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Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications.

de Gaetano M, McEvoy C, Andrews D, Cacace A, Hunter J, Brennan E, Godson C.

Front Pharmacol. 2018 Dec 19;9:1488. doi: 10.3389/fphar.2018.01488. eCollection 2018. Review.


Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms).

de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C, Guiry PJ.

Eur J Med Chem. 2019 Jan 15;162:80-108. doi: 10.1016/j.ejmech.2018.10.049. Epub 2018 Oct 23.


Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain.

Hopp SC, Bihlmeyer NA, Corradi JP, Vanderburg C, Cacace AM, Das S, Clark TW, Betensky RA, Hyman BT, Hudry E.

J Neurochem. 2018 Oct;147(1):24-39. doi: 10.1111/jnc.14469. Epub 2018 Sep 7.


MRI compatible MS2 nanoparticles designed to cross the blood-brain-barrier: providing a path towards tinnitus treatment.

Apawu AK, Curley SM, Dixon AR, Hali M, Sinan M, Braun RD, Castracane J, Cacace AT, Bergkvist M, Holt AG.

Nanomedicine. 2018 Oct;14(7):1999-2008. doi: 10.1016/j.nano.2018.04.003. Epub 2018 Apr 14.


Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.

Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Hnisz D, Li CH, Yuan B, Xu C, Li Y, Vershkov D, Cacace A, Young RA, Jaenisch R.

Cell. 2018 Feb 22;172(5):979-992.e6. doi: 10.1016/j.cell.2018.01.012. Epub 2018 Feb 15.


Glutamate is down-regulated and tinnitus loudness-levels decreased following rTMS over auditory cortex of the left hemisphere: A prospective randomized single-blinded sham-controlled cross-over study.

Cacace AT, Hu J, Romero S, Xuan Y, Burkard RF, Tyler RS.

Hear Res. 2017 Nov 14. pii: S0378-5955(17)30487-2. doi: 10.1016/j.heares.2017.10.017. [Epub ahead of print]


Vagus Nerve Stimulation Paired with Tones for the Treatment of Tinnitus: A Prospective Randomized Double-blind Controlled Pilot Study in Humans.

Tyler R, Cacace A, Stocking C, Tarver B, Engineer N, Martin J, Deshpande A, Stecker N, Pereira M, Kilgard M, Burress C, Pierce D, Rennaker R, Vanneste S.

Sci Rep. 2017 Sep 20;7(1):11960. doi: 10.1038/s41598-017-12178-w.


Specialized pro-resolving mediators in renal fibrosis.

Brennan EP, Cacace A, Godson C.

Mol Aspects Med. 2017 Dec;58:102-113. doi: 10.1016/j.mam.2017.05.001. Epub 2017 May 11. Review.


Generation of a clonal induced pluripotent stem cell (iPSC) line expressing the mutant MECP2 allele from a Rett Syndrome patient fibroblast line.

Hunihan L, Brown J, Cacace A, Fernandes A, Weston A.

Stem Cell Res. 2017 Apr;20:67-69. doi: 10.1016/j.scr.2017.02.017. Epub 2017 Mar 7.


Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism.

Cacace A, Sboarina M, Vazeille T, Sonveaux P.

Oncogene. 2017 Apr;36(15):2074-2084. doi: 10.1038/onc.2016.364. Epub 2016 Oct 17.


Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.

Pérez-Escuredo J, Dadhich RK, Dhup S, Cacace A, Van Hée VF, De Saedeleer CJ, Sboarina M, Rodriguez F, Fontenille MJ, Brisson L, Porporato PE, Sonveaux P.

Cell Cycle. 2016;15(1):72-83. doi: 10.1080/15384101.2015.1120930.


Lactate does not activate NF-κB in oxidative tumor cells.

Van Hée VF, Pérez-Escuredo J, Cacace A, Copetti T, Sonveaux P.

Front Pharmacol. 2015 Oct 13;6:228. doi: 10.3389/fphar.2015.00228. eCollection 2015.


Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.

Lewis MA, Hunihan L, Watson J, Gentles RG, Hu S, Huang Y, Bronson J, Macor JE, Beno BR, Ferrante M, Hendricson A, Knox RJ, Molski TF, Kong Y, Cvijic ME, Rockwell KL, Weed MR, Cacace AM, Westphal RS, Alt A, Brown JM.

J Pharmacol Exp Ther. 2015 Sep;354(3):340-9. doi: 10.1124/jpet.115.224071. Epub 2015 Jun 24.


Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.

Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, Barrezueta N, Polson C, Wes P, Rangan VS, Cacace A, Albright CF, Meredith J Jr, Trojanowski JQ, Lee VM, Brunden KR, Ahlijanian M.

PLoS One. 2015 May 1;10(5):e0125614. doi: 10.1371/journal.pone.0125614. eCollection 2015.


The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.

Bi Y, Dzierba CD, Fink C, Garcia Y, Green M, Han J, Kwon S, Kumi G, Liang Z, Liu Y, Qiao Y, Zhang Y, Zipp G, Burford N, Ferrante M, Bertekap R, Lewis M, Cacace A, Westphal RS, Kimball D, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1443-7. doi: 10.1016/j.bmcl.2015.02.038. Epub 2015 Feb 21.


Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.

Dzierba CD, Bi Y, Dasgupta B, Hartz RA, Ahuja V, Cianchetta G, Kumi G, Dong L, Aleem S, Fink C, Garcia Y, Green M, Han J, Kwon S, Qiao Y, Wang J, Zhang Y, Liu Y, Zipp G, Liang Z, Burford N, Ferrante M, Bertekap R, Lewis M, Cacace A, Grace J, Wilson A, Nouraldeen A, Westphal R, Kimball D, Carson K, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1448-52. doi: 10.1016/j.bmcl.2015.01.036. Epub 2015 Jan 28.


Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder.

Arion D, Corradi JP, Tang S, Datta D, Boothe F, He A, Cacace AM, Zaczek R, Albright CF, Tseng G, Lewis DA.

Mol Psychiatry. 2015 Nov;20(11):1397-405. doi: 10.1038/mp.2014.171. Epub 2015 Jan 6.


A review of hyperacusis and future directions: part II. Measurement, mechanisms, and treatment.

Pienkowski M, Tyler RS, Roncancio ER, Jun HJ, Brozoski T, Dauman N, Coelho CB, Andersson G, Keiner AJ, Cacace AT, Martin N, Moore BC.

Am J Audiol. 2014 Dec;23(4):420-36. doi: 10.1044/2014_AJA-13-0037. Review.


Modality Specificity trumps other methods for diagnosing the auditory processing disorder (APD): response to Dillon et al.

Cacace AT, McFarland DJ.

J Am Acad Audiol. 2014 Jul-Aug;25(7):703-5. No abstract available.


Modality specificity is the preferred method for diagnosing the auditory processing disorder (APD): response to Moore and Ferguson.

McFarland DJ, Cacace AT.

J Am Acad Audiol. 2014 Jul-Aug;25(7):698-9. No abstract available.


Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease.

Wes PD, Easton A, Corradi J, Barten DM, Devidze N, DeCarr LB, Truong A, He A, Barrezueta NX, Polson C, Bourin C, Flynn ME, Keenan S, Lidge R, Meredith J, Natale J, Sankaranarayanan S, Cadelina GW, Albright CF, Cacace AM.

PLoS One. 2014 Aug 25;9(8):e106050. doi: 10.1371/journal.pone.0106050. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0121509.


A review of hyperacusis and future directions: part I. Definitions and manifestations.

Tyler RS, Pienkowski M, Roncancio ER, Jun HJ, Brozoski T, Dauman N, Dauman N, Andersson G, Keiner AJ, Cacace AT, Martin N, Moore BC.

Am J Audiol. 2014 Dec;23(4):402-19. Review.


Jendrassik maneuver facilitates cVEMP amplitude: some preliminary observations.

Roberts L, Cacace AT.

J Am Acad Audiol. 2014 Mar;25(3):237-43. doi: 10.3766/jaaa.25.3.2.


The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.

Kiefer SE, Chang CJ, Kimura SR, Gao M, Xie D, Zhang Y, Zhang G, Gill MB, Mastalerz H, Thompson LA, Cacace AM, Sheriff S.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):173-81. doi: 10.1107/S2053230X14000144. Epub 2014 Jan 21.


Manganese enhanced magnetic resonance imaging (MEMRI): a powerful new imaging method to study tinnitus.

Cacace AT, Brozoski T, Berkowitz B, Bauer C, Odintsov B, Bergkvist M, Castracane J, Zhang J, Holt AG.

Hear Res. 2014 May;311:49-62. doi: 10.1016/j.heares.2014.02.003. Epub 2014 Feb 26. Review.


Left hemisphere fractional anisotropy increase in noise-induced tinnitus: a diffusion tensor imaging (DTI) study of white matter tracts in the brain.

