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Items: 1 to 50 of 69


A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer.

Bangi E, Ang C, Smibert P, Uzilov AV, Teague AG, Antipin Y, Chen R, Hecht C, Gruszczynski N, Yon WJ, Malyshev D, Laspina D, Selkridge I, Rainey H, Moe AS, Lau CY, Taik P, Wilck E, Bhardwaj A, Sung M, Kim S, Yum K, Sebra R, Donovan M, Misiukiewicz K, Schadt EE, Posner MR, Cagan RL.

Sci Adv. 2019 May 22;5(5):eaav6528. doi: 10.1126/sciadv.aav6528. eCollection 2019 May.


modEnrichr: a suite of gene set enrichment analysis tools for model organisms.

Kuleshov MV, Diaz JEL, Flamholz ZN, Keenan AB, Lachmann A, Wojciechowicz ML, Cagan RL, Ma'ayan A.

Nucleic Acids Res. 2019 Jul 2;47(W1):W183-W190. doi: 10.1093/nar/gkz347.


Modeling Cancer with Flies and Fish.

Cagan RL, Zon LI, White RM.

Dev Cell. 2019 May 6;49(3):317-324. doi: 10.1016/j.devcel.2019.04.013. Review.


Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network.

Ung PMU, Sonoshita M, Scopton AP, Dar AC, Cagan RL, Schlessinger A.

PLoS Comput Biol. 2019 Apr 26;15(4):e1006878. doi: 10.1371/journal.pcbi.1006878. eCollection 2019 Apr.


Restraining Network Response to Targeted Cancer Therapies Improves Efficacy and Reduces Cellular Resistance.

Das TK, Esernio J, Cagan RL.

Cancer Res. 2018 Aug 1;78(15):4344-4359. doi: 10.1158/0008-5472.CAN-17-2001. Epub 2018 May 29.


A whole-animal platform to advance a clinical kinase inhibitor into new disease space.

Sonoshita M, Scopton AP, Ung PMU, Murray MA, Silber L, Maldonado AY, Real A, Schlessinger A, Cagan RL, Dar AC.

Nat Chem Biol. 2018 Mar;14(3):291-298. doi: 10.1038/nchembio.2556. Epub 2018 Jan 22.


Non-mammalian models of multiple endocrine neoplasia type 2.

Das TK, Cagan RL.

Endocr Relat Cancer. 2018 Feb;25(2):T91-T104. doi: 10.1530/ERC-17-0411. Review.


Multi-targeting Drug Community Challenge.

Schlessinger A, Abagyan R, Carlson HA, Dang KK, Guinney J, Cagan RL.

Cell Chem Biol. 2017 Dec 21;24(12):1434-1435. doi: 10.1016/j.chembiol.2017.12.006. No abstract available.


KIF5B-RET Oncoprotein Signals through a Multi-kinase Signaling Hub.

Das TK, Cagan RL.

Cell Rep. 2017 Sep 5;20(10):2368-2383. doi: 10.1016/j.celrep.2017.08.037.


Modeling Human Cancers in Drosophila.

Sonoshita M, Cagan RL.

Curr Top Dev Biol. 2017;121:287-309. doi: 10.1016/bs.ctdb.2016.07.008. Epub 2016 Jul 30. Review.


Functional exploration of colorectal cancer genomes using Drosophila.

Bangi E, Murgia C, Teague AG, Sansom OJ, Cagan RL.

Nat Commun. 2016 Nov 29;7:13615. doi: 10.1038/ncomms13615.


Drosophila Cancer Models Identify Functional Differences between Ret Fusions.

Levinson S, Cagan RL.

Cell Rep. 2016 Sep 13;16(11):3052-3061. doi: 10.1016/j.celrep.2016.08.019.


Drosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic.

Levine BD, Cagan RL.

Cell Rep. 2016 Feb 16;14(6):1477-1487. doi: 10.1016/j.celrep.2015.12.105. Epub 2016 Jan 28.


