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Disulfide Chaperone Knockouts Enable In Vivo Double Spin Labeling of an Outer Membrane Transporter.

Nilaweera TD, Nyenhuis DA, Nakamoto RK, Cafiso DS.

Biophys J. 2019 Oct 15;117(8):1476-1484. doi: 10.1016/j.bpj.2019.09.002. Epub 2019 Sep 10.


Phosphatidylinositol 4,5 Bisphosphate Controls the cis and trans Interactions of Synaptotagmin 1.

Nyenhuis SB, Thapa A, Cafiso DS.

Biophys J. 2019 Jul 23;117(2):247-257. doi: 10.1016/j.bpj.2019.06.016. Epub 2019 Jun 22.


In situ observation of conformational dynamics and protein ligand-substrate interactions in outer-membrane proteins with DEER/PELDOR spectroscopy.

Joseph B, Jaumann EA, Sikora A, Barth K, Prisner TF, Cafiso DS.

Nat Protoc. 2019 Aug;14(8):2344-2369. doi: 10.1038/s41596-019-0182-2. Epub 2019 Jul 5.


Hybrid Refinement of Heterogeneous Conformational Ensembles Using Spectroscopic Data.

Hays JM, Cafiso DS, Kasson PM.

J Phys Chem Lett. 2019 Jun 20;10(12):3410-3414. doi: 10.1021/acs.jpclett.9b01407. Epub 2019 Jun 7.


Exploration of the TRIM Fold of MuRF1 Using EPR Reveals a Canonical Antiparallel Structure and Extended COS-Box.

Stevens M, Franke B, Skorupka KA, Cafiso DS, Pornillos O, Mayans O, Norman DG.

J Mol Biol. 2019 Jul 12;431(15):2900-2909. doi: 10.1016/j.jmb.2019.05.025. Epub 2019 May 22.


A molecular mechanism for calcium-mediated synaptotagmin-triggered exocytosis.

Kiessling V, Kreutzberger AJB, Liang B, Nyenhuis SB, Seelheim P, Castle JD, Cafiso DS, Tamm LK.

Nat Struct Mol Biol. 2018 Oct;25(10):911-917. doi: 10.1038/s41594-018-0130-9. Epub 2018 Oct 5.


Choice of reconstitution protocol modulates the aggregation state of full-length membrane-reconstituted synaptotagmin-1.

Nyenhuis SB, Cafiso DS.

Protein Sci. 2018 May;27(5):1008-1012. doi: 10.1002/pro.3398. Epub 2018 Mar 22.


A Dynamic Protein-Protein Coupling between the TonB-Dependent Transporter FhuA and TonB.

Sarver JL, Zhang M, Liu L, Nyenhuis D, Cafiso DS.

Biochemistry. 2018 Feb 13;57(6):1045-1053. doi: 10.1021/acs.biochem.7b01223. Epub 2018 Jan 26.


TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition.

Roganowicz MD, Komurlu S, Mukherjee S, Plewka J, Alam SL, Skorupka KA, Wan Y, Dawidowski D, Cafiso DS, Ganser-Pornillos BK, Campbell EM, Pornillos O.

PLoS Pathog. 2017 Oct 17;13(10):e1006686. doi: 10.1371/journal.ppat.1006686. eCollection 2017 Oct.


Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity.

Lee J, Nyenhuis DA, Nelson EA, Cafiso DS, White JM, Tamm LK.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7987-E7996. doi: 10.1073/pnas.1708052114. Epub 2017 Sep 5.


Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions.

Katti S, Nyenhuis SB, Her B, Srivastava AK, Taylor AB, Hart PJ, Cafiso DS, Igumenova TI.

Biochemistry. 2017 Jun 27;56(25):3283-3295. doi: 10.1021/acs.biochem.7b00188. Epub 2017 Jun 15.


Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion.

Zdanowicz R, Kreutzberger A, Liang B, Kiessling V, Tamm LK, Cafiso DS.

Biophys J. 2017 Sep 19;113(6):1235-1250. doi: 10.1016/j.bpj.2017.04.002. Epub 2017 Apr 26.


Allosteric Signaling Is Bidirectional in an Outer-Membrane Transport Protein.

Sikora A, Joseph B, Matson M, Staley JR, Cafiso DS.

Biophys J. 2016 Nov 1;111(9):1908-1918. doi: 10.1016/j.bpj.2016.09.038.


PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.

Pérez-Lara Á, Thapa A, Nyenhuis SB, Nyenhuis DA, Halder P, Tietzel M, Tittmann K, Cafiso DS, Jahn R.

Elife. 2016 Oct 28;5. pii: e15886. doi: 10.7554/eLife.15886.


Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex.

Dawidowski D, Cafiso DS.

Structure. 2016 Mar 1;24(3):392-400. doi: 10.1016/j.str.2016.01.005. Epub 2016 Feb 11.


Ligand Induced Conformational Changes of a Membrane Transporter in E. coli Cells Observed with DEER/PELDOR.

