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Items: 47

1.

Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism.

Starrett GJ, Serebrenik AA, Roelofs PA, McCann JL, Verhalen B, Jarvis MC, Stewart TA, Law EK, Krupp A, Jiang M, Martens JWM, Cahir-McFarland E, Span PN, Harris RS.

MBio. 2019 Feb 5;10(1). pii: e02690-18. doi: 10.1128/mBio.02690-18.

2.

CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling.

Henry KL, Kellner D, Bajrami B, Anderson JE, Beyna M, Bhisetti G, Cameron T, Capacci AG, Bertolotti-Ciarlet A, Feng J, Gao B, Hopkins B, Jenkins T, Li K, May-Dracka T, Murugan P, Wei R, Zeng W, Allaire N, Buckler A, Loh C, Juhasz P, Lucas B, Ennis KA, Vollman E, Cahir-McFarland E, Hett EC, Ols ML.

Sci Signal. 2018 Jul 31;11(541). pii: eaam8216. doi: 10.1126/scisignal.aam8216.

PMID:
30065029
3.

Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.

May-Dracka TL, Arduini R, Bertolotti-Ciarlet A, Bhisetti G, Brickelmaier M, Cahir-McFarland E, Enyedy I, Fontenot JD, Hesson T, Little K, Lyssikatos J, Marcotte D, McKee T, Murugan P, Patterson T, Peng H, Rushe M, Silvian L, Spilker K, Wu P, Xin Z, Burkly LC.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1964-1971. doi: 10.1016/j.bmcl.2018.03.032. Epub 2018 Mar 26.

PMID:
29636220
4.

Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses.

Geoghegan EM, Pastrana DV, Schowalter RM, Ray U, Gao W, Ho M, Pauly GT, Sigano DM, Kaynor C, Cahir-McFarland E, Combaluzier B, Grimm J, Buck CB.

Cell Rep. 2017 Oct 31;21(5):1169-1179. doi: 10.1016/j.celrep.2017.10.027.

5.

CD62L is not a reliable biomarker for predicting PML risk in natalizumab-treated R-MS patients. Author Response.

Cahir-McFarland E, Ransohoff RM, Lieberman L, Plavina T.

Neurology. 2016 Aug 30;87(9):958-9. doi: 10.​1212/​01.​wnl.​0000496643.​57775.​41. No abstract available.

PMID:
28296380
6.

Distribution and Quantity of Sites of John Cunningham Virus Persistence in Immunologically Healthy Patients: Correlation With John Cunningham Virus Antibody and Urine John Cunningham Virus DNA.

Berger JR, Miller CS, Danaher RJ, Doyle K, Simon KJ, Norton E, Gorelik L, Cahir-McFarland E, Singhal D, Hack N, Owens JR, Nelson PT, Neltner JH.

JAMA Neurol. 2017 Apr 1;74(4):437-444. doi: 10.1001/jamaneurol.2016.5537.

PMID:
28241186
7.

Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9.

Chou YY, Krupp A, Kaynor C, Gaudin R, Ma M, Cahir-McFarland E, Kirchhausen T.

Sci Rep. 2016 Nov 14;6:36921. doi: 10.1038/srep36921.

8.

JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection.

Wharton KA Jr, Quigley C, Themeles M, Dunstan RW, Doyle K, Cahir-McFarland E, Wei J, Buko A, Reid CE, Sun C, Carmillo P, Sur G, Carulli JP, Mansfield KG, Westmoreland SV, Staugaitis SM, Fox RJ, Meier W, Goelz SE.

PLoS One. 2016 May 18;11(5):e0155897. doi: 10.1371/journal.pone.0155897. eCollection 2016.

9.

CD62L is not a reliable biomarker for predicting PML risk in natalizumab-treated R-MS patients.

Lieberman LA, Zeng W, Singh C, Wang W, Otipoby KL, Loh C, Plavina T, Gorelik L, Ransohoff RM, Cahir-McFarland E.

Neurology. 2016 Jan 26;86(4):375-81. doi: 10.1212/WNL.0000000000002314. Epub 2015 Dec 30. Erratum in: Neurology. 2016 Aug 30;87(9):960.

10.

The NF-κB genomic landscape in lymphoblastoid B cells.

Zhao B, Barrera LA, Ersing I, Willox B, Schmidt SC, Greenfeld H, Zhou H, Mollo SB, Shi TT, Takasaki K, Jiang S, Cahir-McFarland E, Kellis M, Bulyk ML, Kieff E, Gewurz BE.

Cell Rep. 2014 Sep 11;8(5):1595-606. doi: 10.1016/j.celrep.2014.07.037. Epub 2014 Aug 21.

