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Items: 1 to 50 of 136

1.

Emerging Roles of Lysyl Oxidases in the Cardiovascular System: New Concepts and Therapeutic Challenges.

Martínez-González J, Varona S, Cañes L, Galán M, Briones AM, Cachofeiro V, Rodríguez C.

Biomolecules. 2019 Oct 14;9(10). pii: E610. doi: 10.3390/biom9100610. Review.

2.

The role of mitochondrial oxidative stress in the metabolic alterations in diet-induced obesity in rats.

Marín-Royo G, Rodríguez C, Le Pape A, Jurado-López R, Luaces M, Antequera A, Martínez-González J, Souza-Neto FV, Nieto ML, Martínez-Martínez E, Cachofeiro V.

FASEB J. 2019 Nov;33(11):12060-12072. doi: 10.1096/fj.201900347RR. Epub 2019 Aug 1.

PMID:
31370681
3.

The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction.

Marín-Royo G, Ortega-Hernández A, Martínez-Martínez E, Jurado-López R, Luaces M, Islas F, Gómez-Garre D, Delgado-Valero B, Lagunas E, Ramchandani B, García-Bouza M, Nieto ML, Cachofeiro V.

Sci Rep. 2019 Jan 24;9(1):444. doi: 10.1038/s41598-018-36914-y.

4.

mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative Stress.

Avendaño MS, García-Redondo AB, Zalba G, González-Amor M, Aguado A, Martínez-Revelles S, Beltrán LM, Camacho M, Cachofeiro V, Alonso MJ, Salaices M, Briones AM.

Hypertension. 2018 Aug;72(2):492-502. doi: 10.1161/HYPERTENSIONAHA.118.10833. Epub 2018 Jun 11.

PMID:
29891646
5.

Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12.

Ibarrola J, Sadaba R, Martinez-Martinez E, Garcia-Peña A, Arrieta V, Alvarez V, Fernández-Celis A, Gainza A, Cachofeiro V, Santamaria E, Fernandez-Irigoyen J, Jaisser F, Lopez-Andres N.

Sci Rep. 2018 May 1;8(1):6801. doi: 10.1038/s41598-018-25068-6.

6.

Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage.

Ibarrola J, Arrieta V, Sádaba R, Martinez-Martinez E, Garcia-Peña A, Alvarez V, Fernández-Celis A, Gainza A, Santamaría E, Fernández-Irigoyen J, Cachofeiro V, Zalba G, Fay R, Rossignol P, López-Andrés N.

Clin Sci (Lond). 2018 Jul 18;132(13):1471-1485. doi: 10.1042/CS20171389. Print 2018 Jul 18.

PMID:
29674526
7.

A role for fumarate hydratase in mediating oxidative effects of galectin-3 in human cardiac fibroblasts.

Ibarrola J, Sádaba R, Garcia-Peña A, Arrieta V, Martinez-Martinez E, Alvarez V, Fernández-Celis A, Gainza A, Santamaría E, Fernández-Irigoyen J, Cachofeiro V, Fay R, Rossignol P, López-Andrés N.

Int J Cardiol. 2018 May 1;258:217-223. doi: 10.1016/j.ijcard.2017.12.103.

PMID:
29544935
8.

Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity.

Marín-Royo G, Gallardo I, Martínez-Martínez E, Gutiérrez B, Jurado-López R, López-Andrés N, Gutiérrez-Tenorio J, Rial E, Bartolomé MAV, Nieto ML, Cachofeiro V.

Dis Model Mech. 2018 Feb 5;11(2). pii: dmm032086. doi: 10.1242/dmm.032086.

9.

The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity.

Gutiérrez-Tenorio J, Marín-Royo G, Martínez-Martínez E, Martín R, Miana M, López-Andrés N, Jurado-López R, Gallardo I, Luaces M, San Román JA, González-Amor M, Salaices M, Nieto ML, Cachofeiro V.

Sci Rep. 2017 Dec 1;7(1):16802. doi: 10.1038/s41598-017-17103-9.

10.

The impact of obesity in the cardiac lipidome and its consequences in the cardiac damage observed in obese rats.

Marín-Royo G, Martínez-Martínez E, Gutiérrez B, Jurado-López R, Gallardo I, Montero O, Bartolomé MV, San Román JA, Salaices M, Nieto ML, Cachofeiro V.