Joseph B, Sikora A, Cafiso DS.

J Am Chem Soc. 2016 Feb 17;138(6):1844-7. doi: 10.1021/jacs.5b13382. Epub 2016 Feb 2.


Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strength.

Park Y, Seo JB, Fraind A, Pérez-Lara A, Yavuz H, Han K, Jung SR, Kattan I, Walla PJ, Choi M, Cafiso DS, Koh DS, Jahn R.

Nat Struct Mol Biol. 2015 Oct;22(10):815-23. doi: 10.1038/nsmb.3097. Epub 2015 Sep 21.


Distance Measurement on an Endogenous Membrane Transporter in E. coli Cells and Native Membranes Using EPR Spectroscopy.

Joseph B, Sikora A, Bordignon E, Jeschke G, Cafiso DS, Prisner TF.

Angew Chem Int Ed Engl. 2015 May 18;54(21):6196-9. doi: 10.1002/anie.201501086. Epub 2015 Mar 31.


Closure of the cytoplasmic gate formed by TM5 and TM11 during transport in the oxalate/formate exchanger from Oxalobacter formigenes.

Iyalomhe O, Herrick DZ, Cafiso DS, Maloney PC.

Biochemistry. 2014 Dec 16;53(49):7735-44. doi: 10.1021/bi5012173. Epub 2014 Dec 2.


Identifying and quantitating conformational exchange in membrane proteins using site-directed spin labeling.

Cafiso DS.

Acc Chem Res. 2014 Oct 21;47(10):3102-9. doi: 10.1021/ar500228s. Epub 2014 Aug 25. Review.


The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding.

Lu B, Kiessling V, Tamm LK, Cafiso DS.

J Biol Chem. 2014 Aug 8;289(32):22161-71. doi: 10.1074/jbc.M114.569327. Epub 2014 Jun 27.


The SNARE motif of synaptobrevin exhibits an aqueous-interfacial partitioning that is modulated by membrane curvature.

Liang B, Dawidowski D, Ellena JF, Tamm LK, Cafiso DS.

Biochemistry. 2014 Mar 11;53(9):1485-94. doi: 10.1021/bi401638u. Epub 2014 Feb 28.


Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited.

Regan MC, Horanyi PS, Pryor EE Jr, Sarver JL, Cafiso DS, Bushweller JH.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13374-9. doi: 10.1073/pnas.1301726110. Epub 2013 Jul 29.


Allosteric control of syntaxin 1a by Munc18-1: characterization of the open and closed conformations of syntaxin.

Dawidowski D, Cafiso DS.

Biophys J. 2013 Apr 2;104(7):1585-94. doi: 10.1016/j.bpj.2013.02.004.


Monomeric TonB and the Ton box are required for the formation of a high-affinity transporter-TonB complex.

Freed DM, Lukasik SM, Sikora A, Mokdad A, Cafiso DS.

Biochemistry. 2013 Apr 16;52(15):2638-48. doi: 10.1021/bi3016108. Epub 2013 Apr 4.


Taking the pulse of protein interactions by EPR spectroscopy.

Cafiso DS.

Biophys J. 2012 Nov 21;103(10):2047-8. doi: 10.1016/j.bpj.2012.10.005. Epub 2012 Nov 20.


Ligand-induced structural changes in the Escherichia coli ferric citrate transporter reveal modes for regulating protein-protein interactions.

Mokdad A, Herrick DZ, Kahn AK, Andrews E, Kim M, Cafiso DS.

J Mol Biol. 2012 Nov 9;423(5):818-30. doi: 10.1016/j.jmb.2012.09.003. Epub 2012 Sep 11.


Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission.

Boura E, Różycki B, Chung HS, Herrick DZ, Canagarajah B, Cafiso DS, Eaton WA, Hummer G, Hurley JH.

Structure. 2012 May 9;20(5):874-86. doi: 10.1016/j.str.2012.03.008.


The N-terminal domain of a TonB-dependent transporter undergoes a reversible stepwise denaturation.

Flores Jiménez RH, Cafiso DS.

Biochemistry. 2012 May 1;51(17):3642-50. doi: 10.1021/bi300118a. Epub 2012 Apr 22.


Lipid and membrane mimetic environments modulate spin label side chain configuration in the outer membrane protein A.

Jiménez RH, Freed DM, Cafiso DS.

J Phys Chem B. 2011 Dec 15;115(49):14822-30. doi: 10.1021/jp207420d. Epub 2011 Nov 15.


Molecular origin of electron paramagnetic resonance line shapes on β-barrel membrane proteins: the local solvation environment modulates spin-label configuration.

Freed DM, Khan AK, Horanyi PS, Cafiso DS.

Biochemistry. 2011 Oct 18;50(41):8792-803. doi: 10.1021/bi200971x. Epub 2011 Sep 22.


Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine.

Lai AL, Tamm LK, Ellena JF, Cafiso DS.

