Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 85

1.

Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells.

Sciarretta F, Fulci C, Palumbo C, Rotili D, Tentori L, Graziani G, Caccuri AM.

Chemotherapy. 2019;64(3):138-145. doi: 10.1159/000503339. Epub 2019 Oct 22.

2.

Activation of retinal Müller cells in response to glucose variability.

Picconi F, Parravano M, Sciarretta F, Fulci C, Nali M, Frontoni S, Varano M, Caccuri AM.

Endocrine. 2019 Sep;65(3):542-549. doi: 10.1007/s12020-019-02017-5. Epub 2019 Jul 20.

PMID:
31327157
3.

Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis.

Di Paolo V, Fulci C, Rotili D, Sciarretta F, Lucidi A, Morozzo Della Rocca B, De Luca A, Rosato A, Quintieri L, Caccuri AM.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1131-1139. doi: 10.1080/14756366.2019.1617287.

4.

Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells.

Sciarretta F, Fulci C, Palumbo C, Aquilano K, Pastore A, Iorio E, Lettieri-Barbato D, Cicconi R, Minutolo A, Parravano M, Gilardi M, Varano M, Caccuri AM.

J Cell Physiol. 2019 Feb 11. doi: 10.1002/jcp.28246. [Epub ahead of print]

PMID:
30741416
5.

Studying the TRAF2 binding to model membranes: The role of subunits dissociation.

Di Venere A, Nicolai E, Sinibaldi F, Di Pierro D, Caccuri AM, Mei G.

Biotechnol Appl Biochem. 2018 Jan;65(1):38-45. doi: 10.1002/bab.1615.

PMID:
28960521
6.

New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains.

Ceccarelli A, Di Venere A, Nicolai E, De Luca A, Rosato N, Gratton E, Mei G, Caccuri AM.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):813-822. doi: 10.1016/j.bbalip.2017.05.003. Epub 2017 May 9.

7.

The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis.

De Luca A, Carpanese D, Rapanotti MC, Viguria TM, Forgione MA, Rotili D, Fulci C, Iorio E, Quintieri L, Chimenti S, Bianchi L, Rosato A, Caccuri AM.

Oncotarget. 2017 Feb 28;8(9):15520-15538. doi: 10.18632/oncotarget.14690.

8.

A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability.

Fulci C, Rotili D, De Luca A, Stella L, Morozzo Della Rocca B, Forgione M, Di Paolo V, Mai A, Falconi M, Quintieri L, Caccuri AM.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):240-247. doi: 10.1080/14756366.2016.1247059.

9.

Evolution of Negative Cooperativity in Glutathione Transferase Enabled Preservation of Enzyme Function.

Bocedi A, Fabrini R, Lo Bello M, Caccuri AM, Federici G, Mannervik B, Cornish-Bowden A, Ricci G.

J Biol Chem. 2016 Dec 23;291(52):26739-26749. doi: 10.1074/jbc.M116.749507. Epub 2016 Nov 4.

10.

Thiol-Activated Anticancer Agents: The State of the Art.

Dalzoppo D, Di Paolo V, Calderan L, Pasut G, Rosato A, Caccuri AM, Quintieri L.

Anticancer Agents Med Chem. 2017;17(1):4-20. Review.

PMID:
27539318
11.

c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition.

Palumbo C, De Luca A, Rosato N, Forgione M, Rotili D, Caccuri AM.

J Transl Med. 2016 Feb 4;14:37. doi: 10.1186/s12967-016-0796-x.

12.

TNFR-Associated Factor-2 (TRAF2): Not Only a Trimer.

Ceccarelli A, Di Venere A, Nicolai E, De Luca A, Minicozzi V, Rosato N, Caccuri AM, Mei G.

Biochemistry. 2015 Oct 13;54(40):6153-61. doi: 10.1021/acs.biochem.5b00674. Epub 2015 Sep 30.

PMID:
26390021
13.

Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione.

Luisi G, Mollica A, Carradori S, Lenoci A, De Luca A, Caccuri AM.

J Enzyme Inhib Med Chem. 2016 Dec;31(6):924-30. doi: 10.3109/14756366.2015.1070845. Epub 2015 Sep 2.

