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Items: 25


Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism.

Silvian LF, Friedman JE, Strauch K, Cachero TG, Day ES, Qian F, Cunningham B, Fung A, Sun L, Shipps GW, Su L, Zheng Z, Kumaravel G, Whitty A.

ACS Chem Biol. 2011 Jun 17;6(6):636-47. doi: 10.1021/cb2000346. Epub 2011 Apr 20. Erratum in: ACS Chem Biol. 2011 Jul 15;6(7):761. Shipps, Gerald W [added].


TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.

Bossen C, Cachero TG, Tardivel A, Ingold K, Willen L, Dobles M, Scott ML, Maquelin A, Belnoue E, Siegrist CA, Chevrier S, Acha-Orbea H, Leung H, Mackay F, Tschopp J, Schneider P.

Blood. 2008 Feb 1;111(3):1004-12. Epub 2007 Oct 17.


A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses.

Huntington ND, Tomioka R, Clavarino C, Chow AM, Liñares D, Maña P, Rossjohn J, Cachero TG, Qian F, Kalled SL, Bernard CC, Reid HH.

Int Immunol. 2006 Oct;18(10):1473-85. Epub 2006 Aug 16.


Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody.

Reid C, Rushe M, Jarpe M, van Vlijmen H, Dolinski B, Qian F, Cachero TG, Cuervo H, Yanachkova M, Nwankwo C, Wang X, Etienne N, Garber E, Bailly V, de Fougerolles A, Boriack-Sjodin PA.

Protein Eng Des Sel. 2006 Jul;19(7):317-24. Epub 2006 May 8.


Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor).

Cachero TG, Schwartz IM, Qian F, Day ES, Bossen C, Ingold K, Tardivel A, Krushinskie D, Eldredge J, Silvian L, Lugovskoy A, Farrington GK, Strauch K, Schneider P, Whitty A.

Biochemistry. 2006 Feb 21;45(7):2006-13.


Small-molecule inhibition of TNF-alpha.

He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC.

Science. 2005 Nov 11;310(5750):1022-5.


Identification of proteoglycans as the APRIL-specific binding partners.

Ingold K, Zumsteg A, Tardivel A, Huard B, Steiner QG, Cachero TG, Qiang F, Gorelik L, Kalled SL, Acha-Orbea H, Rennert PD, Tschopp J, Schneider P.

J Exp Med. 2005 May 2;201(9):1375-83. Epub 2005 Apr 25.


Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA.

Day ES, Cachero TG, Qian F, Sun Y, Wen D, Pelletier M, Hsu YM, Whitty A.

Biochemistry. 2005 Feb 15;44(6):1919-31.


B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells.

Ng LG, Sutherland AP, Newton R, Qian F, Cachero TG, Scott ML, Thompson JS, Wheway J, Chtanova T, Groom J, Sutton IJ, Xin C, Tangye SG, Kalled SL, Mackay F, Mackay CR.

J Immunol. 2004 Jul 15;173(2):807-17.


Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin.

Hattan D, Nesti E, Cachero TG, Morielli AD.

J Biol Chem. 2002 Oct 11;277(41):38596-606. Epub 2002 Jul 31.


Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes.

Karpusas M, Cachero TG, Qian F, Boriack-Sjodin A, Mullen C, Strauch K, Hsu YM, Kalled SL.

J Mol Biol. 2002 Feb 1;315(5):1145-54.


Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome.

Groom J, Kalled SL, Cutler AH, Olson C, Woodcock SA, Schneider P, Tschopp J, Cachero TG, Batten M, Wheway J, Mauri D, Cavill D, Gordon TP, Mackay CR, Mackay F.

J Clin Invest. 2002 Jan;109(1):59-68.


Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen.

Schneider P, Takatsuka H, Wilson A, Mackay F, Tardivel A, Lens S, Cachero TG, Finke D, Beermann F, Tschopp J.

J Exp Med. 2001 Dec 3;194(11):1691-7.


BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.

Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C.

Science. 2001 Sep 14;293(5537):2108-11. Epub 2001 Aug 16.


An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.

Schiemann B, Gommerman JL, Vora K, Cachero TG, Shulga-Morskaya S, Dobles M, Frew E, Scott ML.

Science. 2001 Sep 14;293(5537):2111-4. Epub 2001 Aug 16.


A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth.

Rennert P, Schneider P, Cachero TG, Thompson J, Trabach L, Hertig S, Holler N, Qian F, Mullen C, Strauch K, Browning JL, Ambrose C, Tschopp J.

J Exp Med. 2000 Dec 4;192(11):1677-84.


BAFF mediates survival of peripheral immature B lymphocytes.

Batten M, Groom J, Cachero TG, Qian F, Schneider P, Tschopp J, Browning JL, Mackay F.

J Exp Med. 2000 Nov 20;192(10):1453-66.


BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population.

Thompson JS, Schneider P, Kalled SL, Wang L, Lefevre EA, Cachero TG, MacKay F, Bixler SA, Zafari M, Liu ZY, Woodcock SA, Qian F, Batten M, Madry C, Richard Y, Benjamin CD, Browning JL, Tsapis A, Tschopp J, Ambrose C.

J Exp Med. 2000 Jul 3;192(1):129-35.


The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel.

Cachero TG, Morielli AD, Peralta EG.

Cell. 1998 Jun 12;93(6):1077-85.


Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor.

Felsch JS, Cachero TG, Peralta EG.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5051-6.


Cholera and pertussis toxins reveal multiple regulation of cAMP levels in the rabbit carotid body.

Cachero TG, Rigual R, Rocher A, Gonzalez C.

Eur J Neurosci. 1996 Nov;8(11):2320-7.


Effects of fluoride and cholera and pertussis toxins on sensory transduction in the carotid body.

Cachero TG, Rocher A, Rigual RJ, Gonzalez C.

Am J Physiol. 1995 Nov;269(5 Pt 1):C1271-9.


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