J Biol Chem. 2011 Jul 15;286(28):25291-300. doi: 10.1074/jbc.M111.258848. Epub 2011 May 24.


Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy.

Boura E, Rózycki B, Herrick DZ, Chung HS, Vecer J, Eaton WA, Cafiso DS, Hummer G, Hurley JH.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9437-42. doi: 10.1073/pnas.1101763108. Epub 2011 May 19.


Membrane thickness varies around the circumference of the transmembrane protein BtuB.

Ellena JF, Lackowicz P, Mongomery H, Cafiso DS.

Biophys J. 2011 Mar 2;100(5):1280-7. doi: 10.1016/j.bpj.2011.01.055.


Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together.

Kuo W, Herrick DZ, Cafiso DS.

Biochemistry. 2011 Apr 5;50(13):2633-41. doi: 10.1021/bi200049c. Epub 2011 Mar 7.


Partitioning of synaptotagmin I C2 domains between liquid-ordered and liquid-disordered inner leaflet lipid phases.

Wan C, Kiessling V, Cafiso DS, Tamm LK.

Biochemistry. 2011 Apr 5;50(13):2478-85. doi: 10.1021/bi101864k. Epub 2011 Mar 7.


Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous.

Lai AL, Huang H, Herrick DZ, Epp N, Cafiso DS.

J Mol Biol. 2011 Jan 21;405(3):696-706. doi: 10.1016/j.jmb.2010.11.015. Epub 2010 Nov 16.


Conformational exchange in a membrane transport protein is altered in protein crystals.

Freed DM, Horanyi PS, Wiener MC, Cafiso DS.

Biophys J. 2010 Sep 8;99(5):1604-10. doi: 10.1016/j.bpj.2010.06.026.


Osmolytes modulate conformational exchange in solvent-exposed regions of membrane proteins.

Flores Jiménez RH, Do Cao MA, Kim M, Cafiso DS.

Protein Sci. 2010 Feb;19(2):269-78. doi: 10.1002/pro.305.


Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation.

Ellena JF, Liang B, Wiktor M, Stein A, Cafiso DS, Jahn R, Tamm LK.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20306-11. doi: 10.1073/pnas.0908317106. Epub 2009 Nov 16.


Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging.

Herrick DZ, Kuo W, Huang H, Schwieters CD, Ellena JF, Cafiso DS.

J Mol Biol. 2009 Jul 31;390(5):913-23. doi: 10.1016/j.jmb.2009.06.007. Epub 2009 Jun 6.


Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach.

Do Cao MA, Crouzy S, Kim M, Becchi M, Cafiso DS, Di Pietro A, Jault JM.

Protein Sci. 2009 Jul;18(7):1507-20. doi: 10.1002/pro.141.


The calcium-dependent and calcium-independent membrane binding of synaptotagmin 1: two modes of C2B binding.

Kuo W, Herrick DZ, Ellena JF, Cafiso DS.

J Mol Biol. 2009 Mar 27;387(2):284-94. doi: 10.1016/j.jmb.2009.01.064.


NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation.

Zhou Y, Cierpicki T, Jimenez RH, Lukasik SM, Ellena JF, Cafiso DS, Kadokura H, Beckwith J, Bushweller JH.

Mol Cell. 2008 Sep 26;31(6):896-908. doi: 10.1016/j.molcel.2008.08.028.


Spin-diffusion couples proton relaxation rates for proteins in exchange with a membrane interface.

Bhowmik A, Ellena JF, Bryant RG, Cafiso DS.

J Magn Reson. 2008 Oct;194(2):283-8. doi: 10.1016/j.jmr.2008.07.023. Epub 2008 Aug 3.


Membrane hydrocarbon thickness modulates the dynamics of a membrane transport protein.

Xu Q, Kim M, Ho KW, Lachowicz P, Fanucci GE, Cafiso DS.

Biophys J. 2008 Sep 15;95(6):2849-58. doi: 10.1529/biophysj.108.133629. Epub 2008 Jun 27.


Intra and inter-molecular interactions dictate the aggregation state of irinotecan co-encapsulated with floxuridine inside liposomes.

Dicko A, Frazier AA, Liboiron BD, Hinderliter A, Ellena JF, Xie X, Cho C, Weber T, Tardi PG, Cabral-Lilly D, Cafiso DS, Mayer LD.

Pharm Res. 2008 Jul;25(7):1702-13. doi: 10.1007/s11095-008-9561-z. Epub 2008 Mar 5.


Solutes alter the conformation of the ligand binding loops in outer membrane transporters.

Kim M, Xu Q, Murray D, Cafiso DS.

Biochemistry. 2008 Jan 15;47(2):670-9. Epub 2007 Dec 20.


The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly.

Derewenda U, Tarricone C, Choi WC, Cooper DR, Lukasik S, Perrina F, Tripathy A, Kim MH, Cafiso DS, Musacchio A, Derewenda ZS.

Structure. 2007 Nov;15(11):1467-81.

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