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Items: 50

1.

LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.

Cadenas C, Vosbeck S, Edlund K, Grgas K, Madjar K, Hellwig B, Adawy A, Glotzbach A, Stewart JD, Lesjak MS, Franckenstein D, Claus M, Hayen H, Schriewer A, Gianmoena K, Thaler S, Schmidt M, Micke P, Pontén F, Mardinoglu A, Zhang C, Käfferlein HU, Watzl C, Frank S, Rahnenführer J, Marchan R, Hengstler JG.

Int J Cancer. 2019 Jan 17. doi: 10.1002/ijc.32138. [Epub ahead of print]

PMID:
30653260
2.

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.

Grinberg M, Stöber RM, Albrecht W, Edlund K, Schug M, Godoy P, Cadenas C, Marchan R, Lampen A, Braeuning A, Buhrke T, Leist M, Oberemm A, Hellwig B, Kamp H, Gardner I, Escher S, Taboureau O, Aguayo-Orozco A, Sachinidis A, Ellinger-Ziegelbauer H, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3. Epub 2018 Dec 3.

PMID:
30511339
3.

Genetic determinants of steatosis and fibrosis progression in paediatric non-alcoholic fatty liver disease.

Hudert CA, Selinski S, Rudolph B, Bläker H, Loddenkemper C, Thielhorn R, Berndt N, Golka K, Cadenas C, Reinders J, Henning S, Bufler P, Jansen PLM, Holzhütter HG, Meierhofer D, Hengstler JG, Wiegand S.

Liver Int. 2019 Mar;39(3):540-556. doi: 10.1111/liv.14006. Epub 2018 Dec 21.

PMID:
30444569
4.

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.

Gu X, Albrecht W, Edlund K, Kappenberg F, Rahnenführer J, Leist M, Moritz W, Godoy P, Cadenas C, Marchan R, Brecklinghaus T, Pardo LT, Castell JV, Gardner I, Han B, Hengstler JG, Stoeber R.

Arch Toxicol. 2018 Dec;92(12):3505-3515. doi: 10.1007/s00204-018-2302-0. Epub 2018 Oct 13.

PMID:
30317417
5.

A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains.

Salhab A, Nordström K, Gasparoni G, Kattler K, Ebert P, Ramirez F, Arrigoni L, Müller F, Polansky JK, Cadenas C, G Hengstler J, Lengauer T, Manke T; DEEP Consortium, Walter J.

Genome Biol. 2018 Sep 28;19(1):150. doi: 10.1186/s13059-018-1510-5.

6.
7.

Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning 1 H NMR spectroscopy.

Gogiashvili M, Horsch S, Marchan R, Gianmoena K, Cadenas C, Tanner B, Naumann S, Ersova D, Lippek F, Rahnenführer J, Andersson JT, Hergenröder R, Lambert J, Hengstler JG, Edlund K.

NMR Biomed. 2018 Feb;31(2). doi: 10.1002/nbm.3862. Epub 2017 Dec 5.

PMID:
29206323
8.

Oxalic acid quantification in mouse urine and primary mouse hepatocyte cell culture samples by ion exclusion chromatography-mass spectrometry.

Schriewer A, Brink M, Gianmoena K, Cadenas C, Hayen H.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:239-244. doi: 10.1016/j.jchromb.2017.10.032. Epub 2017 Oct 16.

PMID:
29111333
9.

Adverse outcome pathways: opportunities, limitations and open questions.

Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou SH, Limonciel A, Vinken M, Schildknecht S, Waldmann T, Danen E, van Ravenzwaay B, Kamp H, Gardner I, Godoy P, Bois FY, Braeuning A, Reif R, Oesch F, Drasdo D, Höhme S, Schwarz M, Hartung T, Braunbeck T, Beltman J, Vrieling H, Sanz F, Forsby A, Gadaleta D, Fisher C, Kelm J, Fluri D, Ecker G, Zdrazil B, Terron A, Jennings P, van der Burg B, Dooley S, Meijer AH, Willighagen E, Martens M, Evelo C, Mombelli E, Taboureau O, Mantovani A, Hardy B, Koch B, Escher S, van Thriel C, Cadenas C, Kroese D, van de Water B, Hengstler JG.

Arch Toxicol. 2017 Nov;91(11):3477-3505. doi: 10.1007/s00204-017-2045-3. Epub 2017 Oct 19. Review.

PMID:
29051992
10.

Hydrophilic interaction liquid chromatography tandem mass spectrometry analysis of malonyl-coenzyme A in breast cancer cell cultures applying online solid-phase extraction.

Schriewer A, Cadenas C, Hayen H.

J Sep Sci. 2017 Nov;40(22):4303-4310. doi: 10.1002/jssc.201700617. Epub 2017 Oct 4.

