):2325-2338. doi: 10.1172/JCI96711. Epub 2018 Apr 30.

10.

Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer.

Beatty A, Fink LS, Singh T, Strigun A, Peter E, Ferrer CM, Nicolas E, Cai KQ, Moran TP, Reginato MJ, Rennefahrt U, Peterson JR.

Mol Cancer Ther. 2018 Jan;17(1):264-275. doi: 10.1158/1535-7163.MCT-17-0407. Epub 2017 Oct 11.

11.

Succinate dehydrogenase deficiency in a PDGFRA mutated GIST.

Belinsky MG, Cai KQ, Zhou Y, Luo B, Pei J, Rink L, von Mehren M.

BMC Cancer. 2017 Aug 2;17(1):512. doi: 10.1186/s12885-017-3499-7. Review.

12.

LincIN, a novel NF90-binding long non-coding RNA, is overexpressed in advanced breast tumors and involved in metastasis.

Jiang Z, Slater CM, Zhou Y, Devarajan K, Ruth KJ, Li Y, Cai KQ, Daly M, Chen X.

Breast Cancer Res. 2017 May 30;19(1):62. doi: 10.1186/s13058-017-0853-2.

13.

Pten facilitates epiblast epithelial polarization and proamniotic lumen formation in early mouse embryos.

Meng Y, Cai KQ, Moore R, Tao W, Tse JD, Smith ER, Xu XX.

Dev Dyn. 2017 Jul;246(7):517-530. doi: 10.1002/dvdy.24503. Epub 2017 May 18.

14.

The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling.

Tan Y, Sementino E, Xu J, Pei J, Liu Z, Ito TK, Cai KQ, Peri S, Klein-Szanto AJ, Wiest DL, Testa JR.

Oncotarget. 2017 Feb 28;8(9):14941-14956. doi: 10.18632/oncotarget.14784.

15.

Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models.

Bobrov E, Skobeleva N, Restifo D, Beglyarova N, Cai KQ, Handorf E, Campbell K, Proia DA, Khazak V, Golemis EA, Astsaturov I.

Oncotarget. 2017 Jan 17;8(3):4399-4409. doi: 10.18632/oncotarget.12642.

16.

RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance.

Wang Y, Krais JJ, Bernhardy AJ, Nicolas E, Cai KQ, Harrell MI, Kim HH, George E, Swisher EM, Simpkins F, Johnson N.

J Clin Invest. 2016 Aug 1;126(8):3145-57. doi: 10.1172/JCI87033. Epub 2016 Jul 25.

17.

Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis.

Wang Y, Cai KQ, Smith ER, Yeasky TM, Moore R, Ganjei-Azar P, Klein-Szanto AJ, Godwin AK, Hamilton TC, Xu XX.

Mol Cell Biol. 2016 Aug 26;36(18):2418-30. doi: 10.1128/MCB.00202-16. Print 2016 Sep 15.

18.

Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis.

Kudinov AE, Deneka A, Nikonova AS, Beck TN, Ahn YH, Liu X, Martinez CF, Schultz FA, Reynolds S, Yang DH, Cai KQ, Yaghmour KM, Baker KA, Egleston BL, Nicolas E, Chikwem A, Andrianov G, Singh S, Borghaei H, Serebriiskii IG, Gibbons DL, Kurie JM, Golemis EA, Boumber Y.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6955-60. doi: 10.1073/pnas.1513616113. Epub 2016 Jun 6.

19.

A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer.

Gaponova AV, Nikonova AS, Deneka A, Kopp MC, Kudinov AE, Skobeleva N, Khazak V, Ogawa LS, Cai KQ, Duncan KE, Duncan JS, Egleston BL, Proia DA, Boumber Y, Golemis EA.

Clin Cancer Res. 2016 Oct 15;22(20):5120-5129. doi: 10.1158/1078-0432.CCR-15-3068. Epub 2016 Jun 7.

20.

Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma.

Rao S, Cai KQ, Stadanlick JE, Greenberg-Kushnir N, Solanki-Patel N, Lee SY, Fahl SP, Testa JR, Wiest DL.

Cancer Res. 2016 Jun 1;76(11):3387-96. doi: 10.1158/0008-5472.CAN-15-2698. Epub 2016 Apr 5.

21.

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.

Jennis M, Kung CP, Basu S, Budina-Kolomets A, Leu JI, Khaku S, Scott JP, Cai KQ, Campbell MR, Porter DK, Wang X, Bell DA, Li X, Garlick DS, Liu Q, Hollstein M, George DL, Murphy ME.

Genes Dev. 2016 Apr 15;30(8):918-30. doi: 10.1101/gad.275891.115. Epub 2016 Mar 31.

22.

Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma.

Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJ, Pietrofesa RA, Christofidou-Solomidou M, Cheung M, Mossman BT, Shukla A, Testa JR.