Salt-inducible kinases mediate nutrient-sensing to link dietary sugar and tumorigenesis in Drosophila.

Hirabayashi S, Cagan RL.

Elife. 2015 Nov 17;4:e08501. doi: 10.7554/eLife.08501.


Diet-Induced Podocyte Dysfunction in Drosophila and Mammals.

Na J, Sweetwyne MT, Park AS, Susztak K, Cagan RL.

Cell Rep. 2015 Jul 28;12(4):636-47. doi: 10.1016/j.celrep.2015.06.056. Epub 2015 Jul 16.


A Drosophila approach to thyroid cancer therapeutics.

Das TK, Cagan RL.

Drug Discov Today Technol. 2013 Spring;10(1):e65-71. doi: 10.1016/j.ddtec.2012.09.004. Review.


Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis.

Das TK, Dana D, Paroly SS, Perumal SK, Singh S, Jhun H, Pendse J, Cagan RL, Talele TT, Kumar S.

Oncogenesis. 2013 Sep 9;2:e69. doi: 10.1038/oncsis.2013.34.


Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling.

Hirabayashi S, Baranski TJ, Cagan RL.

Cell. 2013 Aug 1;154(3):664-75. doi: 10.1016/j.cell.2013.06.030.


A Jnk-Rho-Actin remodeling positive feedback network directs Src-driven invasion.

Rudrapatna VA, Bangi E, Cagan RL.

Oncogene. 2014 May 22;33(21):2801-6. doi: 10.1038/onc.2013.232. Epub 2013 Jul 8.


Bridging the gap between basic and applied biology: towards preclinical translation.

Cagan RL, Justice MJ, Tidmarsh GF.

Dis Model Mech. 2013 May;6(3):559-61. doi: 10.1242/dmm.012450.


A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX.

Pendse J, Ramachandran PV, Na J, Narisu N, Fink JL, Cagan RL, Collins FS, Baranski TJ.

BMC Genomics. 2013 Feb 27;14:136. doi: 10.1186/1471-2164-14-136.


Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion.

Rudrapatna VA, Bangi E, Cagan RL.

EMBO Rep. 2013 Feb;14(2):172-7. doi: 10.1038/embor.2012.217. Epub 2013 Jan 11.


Interactions between Drosophila IgCAM adhesion receptors and cindr, the Cd2ap/Cin85 ortholog.

Johnson RI, Bao S, Cagan RL.

Dev Dyn. 2012 Dec;241(12):1933-43. doi: 10.1002/dvdy.23879. Epub 2012 Oct 29.


Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors.

Das TK, Sangodkar J, Negre N, Narla G, Cagan RL.

Oncogene. 2013 Jun 27;32(26):3184-97. doi: 10.1038/onc.2012.326. Epub 2012 Aug 13.


Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.

Dar AC, Das TK, Shokat KM, Cagan RL.

Nature. 2012 Jun 6;486(7401):80-4. doi: 10.1038/nature11127.


A local view of cancer.

Cagan RL, Aguirre-Ghiso JA.

Dev Cell. 2012 Mar 13;22(3):472-4. doi: 10.1016/j.devcel.2012.02.014.


Drosophila cancer models.

Rudrapatna VA, Cagan RL, Das TK.

Dev Dyn. 2012 Jan;241(1):107-18. doi: 10.1002/dvdy.22771. Epub 2011 Oct 28. Review.


Role for a Cindr-Arf6 axis in patterning emerging epithelia.

Johnson RI, Sedgwick A, D'Souza-Schorey C, Cagan RL.

Mol Biol Cell. 2011 Dec;22(23):4513-26. doi: 10.1091/mbc.E11-04-0305. Epub 2011 Oct 5.


A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila.

Musselman LP, Fink JL, Narzinski K, Ramachandran PV, Hathiramani SS, Cagan RL, Baranski TJ.

Dis Model Mech. 2011 Nov;4(6):842-9. doi: 10.1242/dmm.007948. Epub 2011 Jun 30.