PMID:
28877409
11.

Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma.

Marchan R, Büttner B, Lambert J, Edlund K, Glaeser I, Blaszkewicz M, Leonhardt G, Marienhoff L, Kaszta D, Anft M, Watzl C, Madjar K, Grinberg M, Rempel E, Hergenröder R, Selinski S, Rahnenführer J, Lesjak MS, Stewart JD, Cadenas C, Hengstler JG.

Cancer Res. 2017 Sep 1;77(17):4589-4601. doi: 10.1158/0008-5472.CAN-16-2065. Epub 2017 Jun 26.

12.

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy.

Hellwig B, Madjar K, Edlund K, Marchan R, Cadenas C, Heimes AS, Almstedt K, Lebrecht A, Sicking I, Battista MJ, Micke P, Schmidt M, Hengstler JG, Rahnenführer J.

PLoS One. 2016 Dec 7;11(12):e0167585. doi: 10.1371/journal.pone.0167585. eCollection 2016.

13.

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.

Schmidt F, Gasparoni N, Gasparoni G, Gianmoena K, Cadenas C, Polansky JK, Ebert P, Nordström K, Barann M, Sinha A, Fröhler S, Xiong J, Dehghani Amirabad A, Behjati Ardakani F, Hutter B, Zipprich G, Felder B, Eils J, Brors B, Chen W, Hengstler JG, Hamann A, Lengauer T, Rosenstiel P, Walter J, Schulz MH.

Nucleic Acids Res. 2017 Jan 9;45(1):54-66. doi: 10.1093/nar/gkw1061. Epub 2016 Nov 29.

14.

Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway.

Gogiashvili M, Edlund K, Gianmoena K, Marchan R, Brik A, Andersson JT, Lambert J, Madjar K, Hellwig B, Rahnenführer J, Hengstler JG, Hergenröder R, Cadenas C.

Anal Bioanal Chem. 2017 Feb;409(6):1591-1606. doi: 10.1007/s00216-016-0100-1. Epub 2016 Nov 28.

PMID:
27896396
15.

Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.

Pink M, Ratsch BA, Mardahl M, Durek P, Polansky JK, Karl M, Baumgrass R, Wallner S, Cadenas C, Gianmoena K, Floess S, Chen W, Nordstroem K, Tierling S, Olek S, Walter J, Hamann A, Syrbe U.

J Immunol. 2016 Oct 15;197(8):3406-3414. Epub 2016 Sep 2.

16.

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG.

Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23.

17.

Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis.

Arbo MD, Melega S, Stöber R, Schug M, Rempel E, Rahnenführer J, Godoy P, Reif R, Cadenas C, de Lourdes Bastos M, Carmo H, Hengstler JG.

Arch Toxicol. 2016 Dec;90(12):3045-3060. Epub 2016 Jan 28.

PMID:
26821219
18.

Highlight report: toxicology of copper.

Cadenas C.

Arch Toxicol. 2015 Dec;89(12):2471-2. doi: 10.1007/s00204-015-1648-9. No abstract available.

PMID:
26612362
19.

Gelsolin Is Associated with Longer Metastasis-free Survival and Reduced Cell Migration in Estrogen Receptor-positive Breast Cancer.

Stock AM, Klee F, Edlund K, Grinberg M, Hammad S, Marchan R, Cadenas C, Niggemann B, Zänker KS, Rahnenführer J, Schmidt M, Hengstler JG, Entschladen F.

Anticancer Res. 2015 Oct;35(10):5277-85.

PMID:
26408687
20.

Loss of circadian clock gene expression is associated with tumor progression in breast cancer.

Cadenas C, van de Sandt L, Edlund K, Lohr M, Hellwig B, Marchan R, Schmidt M, Rahnenführer J, Oster H, Hengstler JG.

Cell Cycle. 2014;13(20):3282-91. doi: 10.4161/15384101.2014.954454.

21.

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity.

Campos G, Schmidt-Heck W, Ghallab A, Rochlitz K, Pütter L, Medinas DB, Hetz C, Widera A, Cadenas C, Begher-Tibbe B, Reif R, Günther G, Sachinidis A, Hengstler JG, Godoy P.

Arch Toxicol. 2014 Jun;88(6):1267-80. doi: 10.1007/s00204-014-1240-8. Epub 2014 Apr 20.

PMID:
24748426
22.

Unique metabolic features of stem cells, cardiomyocytes, and their progenitors.

Gaspar JA, Doss MX, Hengstler JG, Cadenas C, Hescheler J, Sachinidis A.

Circ Res. 2014 Apr 11;114(8):1346-60. doi: 10.1161/CIRCRESAHA.113.302021. Review.

PMID:
24723659
23.

Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.

