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Characterisation of the Major Extracellular Proteases of Stenotrophomonas maltophilia and Their Effects on Pulmonary Antiproteases.

Molloy K, Smith SG, Cagney G, Dillon ET, Greene CM, McElvaney NG.

Pathogens. 2019 Jun 28;8(3). pii: E92. doi: 10.3390/pathogens8030092.


ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort.

Sabherwal S, Föcking M, English JA, Fitzsimons S, Hryniewiecka M, Wynne K, Scaife C, Healy C, Cannon M, Belton O, Zammit S, Cagney G, Cotter DR.

Schizophr Res. 2019 Jul;209:141-147. doi: 10.1016/j.schres.2019.05.002. Epub 2019 May 10.


SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

Alsulami M, Munawar N, Dillon E, Oliviero G, Wynne K, Alsolami M, Moss C, Ó Gaora P, O'Meara F, Cotter D, Cagney G.

Mol Cell Proteomics. 2019 Jul;18(7):1428-1436. doi: 10.1074/mcp.RA119.001518. Epub 2019 May 10.


Epigenetic Factors in Schizophrenia: Mechanisms and Experimental Approaches.

Föcking M, Doyle B, Munawar N, Dillon ET, Cotter D, Cagney G.

Mol Neuropsychiatry. 2019 Mar;5(1):6-12. doi: 10.1159/000495063. Epub 2019 Feb 15. Review.


Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children.

Madrid-Gambin F, Föcking M, Sabherwal S, Heurich M, English JA, O'Gorman A, Suvitaival T, Ahonen L, Cannon M, Lewis G, Mattila I, Scaife C, Madden S, Hyötyläinen T, Orešič M, Zammit S, Cagney G, Cotter DR, Brennan L.

Biol Psychiatry. 2019 Jul 1;86(1):25-34. doi: 10.1016/j.biopsych.2019.01.018. Epub 2019 Jan 30.


Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.

Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O'Brien C, Cagney G, Crean J.

FASEB J. 2019 May;33(5):6667-6681. doi: 10.1096/fj.201800566RR. Epub 2019 Feb 19.


Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress.

Föcking M, Sabherwal S, Cates HM, Scaife C, Dicker P, Hryniewiecka M, Wynne K, Rutten BPF, Lewis G, Cannon M, Nestler EJ, Heurich M, Cagney G, Zammit S, Cotter DR.

Mol Psychiatry. 2019 Jan 11. doi: 10.1038/s41380-018-0306-z. [Epub ahead of print]


Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma.

Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP, Vermeulen M, Qi J, Fröhling S, Gray NS, Bradner JE, Vakoc CR, Armstrong SA.

Elife. 2018 Nov 15;7. pii: e41305. doi: 10.7554/eLife.41305.


The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ.

Cell. 2018 Jul 26;174(3):505-520. doi: 10.1016/j.cell.2018.06.016. Review.


Casein Hydrolysate with Glycemic Control Properties: Evidence from Cells, Animal Models, and Humans.

Drummond E, Flynn S, Whelan H, Nongonierma AB, Holton TA, Robinson A, Egan T, Cagney G, Shields DC, Gibney ER, Newsholme P, Gaudel C, Jacquier JC, Noronha N, FitzGerald RJ, Brennan L.

J Agric Food Chem. 2018 May 2;66(17):4352-4363. doi: 10.1021/acs.jafc.7b05550. Epub 2018 Apr 24.


A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.

Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP.

Mol Cell. 2018 May 3;70(3):408-421.e8. doi: 10.1016/j.molcel.2018.03.005. Epub 2018 Apr 5.


The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells.

Streubel G, Watson A, Jammula SG, Scelfo A, Fitzpatrick DJ, Oliviero G, McCole R, Conway E, Glancy E, Negri GL, Dillon E, Wynne K, Pasini D, Krogan NJ, Bracken AP, Cagney G.

Mol Cell. 2018 Apr 19;70(2):371-379.e5. doi: 10.1016/j.molcel.2018.02.027. Epub 2018 Mar 29.