Clin Investig Arterioscler. 2018 Jan - Feb;30(1):10-20. doi: 10.1016/j.arteri.2017.07.004. Epub 2017 Aug 30. English, Spanish.

11.

Galectin-3 pharmacological inhibition attenuates early renal damage in spontaneously hypertensive rats.

Martínez-Martínez E, Ibarrola J, Fernández-Celis A, Calvier L, Leroy C, Cachofeiro V, Rossignol P, López-Andrés N.

J Hypertens. 2018 Feb;36(2):368-376. doi: 10.1097/HJH.0000000000001545.

PMID:
28858976
12.

A role for galectin-3 in the development of early molecular alterations in short-term aortic stenosis.

Arrieta V, Martinez-Martinez E, Ibarrola J, Alvarez V, Sádaba R, Garcia-Peña A, Fernández-Celis A, Cachofeiro V, Rossignol P, López-Andrés N.

Clin Sci (Lond). 2017 May 1;131(10):935-949. doi: 10.1042/CS20170145. Epub 2017 Mar 30.

PMID:
28360193
13.

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels.

Lucas E, Vila-Bedmar R, Arcones AC, Cruces-Sande M, Cachofeiro V, Mayor F Jr, Murga C.

Cardiovasc Diabetol. 2016 Nov 10;15(1):155.

14.

Galectin-3 Blockade Reduces Renal Fibrosis in Two Normotensive Experimental Models of Renal Damage.

Martinez-Martinez E, Ibarrola J, Calvier L, Fernandez-Celis A, Leroy C, Cachofeiro V, Rossignol P, Lopez-Andres N.

PLoS One. 2016 Nov 9;11(11):e0166272. doi: 10.1371/journal.pone.0166272. eCollection 2016.

15.

Role for Galectin-3 in Calcific Aortic Valve Stenosis.

Sádaba JR, Martínez-Martínez E, Arrieta V, Álvarez V, Fernández-Celis A, Ibarrola J, Melero A, Rossignol P, Cachofeiro V, López-Andrés N.

J Am Heart Assoc. 2016 Nov 4;5(11). pii: e004360.

16.

High levels of circulating TNFR1 increase the risk of all-cause mortality and progression of renal disease in type 2 diabetic nephropathy.

Fernández-Juárez G, Villacorta Perez J, Luño Fernández JL, Martinez-Martinez E, Cachofeiro V, Barrio Lucia V, Tato Ribera AM, Mendez Abreu A, Cordon A, Oliva Dominguez JA, Praga Terente M.

Nephrology (Carlton). 2017 May;22(5):354-360. doi: 10.1111/nep.12781.

PMID:
27003829
17.

Galectin-3 inhibition prevents adipose tissue remodelling in obesity.

Martínez-Martínez E, Calvier L, Rossignol P, Rousseau E, Fernández-Celis A, Jurado-López R, Laville M, Cachofeiro V, López-Andrés N.

Int J Obes (Lond). 2016 Jun;40(6):1034-8. doi: 10.1038/ijo.2016.19. Epub 2016 Feb 8.

PMID:
26853916
18.

The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.

Martínez-Martínez E, Rodríguez C, Galán M, Miana M, Jurado-López R, Bartolomé MV, Luaces M, Islas F, Martínez-González J, López-Andrés N, Cachofeiro V.

J Mol Cell Cardiol. 2016 Mar;92:96-104. doi: 10.1016/j.yjmcc.2016.01.012. Epub 2016 Jan 15.

PMID:
26780438
19.

Galectin-3 Participates in Cardiovascular Remodeling Associated With Obesity.

Martínez-Martínez E, López-Ándres N, Jurado-López R, Rousseau E, Bartolomé MV, Fernández-Celis A, Rossignol P, Islas F, Antequera A, Prieto S, Luaces M, Cachofeiro V.

Hypertension. 2015 Nov;66(5):961-9. doi: 10.1161/HYPERTENSIONAHA.115.06032. Epub 2015 Sep 8.

PMID:
26351031
20.

Red wine intake but not other alcoholic beverages increases total antioxidant capacity and improves pro-inflammatory profile after an oral fat diet in healthy volunteers.

