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Items: 1 to 50 of 329


Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin.

Olatunji S, Yu X, Bailey J, Huang CY, Zapotoczna M, Bowen K, Remškar M, Müller R, Scanlan EM, Geoghegan JA, Olieric V, Caffrey M.

Nat Commun. 2020 Jan 9;11(1):140. doi: 10.1038/s41467-019-13724-y.


X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.

Thomaston JL, Konstantinidi A, Liu L, Lambrinidis G, Tan J, Caffrey M, Wang J, Degrado WF, Kolocouris A.

Biochemistry. 2020 Feb 4;59(4):627-634. doi: 10.1021/acs.biochem.9b00971. Epub 2020 Jan 13.


Gathering evidence on insulin rationing: answers and future questions.

Caffrey M.

Am J Manag Care. 2019 Sep 1;25(10 Spec No.). pii: 88168. No abstract available.


Identification of a pH sensor in Influenza hemagglutinin using X-ray crystallography.

Antanasijevic A, Durst MA, Lavie A, Caffrey M.

J Struct Biol. 2020 Jan 1;209(1):107412. doi: 10.1016/j.jsb.2019.107412. Epub 2019 Nov 2.


NavWell: A simplified virtual-reality platform for spatial navigation and memory experiments.

Commins S, Duffin J, Chaves K, Leahy D, Corcoran K, Caffrey M, Keenan L, Finan D, Thornberry C.

Behav Res Methods. 2019 Oct 21. doi: 10.3758/s13428-019-01310-5. [Epub ahead of print]


NMR-based metabolite studies with 15N amino acids.

Ramirez B, Durst MA, Lavie A, Caffrey M.

Sci Rep. 2019 Sep 5;9(1):12798. doi: 10.1038/s41598-019-49208-8.


COTA collaboration: helping FDA figure out what's possible, what's not in embrace of real-world evidence.

Norden A, Caffrey M.

Am J Manag Care. 2019 Aug;25(9 Spec No.):SP266-SP268. No abstract available.


Understanding the role of the OB/GYN in evaluating hereditary cancer risk.

Levy BS, Caffrey M.

Am J Manag Care. 2019 Aug;25(9 Spec No.):SP274-SP275. No abstract available.


Three years after advocates report flaws, Medicare diabetes test strip bidding program nears collapse.

Caffrey M, DiGrande S.

Am J Manag Care. 2019 Mar;25(4 Spec No.):SP120-SP122. No abstract available.


Finding the right combination for neoadjuvant therapy in high-risk, stage III melanoma.

Amaria R, Caffrey M.

Am J Manag Care. 2019 Feb;25(2 Spec No.):SP43-SP44. No abstract available.


Time for a "new goalpost" in cardiovascular outcomes trials, Kosiborod suggests.

Kosiborod M, Caffrey M.

Am J Manag Care. 2018 Dec;24(14 Spec No.):SP602-SP604. No abstract available.


Squaring value-based payment with innovation in oncology.

Caffrey M.

Am J Manag Care. 2018 Oct;24(12 Spec No.):SP482-SP484. No abstract available.


In situ serial crystallography for rapid de novo membrane protein structure determination.

Huang CY, Olieric V, Howe N, Warshamanage R, Weinert T, Panepucci E, Vogeley L, Basu S, Diederichs K, Caffrey M, Wang M.

Commun Biol. 2018 Aug 27;1:124. doi: 10.1038/s42003-018-0123-6. eCollection 2018.


Patching a leak in an R1 university gateway STEM course.

Lee S, Crane BR, Ruttledge T, Guelce D, Yee EF, Lenetsky M, Caffrey M, Johnsen WA, Lin A, Lu S, Rodriguez MA, Wague A, Wu K.

PLoS One. 2018 Sep 6;13(9):e0202041. doi: 10.1371/journal.pone.0202041. eCollection 2018.


Membrane (and Soluble) Protein Stability and Binding Measurements in the Lipid Cubic Phase Using Label-Free Differential Scanning Fluorimetry.