Three novel proteins co-localise with polyhydroxybutyrate (PHB) granules in Rhodospirillum rubrum S1.

Narancic T, Scollica E, Cagney G, O'Connor KE.

Microbiology. 2018 Apr;164(4):625-634. doi: 10.1099/mic.0.000642. Epub 2018 Mar 1.


Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case-Control Study of the ALSPAC Longitudinal Birth Cohort.

English JA, Lopez LM, O'Gorman A, Föcking M, Hryniewiecka M, Scaife C, Sabherwal S, Wynne K, Dicker P, Rutten BPF, Lewis G, Zammit S, Cannon M, Cagney G, Cotter DR.

Schizophr Bull. 2018 Feb 15;44(2):297-306. doi: 10.1093/schbul/sbx075.


A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model.

Daly C, Shine L, Heffernan T, Deeti S, Reynolds AL, O'Connor JJ, Dillon ET, Duffy DJ, Kolch W, Cagney G, Kennedy BN.

Sci Rep. 2017 Sep 12;7(1):11320. doi: 10.1038/s41598-017-11513-5.


Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells.

Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ.

Cell Rep. 2017 Sep 5;20(10):2525. doi: 10.1016/j.celrep.2017.08.073. No abstract available.


The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex:  A Proteomic Analysis.

Farrelly L, Rosato-Siri MV, Föcking M, Codagnone M, Reines A, Dicker P, Wynne K, Farrell M, Cannon M, Cagney G, Pasquini JM, Cotter DR.

Proteomics. 2017 Sep;17(17-18). doi: 10.1002/pmic.201600407.


Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.

Streubel G, Fitzpatrick DJ, Oliviero G, Scelfo A, Moran B, Das S, Munawar N, Watson A, Wynne K, Negri GL, Dillon ET, Jammula S, Hokamp K, O'Connor DP, Pasini D, Cagney G, Bracken AP.

EMBO J. 2017 Aug 1;36(15):2216-2232. doi: 10.15252/embj.201696307. Epub 2017 May 29.


Corrigendum: miR302 regulates SNAI1 expression to control mesangial cell plasticity.

De Chiara L, Andrews D, Watson A, Oliviero G, Cagney G, Crean J.

Sci Rep. 2017 Feb 14;7:46802. doi: 10.1038/srep46802. No abstract available.


miR302 regulates SNAI1 expression to control mesangial cell plasticity.

De Chiara L, Andrews D, Watson A, Oliviero G, Cagney G, Crean J.

Sci Rep. 2017 Feb 14;7:42407. doi: 10.1038/srep42407. Erratum in: Sci Rep. 2017 Feb 14;7:46802.


A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab.

Butler CT, Reynolds AL, Tosetto M, Dillon ET, Guiry PJ, Cagney G, O'Sullivan J, Kennedy BN.

J Biol Chem. 2017 Mar 3;292(9):3552-3567. doi: 10.1074/jbc.M116.747766. Epub 2016 Dec 29.


Functional characterisation of the YIPF protein family in mammalian cells.

Kranjc T, Dempsey E, Cagney G, Nakamura N, Shields DC, Simpson JC.

Histochem Cell Biol. 2017 Apr;147(4):439-451. doi: 10.1007/s00418-016-1527-3. Epub 2016 Dec 20.


Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder.

Föcking M, Dicker P, Lopez LM, Hryniewiecka M, Wynne K, English JA, Cagney G, Cotter DR.

Transl Psychiatry. 2016 Nov 29;6(11):e959. doi: 10.1038/tp.2016.224.


Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

Oliviero G, Brien GL, Waston A, Streubel G, Jerman E, Andrews D, Doyle B, Munawar N, Wynne K, Crean J, Bracken AP, Cagney G.

Mol Cell Proteomics. 2016 Nov;15(11):3450-3460. Epub 2016 Sep 15.


Blood biomarker discovery in drug-free schizophrenia: the contributionof proteomics and multiplex immunoassays.