Torres A, Cachofeiro V, Millán J, Lahera V, Nieto ML, Martín R, Bello E, Alvarez-Sala LA.

Rev Clin Esp. 2015 Dec;215(9):486-94. doi: 10.1016/j.rce.2015.07.002. Epub 2015 Aug 18. English, Spanish.

PMID:
26297333
21.

Galectin-3 blockade inhibits cardiac inflammation and fibrosis in experimental hyperaldosteronism and hypertension.

Martínez-Martínez E, Calvier L, Fernández-Celis A, Rousseau E, Jurado-López R, Rossoni LV, Jaisser F, Zannad F, Rossignol P, Cachofeiro V, López-Andrés N.

Hypertension. 2015 Oct;66(4):767-75. doi: 10.1161/HYPERTENSIONAHA.115.05876. Epub 2015 Aug 3.

PMID:
26238446
22.

The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats.

Miana M, Galán M, Martínez-Martínez E, Varona S, Jurado-López R, Bausa-Miranda B, Antequera A, Luaces M, Martínez-González J, Rodríguez C, Cachofeiro V.

Dis Model Mech. 2015 Jun;8(6):543-51. doi: 10.1242/dmm.020107. Epub 2015 Apr 7.

23.

Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation.

Martínez-Martínez E, Cachofeiro V, Rousseau E, Álvarez V, Calvier L, Fernández-Celis A, Leroy C, Miana M, Jurado-López R, Briones AM, Jaisser F, Zannad F, Rossignol P, López-Andrés N.

Mol Cell Endocrinol. 2015 Aug 15;411:20-7. doi: 10.1016/j.mce.2015.04.007. Epub 2015 Apr 17.

PMID:
25896545
24.

Toll-like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II-induced hypertension.

Hernanz R, Martínez-Revelles S, Palacios R, Martín A, Cachofeiro V, Aguado A, García-Redondo L, Barrús MT, de Batista PR, Briones AM, Salaices M, Alonso MJ.

Br J Pharmacol. 2015 Jun;172(12):3159-76. doi: 10.1111/bph.13117. Epub 2015 Apr 10.

25.

The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries.

Calvier L, Martinez-Martinez E, Miana M, Cachofeiro V, Rousseau E, Sádaba JR, Zannad F, Rossignol P, López-Andrés N.

JACC Heart Fail. 2015 Jan;3(1):59-67. doi: 10.1016/j.jchf.2014.08.002. Epub 2014 Nov 11.

26.

The endocrine and cardiovascular systems: a close liaison.

Cachofeiro V, Lahera V.

Horm Mol Biol Clin Investig. 2014 Apr;18(1):1-2. doi: 10.1515/hmbci-2014-0018. No abstract available.

PMID:
25390001
27.

Leptin, a mediator of cardiac damage associated with obesity.

Martínez-Martínez E, Jurado-López R, Cervantes-Escalera P, Cachofeiro V, Miana M.

Horm Mol Biol Clin Investig. 2014 Apr;18(1):3-14. doi: 10.1515/hmbci-2013-0060. Review.

28.

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage.

Gómez-Hernández A, Perdomo L, de las Heras N, Beneit N, Escribano O, Otero YF, Guillén C, Díaz-Castroverde S, Gozalbo-López B, Cachofeiro V, Lahera V, Benito M.

Cardiovasc Diabetol. 2014 Jul 31;13:108. doi: 10.1186/s12933-014-0108-9.

29.

Oleanolic acid modulates the immune-inflammatory response in mice with experimental autoimmune myocarditis and protects from cardiac injury. Therapeutic implications for the human disease.

Martín R, Cordova C, San Román JA, Gutierrez B, Cachofeiro V, Nieto ML.

J Mol Cell Cardiol. 2014 Jul;72:250-62. doi: 10.1016/j.yjmcc.2014.04.002. Epub 2014 Apr 13.

PMID:
24732212
30.

Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress: potential role in obesity.

Martínez-Martínez E, Jurado-López R, Valero-Muñoz M, Bartolomé MV, Ballesteros S, Luaces M, Briones AM, López-Andrés N, Miana M, Cachofeiro V.

J Hypertens. 2014 May;32(5):1104-14; discussion 1114. doi: 10.1097/HJH.0000000000000149.

PMID:
24695395
31.

[Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue].

