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Items: 1 to 50 of 107

1.

Cysteine proteases during larval migration and development of helminths in their final host.

Grote A, Caffrey CR, Rebello KM, Smith D, Dalton JP, Lustigman S.

PLoS Negl Trop Dis. 2018 Aug 23;12(8):e0005919. doi: 10.1371/journal.pntd.0005919. eCollection 2018 Aug. Review.

2.

Cysteine proteases as digestive enzymes in parasitic helminths.

Caffrey CR, Goupil L, Rebello KM, Dalton JP, Smith D.

PLoS Negl Trop Dis. 2018 Aug 23;12(8):e0005840. doi: 10.1371/journal.pntd.0005840. eCollection 2018 Aug. Review.

3.

Effect of Phenotypic Screening of Extracts and Fractions of Erythrophleum ivorense Leaf and Stem Bark on Immature and Adult Stages of Schistosoma mansoni.

Kyere-Davies G, Agyare C, Boakye YD, Suzuki BM, Caffrey CR.

J Parasitol Res. 2018 Jun 7;2018:9431467. doi: 10.1155/2018/9431467. eCollection 2018.

4.

Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis.

Monti L, Wang SC, Oukoloff K, Smith AB 3rd, Brunden KR, Caffrey CR, Ballatore C.

ChemMedChem. 2018 Sep 6;13(17):1751-1754. doi: 10.1002/cmdc.201800404. Epub 2018 Aug 7.

PMID:
29969537
5.

Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development.

El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P.

Dis Model Mech. 2018 Jul 30;11(7). pii: dmm033563. doi: 10.1242/dmm.033563.

6.

Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L.

Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF.

Front Mol Biosci. 2018 Apr 19;5:40. doi: 10.3389/fmolb.2018.00040. eCollection 2018.

7.

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.

Leontovyč A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvořák J, Horn M.

PLoS Negl Trop Dis. 2018 Apr 20;12(4):e0006446. doi: 10.1371/journal.pntd.0006446. eCollection 2018 Apr.

8.

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing.

Weeks JC, Roberts WM, Leasure C, Suzuki BM, Robinson KJ, Currey H, Wangchuk P, Eichenberger RM, Saxton AD, Bird TD, Kraemer BC, Loukas A, Hawdon JM, Caffrey CR, Liachko NF.

Sci Rep. 2018 Jan 17;8(1):975. doi: 10.1038/s41598-017-18457-w.

9.

When good times go bad: managing 'legal high' complications in the emergency department.

Caffrey CR, Lank PM.

Open Access Emerg Med. 2017 Dec 20;10:9-23. doi: 10.2147/OAEM.S120120. eCollection 2018. Review.

10.

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.

Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA Jr, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR.

PLoS Negl Trop Dis. 2017 Jul 13;11(7):e0005680. doi: 10.1371/journal.pntd.0005680. eCollection 2017 Jul.

11.

Targeting proteasomes in infectious organisms to combat disease.

Bibo-Verdugo B, Jiang Z, Caffrey CR, O'Donoghue AJ.

FEBS J. 2017 May;284(10):1503-1517. doi: 10.1111/febs.14029. Epub 2017 Feb 16. Review.

12.

Anthelmintics: From discovery to resistance II (San Diego, 2016).

Martin RJ, Wolstenholme AJ, Caffrey CR.

Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):297-298. doi: 10.1016/j.ijpddr.2016.09.002. Epub 2016 Sep 29.

13.

Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation.

Picard MA, Boissier J, Roquis D, Grunau C, Allienne JF, Duval D, Toulza E, Arancibia N, Caffrey CR, Long T, Nidelet S, Rohmer M, Cosseau C.

PLoS Negl Trop Dis. 2016 Sep 27;10(9):e0004930. doi: 10.1371/journal.pntd.0004930. eCollection 2016 Sep.

14.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

15.

Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo.

Vermeire JJ, Suzuki BM, Caffrey CR.

Pharmaceuticals (Basel). 2016 Jul 4;9(3). pii: E39. doi: 10.3390/ph9030039.

16.

Algorithmic Mapping and Characterization of the Drug-Induced Phenotypic-Response Space of Parasites Causing Schistosomiasis.

Singh R, Beasley R, Long T, Caffrey CR.

IEEE/ACM Trans Comput Biol Bioinform. 2018 Mar-Apr;15(2):469-481. doi: 10.1109/TCBB.2016.2550444. Epub 2016 Apr 7.

PMID:
27071187
17.

Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil.