Boland C, Olatunji S, Bailey J, Howe N, Weichert D, Fetics SK, Yu X, Merino-Gracia J, Delsaut C, Caffrey M.

Anal Chem. 2018 Oct 16;90(20):12152-12160. doi: 10.1021/acs.analchem.8b03176. Epub 2018 Oct 4.


Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists.

Gardelli C, Wada H, Ray A, Caffrey M, Llinas A, Shamovsky I, Tholander J, Larsson J, Sivars U, Hultin L, Andersson U, Sanganee HJ, Stenvall K, Leidvik B, Gedda K, Jinton L, Rydén Landergren M, Karabelas K.

J Med Chem. 2018 Jul 26;61(14):5974-5987. doi: 10.1021/acs.jmedchem.8b00322. Epub 2018 Jul 6.


Provocative questions, better biomarkers, and the prospect of triple therapy: a conversation with NYU's Jeffrey S. Weber, MD, PhD.

Weber JS, Caffrey MK.

Am J Manag Care. 2018 Feb;24(2 Spec No.):SP53-SP54. No abstract available.


Biophysical characterization and stabilization of detergent-solubilized lipoprotein N-acyl transferase from P. aeruginosa and E. coli.

Wiktor M, Caffrey M.

Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1384-1393. doi: 10.1016/j.bbamem.2018.03.018. Epub 2018 Mar 21.


Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist.

Yin W, Zhou XE, Yang D, de Waal PW, Wang M, Dai A, Cai X, Huang CY, Liu P, Wang X, Yin Y, Liu B, Zhou Y, Wang J, Liu H, Caffrey M, Melcher K, Xu Y, Wang MW, Xu HE, Jiang Y.

Cell Discov. 2018 Mar 13;4:12. doi: 10.1038/s41421-018-0009-2. eCollection 2018.


Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis.

El Ghachi M, Howe N, Huang CY, Olieric V, Warshamanage R, Touzé T, Weichert D, Stansfeld PJ, Wang M, Kerff F, Caffrey M.

Nat Commun. 2018 Mar 14;9(1):1078. doi: 10.1038/s41467-018-03477-5.


A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo.

Nguyen HA, Su Y, Zhang JY, Antanasijevic A, Caffrey M, Schalk AM, Liu L, Rondelli D, Oh A, Mahmud DL, Bosland MC, Kajdacsy-Balla A, Peirs S, Lammens T, Mondelaers V, De Moerloose B, Goossens S, Schlicht MJ, Kabirov KK, Lyubimov AV, Merrill BJ, Saunthararajah Y, Van Vlierberghe P, Lavie A.

Cancer Res. 2018 Mar 15;78(6):1549-1560. doi: 10.1158/0008-5472.CAN-17-2106. Epub 2018 Jan 17.


How technology, social media are changing the way clinical trials connect with patients.

Caffrey M.

Am J Manag Care. 2017 Dec;23(13 Spec No.):SP548-SP549. No abstract available.


Aniline-Based Inhibitors of Influenza H1N1 Virus Acting on Hemagglutinin-Mediated Fusion.

Leiva R, Barniol-Xicota M, Codony S, Ginex T, Vanderlinden E, Montes M, Caffrey M, Luque FJ, Naesens L, Vázquez S.

J Med Chem. 2018 Jan 11;61(1):98-118. doi: 10.1021/acs.jmedchem.7b00908. Epub 2017 Dec 22.


Proton movement and coupling in the POT family of peptide transporters.

Parker JL, Li C, Brinth A, Wang Z, Vogeley L, Solcan N, Ledderboge-Vucinic G, Swanson JMJ, Caffrey M, Voth GA, Newstead S.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13182-13187. doi: 10.1073/pnas.1710727114. Epub 2017 Nov 27.


Probing the metastable state of influenza hemagglutinin.

Kingsley CN, Antanasijevic A, Palka-Hamblin H, Durst M, Ramirez B, Lavie A, Caffrey M.

J Biol Chem. 2017 Dec 29;292(52):21590-21597. doi: 10.1074/jbc.M117.815043. Epub 2017 Nov 10.


Editorial overview: Membranes.