Cancer Prev Res (Phila). 2016 May;9(5):406-414. doi: 10.1158/1940-6207.CAPR-15-0347. Epub 2016 Mar 2.

23.

Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations.

Kadariya Y, Cheung M, Xu J, Pei J, Sementino E, Menges CW, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Testa JR.

Cancer Res. 2016 May 1;76(9):2836-44. doi: 10.1158/0008-5472.CAN-15-3371. Epub 2016 Feb 19.

24.

Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case.

Belinsky MG, Rink L, Cai KQ, Capuzzi SJ, Hoang Y, Chien J, Godwin AK, von Mehren M.

BMC Cancer. 2015 Nov 10;15:887. doi: 10.1186/s12885-015-1872-y.

25.

Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis.

Tricarico R, Cortellino S, Riccio A, Jagmohan-Changur S, Van der Klift H, Wijnen J, Turner D, Ventura A, Rovella V, Percesepe A, Lucci-Cordisco E, Radice P, Bertario L, Pedroni M, Ponz de Leon M, Mancuso P, Devarajan K, Cai KQ, Klein-Szanto AJ, Neri G, Møller P, Viel A, Genuardi M, Fodde R, Bellacosa A.

Oncotarget. 2015 Dec 15;6(40):42892-904. doi: 10.18632/oncotarget.5740.

26.

Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR.

Gabitova L, Restifo D, Gorin A, Manocha K, Handorf E, Yang DH, Cai KQ, Klein-Szanto AJ, Cunningham D, Kratz LE, Herman GE, Golemis EA, Astsaturov I.

Cell Rep. 2015 Sep 22;12(11):1927-38. doi: 10.1016/j.celrep.2015.08.023. Epub 2015 Sep 3.

27.

Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells.

Prudnikova TY, Villamar-Cruz O, Rawat SJ, Cai KQ, Chernoff J.

Oncogene. 2016 Apr 28;35(17):2178-85. doi: 10.1038/onc.2015.278. Epub 2015 Aug 10.

28.

Terminal-Area Aircraft Intent Inference Approach Based on Online Trajectory Clustering.

Yang Y, Zhang J, Cai KQ.

ScientificWorldJournal. 2015;2015:671360. doi: 10.1155/2015/671360. Epub 2015 Jun 10.

29.

Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice.

Cai KQ, Wang Y, Smith ER, Smedberg JL, Yang DH, Yang WL, Xu XX.

Neoplasia. 2015 Jan;17(1):89-100. doi: 10.1016/j.neo.2014.11.005.

30.

Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates.

Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick SM, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL.

Immunity. 2014 Dec 18;41(6):934-46. doi: 10.1016/j.immuni.2014.10.021. Epub 2014 Nov 28.

31.

Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.

Smithline ZB, Nikonova AS, Hensley HH, Cai KQ, Egleston BL, Proia DA, Seeger-Nukpezah T, Golemis EA.

PLoS One. 2014 Dec 4;9(12):e114403. doi: 10.1371/journal.pone.0114403. eCollection 2014.

32.

Nedd9 restrains renal cystogenesis in Pkd1-/- mice.

Nikonova AS, Plotnikova OV, Serzhanova V, Efimov A, Bogush I, Cai KQ, Hensley HH, Egleston BL, Klein-Szanto A, Seeger-Nukpezah T, Golemis EA.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12859-64. doi: 10.1073/pnas.1405362111. Epub 2014 Aug 19.

33.

Identifying a highly-aggressive DCIS subgroup by studying intra-individual DCIS heterogeneity among invasive breast cancer patients.

Pape-Zambito D, Jiang Z, Wu H, Devarajan K, Slater CM, Cai KQ, Patchefsky A, Daly MB, Chen X.

PLoS One. 2014 Jun 30;9(6):e100488. doi: 10.1371/journal.pone.0100488. eCollection 2014.

34.

ID1 promotes breast cancer metastasis by S100A9 regulation.

Gumireddy K, Li A, Kossenkov AV, Cai KQ, Liu Q, Yan J, Xu H, Showe L, Zhang L, Huang Q.

Mol Cancer Res. 2014 Sep;12(9):1334-43. doi: 10.1158/1541-7786.MCR-14-0049. Epub 2014 Jun 19.

35.

Abcc10 status affects mammary tumour growth, metastasis, and docetaxel treatment response.

Domanitskaya N, Wangari-Talbot J, Jacobs J, Peiffer E, Mahdaviyeh Y, Paulose C, Malofeeva E, Foster K, Cai KQ, Zhou Y, Egleston B, Hopper-Borge E.

Br J Cancer. 2014 Aug 12;111(4):696-707. doi: 10.1038/bjc.2014.326. Epub 2014 Jun 17.

36.

Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma.