Kessler SM, Simon Y, Gemperlein K, Gianmoena K, Cadenas C, Zimmer V, Pokorny J, Barghash A, Helms V, van Rooijen N, Bohle RM, Lammert F, Hengstler JG, Mueller R, Haybaeck J, Kiemer AK.

Int J Mol Sci. 2014 Apr 4;15(4):5762-73. doi: 10.3390/ijms15045762.

24.

Modeling MC1R rare variants: a structural evaluation of variants detected in a Mediterranean case-control study.

Ibarrola-Villava M, Peña-Chilet M, Llorca-Cardeñosa MJ, Oltra S, Cadenas CM, Bravo J, Ribas G.

J Invest Dermatol. 2014 Apr;134(4):1146-1149. doi: 10.1038/jid.2013.469. Epub 2013 Nov 11. No abstract available.

25.

The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer.

Lohr M, Edlund K, Botling J, Hammad S, Hellwig B, Othman A, Berglund A, Lambe M, Holmberg L, Ekman S, Bergqvist M, Pontén F, Cadenas C, Marchan R, Hengstler JG, Rahnenführer J, Micke P.

Cancer Lett. 2013 Jun 10;333(2):222-8. doi: 10.1016/j.canlet.2013.01.036. Epub 2013 Jan 28.

PMID:
23370224
26.

Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients.

Siggelkow W, Boehm D, Gebhard S, Battista M, Sicking I, Lebrecht A, Solbach C, Hellwig B, Rahnenführer J, Koelbl H, Gehrmann M, Marchan R, Cadenas C, Hengstler JG, Schmidt M.

BMC Cancer. 2012 Nov 27;12:562. doi: 10.1186/1471-2407-12-562.

27.

Role of heat shock proteins in stress response and carcinogenesis.

Cadenas C, Marchan R, Bolt HM.

Arch Toxicol. 2013 Jan;87(1):1-2. doi: 10.1007/s00204-012-0985-1. No abstract available.

PMID:
23184253
28.

Buckyballs (fullerenes): free radical sponges or inflammatory agents?

Cadenas C, Marchan R, Hengstler JG.

Arch Toxicol. 2012 Dec;86(12):1807-8. doi: 10.1007/s00204-012-0972-6. No abstract available.

PMID:
23128830
29.

Immunoglobulin kappa C predicts overall survival in node-negative breast cancer.

Chen Z, Gerhold-Ay A, Gebhard S, Boehm D, Solbach C, Lebrecht A, Battista M, Sicking I, Cotarelo C, Cadenas C, Marchan R, Stewart JD, Gehrmann M, Koelbl H, Hengstler JG, Schmidt M.

PLoS One. 2012;7(9):e44741. doi: 10.1371/journal.pone.0044741. Epub 2012 Sep 28.

30.

Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response.

Godoy P, Cadenas C, Hellwig B, Marchan R, Stewart J, Reif R, Lohr M, Gehrmann M, Rahnenführer J, Schmidt M, Hengstler JG.

Breast Cancer. 2014 Jul;21(4):491-9. doi: 10.1007/s12282-012-0404-8. Epub 2012 Sep 22.

PMID:
23001506
31.

Estrogen receptors in human disease.

Cadenas C, Bolt HM.

Arch Toxicol. 2012 Oct;86(10):1489-90. doi: 10.1007/s00204-012-0928-x. No abstract available.

PMID:
22941009
32.

[Patient safety in clinical trials with drugs for human use].

Verdejo IC, Cadenas CL, Laiz RD, Mota SP.

Rev Enferm. 2012 Jun;35(6):42-5. Spanish.

PMID:
22908748
33.

Zinc as a multipurpose trace element.

Marchan R, Cadenas C, Bolt HM.

Arch Toxicol. 2012 Apr;86(4):519-20. doi: 10.1007/s00204-012-0843-1. No abstract available.

PMID:
22415766
34.

ERBB2 overexpression triggers transient high mechanoactivity of breast tumor cells.

Martin M, Müller K, Cadenas C, Hermes M, Zink M, Hengstler JG, Käs JA.

Cytoskeleton (Hoboken). 2012 May;69(5):267-77. doi: 10.1002/cm.21023. Epub 2012 Apr 12.

PMID:
22407943
35.

A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin κ C as a compatible prognostic marker in human solid tumors.

Schmidt M, Hellwig B, Hammad S, Othman A, Lohr M, Chen Z, Boehm D, Gebhard S, Petry I, Lebrecht A, Cadenas C, Marchan R, Stewart JD, Solbach C, Holmberg L, Edlund K, Kultima HG, Rody A, Berglund A, Lambe M, Isaksson A, Botling J, Karn T, Müller V, Gerhold-Ay A, Cotarelo C, Sebastian M, Kronenwett R, Bojar H, Lehr HA, Sahin U, Koelbl H, Gehrmann M, Micke P, Rahnenführer J, Hengstler JG.