Caffrey M, Drew D.

Curr Opin Struct Biol. 2017 Aug;45:vii-ix. doi: 10.1016/ Epub 2017 Sep 1. No abstract available.


The cubicon method for concentrating membrane proteins in the cubic mesophase.

Ma P, Weichert D, Aleksandrov LA, Jensen TJ, Riordan JR, Liu X, Kobilka BK, Caffrey M.

Nat Protoc. 2017 Sep;12(9):1745-1762. doi: 10.1038/nprot.2017.057. Epub 2017 Aug 3.


Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis.

Wiktor M, Weichert D, Howe N, Huang CY, Olieric V, Boland C, Bailey J, Vogeley L, Stansfeld PJ, Buddelmeijer N, Wang M, Caffrey M.

Nat Commun. 2017 Jul 4;8:15952. doi: 10.1038/ncomms15952.


Molecular Mechanism Underlying the Action of Influenza A Virus Fusion Inhibitor MBX2546.

Basu A, Komazin-Meredith G, McCarthy C, Antanasijevic A, Cardinale SC, Mishra RK, Barnard DL, Caffrey M, Rong L, Bowlin TL.

ACS Infect Dis. 2017 May 12;3(5):330-335. doi: 10.1021/acsinfecdis.6b00194. Epub 2017 Apr 3.


A Chemical Probe Strategy for Interrogating Inhibitor Selectivity Across the MEK Kinase Family.

Deibler KK, Mishra RK, Clutter MR, Antanasijevic A, Bergan R, Caffrey M, Scheidt KA.

ACS Chem Biol. 2017 May 19;12(5):1245-1256. doi: 10.1021/acschembio.6b01060. Epub 2017 Mar 20.


Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis.

Ghachi ME, Howe N, Auger R, Lambion A, Guiseppi A, Delbrassine F, Manat G, Roure S, Peslier S, Sauvage E, Vogeley L, Rengifo-Gonzalez JC, Charlier P, Mengin-Lecreulx D, Foglino M, Touzé T, Caffrey M, Kerff F.

Cell Mol Life Sci. 2017 Jun;74(12):2319-2332. doi: 10.1007/s00018-017-2464-6. Epub 2017 Feb 6.


The synthesis of a tritium, carbon-14, and stable isotope-labeled cathepsin C inhibitors.

Allen P, Bragg RA, Caffrey M, Ericsson C, Hickey MJ, Kingston LP, Elmore CS.

J Labelled Comp Radiopharm. 2017 Feb;60(2):124-129. doi: 10.1002/jlcr.3483. Epub 2016 Dec 21.


Stabilization and Improvement of a Promising Influenza Antiviral: Making a PAIN PAINless.

Antanasijevic A, Hafeman NJ, Tundup S, Kingsley C, Mishra RK, Rong L, Manicassamy B, Wardrop D, Caffrey M.

ACS Infect Dis. 2016 Sep 9;2(9):608-615. Epub 2016 Aug 1.


Cell-Free Production of Membrane Proteins in Escherichia coli Lysates for Functional and Structural Studies.

Rues RB, Henrich E, Boland C, Caffrey M, Bernhard F.

Methods Mol Biol. 2016;1432:1-21. doi: 10.1007/978-1-4939-3637-3_1.


Syntheses of a radiolabelled CXCR2 antagonist AZD5069 and its major human metabolite.

Hickey MJ, Allen PH, Caffrey M, Hansen P, Kingston LP, Wilkinson DJ.

J Labelled Comp Radiopharm. 2016 Sep;59(11):432-8. doi: 10.1002/jlcr.3429. Epub 2016 Jul 27.


Fast two-dimensional grid and transmission X-ray microscopy scanning methods for visualizing and characterizing protein crystals.

Wojdyla JA, Panepucci E, Martiel I, Ebner S, Huang CY, Caffrey M, Bunk O, Wang M.

J Appl Crystallogr. 2016 May 16;49(Pt 3):944-952. eCollection 2016 Jun 1.


X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex.

