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Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-κB Activation.

Skupsky J, Sabui S, Hwang M, Nakasaki M, Cahalan MD, Said HM.

Cell Mol Gastroenterol Hepatol. 2019 Nov 29. pii: S2352-345X(19)30166-3. doi: 10.1016/j.jcmgh.2019.11.011. [Epub ahead of print]


Cxcl17-/- mice develop exacerbated disease in a T cell-dependent autoimmune model.

Hernández-Ruiz M, Othy S, Herrera C, Nguyen HT, Arrevillaga-Boni G, Catalan-Dibene J, Cahalan MD, Zlotnik A.

J Leukoc Biol. 2019 May;105(5):1027-1039. doi: 10.1002/JLB.3A0918-345RR. Epub 2019 Mar 12.


T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse.

Dong TX, Othy S, Jairaman A, Skupsky J, Zavala A, Parker I, Dynes JL, Cahalan MD.

Elife. 2017 Dec 14;6. pii: e32417. doi: 10.7554/eLife.32417.


Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility.

Dong TX, Othy S, Greenberg ML, Jairaman A, Akunwafo C, Leverrier S, Yu Y, Parker I, Dynes JL, Cahalan MD.

Elife. 2017 Dec 14;6. pii: e27827. doi: 10.7554/eLife.27827.


iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.

Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings BJ, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M.

Neuron. 2017 Apr 19;94(2):278-293.e9. doi: 10.1016/j.neuron.2017.03.042.


Correction: Antidepressant and Neurocognitive Effects of Isoflurane Anesthesia versus Electroconvulsive Therapy in Refractory Depression.

Weeks HR 3rd, Tadler SC, Smith KW, Iacob E, Saccoman M, White AT, Landvatter JD, Chelune GJ, Suchy Y, Clark E, Cahalan MK, Bushnell L, Sakata D, Light AR, Light KC.

PLoS One. 2017 Apr 6;12(4):e0175668. doi: 10.1371/journal.pone.0175668. eCollection 2017.


Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx.

Dynes JL, Amcheslavsky A, Cahalan MD.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):440-5. doi: 10.1073/pnas.1523410113. Epub 2015 Dec 28.


Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry.

Perni S, Dynes JL, Yeromin AV, Cahalan MD, Franzini-Armstrong C.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5533-42. doi: 10.1073/pnas.1515606112. Epub 2015 Sep 8.


Two-photon imaging of cellular dynamics in the mouse spinal cord.

Weinger JG, Greenberg ML, Matheu MP, Parker I, Walsh CM, Lane TE, Cahalan MD.

J Vis Exp. 2015 Feb 22;(96). doi: 10.3791/52580.


Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.

Matheu MP, Othy S, Greenberg ML, Dong TX, Schuijs M, Deswarte K, Hammad H, Lambrecht BN, Parker I, Cahalan MD.

Nat Commun. 2015 Feb 5;6:6219. doi: 10.1038/ncomms7219.


Molecular biophysics of Orai store-operated Ca2+ channels.

Amcheslavsky A, Wood ML, Yeromin AV, Parker I, Freites JA, Tobias DJ, Cahalan MD.

Biophys J. 2015 Jan 20;108(2):237-46. doi: 10.1016/j.bpj.2014.11.3473. Review.


Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies.

Marro BS, Blanc CA, Loring JF, Cahalan MD, Lane TE.

Expert Rev Neurother. 2014 Oct;14(10):1169-79. doi: 10.1586/14737175.2014.955854. Review.


Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis.

Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2349-55. doi: 10.1073/pnas.1406658111. Epub 2014 May 19.


State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation.

Amcheslavsky A, Safrina O, Cahalan MD.

J Gen Physiol. 2014 May;143(5):621-31. doi: 10.1085/jgp.201411171. Epub 2014 Apr 14.


Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101.

Amcheslavsky A, Safrina O, Cahalan MD.

J Gen Physiol. 2013 Oct;142(4):405-12. doi: 10.1085/jgp.201311030.


Antidepressant and neurocognitive effects of isoflurane anesthesia versus electroconvulsive therapy in refractory depression.