Sabherwal S, English JA, Föcking M, Cagney G, Cotter DR.

Expert Rev Proteomics. 2016 Dec;13(12):1141-1155. Epub 2016 Nov 11. Review.


Understanding the physiological roles of polyhydroxybutyrate (PHB) in Rhodospirillum rubrum S1 under aerobic chemoheterotrophic conditions.

Narancic T, Scollica E, Kenny ST, Gibbons H, Carr E, Brennan L, Cagney G, Wynne K, Murphy C, Raberg M, Heinrich D, Steinbüchel A, O'Connor KE.

Appl Microbiol Biotechnol. 2016 Oct;100(20):8901-12. doi: 10.1007/s00253-016-7711-5. Epub 2016 Aug 1.


Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells.

Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ.

Cell Rep. 2016 May 3;15(5):1024-1036. doi: 10.1016/j.celrep.2016.03.090. Epub 2016 Apr 21. Erratum in: Cell Rep. 2017 Sep 5;20(10):2525.


Dataset of mouse hippocampus profiled by LC-MS/MS for label-free quantitation.

English JA, Scaife C, Harauma A, Focking M, Wynne K, Cagney G, Moriguchi T, Cotter DR.

Data Brief. 2016 Feb 15;7:341-3. doi: 10.1016/j.dib.2015.12.057. eCollection 2016 Jun.


The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

Oliviero G, Munawar N, Watson A, Streubel G, Manning G, Bardwell V, Bracken AP, Cagney G.

Sci Rep. 2015 Dec 21;5:18388. doi: 10.1038/srep18388.


Reduced protein synthesis in schizophrenia patient-derived olfactory cells.

English JA, Fan Y, Föcking M, Lopez LM, Hryniewiecka M, Wynne K, Dicker P, Matigian N, Cagney G, Mackay-Sim A, Cotter DR.

Transl Psychiatry. 2015 Oct 20;5:e663. doi: 10.1038/tp.2015.119.


Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients.

Topol A, English JA, Flaherty E, Rajarajan P, Hartley BJ, Gupta S, Desland F, Zhu S, Goff T, Friedman L, Rapoport J, Felsenfeld D, Cagney G, Mackay-Sim A, Savas JN, Aronow B, Fang G, Zhang B, Cotter D, Brennand KJ.

Transl Psychiatry. 2015 Oct 20;5:e662. doi: 10.1038/tp.2015.118.


Native gel analysis of macromolecular protein complexes in cultured mammalian cells.

Munawar N, Olivero G, Jerman E, Doyle B, Streubel G, Wynne K, Bracken A, Cagney G.

Proteomics. 2015 Nov;15(21):3603-12. doi: 10.1002/pmic.201500045. Epub 2015 Aug 24.


Maternal immune activation induces changes in myelin and metabolic proteins, some of which can be prevented with risperidone in adolescence.

Farrelly L, Föcking M, Piontkewitz Y, Dicker P, English J, Wynne K, Cannon M, Cagney G, Cotter DR.

Dev Neurosci. 2015;37(1):43-55. doi: 10.1159/000368305. Epub 2015 Jan 13.


Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.

Föcking M, Lopez LM, English JA, Dicker P, Wolff A, Brindley E, Wynne K, Cagney G, Cotter DR.

Mol Psychiatry. 2015 Apr;20(4):424-32. doi: 10.1038/mp.2014.63. Epub 2014 Jul 22.


Adolescent Risperidone treatment alters protein expression associated with protein trafficking and cellular metabolism in the adult rat prefrontal cortex.

Farrelly LA, Dicker P, Wynne K, English J, Cagney G, Föcking M, Cotter DR.

Proteomics. 2014 Jun;14(12):1574-8. doi: 10.1002/pmic.201300466. Epub 2014 May 16.


Targeted proteomics for validation of biomarkers in early psychosis.

English JA, Wynne K, Cagney G, Cotter DR.