Zhou XE, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Suino-Powell KM, Boutet S, Williams GJ, Wang M, Li D, Caffrey M, Chapman HN, Spence JC, Fromme P, Weierstall U, Stevens RC, Cherezov V, Melcher K, Xu HE.

Sci Data. 2016 Apr 12;3:160021. doi: 10.1038/sdata.2016.21.


Data-collection strategy for challenging native SAD phasing.

Olieric V, Weinert T, Finke AD, Anders C, Li D, Olieric N, Borca CN, Steinmetz MO, Caffrey M, Jinek M, Wang M.

Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):421-9. doi: 10.1107/S2059798315024110. Epub 2016 Mar 1.


Application of virus-like particles (VLP) to NMR characterization of viral membrane protein interactions.

Antanasijevic A, Kingsley C, Basu A, Bowlin TL, Rong L, Caffrey M.

J Biomol NMR. 2016 Mar;64(3):255-65. doi: 10.1007/s10858-016-0025-1. Epub 2016 Feb 26.


Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin.

Vogeley L, El Arnaout T, Bailey J, Stansfeld PJ, Boland C, Caffrey M.

Science. 2016 Feb 19;351(6275):876-80. doi: 10.1126/science.aad3747.


In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.

Huang CY, Olieric V, Ma P, Howe N, Vogeley L, Liu X, Warshamanage R, Weinert T, Panepucci E, Kobilka B, Diederichs K, Wang M, Caffrey M.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):93-112. doi: 10.1107/S2059798315021683. Epub 2016 Jan 1.


Experimental Data in Support of a Direct Displacement Mechanism for Type I/II L-Asparaginases.

Schalk AM, Antansijevic A, Caffrey M, Lavie A.

J Biol Chem. 2016 Mar 4;291(10):5088-100. doi: 10.1074/jbc.M115.699884. Epub 2016 Jan 5.


Ternary structure reveals mechanism of a membrane diacylglycerol kinase.

Li D, Stansfeld PJ, Sansom MSP, Keogh A, Vogeley L, Howe N, Lyons JA, Aragao D, Fromme P, Fromme R, Basu S, Grotjohann I, Kupitz C, Rendek K, Weierstall U, Zatsepin NA, Cherezov V, Liu W, Bandaru S, English NJ, Gati C, Barty A, Yefanov O, Chapman HN, Diederichs K, Messerschmidt M, Boutet S, Williams GJ, Marvin Seibert M, Caffrey M.

Nat Commun. 2015 Dec 17;6:10140. doi: 10.1038/ncomms10140.


Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates.

Light SH, Minasov G, Shuvalova L, Duban ME, Caffrey M, Anderson WF, Lavie A.

J Biol Chem. 2015 Jul 31;290(31):19008. doi: 10.1074/jbc.A110.192831. No abstract available.


Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.

Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE.

Nature. 2015 Jul 30;523(7562):561-7. doi: 10.1038/nature14656. Epub 2015 Jul 22.


MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes.

Stansfeld PJ, Goose JE, Caffrey M, Carpenter EP, Parker JL, Newstead S, Sansom MS.

Structure. 2015 Jul 7;23(7):1350-61. doi: 10.1016/j.str.2015.05.006. Epub 2015 Jun 11.


In meso in situ serial X-ray crystallography of soluble and membrane proteins.

Huang CY, Olieric V, Ma P, Panepucci E, Diederichs K, Wang M, Caffrey M.

Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1238-56. doi: 10.1107/S1399004715005210. Epub 2015 May 14.


Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins.

Nomme J, Antanasijevic A, Caffrey M, Van Itallie CM, Anderson JM, Fanning AS, Lavie A.

J Biol Chem. 2015 Jul 3;290(27):16595-606. doi: 10.1074/jbc.M115.646695. Epub 2015 May 28.


Diabetes navigator program reduces A1C levels for patients in Alabama.

Caffrey MK.

Am J Manag Care. 2014 Jul;20(10 Spec No):E15. No abstract available.


Results presented on motivating patients with diabetes.

Caffrey MK.

Am J Manag Care. 2014 Jul;20(10 Spec No):E14. No abstract available.


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