Silveira AM, Costa EG, Ray D, Suzuki BM, Hsieh MH, Fraga LA, Caffrey CR.

PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004357. doi: 10.1371/journal.pntd.0004357. eCollection 2016 Jan.

18.

Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni.

Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR.

PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004356. doi: 10.1371/journal.pntd.0004356. eCollection 2016 Jan.

19.

Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.

Dvořák J, Fajtová P, Ulrychová L, Leontovyč A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ.

Biochimie. 2016 Mar;122:99-109. doi: 10.1016/j.biochi.2015.09.025. Epub 2015 Sep 26.

20.

Caenorhabditis elegans is a useful model for anthelmintic discovery.

Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ.

Nat Commun. 2015 Jun 25;6:7485. doi: 10.1038/ncomms8485.

21.

Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni.

Glaser J, Schurigt U, Suzuki BM, Caffrey CR, Holzgrabe U.

Molecules. 2015 Jun 12;20(6):10873-83. doi: 10.3390/molecules200610873.

22.

Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors.

Fajtová P, Štefanić S, Hradilek M, Dvořák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M.

PLoS Negl Trop Dis. 2015 Jun 3;9(6):e0003827. doi: 10.1371/journal.pntd.0003827. eCollection 2015.

23.

Schistosomiasis and its treatment.

Caffrey CR.

Future Med Chem. 2015;7(6):675-6. doi: 10.4155/fmc.15.27. No abstract available.

PMID:
25996057
24.

Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.

Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS.

Antimicrob Agents Chemother. 2015 May;59(5):2666-77. doi: 10.1128/AAC.04601-14. Epub 2015 Feb 23.

25.

Anthelmintic drug discovery: into the future.

Geary TG, Sakanari JA, Caffrey CR.

J Parasitol. 2015 Apr;101(2):125-33. doi: 10.1645/14-703.1. Epub 2015 Jan 13. Review.

PMID:
25584662
26.

The QDREC web server: determining dose-response characteristics of complex macroparasites in phenotypic drug screens.

Asarnow D, Rojo-Arreola L, Suzuki BM, Caffrey CR, Singh R.

Bioinformatics. 2015 May 1;31(9):1515-8. doi: 10.1093/bioinformatics/btu831. Epub 2014 Dec 24.

27.

Serum albumin and α-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib.

Beckmann S, Long T, Scheld C, Geyer R, Caffrey CR, Grevelding CG.

Int J Parasitol Drugs Drug Resist. 2014 Aug 7;4(3):287-95. doi: 10.1016/j.ijpddr.2014.07.005. eCollection 2014 Dec.

28.

Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch.

Jílková A, Horn M, Řezáčová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey CR, Mareš M.

Structure. 2014 Dec 2;22(12):1786-1798. doi: 10.1016/j.str.2014.09.015. Epub 2014 Nov 13.

29.

Regulation of Schistosoma mansoni development and reproduction by the mitogen-activated protein kinase signaling pathway.

Andrade LF, Mourão Mde M, Geraldo JA, Coelho FS, Silva LL, Neves RH, Volpini A, Machado-Silva JR, Araujo N, Nacif-Pimenta R, Caffrey CR, Oliveira G.

PLoS Negl Trop Dis. 2014 Jun 19;8(6):e2949. doi: 10.1371/journal.pntd.0002949. eCollection 2014 Jun. Erratum in: PLoS Negl Trop Dis. 2014 Jul;8(7):e3081.

30.

Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'.

Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey CR, Dvořák J.

PLoS Negl Trop Dis. 2014 Mar 27;8(3):e2766. doi: 10.1371/journal.pntd.0002766. eCollection 2014 Mar.

31.

Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.

Rojo-Arreola L, Long T, Asarnow D, Suzuki BM, Singh R, Caffrey CR.

PLoS One. 2014 Jan 29;9(1):e87594. doi: 10.1371/journal.pone.0087594. eCollection 2014.

32.

A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection.

Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR.

Antimicrob Agents Chemother. 2013 Dec;57(12):6063-73. doi: 10.1128/AAC.00734-13. Epub 2013 Sep 23.

33.

Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica.

Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF.

PLoS Negl Trop Dis. 2013 Jul 11;7(7):e2269. doi: 10.1371/journal.pntd.0002269. Print 2013.

34.

New insights into the machinery of blood digestion by ticks.

Sojka D, Franta Z, Horn M, Caffrey CR, Mareš M, Kopáček P.

