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Items: 1 to 50 of 76

1.

Chromatin and other obstacles to base excision repair: potential roles in carcinogenesis.

Caffrey PJ, Delaney S.

Mutagenesis. 2019 Oct 14. pii: gez029. doi: 10.1093/mutage/gez029. [Epub ahead of print]

PMID:
31612219
2.

Initiating base excision repair in chromatin.

Kennedy EE, Caffrey PJ, Delaney S.

DNA Repair (Amst). 2018 Nov;71:87-92. doi: 10.1016/j.dnarep.2018.08.011. Epub 2018 Aug 24. Review.

3.

Phase I trial of selenium plus chemotherapy in gynecologic cancers.

Song M, Kumaran MN, Gounder M, Gibbon DG, Nieves-Neira W, Vaidya A, Hellmann M, Kane MP, Buckley B, Shih W, Caffrey PB, Frenkel GD, Rodriguez-Rodriguez L.

Gynecol Oncol. 2018 Sep;150(3):478-486. doi: 10.1016/j.ygyno.2018.07.001. Epub 2018 Jul 29.

4.

New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus.

Sheehan J, Murphy CD, Caffrey P.

Mol Biosyst. 2017 May 2;13(5):866-873. doi: 10.1039/c7mb00112f.

PMID:
28383583
5.

Engineered biosynthesis and characterisation of disaccharide-modified 8-deoxyamphoteronolides.

Walmsley S, De Poire E, Rawlings B, Caffrey P.

Appl Microbiol Biotechnol. 2017 Mar;101(5):1899-1905. doi: 10.1007/s00253-016-7986-6. Epub 2016 Nov 17.

PMID:
27858138
6.

A Model of the Development of Cisplatin Resistance in Human Small Cell Lung Cancer Xenografts.

Caffrey PB, Frenkel GD, McAndrew KL, Marks K.

In Vivo. 2016 11-12;30(6):745-749.

PMID:
27815457
7.

Corrigendum to "Dissecting complex polyketide biosynthesis" [Comput Struct Biotechnol J 3(4) (2012) 1-8].

Caffrey P.

Comput Struct Biotechnol J. 2015 Nov 27;14:86. doi: 10.1016/j.csbj.2015.11.003. eCollection 2016.

8.

Polyene macrolide biosynthesis in streptomycetes and related bacteria: recent advances from genome sequencing and experimental studies.

Caffrey P, De Poire E, Sheehan J, Sweeney P.

Appl Microbiol Biotechnol. 2016 May;100(9):3893-908. doi: 10.1007/s00253-016-7474-z. Epub 2016 Mar 29. Review.

PMID:
27023916
9.

Exploiting the genome sequence of Streptomyces nodosus for enhanced antibiotic production.

Sweeney P, Murphy CD, Caffrey P.

Appl Microbiol Biotechnol. 2016 Feb;100(3):1285-1295. doi: 10.1007/s00253-015-7060-9. Epub 2015 Oct 26.

PMID:
26497174
10.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

11.

Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane.

Yamamoto T, Umegawa Y, Tsuchikawa H, Matsumori N, Hanashima S, Murata M, Haser R, Rawlings BJ, Caffrey P.

Bioorg Med Chem. 2015 Sep 1;23(17):5782-8. doi: 10.1016/j.bmc.2015.07.009. Epub 2015 Jul 11.

PMID:
26209267
12.

Prevention of carboplatin-induced resistance in human ovarian tumor xenografts by selenite.

Caffrey PB, Frenkel GD.

Anticancer Res. 2013 Oct;33(10):4249-54.

PMID:
24122988
13.

Engineered biosynthesis of disaccharide-modified polyene macrolides.

De Poire E, Stephens N, Rawlings B, Caffrey P.

Appl Environ Microbiol. 2013 Oct;79(19):6156-9. doi: 10.1128/AEM.02197-13. Epub 2013 Aug 2.

14.

Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis.

Stephens N, Rawlings B, Caffrey P.

Biosci Biotechnol Biochem. 2013;77(4):880-3. Epub 2013 Apr 7.

15.
16.

Ultrafast laser-induced microstructure/nanostructure replication and optical properties.

Caffrey PO, Nayak BK, Gupta MC.

Appl Opt. 2012 Feb 10;51(5):604-9. doi: 10.1364/AO.51.000604.

PMID:
22330293
17.

Streptomyces nodosus host strains optimized for polyene glycosylation engineering.