11.

Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis.

Qiu W, Rogers AJ, Damask A, Raby BA, Klanderman BJ, Duan QL, Tyagi S, Niu S, Anderson C, Cahir-Mcfarland E, Mariani TJ, Carey V, Tantisira KG.

Hum Mol Genet. 2014 Sep 15;23(18):5017-24. doi: 10.1093/hmg/ddu191. Epub 2014 Apr 25.

12.

Autophagy prolongs survival after NFκB inhibition in B-cell lymphomas.

Sommermann TG, Mack HI, Cahir-McFarland E.

Autophagy. 2012 Feb 1;8(2):265-7. doi: 10.4161/auto.8.2.18763. Epub 2012 Feb 1.

13.

Genome-wide siRNA screen for mediators of NF-κB activation.

Gewurz BE, Towfic F, Mar JC, Shinners NP, Takasaki K, Zhao B, Cahir-McFarland ED, Quackenbush J, Xavier RJ, Kieff E.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2467-72. doi: 10.1073/pnas.1120542109. Epub 2012 Jan 17.

14.

IKKβ and NF-κB transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1.

Sommermann TG, O'Neill K, Plas DR, Cahir-McFarland E.

Cancer Res. 2011 Dec 1;71(23):7291-300. doi: 10.1158/0008-5472.CAN-11-1715. Epub 2011 Oct 10.

15.

Latent membrane protein 1 is dispensable for Epstein-Barr virus replication in human embryonic kidney 293 cells.

Geiser V, Cahir-McFarland E, Kieff E.

PLoS One. 2011;6(8):e22929. doi: 10.1371/journal.pone.0022929. Epub 2011 Aug 11.

16.

Canonical NF-kappaB activation is essential for Epstein-Barr virus latent membrane protein 1 TES2/CTAR2 gene regulation.

Gewurz BE, Mar JC, Padi M, Zhao B, Shinners NP, Takasaki K, Bedoya E, Zou JY, Cahir-McFarland E, Quackenbush J, Kieff E.

J Virol. 2011 Jul;85(13):6764-73. doi: 10.1128/JVI.00422-11. Epub 2011 May 4.

17.

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation.

Verweij FJ, van Eijndhoven MA, Hopmans ES, Vendrig T, Wurdinger T, Cahir-McFarland E, Kieff E, Geerts D, van der Kant R, Neefjes J, Middeldorp JM, Pegtel DM.

EMBO J. 2011 Jun 1;30(11):2115-29. doi: 10.1038/emboj.2011.123. Epub 2011 Apr 28.

18.

Epstein-Barr latent membrane protein 1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419.

Boehm D, Gewurz BE, Kieff E, Cahir-McFarland E.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18103-8. doi: 10.1073/pnas.1011752107. Epub 2010 Oct 5.

19.

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer.

Fernandez AF, Rosales C, Lopez-Nieva P, Graña O, Ballestar E, Ropero S, Espada J, Melo SA, Lujambio A, Fraga MF, Pino I, Javierre B, Carmona FJ, Acquadro F, Steenbergen RD, Snijders PJ, Meijer CJ, Pineau P, Dejean A, Lloveras B, Capella G, Quer J, Buti M, Esteban JI, Allende H, Rodriguez-Frias F, Castellsague X, Minarovits J, Ponce J, Capello D, Gaidano G, Cigudosa JC, Gomez-Lopez G, Pisano DG, Valencia A, Piris MA, Bosch FX, Cahir-McFarland E, Kieff E, Esteller M.

Genome Res. 2009 Mar;19(3):438-51. doi: 10.1101/gr.083550.108. Epub 2009 Feb 10.

20.

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.

Choy E, Yelensky R, Bonakdar S, Plenge RM, Saxena R, De Jager PL, Shaw SY, Wolfish CS, Slavik JM, Cotsapas C, Rivas M, Dermitzakis ET, Cahir-McFarland E, Kieff E, Hafler D, Daly MJ, Altshuler D.

PLoS Genet. 2008 Nov;4(11):e1000287. doi: 10.1371/journal.pgen.1000287. Epub 2008 Nov 28.

21.

LMP1 TRAFficking activates growth and survival pathways.

Soni V, Cahir-McFarland E, Kieff E.

Adv Exp Med Biol. 2007;597:173-87. Review.

PMID:
17633026
22.

LMP1 transmembrane domain 1 and 2 (TM1-2) FWLY mediates intermolecular interactions with TM3-6 to activate NF-kappaB.

Soni V, Yasui T, Cahir-McFarland E, Kieff E.