PMID:
26329912
14.

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib.

Graziani G, Artuso S, De Luca A, Muzi A, Rotili D, Scimeca M, Atzori MG, Ceci C, Mai A, Leonetti C, Levati L, Bonanno E, Tentori L, Caccuri AM.

Biochem Pharmacol. 2015 May 1;95(1):16-27. doi: 10.1016/j.bcp.2015.03.004. Epub 2015 Mar 17.

PMID:
25795251
15.

A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts.

De Luca A, Rotili D, Carpanese D, Lenoci A, Calderan L, Scimeca M, Mai A, Bonanno E, Rosato A, Geroni C, Quintieri L, Caccuri AM.

Oncotarget. 2015 Feb 28;6(6):4126-43.

16.

Synthesis and structure--activity relationship of new cytotoxic agents targeting human glutathione-S-transferases.

Rotili D, De Luca A, Tarantino D, Pezzola S, Forgione M, Morozzo Della Rocca B, Falconi M, Mai A, Caccuri AM.

Eur J Med Chem. 2015 Jan 7;89:156-71. doi: 10.1016/j.ejmech.2014.10.033. Epub 2014 Oct 13.

PMID:
25462236
17.

The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex.

De Luca A, Mei G, Rosato N, Nicolai E, Federici L, Palumbo C, Pastore A, Serra M, Caccuri AM.

Cell Death Dis. 2014 Jan 23;5:e1015. doi: 10.1038/cddis.2013.529.

18.

Glutathione S-transferase P1-1 as a target for mesothelioma treatment.

De Luca A, Pellizzari Tregno F, Sau A, Pastore A, Palumbo C, Alama A, Cicconi R, Federici G, Caccuri AM.

Cancer Sci. 2013 Feb;104(2):223-30. doi: 10.1111/cas.12061. Epub 2012 Dec 24.

19.

New insights into the mechanism of JNK1 inhibition by glutathione transferase P1-1.

De Luca A, Federici L, De Canio M, Stella L, Caccuri AM.

Biochemistry. 2012 Sep 18;51(37):7304-12. doi: 10.1021/bi300559m. Epub 2012 Sep 5.

PMID:
22920299
20.

Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines.

Sau A, Filomeni G, Pezzola S, D'Aguanno S, Tregno FP, Urbani A, Serra M, Pasello M, Picci P, Federici G, Caccuri AM.

Mol Biosyst. 2012 Apr;8(4):994-1006. doi: 10.1039/c1mb05295k. Epub 2011 Nov 9.

PMID:
22068640
21.

Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents.

Uboldi S, Bernasconi S, Romano M, Marchini S, Fuso Nerini I, Damia G, Ganzinelli M, Marangon E, Sala F, Clivio L, Chiorino G, Di Giandomenico S, Rocchi M, Capozzi O, Margison GP, Watson AJ, Caccuri AM, Pastore A, Fossati A, Mantovani R, Grosso F, Tercero JC, Erba E, D'Incalci M.

Int J Cancer. 2012 Jul 1;131(1):59-69. doi: 10.1002/ijc.26340. Epub 2011 Aug 30.

22.

The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma.

Tentori L, Dorio AS, Mazzon E, Muzi A, Sau A, Cuzzocrea S, Vernole P, Federici G, Caccuri AM, Graziani G.

Eur J Cancer. 2011 May;47(8):1219-30. doi: 10.1016/j.ejca.2010.12.008. Epub 2011 Jan 25.

PMID:
21269821
23.

Glutathione transferases and development of new principles to overcome drug resistance.

Sau A, Pellizzari Tregno F, Valentino F, Federici G, Caccuri AM.

Arch Biochem Biophys. 2010 Aug 15;500(2):116-22. doi: 10.1016/j.abb.2010.05.012. Epub 2010 May 28. Review.

PMID:
20494652
24.

Role of glutathione transferases in the mechanism of brostallicin activation.

Pezzola S, Antonini G, Geroni C, Beria I, Colombo M, Broggini M, Marchini S, Mongelli N, Leboffe L, MacArthur R, Mozzi AF, Federici G, Caccuri AM.