Weeks HR 3rd, Tadler SC, Smith KW, Iacob E, Saccoman M, White AT, Landvatter JD, Chelune GJ, Suchy Y, Clark E, Cahalan MK, Bushnell L, Sakata D, Light AR, Light KC.

PLoS One. 2013 Jul 26;8(7):e69809. doi: 10.1371/journal.pone.0069809. Print 2013. Erratum in: PLoS One. 2017 Apr 6;12 (4):e0175668.


Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy.

Matheu MP, Teijaro JR, Walsh KB, Greenberg ML, Marsolais D, Parker I, Rosen H, Oldstone MB, Cahalan MD.

PLoS One. 2013;8(3):e58033. doi: 10.1371/journal.pone.0058033. Epub 2013 Mar 22.


Orai1 function is essential for T cell homing to lymph nodes.

Greenberg ML, Yu Y, Leverrier S, Zhang SL, Parker I, Cahalan MD.

J Immunol. 2013 Apr 1;190(7):3197-206. doi: 10.4049/jimmunol.1202212. Epub 2013 Mar 1.


A decade of imaging cellular motility and interaction dynamics in the immune system.

Germain RN, Robey EA, Cahalan MD.

Science. 2012 Jun 29;336(6089):1676-81. doi: 10.1126/science.1221063. Review.


Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance.

Matheu MP, Su Y, Greenberg ML, Blanc CA, Parker I, Scott DW, Cahalan MD.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1258-66. doi: 10.1073/pnas.1205150109. Epub 2012 Apr 17.


CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.

Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF, Cahalan MD, Vacher P, Legembre P.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19072-7. doi: 10.1073/pnas.1116946108. Epub 2011 Nov 7.


Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states.

Demuro A, Penna A, Safrina O, Yeromin AV, Amcheslavsky A, Cahalan MD, Parker I.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17832-7. doi: 10.1073/pnas.1114814108. Epub 2011 Oct 10.


Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.

Zhang SL, Yeromin AV, Hu J, Amcheslavsky A, Zheng H, Cahalan MD.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17838-43. doi: 10.1073/pnas.1114821108. Epub 2011 Oct 10.


Analysis of transient migration behavior of natural killer cells imaged in situ and in vitro.

Khorshidi MA, Vanherberghen B, Kowalewski JM, Garrod KR, Lindström S, Andersson-Svahn H, Brismar H, Cahalan MD, Önfelt B.

Integr Biol (Camb). 2011 Jul;3(7):770-8. doi: 10.1039/c1ib00007a. Epub 2011 Jun 20.


Imaging transplant rejection: a new view.

Cahalan MD.

Nat Med. 2011 Jun;17(6):662-3. doi: 10.1038/nm0611-662. No abstract available.


Immunoimaging: studying immune system dynamics using two-photon microscopy.

Matheu MP, Cahalan MD, Parker I.

Cold Spring Harb Protoc. 2011 Feb 1;2011(2):pdb.top99. doi: 10.1101/pdb.top99. No abstract available.


In vivo lymph node imaging.

Matheu MP, Cahalan MD, Parker I.

Cold Spring Harb Protoc. 2011 Feb 1;2011(2):pdb.prot5568. doi: 10.1101/pdb.prot5568. No abstract available.


In situ lymph node imaging.

Matheu MP, Cahalan MD, Parker I.

Cold Spring Harb Protoc. 2011 Feb 1;2011(2):pdb.prot5567. doi: 10.1101/pdb.prot5567. No abstract available.


Induction of an immune response for imaging antigen-presenting cell/T-cell interactions.

Matheu MP, Cahalan MD, Parker I.

Cold Spring Harb Protoc. 2011 Feb 1;2011(2):pdb.prot5566. doi: 10.1101/pdb.prot5566. No abstract available.


General approach to adoptive transfer and cell labeling for immunoimaging.

Matheu MP, Cahalan MD, Parker I.

Cold Spring Harb Protoc. 2011 Feb 1;2011(2):pdb.prot5565. doi: 10.1101/pdb.prot5565. No abstract available.


Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.

Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM.

J Immunol. 2011 Jan 15;186(2):940-50. doi: 10.4049/jimmunol.1000942. Epub 2010 Dec 10.


Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.

Flach H, Rosenbaum M, Duchniewicz M, Kim S, Zhang SL, Cahalan MD, Mittler G, Grosschedl R.

Immunity. 2010 Nov 24;33(5):723-35. doi: 10.1016/j.immuni.2010.11.013.


Cell biology. How to STIMulate calcium channels.

Cahalan MD.

Science. 2010 Oct 1;330(6000):43-4. doi: 10.1126/science.1196348. No abstract available.


Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants.

Sen D, Forrest L, Kepler TB, Parker I, Cahalan MD.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8334-9. doi: 10.1073/pnas.0912817107. Epub 2010 Apr 19.


The immunological synapse: a dynamic platform for local signaling.

Krummel MF, Cahalan MD.

J Clin Immunol. 2010 May;30(3):364-72. doi: 10.1007/s10875-010-9393-6. Review.


NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity.

Garrod KR, Liu FC, Forrest LE, Parker I, Kang SM, Cahalan MD.

J Immunol. 2010 Mar 1;184(5):2329-36. doi: 10.4049/jimmunol.0902748. Epub 2010 Feb 5.


The impact of routine trans-oesophageal echocardiography (TOE) in cardiac surgery.

Desjardins G, Cahalan M.

Best Pract Res Clin Anaesthesiol. 2009 Sep;23(3):263-71. Review.


The functional network of ion channels in T lymphocytes.

Cahalan MD, Chandy KG.

Immunol Rev. 2009 Sep;231(1):59-87. doi: 10.1111/j.1600-065X.2009.00816.x. Review.


STIMulating store-operated Ca(2+) entry.

Cahalan MD.

Nat Cell Biol. 2009 Jun;11(6):669-77. doi: 10.1038/ncb0609-669. Review.


A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.

Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY, Thistlethwaite PA, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ, Yuan JX.

Circulation. 2009 May 5;119(17):2313-22. doi: 10.1161/CIRCULATIONAHA.108.782458. Epub 2009 Apr 20.


Murine skin transplantation.

Garrod KR, Cahalan MD.

J Vis Exp. 2008 Jan 16;(11). pii: 634. doi: 10.3791/634.


Generation of bone marrow derived murine dendritic cells for use in 2-photon imaging.

Matheu MP, Sen D, Cahalan MD, Parker I.

J Vis Exp. 2008 Jul 9;(17). pii: 773. doi: 10.3791/773.


Purifying plasmid DNA from bacterial colonies using the QIAGEN Miniprep Kit.

Zhang S, Cahalan MD.

J Vis Exp. 2007;(6):247. doi: 10.3791/247. Epub 2007 Jul 29.


Isolation of CD4+ T cells from mouse lymph nodes using Miltenyi MACS purification.

Matheu MP, Cahalan MD.

J Vis Exp. 2007;(9):409. doi: 10.3791/409. Epub 2007 Nov 1.


Dissection and 2-photon imaging of peripheral lymph nodes in mice.

Matheu MP, Parker I, Cahalan MD.

J Vis Exp. 2007;(7):265. doi: 10.3791/265. Epub 2007 Aug 23.


Western Blotting using the Invitrogen NuPage Novex Bis Tris minigels.

Penna A, Cahalan M.

J Vis Exp. 2007;(7):264. doi: 10.3791/264. Epub 2007 Aug 22.


Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.

Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD.

Immunity. 2008 Oct 17;29(4):602-14. doi: 10.1016/j.immuni.2008.07.015. Epub 2008 Oct 2.


Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo.

Sen D, Deerinck TJ, Ellisman MH, Parker I, Cahalan MD.

PLoS One. 2008 Sep 29;3(9):e3290. doi: 10.1371/journal.pone.0003290.


The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers.

Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I, Cahalan MD.

Nature. 2008 Nov 6;456(7218):116-20. doi: 10.1038/nature07338. Epub 2008 Sep 28.


Perioperative echocardiography: two-dimensional and three-dimensional applications.

Yeates TM, Zimmerman JM, Cahalan MK.

Anesthesiol Clin. 2008 Sep;26(3):419-35. doi: 10.1016/j.anclin.2008.03.004.


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