Trends Parasitol. 2013 Jun;29(6):276-85. doi: 10.1016/j.pt.2013.04.002. Epub 2013 May 7. Review.

PMID:
23664173
35.

A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets.

Mashiyama ST, Koupparis K, Caffrey CR, McKerrow JH, Babbitt PC.

PLoS Negl Trop Dis. 2012;6(12):e1942. doi: 10.1371/journal.pntd.0001942. Epub 2012 Dec 6.

36.

Cure of hookworm infection with a cysteine protease inhibitor.

Vermeire JJ, Lantz LD, Caffrey CR.

PLoS Negl Trop Dis. 2012;6(7):e1680. doi: 10.1371/journal.pntd.0001680. Epub 2012 Jul 3.

37.

Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target.

Steverding D, Sexton DW, Wang X, Gehrke SS, Wagner GK, Caffrey CR.

Int J Parasitol. 2012 May 1;42(5):481-8. doi: 10.1016/j.ijpara.2012.03.009. Epub 2012 Apr 24.

PMID:
22549023
38.

Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1).

Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P.

J Biol Chem. 2012 Jun 15;287(25):21152-63. doi: 10.1074/jbc.M112.347922. Epub 2012 Apr 26.

39.

Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis.

Lee H, Moody-Davis A, Saha U, Suzuki BM, Asarnow D, Chen S, Arkin M, Caffrey CR, Singh R.

BMC Genomics. 2012;13 Suppl 1:S4. doi: 10.1186/1471-2164-13-S1-S4. Epub 2012 Jan 17.

40.

Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs.

Abdulla MH, Lim KC, McKerrow JH, Caffrey CR.

PLoS Negl Trop Dis. 2011 Oct;5(10):e1368. doi: 10.1371/journal.pntd.0001368. Epub 2011 Oct 25.

41.

Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery.

Swain MT, Larkin DM, Caffrey CR, Davies SJ, Loukas A, Skelly PJ, Hoffmann KF.

Trends Parasitol. 2011 Dec;27(12):555-64. doi: 10.1016/j.pt.2011.09.003. Epub 2011 Oct 23. Review.

42.

Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni.

Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey CR, Mares M.

J Biol Chem. 2011 Oct 14;286(41):35770-81. doi: 10.1074/jbc.M111.271304. Epub 2011 Aug 10.

43.

IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus.

Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P.

Int J Parasitol. 2011 Oct;41(12):1253-62. doi: 10.1016/j.ijpara.2011.06.006. Epub 2011 Jul 23.

PMID:
21819989
44.

Schistosomiasis: from drug deployment to drug development.

Caffrey CR, Secor WE.

Curr Opin Infect Dis. 2011 Oct;24(5):410-7. doi: 10.1097/QCO.0b013e328349156f. Review.

PMID:
21734570
45.

Cysteine peptidases of kinetoplastid parasites.

Caffrey CR, Lima AP, Steverding D.

Adv Exp Med Biol. 2011;712:84-99. doi: 10.1007/978-1-4419-8414-2_6. Review.

PMID:
21660660
46.

Mapping the pro-peptide of the Schistosoma mansoni cathepsin B1 drug target: modulation of inhibition by heparin and design of mimetic inhibitors.

Horn M, Jílková A, Vondrásek J, Maresová L, Caffrey CR, Mares M.

ACS Chem Biol. 2011 Jun 17;6(6):609-17. doi: 10.1021/cb100411v. Epub 2011 Mar 17.

PMID:
21375333
47.

Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection.

de Oliveira Fraga LA, Lamb EW, Moreno EC, Chatterjee M, Dvořák J, Delcroix M, Sajid M, Caffrey CR, Davies SJ.

BMC Immunol. 2010 Nov 15;11:56. doi: 10.1186/1471-2172-11-56.

48.

RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening.

Stefanić S, Dvořák J, Horn M, Braschi S, Sojka D, Ruelas DS, Suzuki B, Lim KC, Hopkins SD, McKerrow JH, Caffrey CR.

PLoS Negl Trop Dis. 2010 Oct 19;4(10):e850. doi: 10.1371/journal.pntd.0000850.

49.

From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis.

Utzinger J, N'goran EK, Caffrey CR, Keiser J.

Acta Trop. 2011 Sep;120 Suppl 1:S121-37. doi: 10.1016/j.actatropica.2010.08.020. Epub 2010 Sep 8. Review.

50.

Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides.

Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey CR, Daffre S.

Parasit Vectors. 2010 Jul 27;3:63. doi: 10.1186/1756-3305-3-63.

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