Biochemistry. 2010 Jan 12;49(1):226-35. doi: 10.1021/bi901689s. Erratum in: Biochemistry. 2010 Jun 15;49(23):4930. Marchini, Sergio [added].

PMID:
19950984
25.

Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases.

Federici L, Lo Sterzo C, Pezzola S, Di Matteo A, Scaloni F, Federici G, Caccuri AM.

Cancer Res. 2009 Oct 15;69(20):8025-34. doi: 10.1158/0008-5472.CAN-09-1314. Epub 2009 Oct 6.

26.

In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma.

Pellizzari Tregno F, Sau A, Pezzola S, Geroni C, Lapenta C, Spada M, Filomeni G, Bonanno E, Federici G, Caccuri AM.

Eur J Cancer. 2009 Sep;45(14):2606-17. doi: 10.1016/j.ejca.2009.06.033. Epub 2009 Aug 6.

PMID:
19665369
27.

Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome.

Scotlandi K, Remondini D, Castellani G, Manara MC, Nardi F, Cantiani L, Francesconi M, Mercuri M, Caccuri AM, Serra M, Knuutila S, Picci P.

J Clin Oncol. 2009 May 1;27(13):2209-16. doi: 10.1200/JCO.2008.19.2542. Epub 2009 Mar 23.

PMID:
19307502
28.

The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells.

Ascione A, Cianfriglia M, Dupuis ML, Mallano A, Sau A, Pellizzari Tregno F, Pezzola S, Caccuri AM.

Cancer Chemother Pharmacol. 2009 Jul;64(2):419-24. doi: 10.1007/s00280-009-0960-6. Epub 2009 Mar 15.

PMID:
19288261
29.

Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma.

Pasello M, Michelacci F, Scionti I, Hattinger CM, Zuntini M, Caccuri AM, Scotlandi K, Picci P, Serra M.

Cancer Res. 2008 Aug 15;68(16):6661-8. doi: 10.1158/0008-5472.CAN-07-5840.

30.
31.

6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer.

Filomeni G, Turella P, Dupuis ML, Forini O, Ciriolo MR, Cianfriglia M, Pezzola S, Federici G, Caccuri AM.

Mol Cancer Ther. 2008 Feb;7(2):371-9. doi: 10.1158/1535-7163.MCT-07-0487.

32.

Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells. A protection mechanism against excess nitric oxide.

Pedersen JZ, De Maria F, Turella P, Federici G, Mattei M, Fabrini R, Dawood KF, Massimi M, Caccuri AM, Ricci G.

J Biol Chem. 2007 Mar 2;282(9):6364-71. Epub 2006 Dec 30.

33.

A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.

Turella P, Filomeni G, Dupuis ML, Ciriolo MR, Molinari A, De Maria F, Tombesi M, Cianfriglia M, Federici G, Ricci G, Caccuri AM.

J Biol Chem. 2006 Aug 18;281(33):23725-32. Epub 2006 Jun 12.

34.

Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo.

Cesareo E, Parker LJ, Pedersen JZ, Nuccetelli M, Mazzetti AP, Pastore A, Federici G, Caccuri AM, Ricci G, Adams JJ, Parker MW, Lo Bello M.

J Biol Chem. 2005 Dec 23;280(51):42172-80. Epub 2005 Sep 29.

35.

Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate.

Cacciatore I, Caccuri AM, Cocco A, De Maria F, Di Stefano A, Luisi G, Pinnen F, Ricci G, Sozio P, Turella P.

Amino Acids. 2005 Nov;29(3):255-61. Epub 2005 Aug 8.

PMID:
16082503
36.

7-Nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases. Mechanism of action of potential anticancer drugs.

Ricci G, De Maria F, Antonini G, Turella P, Bullo A, Stella L, Filomeni G, Federici G, Caccuri AM.

J Biol Chem. 2005 Jul 15;280(28):26397-405. Epub 2005 May 11.

37.

Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum.

Liebau E, De Maria F, Burmeister C, Perbandt M, Turella P, Antonini G, Federici G, Giansanti F, Stella L, Lo Bello M, Caccuri AM, Ricci G.