The Drosophila nephrocyte.

Cagan RL.

Curr Opin Nephrol Hypertens. 2011 Jul;20(4):409-15. doi: 10.1097/MNH.0b013e328347ae02.


Preface. Aspects of eye development: advances over the past twenty years.

Cagan RL, Reh TA.

Curr Top Dev Biol. 2010;93:xi-xii. doi: 10.1016/B978-0-12-385044-7.00015-1. No abstract available.


Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter.

Cordero JB, Macagno JP, Stefanatos RK, Strathdee KE, Cagan RL, Vidal M.

Dev Cell. 2010 Jun 15;18(6):999-1011. doi: 10.1016/j.devcel.2010.05.014.


Computer simulation of cellular patterning within the Drosophila pupal eye.

Larson DE, Johnson RI, Swat M, Cordero JB, Glazier JA, Cagan RL.

PLoS Comput Biol. 2010 Jul 1;6:e1000841. doi: 10.1371/journal.pcbi.1000841.


Preferential adhesion maintains separation of ommatidia in the Drosophila eye.

Bao S, Fischbach KF, Corbin V, Cagan RL.

Dev Biol. 2010 Aug 15;344(2):948-56. doi: 10.1016/j.ydbio.2010.06.013. Epub 2010 Jun 16.


Canonical wingless signaling regulates cone cell specification in the Drosophila retina.

Cordero JB, Cagan RL.

Dev Dyn. 2010 Mar;239(3):875-84. doi: 10.1002/dvdy.22235.


A quantitative method to analyze Drosophila pupal eye patterning.

Johnson RI, Cagan RL.

PLoS One. 2009 Sep 15;4(9):e7008. doi: 10.1371/journal.pone.0007008.


Polychaetoid controls patterning by modulating adhesion in the Drosophila pupal retina.

Seppa MJ, Johnson RI, Bao S, Cagan RL.

Dev Biol. 2008 Jun 1;318(1):1-16. doi: 10.1016/j.ydbio.2008.02.022. Epub 2008 Mar 4.


The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning.

Johnson RI, Seppa MJ, Cagan RL.

J Cell Biol. 2008 Mar 24;180(6):1191-204. doi: 10.1083/jcb.200706108.


Cellular behavior in the developing Drosophila pupal retina.

Larson DE, Liberman Z, Cagan RL.

Mech Dev. 2008 Mar-Apr;125(3-4):223-32. doi: 10.1016/j.mod.2007.11.007. Epub 2007 Nov 24.


Differing Src signaling levels have distinct outcomes in Drosophila.

Vidal M, Warner S, Read R, Cagan RL.

Cancer Res. 2007 Nov 1;67(21):10278-85.


Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye.

Bruinsma SP, Cagan RL, Baranski TJ.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7098-103. Epub 2007 Apr 16.


Systematic analysis of the transcriptional switch inducing migration of border cells.

Borghese L, Fletcher G, Mathieu J, Atzberger A, Eades WC, Cagan RL, Rørth P.

Dev Cell. 2006 Apr;10(4):497-508. Erratum in: Dev Cell. 2009 Aug;17(2):299.


Drosophila models for cancer research.

Vidal M, Cagan RL.

Curr Opin Genet Dev. 2006 Feb;16(1):10-6. Epub 2005 Dec 15. Review.


A Drosophila model of multiple endocrine neoplasia type 2.

Read RD, Goodfellow PJ, Mardis ER, Novak N, Armstrong JR, Cagan RL.

Genetics. 2005 Nov;171(3):1057-81. Epub 2005 Jun 18.


A Drosophila p38 orthologue is required for environmental stress responses.

Craig CR, Fink JL, Yagi Y, Ip YT, Cagan RL.

EMBO Rep. 2004 Nov;5(11):1058-63.


Spermatogenesis: borrowing the apoptotic machinery.

Cagan RL.

Curr Biol. 2003 Aug 5;13(15):R600-2. Review.


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