Valero-Muñoz M, Martín-Fernández B, Ballesteros S, Cachofeiro V, Lahera V, de Las Heras N.

Clin Investig Arterioscler. 2014 Jul-Aug;26(4):161-7. doi: 10.1016/j.arteri.2013.12.005. Epub 2014 Mar 4. Spanish.

PMID:
24612843
32.

The potential role of leptin in the vascular remodeling associated with obesity.

Martínez-Martínez E, Miana M, Jurado-López R, Bartolomé MV, Souza Neto FV, Salaices M, López-Andrés N, Cachofeiro V.

Int J Obes (Lond). 2014 Dec;38(12):1565-72. doi: 10.1038/ijo.2014.37. Epub 2014 Mar 3.

PMID:
24583853
33.

A role for soluble ST2 in vascular remodeling associated with obesity in rats.

Martínez-Martínez E, Miana M, Jurado-López R, Rousseau E, Rossignol P, Zannad F, Cachofeiro V, López-Andrés N.

PLoS One. 2013 Nov 12;8(11):e79176. doi: 10.1371/journal.pone.0079176. eCollection 2013.

34.

Left and right ventricle late remodeling following myocardial infarction in rats.

Stefanon I, Valero-Muñoz M, Fernandes AA, Ribeiro RF Jr, Rodríguez C, Miana M, Martínez-González J, Spalenza JS, Lahera V, Vassallo PF, Cachofeiro V.

PLoS One. 2013 May 31;8(5):e64986. doi: 10.1371/journal.pone.0064986. Print 2013.

35.

Factors involved in rosuvastatin induction of insulin sensitization in rats fed a high fat diet.

de las Heras N, Valero-Muñoz M, Ballesteros S, Gómez-Hernández A, Martín-Fernández B, Blanco-Rivero J, Cachofeiro V, Benito M, Balfagón G, Lahera V.

Nutr Metab Cardiovasc Dis. 2013 Nov;23(11):1107-14. doi: 10.1016/j.numecd.2012.11.009. Epub 2013 Feb 20.

PMID:
23434394
36.

Mercury induces proliferation and reduces cell size in vascular smooth muscle cells through MAPK, oxidative stress and cyclooxygenase-2 pathways.

Aguado A, Galán M, Zhenyukh O, Wiggers GA, Roque FR, Redondo S, Peçanha F, Martín A, Fortuño A, Cachofeiro V, Tejerina T, Salaices M, Briones AM.

Toxicol Appl Pharmacol. 2013 Apr 15;268(2):188-200. doi: 10.1016/j.taap.2013.01.030. Epub 2013 Feb 13.

PMID:
23415682
37.

Relevance of vascular peroxisome proliferator-activated receptor γ coactivator-1α to molecular alterations in atherosclerosis.

Valero-Muñoz M, Martín-Fernández B, Ballesteros S, Martínez-Martínez E, Blanco-Rivero J, Balfagón G, Cachofeiro V, Lahera V, de las Heras N.

Exp Physiol. 2013 May;98(5):999-1008. doi: 10.1113/expphysiol.2012.070557. Epub 2013 Jan 18.

38.

The impact of bariatric surgery on renal and cardiac functions in morbidly obese patients.

Luaces M, Martínez-Martínez E, Medina M, Miana M, González N, Fernández-Pérez C, Cachofeiro V.

Nephrol Dial Transplant. 2012 Dec;27 Suppl 4:iv53-7. doi: 10.1093/ndt/gfs529.

PMID:
23258812
39.

Galectin-3 mediates aldosterone-induced vascular fibrosis.

Calvier L, Miana M, Reboul P, Cachofeiro V, Martinez-Martinez E, de Boer RA, Poirier F, Lacolley P, Zannad F, Rossignol P, López-Andrés N.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):67-75. doi: 10.1161/ATVBAHA.112.300569. Epub 2012 Nov 1.

PMID:
23117656
40.

Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension.

Roque FR, Briones AM, García-Redondo AB, Galán M, Martínez-Revelles S, Avendaño MS, Cachofeiro V, Fernandes T, Vassallo DV, Oliveira EM, Salaices M.

Br J Pharmacol. 2013 Feb;168(3):686-703. doi: 10.1111/j.1476-5381.2012.02224.x.

41.