Xu J, Kadariya Y, Cheung M, Pei J, Talarchek J, Sementino E, Tan Y, Menges CW, Cai KQ, Litwin S, Peng H, Karar J, Rauscher FJ, Testa JR.

Cancer Res. 2014 Aug 15;74(16):4388-97. doi: 10.1158/0008-5472.CAN-14-1328. Epub 2014 Jun 13.

37.

Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.

Moore R, Cai KQ, Tao W, Smith ER, Xu XX.

BMC Dev Biol. 2013 Oct 29;13:39. doi: 10.1186/1471-213X-13-39.

38.

Quantification of excision repair cross-complementing group 1 and survival in p16-negative squamous cell head and neck cancers.

Mehra R, Zhu F, Yang DH, Cai KQ, Weaver J, Singh MK, Nikonova AS, Golemis EA, Flieder DB, Cooper HS, Lango M, Ridge JA, Burtness B.

Clin Cancer Res. 2013 Dec 1;19(23):6633-43. doi: 10.1158/1078-0432.CCR-13-0152. Epub 2013 Oct 2.

39.

Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice.

Smith ER, Yang WL, Yeasky T, Smedberg J, Cai KQ, Xu XX.

Biol Reprod. 2013 Oct 31;89(4):103. doi: 10.1095/biolreprod.113.111070. Print 2013 Oct.

40.

Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.

Seeger-Nukpezah T, Proia DA, Egleston BL, Nikonova AS, Kent T, Cai KQ, Hensley HH, Ying W, Chimmanamada D, Serebriiskii IG, Golemis EA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12786-91. doi: 10.1073/pnas.1301904110. Epub 2013 Jul 15.

41.

Inflammatory breast cancer (IBC): clues for targeted therapies.

Fernandez SV, Robertson FM, Pei J, Aburto-Chumpitaz L, Mu Z, Chu K, Alpaugh RK, Huang Y, Cao Y, Ye Z, Cai KQ, Boley KM, Klein-Szanto AJ, Devarajan K, Addya S, Cristofanilli M.

Breast Cancer Res Treat. 2013 Jul;140(1):23-33. doi: 10.1007/s10549-013-2600-4. Epub 2013 Jun 21.

42.

Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases.

Fu J, Bassi DE, Zhang J, Li T, Cai KQ, Testa CL, Nicolas E, Klein-Szanto AJ.

Neoplasia. 2013 Feb;15(2):169-79.

43.

Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.

Sukhanova A, Gorin A, Serebriiskii IG, Gabitova L, Zheng H, Restifo D, Egleston BL, Cunningham D, Bagnyukova T, Liu H, Nikonova A, Adams GP, Zhou Y, Yang DH, Mehra R, Burtness B, Cai KQ, Klein-Szanto A, Kratz LE, Kelley RI, Weiner LM, Herman GE, Golemis EA, Astsaturov I.

Cancer Discov. 2013 Jan;3(1):96-111. doi: 10.1158/2159-8290.CD-12-0031. Epub 2012 Nov 2.

44.

p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.

Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP, Chernoff J.

Cancer Res. 2012 Nov 15;72(22):5966-75. doi: 10.1158/0008-5472.CAN-12-2246. Epub 2012 Sep 14.

45.

Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer.

Dotan E, Meropol NJ, Zhu F, Zambito F, Bove B, Cai KQ, Godwin AK, Golemis EA, Astsaturov I, Cohen SJ.

Br J Cancer. 2012 Feb 14;106(4):748-55. doi: 10.1038/bjc.2011.587. Epub 2012 Jan 12.

46.

White spotting variant mouse as an experimental model for ovarian aging and menopausal biology.

Smith ER, Yeasky T, Wei JQ, Miki RA, Cai KQ, Smedberg JL, Yang WL, Xu XX.

Menopause. 2012 May;19(5):588-96. doi: 10.1097/gme.0b013e318239cc53.

47.

Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study.

Behbakht K, Sill MW, Darcy KM, Rubin SC, Mannel RS, Waggoner S, Schilder RJ, Cai KQ, Godwin AK, Alpaugh RK.

Gynecol Oncol. 2011 Oct;123(1):19-26. doi: 10.1016/j.ygyno.2011.06.022. Epub 2011 Jul 12.

48.

Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer.

Capo-chichi CD, Cai KQ, Smedberg J, Ganjei-Azar P, Godwin AK, Xu XX.

Chin J Cancer. 2011 Jun;30(6):415-25.

49.

Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer.

Capo-chichi CD, Cai KQ, Simpkins F, Ganjei-Azar P, Godwin AK, Xu XX.

BMC Med. 2011 Mar 26;9:28. doi: 10.1186/1741-7015-9-28.

50.

Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation.

Wang Y, Smedberg JL, Cai KQ, Capo-Chichi DC, Xu XX.

Dev Dyn. 2011 Mar;240(3):566-76. doi: 10.1002/dvdy.22447. Epub 2010 Oct 5.

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