J Virol. 2006 Nov;80(21):10787-93. Epub 2006 Aug 23.

23.

IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.

Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689-94. Epub 2006 Feb 13.

24.

Virus and cell RNAs expressed during Epstein-Barr virus replication.

Yuan J, Cahir-McFarland E, Zhao B, Kieff E.

J Virol. 2006 Mar;80(5):2548-65.

25.

RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines.

Zhao B, Maruo S, Cooper A, R Chase M, Johannsen E, Kieff E, Cahir-McFarland E.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1900-5. Epub 2006 Jan 30.

26.

Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice.

Kang MS, Lu H, Yasui T, Sharpe A, Warren H, Cahir-McFarland E, Bronson R, Hung SC, Kieff E.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):820-5. Epub 2005 Jan 7.

27.

Proteins of purified Epstein-Barr virus.

Johannsen E, Luftig M, Chase MR, Weicksel S, Cahir-McFarland E, Illanes D, Sarracino D, Kieff E.

Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16286-91. Epub 2004 Nov 8.

28.

Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells.

Cahir-McFarland ED, Carter K, Rosenwald A, Giltnane JM, Henrickson SE, Staudt LM, Kieff E.

J Virol. 2004 Apr;78(8):4108-19.

29.

Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.

Luftig M, Yasui T, Soni V, Kang MS, Jacobson N, Cahir-McFarland E, Seed B, Kieff E.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):141-6. Epub 2003 Dec 22.

30.

Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.

Luftig M, Prinarakis E, Yasui T, Tsichritzis T, Cahir-McFarland E, Inoue J, Nakano H, Mak TW, Yeh WC, Li X, Akira S, Suzuki N, Suzuki S, Mosialos G, Kieff E.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15595-600. Epub 2003 Dec 12.

31.

EBNA3A association with RBP-Jkappa down-regulates c-myc and Epstein-Barr virus-transformed lymphoblast growth.

Cooper A, Johannsen E, Maruo S, Cahir-McFarland E, Illanes D, Davidson D, Kieff E.

J Virol. 2003 Jan;77(2):999-1010.

32.

Epstein-barr virus-induced changes in B-lymphocyte gene expression.

Carter KL, Cahir-McFarland E, Kieff E.

J Virol. 2002 Oct;76(20):10427-36.

33.

NF-kappaB inhibition in EBV-transformed lymphoblastoid cell lines.

Cahir-McFarland E, Kieff E.

Recent Results Cancer Res. 2002;159:44-8. Review.

PMID:
11785843
34.

Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.

Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E.

J Biol Chem. 2001 May 4;276(18):14602-6. Epub 2001 Mar 14.

35.

The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B.

Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7470-5.

36.

NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells.

Cahir-McFarland ED, Davidson DM, Schauer SL, Duong J, Kieff E.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):6055-60.

37.

Epstein-barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-kappaB.

Cahir McFarland ED, Izumi KM, Mosialos G.

Oncogene. 1999 Nov 22;18(49):6959-64. Review.

38.
39.

A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

Goldmacher VS, Bartle LM, Skaletskaya A, Dionne CA, Kedersha NL, Vater CA, Han JW, Lutz RJ, Watanabe S, Cahir McFarland ED, Kieff ED, Mocarski ES, Chittenden T.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12536-41.

41.

Role of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expression.

Devergne O, Cahir McFarland ED, Mosialos G, Izumi KM, Ware CF, Kieff E.

J Virol. 1998 Oct;72(10):7900-8.

42.

Definition of amino acids sufficient for plasma membrane association of CD45 and CD45-associated protein.

Cahir McFarland ED, Pingel J, Thomas ML.

Biochemistry. 1997 Jun 10;36(23):7169-75.

PMID:
9188717
43.

CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion.

Roach T, Slater S, Koval M, White L, Cahir McFarland ED, Okumura M, Thomas M, Brown E.

Curr Biol. 1997 Jun 1;7(6):408-17.

44.
45.

Activation of CD45-deficient T cell clones by lectin mitogens but not anti-Thy-1.

Pingel JT, Cahir McFarland ED, Thomas ML.

Int Immunol. 1994 Feb;6(2):169-78.

PMID:
7908828
46.

Protein tyrosine phosphatases involved in lymphocyte signal transduction.

Cahir McFarland ED, Flores E, Matthews RJ, Thomas ML.

Chem Immunol. 1994;59:40-61. Review. No abstract available.

PMID:
7945929
47.

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.

Cahir McFarland ED, Hurley TR, Pingel JT, Sefton BM, Shaw A, Thomas ML.

Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1402-6.

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