Biol Psychiatry. 2014 Sep 15;76(6):e7-9. doi: 10.1016/j.biopsych.2013.11.016. Epub 2013 Nov 22. No abstract available.


Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus.

English JA, Harauma A, Föcking M, Wynne K, Scaife C, Cagney G, Moriguchi T, Cotter DR.

Front Genet. 2013 Oct 28;4:208. doi: 10.3389/fgene.2013.00208. eCollection 2013.


The effect of polyphosphate kinase gene deletion on polyhydroxyalkanoate accumulation and carbon metabolism in Pseudomonas putida KT2440.

Casey WT, Nikodinovic-Runic J, Fonseca Garcia P, Guzik MW, McGrath JW, Quinn JP, Cagney G, Prieto MA, O'Connor KE.

Environ Microbiol Rep. 2013 Oct;5(5):740-6. doi: 10.1111/1758-2229.12076. Epub 2013 Aug 18.


Invadolysin, a conserved lipid-droplet-associated metalloproteinase, is required for mitochondrial function in Drosophila.

Di Cara F, Duca E, Dunbar DR, Cagney G, Heck MM.

J Cell Sci. 2013 Oct 15;126(Pt 20):4769-81. doi: 10.1242/jcs.133306. Epub 2013 Aug 13.


All or nothing: protein complexes flip essentiality between distantly related eukaryotes.

Ryan CJ, Krogan NJ, Cunningham P, Cagney G.

Genome Biol Evol. 2013;5(6):1049-59. doi: 10.1093/gbe/evt074.


Quantitative genetic-interaction mapping in mammalian cells.

Roguev A, Talbot D, Negri GL, Shales M, Cagney G, Bandyopadhyay S, Panning B, Krogan NJ.

Nat Methods. 2013 May;10(5):432-7. doi: 10.1038/nmeth.2398. Epub 2013 Feb 13.


Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.

Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP.

Nat Struct Mol Biol. 2012 Dec;19(12):1273-81. doi: 10.1038/nsmb.2449. Epub 2012 Nov 18.


Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ.

Mol Cell. 2012 Jun 8;46(5):691-704. doi: 10.1016/j.molcel.2012.05.028.


Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal.

Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho-Santos M, Krogan N, Ren B, Song JS, Reiter JF.

PLoS Genet. 2012;8(3):e1002576. doi: 10.1371/journal.pgen.1002576. Epub 2012 Mar 15.


Global landscape of HIV-human protein complexes.

Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ.

Nature. 2011 Dec 21;481(7381):365-70. doi: 10.1038/nature10719.


Imputing and predicting quantitative genetic interactions in epistatic MAPs.

Ryan C, Cagney G, Krogan N, Cunningham P, Greene D.

Methods Mol Biol. 2011;781:353-61. doi: 10.1007/978-1-61779-276-2_17.


Distinct configurations of protein complexes and biochemical pathways revealed by epistatic interaction network motifs.

Casey F, Krogan N, Shields DC, Cagney G.

BMC Syst Biol. 2011 Aug 22;5:133. doi: 10.1186/1752-0509-5-133.


Identification of β2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods.

Johnston O, Cassidy H, O'Connell S, O'Riordan A, Gallagher W, Maguire PB, Wynne K, Cagney G, Ryan MP, Conlon PJ, McMorrow T.

Proteomics Clin Appl. 2011 Aug;5(7-8):422-31. doi: 10.1002/prca.201000160. Epub 2011 Jul 13.


Improved functional overview of protein complexes using inferred epistatic relationships.

Ryan C, Greene D, Guénolé A, van Attikum H, Krogan NJ, Cunningham P, Cagney G.

BMC Syst Biol. 2011 May 23;5:80. doi: 10.1186/1752-0509-5-80.


Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia.

Agbor TA, Cheong A, Comerford KM, Scholz CC, Bruning U, Clarke A, Cummins EP, Cagney G, Taylor CT.

J Biol Chem. 2011 Feb 11;286(6):4718-26. doi: 10.1074/jbc.M110.115931. Epub 2010 Dec 1.

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