Clin Cancer Res. 2012 May 1;18(9):2695-703. doi: 10.1158/1078-0432.CCR-11-2210. Epub 2012 Feb 20.

36.

Key messages of recent publications in the field of toxicology.

Cadenas C, Marchan R, Godoy P, Reif R, von Recklinghausen I, Schöbel N.

EXCLI J. 2012 Nov 9;11:715-42. eCollection 2012. No abstract available.

37.

Prognostic signatures of breast cancer: Perou's molecular subtypes and Schmidt's metagenes.

Cadenas C.

EXCLI J. 2012 May 9;11:204-7. eCollection 2012. No abstract available.

38.

Glycerophospholipid profile in oncogene-induced senescence.

Cadenas C, Vosbeck S, Hein EM, Hellwig B, Langer A, Hayen H, Franckenstein D, Büttner B, Hammad S, Marchan R, Hermes M, Selinski S, Rahnenführer J, Peksel B, Török Z, Vígh L, Hengstler JG.

Biochim Biophys Acta. 2012 Sep;1821(9):1256-68. doi: 10.1016/j.bbalip.2011.11.008. Epub 2011 Dec 10.

PMID:
22178194
39.

A user-friendly guide on how to obtain and accurately interpret information from metabolic databases.

Cadenas C, Marchan R.

Arch Toxicol. 2011 Sep;85(9):1013-4. doi: 10.1007/s00204-011-0744-8. No abstract available.

PMID:
21850519
40.

Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits.

Hardelauf H, Frimat JP, Stewart JD, Schormann W, Chiang YY, Lampen P, Franzke J, Hengstler JG, Cadenas C, Kunz-Schughart LA, West J.

Lab Chip. 2011 Feb 7;11(3):419-28. doi: 10.1039/c0lc00089b. Epub 2010 Nov 16.

PMID:
21079873
41.

Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.

Cadenas C, Franckenstein D, Schmidt M, Gehrmann M, Hermes M, Geppert B, Schormann W, Maccoux LJ, Schug M, Schumann A, Wilhelm C, Freis E, Ickstadt K, Rahnenführer J, Baumbach JI, Sickmann A, Hengstler JG.

Breast Cancer Res. 2010;12(3):R44. doi: 10.1186/bcr2599. Epub 2010 Jun 28.

42.

Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways.

Motzkus D, Loumi S, Cadenas C, Vinson C, Forssmann WG, Maronde E.

Chronobiol Int. 2007;24(5):783-92.

PMID:
17994337
43.

Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism.

Jakubcakova V, Oster H, Tamanini F, Cadenas C, Leitges M, van der Horst GT, Eichele G.

Neuron. 2007 Jun 7;54(5):831-43.

44.
45.

Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility.

Nayernia K, Vauti F, Meinhardt A, Cadenas C, Schweyer S, Meyer BI, Schwandt I, Chowdhury K, Engel W, Arnold HH.

J Biol Chem. 2003 Nov 28;278(48):48377-85. Epub 2003 Sep 16.

46.

Mechanism of adaptation of an atypical alkaline p-nitrophenyl phosphatase from the archaeon Halobacterium salinarum at low-water environments.

Marhuenda-Egea FC, Piera-Velázquez S, Cadenas C, Cadenas E.

Biotechnol Bioeng. 2002 Jun 5;78(5):497-502.

PMID:
12115118
47.

An extreme halophilic enzyme active at low salt in reversed micelles.

Marhuenda-Egea FC, Piera-Velázquez S, Cadenas C, Cadenas E.

J Biotechnol. 2002 Feb 14;93(2):159-64.

PMID:
11738722
48.

Development of high-throughput tools to unravel the complexity of gene expression patterns in the mammalian brain.

Herzig U, Cadenas C, Sieckmann F, Sierralta W, Thaller C, Visel A, Eichele G.

Novartis Found Symp. 2001;239:129-46; discussion 146-59. Review.

PMID:
11529308
49.

Kinetic regulation of an alkaline p-nitrophenylphosphate phosphatase from Halobacterium salinarum in low water system by Mn2+ and monovalent cations.

Marhuenda-Egea FC, Piera-Velázquez S, Cadenas C, Cadenas E.

FEMS Microbiol Lett. 2001 May 1;198(2):111-5.

50.

Stability of an extreme halophilic alkaline phosphatase from Halobacterium salinarium in non-conventional medium.

Marhuenda-Egea FC, Piera-Velázquez S, Cadenas C, Cadenas E.

J Biotechnol. 2001 May 18;87(3):255-61.

PMID:
11334667

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