Stephens N, Rawlings B, Caffrey P.

Biosci Biotechnol Biochem. 2012;76(2):384-7. Epub 2012 Feb 7.

18.

Dissecting complex polyketide biosynthesis.

Caffrey P.

Comput Struct Biotechnol J. 2012 Nov 17;3:e201210010. doi: 10.5936/csbj.201210010. eCollection 2012. Review. Erratum in: Comput Struct Biotechnol J. 2016;14:86.

19.

A labile point in mutant amphotericin polyketide synthases.

Khan N, Rawlings B, Caffrey P.

Biotechnol Lett. 2011 Jun;33(6):1121-6. doi: 10.1007/s10529-011-0538-3. Epub 2011 Jan 26.

PMID:
21267757
20.

Isolation and characterisation of amphotericin B analogues and truncated polyketide intermediates produced by genetic engineering of Streptomyces nodosus.

Murphy B, Anderson K, Borissow C, Caffrey P, Griffith G, Hearn J, Ibrahim O, Khan N, Lamburn N, Lee M, Pugh K, Rawlings B.

Org Biomol Chem. 2010 Aug 21;8(16):3758-70. doi: 10.1039/b922074g. Epub 2010 Jun 23.

PMID:
20571619
21.

Redesign of polyene macrolide glycosylation: engineered biosynthesis of 19-(O)-perosaminyl-amphoteronolide B.

Hutchinson E, Murphy B, Dunne T, Breen C, Rawlings B, Caffrey P.

Chem Biol. 2010 Feb 26;17(2):174-82. doi: 10.1016/j.chembiol.2010.01.007.

22.

Engaging parliamentarians as advocates for women's health: findings from Kenya and Namibia.

Caffrey P, Weiss E, Wood L, Connor E, Orza L, Trasi R.

Glob Public Health. 2009;4(3):271-83. doi: 10.1080/17441690902769651.

PMID:
19437215
23.

Genetic analysis of nystatin and amphotericin biosynthesis.

Zotchev S, Caffrey P.

Methods Enzymol. 2009;459:243-58. doi: 10.1016/S0076-6879(09)04611-4.

PMID:
19362643
24.

Phosphomannose isomerase and phosphomannomutase gene disruptions in Streptomyces nodosus: impact on amphotericin biosynthesis and implications for glycosylation engineering.

Nic Lochlainn L, Caffrey P.

Metab Eng. 2009 Jan;11(1):40-7. doi: 10.1016/j.ymben.2008.08.007. Epub 2008 Sep 17.

PMID:
18824121
25.

Effects of new amphotericin analogues on the scrapie isoform of the prion protein.

Soler L, Caffrey P, McMahon HE.

Biochim Biophys Acta. 2008 Oct;1780(10):1162-7. doi: 10.1016/j.bbagen.2008.07.005. Epub 2008 Jul 18.

PMID:
18691635
26.

Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents.

Caffrey P, Aparicio JF, Malpartida F, Zotchev SB.

Curr Top Med Chem. 2008;8(8):639-53. Review.

PMID:
18473889
27.

Engineered synthesis of 7-oxo- and 15-deoxy-15-oxo-amphotericins: insights into structure-activity relationships in polyene antibiotics.

Power P, Dunne T, Murphy B, Nic Lochlainn L, Rai D, Borissow C, Rawlings B, Caffrey P.

Chem Biol. 2008 Jan;15(1):78-86. doi: 10.1016/j.chembiol.2007.11.008.

28.

Alpha-pinene oxidation in the presence of seed aerosol: estimates of nucleation rates, growth rates, and yield.

Verheggen B, Mozurkewich M, Caffrey P, Frick G, Hoppel W, Sullivan W.

Environ Sci Technol. 2007 Sep 1;41(17):6046-51.

PMID:
17937280
29.

The stereochemistry of ketoreduction.

Caffrey P.

Chem Biol. 2005 Oct;12(10):1060-2. Review.

30.

Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.

Carmody M, Murphy B, Byrne B, Power P, Rai D, Rawlings B, Caffrey P.

J Biol Chem. 2005 Oct 14;280(41):34420-6. Epub 2005 Aug 3.

31.

Measurements of the acid-binding capacity of ingredients used in pig diets.

Lawlor PG, Lynch PB, Caffrey PJ, O'Reilly JJ, O'Connell MK.

Ir Vet J. 2005 Aug 1;58(8):447-52. doi: 10.1186/2046-0481-58-8-447.