J Biol Chem. 2005 Jul 15;280(28):26121-8. Epub 2005 May 11.

38.

Proapoptotic activity of new glutathione S-transferase inhibitors.

Turella P, Cerella C, Filomeni G, Bullo A, De Maria F, Ghibelli L, Ciriolo MR, Cianfriglia M, Mattei M, Federici G, Ricci G, Caccuri AM.

Cancer Res. 2005 May 1;65(9):3751-61.

39.

Binding and kinetic mechanisms of the Zeta class glutathione transferase.

Ricci G, Turella P, De Maria F, Antonini G, Nardocci L, Board PG, Parker MW, Carbonelli MG, Federici G, Caccuri AM.

J Biol Chem. 2004 Aug 6;279(32):33336-42. Epub 2004 Jun 1.

40.

Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage.

Cacciatore I, Caccuri AM, Di Stefano A, Luisi G, Nalli M, Pinnen F, Ricci G, Sozio P.

Farmaco. 2003 Sep;58(9):787-93.

PMID:
13679171
41.

Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme.

Ricci G, Caccuri AM, Lo Bello M, Parker MW, Nuccetelli M, Turella P, Stella L, Di Iorio EE, Federici G.

Biochem J. 2003 Nov 15;376(Pt 1):71-6.

42.

The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide.

De Maria F, Pedersen JZ, Caccuri AM, Antonini G, Turella P, Stella L, Lo Bello M, Federici G, Ricci G.

J Biol Chem. 2003 Oct 24;278(43):42283-93. Epub 2003 Jul 18.

43.

Glutathione transferase superfamily behaves like storage proteins for dinitrosyl-diglutathionyl-iron complex in heterogeneous systems.

Turella P, Pedersen JZ, Caccuri AM, De Maria F, Mastroberardino P, Lo Bello M, Federici G, Ricci G.

J Biol Chem. 2003 Oct 24;278(43):42294-9. Epub 2003 Jul 18.

44.

Proline-glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues.

Paradisi MP, Mollica A, Cacciatore I, Di Stefano A, Pinnen F, Caccuri AM, Ricci G, Duprè S, Spirito A, Lucente G.

Bioorg Med Chem. 2003 Apr 17;11(8):1677-83.

PMID:
12659754
45.

Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1.

Caccuri AM, Antonini G, Allocati N, Di Ilio C, Innocenti F, De Maria F, Parker MW, Masulli M, Polizio F, Federici G, Ricci G.

Biochemistry. 2002 Apr 9;41(14):4686-93.

PMID:
11926831
46.

GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme.

Caccuri AM, Antonini G, Allocati N, Di Ilio C, De Maria F, Innocenti F, Parker MW, Masulli M, Lo Bello M, Turella P, Federici G, Ricci G.

J Biol Chem. 2002 May 24;277(21):18777-84. Epub 2002 Mar 11.

47.

Superefficient enzymes.

Stroppolo ME, Falconi M, Caccuri AM, Desideri A.

Cell Mol Life Sci. 2001 Sep;58(10):1451-60. Review.

PMID:
11693526
48.

Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme.

Lo Bello M, Nuccetelli M, Caccuri AM, Stella L, Parker MW, Rossjohn J, McKinstry WJ, Mozzi AF, Federici G, Polizio F, Pedersen JZ, Ricci G.

J Biol Chem. 2001 Nov 9;276(45):42138-45. Epub 2001 Aug 31.

49.

Valine 10 may act as a driver for product release from the active site of human glutathione transferase P1-1.

Micaloni C, Mazzetti AP, Nuccetelli M, Rossjohn J, McKinstry WJ, Antonini G, Caccuri AM, Oakley AJ, Federici G, Ricci G, Parker MW, Lo Bello M.

Biochemistry. 2000 Dec 26;39(51):15961-70.

PMID:
11123923
50.

Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases.

Caccuri AM, Antonini G, Board PG, Flanagan J, Parker MW, Paolesse R, Turella P, Federici G, Lo Bello M, Ricci G.

J Biol Chem. 2001 Feb 23;276(8):5427-31. Epub 2000 Oct 23.

Supplemental Content

Loading ...
Support Center