Ezetimibe inhibits PMA-induced monocyte/macrophage differentiation by altering microRNA expression: a novel anti-atherosclerotic mechanism.

Muñoz-Pacheco P, Ortega-Hernández A, Miana M, Cachofeiro V, Fernández-Cruz A, Gómez-Garre D.

Pharmacol Res. 2012 Dec;66(6):536-43. doi: 10.1016/j.phrs.2012.09.005. Epub 2012 Sep 15.

PMID:
22989505
42.

Effect of dual blockade of the renin-angiotensin system on the progression of type 2 diabetic nephropathy: a randomized trial.

Fernandez Juarez G, Luño J, Barrio V, de Vinuesa SG, Praga M, Goicoechea M, Cachofeiro V, Nieto J, Fernández Vega F, Tato A, Gutierrez E; PRONEDI Study Group.

Am J Kidney Dis. 2013 Feb;61(2):211-8. doi: 10.1053/j.ajkd.2012.07.011. Epub 2012 Aug 29.

PMID:
22939518
43.

DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.

Martín R, Miana M, Jurado-López R, Martínez-Martínez E, Gómez-Hurtado N, Delgado C, Bartolomé MV, San Román JA, Cordova C, Lahera V, Nieto ML, Cachofeiro V.

PLoS One. 2012;7(7):e41545. doi: 10.1371/journal.pone.0041545. Epub 2012 Jul 23.

44.

Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.

Ruiz-Hurtado G, Gómez-Hurtado N, Fernández-Velasco M, Calderón E, Smani T, Ordoñez A, Cachofeiro V, Boscá L, Díez J, Gómez AM, Delgado C.

Cardiovasc Res. 2012 Oct 1;96(1):81-9. doi: 10.1093/cvr/cvs234. Epub 2012 Jul 11.

PMID:
22787135
45.

A wound-like inflammatory aortic response in chronic portal hypertensive rats.

de Las Heras N, Aller MA, Martín-Fernández B, Miana M, Ballesteros S, Regadera J, Cachofeiro V, Arias J, Lahera V.

Mol Immunol. 2012 Jun;51(2):177-87. doi: 10.1016/j.molimm.2012.03.016. Epub 2012 Mar 29.

PMID:
22463791
46.

Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of serum- and glucocorticoid-regulated kinase type 1.

Martín-Fernández B, de las Heras N, Miana M, Ballesteros S, Valero-Muñoz M, Vassallo D, Davel AP, Rossoni LV, Cachofeiro V, Lahera V.

Exp Physiol. 2012 Jun;97(6):710-8. doi: 10.1113/expphysiol.2011.063230. Epub 2012 Feb 10.

47.

Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction.

Gómez-Hernández A, Otero YF, de las Heras N, Escribano O, Cachofeiro V, Lahera V, Benito M.

Endocrinology. 2012 Mar;153(3):1242-55. doi: 10.1210/en.2011-1765. Epub 2012 Jan 17.

PMID:
22253415
48.

The effects of adiponectin and leptin on human endothelial cell proliferation: a live-cell study.

Alvarez G, Visitación Bartolomé M, Miana M, Jurado-López R, Martín R, Zuluaga P, Martinez-Martinez E, Nieto ML, Alvarez-Sala LA, Millán J, Lahera V, Cachofeiro V.

J Vasc Res. 2012;49(2):111-22. doi: 10.1159/000332332. Epub 2012 Jan 13.

49.

Cardiac benefits of exercise training in aging spontaneously hypertensive rats.

Rossoni LV, Oliveira RA, Caffaro RR, Miana M, Sanz-Rosa D, Koike MK, Do Amaral SL, Michelini LC, Lahera V, Cachofeiro V.

J Hypertens. 2011 Dec;29(12):2349-58. doi: 10.1097/HJH.0b013e32834d2532.

PMID:
22045123
50.

Anatomical and functional alterations of the heart in morbid obesity. Changes after bariatric surgery.

Luaces M, Cachofeiro V, García-Muñoz-Najar A, Medina M, González N, Cancer E, Rodríguez-Robles A, Cánovas G, Antequera-Pérez A.

Rev Esp Cardiol (Engl Ed). 2012 Jan;65(1):14-21. doi: 10.1016/j.recesp.2011.06.018. Epub 2011 Oct 19. English, Spanish.

PMID:
22015018

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