32.

Analysis and manipulation of amphotericin biosynthetic genes by means of modified phage KC515 transduction techniques.

Carmody M, Byrne B, Murphy B, Breen C, Lynch S, Flood E, Finnan S, Caffrey P.

Gene. 2004 Dec 8;343(1):107-15.

PMID:
15563836
33.

New start and finish for complex polyketide biosynthesis.

Caffrey P.

Chem Biol. 2004 Feb;11(2):155-7.

34.

Biosynthesis of deoxyamphotericins and deoxyamphoteronolides by engineered strains of Streptomyces nodosus.

Byrne B, Carmody M, Gibson E, Rawlings B, Caffrey P.

Chem Biol. 2003 Dec;10(12):1215-24.

PMID:
14700629
35.

Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases.

Caffrey P.

Chembiochem. 2003 Jul 7;4(7):654-7. No abstract available.

PMID:
12851937
36.

Polyene antibiotic biosynthesis gene clusters.

Aparicio JF, Caffrey P, Gil JA, Zotchev SB.

Appl Microbiol Biotechnol. 2003 May;61(3):179-88. Epub 2002 Dec 18. Review.

PMID:
12698274
37.

Effect of liquid feeding weaned pigs on growth performance to harvest.

Lawlor PG, Lynch PB, Gardiner GE, Caffrey PJ, O'Doherty JV.

J Anim Sci. 2002 Jul;80(7):1725-35.

PMID:
12162639
38.

A prevention strategy for circumventing drug resistance in cancer chemotherapy.

Frenkel GD, Caffrey PB.

Curr Pharm Des. 2001 Nov;7(16):1595-614. Review.

PMID:
11562301
39.

Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.

Caffrey P, Lynch S, Flood E, Finnan S, Oliynyk M.

Chem Biol. 2001 Jul;8(7):713-23. Erratum in: Chem Biol. 2003 Jan;10(1):93-4..

40.

The eating quality of meat of steers fed grass and/or concentrates.

French P, O'Riordan EG, Monahan FJ, Caffrey PJ, Mooney MT, Troy DJ, Moloney AP.

Meat Sci. 2001 Apr;57(4):379-86.

PMID:
22061710
41.

Fatty acid composition, including conjugated linoleic acid, of intramuscular fat from steers offered grazed grass, grass silage, or concentrate-based diets.

French P, Stanton C, Lawless F, O'Riordan EG, Monahan FJ, Caffrey PJ, Moloney AP.

J Anim Sci. 2000 Nov;78(11):2849-55.

PMID:
11063308
42.

Lactic acidosis associated with nucleoside reverse transcriptase inhibitors.

Caffrey PM.

J Assoc Nurses AIDS Care. 2000 Sep-Oct;11(5):91-5. Review.

PMID:
11022335
43.

Meat quality of steers finished on autumn grass, grass silage or concentrate-based diets.

French P, O'Riordan EG, Monahan FJ, Caffrey PJ, Vidal M, Mooney MT, Troy DJ, Moloney AP.

Meat Sci. 2000 Oct;56(2):173-80.

PMID:
22061906
44.
45.

Rapid development of glutathione-S-transferase-dependent drug resistance in vitro and its prevention by ethacrynic acid.

Caffrey PB, Zhu M, Zhang Y, Chinen N, Frenkel GD.

Cancer Lett. 1999 Feb 8;136(1):47-52.

PMID:
10211938
46.

Prevention of the development of melphalan resistance in vitro by selenite.

Caffrey PB, Zhu M, Frenkel GD.

Biol Trace Elem Res. 1998 Dec;65(3):187-95.

PMID:
9892492
47.

Rapid development of drug resistance in human ovarian tumor xenografts after a single treatment with melphalan in Vivo.

Caffrey PB, Zhang Y, Frenkel GD.

Anticancer Res. 1998 Jul-Aug;18(4C):3021-5.

PMID:
9713503
48.
49.

Sensitivity of melphalan-resistant tumors to selenite in vivo.

Caffrey PB, Frenkel GD.

Cancer Lett. 1997 Dec 23;121(2):177-80.

PMID:
9570356
50.

Evidence for a double-helical structure for modular polyketide synthases.

Staunton J, Caffrey P, Aparicio JF, Roberts GA, Bethell SS, Leadlay PF.

Nat Struct Biol. 1996 Feb;3(2):188-92.

PMID:
8564546

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