Benson RR, Gattu R, Cacace AT.

Hear Res. 2014 Mar;309:8-16. doi: 10.1016/j.heares.2013.10.005. Epub 2013 Nov 8.


Factors influencing tests of auditory processing: a perspective on current issues and relevant concerns.

Cacace AT, McFarland DJ.

J Am Acad Audiol. 2013 Jul-Aug;24(7):572-89. doi: 10.3766/jaaa.24.7.6. Review.


Reliability of broadband middle-ear power reflectance in younger and older adults: application of generalizability theory.

Mahoney MJ, McFarland DJ, Carpenter MS, Rizvi S, Cacace AT.

Am J Audiol. 2013 Dec;22(2):241-51. doi: 10.1044/1059-0889(2013/12-0063).


Beyond amyloid: getting real about nonamyloid targets in Alzheimer's disease.

Herrup K, Carrillo MC, Schenk D, Cacace A, Desanti S, Fremeau R, Bhat R, Glicksman M, May P, Swerdlow R, Van Eldik LJ, Bain LJ, Budd S.

Alzheimers Dement. 2013 Jul;9(4):452-458.e1. doi: 10.1016/j.jalz.2013.01.017.


Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.

Chao H, Turdi H, Herpin TF, Roberge JY, Liu Y, Schnur DM, Poss MA, Rehfuss R, Hua J, Wu Q, Price LA, Abell LM, Schumacher WA, Bostwick JS, Steinbacher TE, Stewart AB, Ogletree ML, Huang CS, Chang M, Cacace AM, Arcuri MJ, Celani D, Wexler RR, Lawrence RM.

J Med Chem. 2013 Feb 28;56(4):1704-14. doi: 10.1021/jm301708u. Epub 2013 Feb 18.


Central presbycusis: a review and evaluation of the evidence.

Humes LE, Dubno JR, Gordon-Salant S, Lister JJ, Cacace AT, Cruickshanks KJ, Gates GA, Wilson RH, Wingfield A.

J Am Acad Audiol. 2012 Sep;23(8):635-66. doi: 10.3766/jaaa.23.8.5. Review.


Methodological aspects of clinical trials in tinnitus: a proposal for an international standard.

Landgrebe M, Azevedo A, Baguley D, Bauer C, Cacace A, Coelho C, Dornhoffer J, Figueiredo R, Flor H, Hajak G, van de Heyning P, Hiller W, Khedr E, Kleinjung T, Koller M, Lainez JM, Londero A, Martin WH, Mennemeier M, Piccirillo J, De Ridder D, Rupprecht R, Searchfield G, Vanneste S, Zeman F, Langguth B.

J Psychosom Res. 2012 Aug;73(2):112-21. doi: 10.1016/j.jpsychores.2012.05.002. Epub 2012 Jun 22.


The p63 protein isoform ΔNp63α modulates Y-box binding protein 1 in its subcellular distribution and regulation of cell survival and motility genes.

Di Costanzo A, Troiano A, di Martino O, Cacace A, Natale CF, Ventre M, Netti P, Caserta S, Pollice A, La Mantia G, Calabrò V.

J Biol Chem. 2012 Aug 31;287(36):30170-80. doi: 10.1074/jbc.M112.349951. Epub 2012 Jul 11.


Questionable reliability of the speech-evoked auditory brainstem response (sABR) in typically-developing children.

McFarland DJ, Cacace AT.

Hear Res. 2012 May;287(1-2):1-2; author reply 3-5. doi: 10.1016/j.heares.2012.02.014. Epub 2012 Mar 15. No abstract available.


Missing links in some curious auditory phenomena: a tale from the middle ear.

Carpenter MS, Cacace AT, Mahoney MJ.

J Am Acad Audiol. 2012 Feb;23(2):106-14. doi: 10.3766/jaaa.23.2.5.


The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex.

Balu DT, Basu AC, Corradi JP, Cacace AM, Coyle JT.

Neurobiol Dis. 2012 Feb;45(2):671-82. doi: 10.1016/j.nbd.2011.10.006. Epub 2011 Oct 17.


Dichotic and dichoptic digit perception in normal adults.

Lawfield A, McFarland DJ, Cacace AT.

J Am Acad Audiol. 2011 Jun;22(6):332-41. doi: 10.3766/jaaa.22.6.3.


Covariance is the proper measure of test-retest reliability.

McFarland DJ, Cacace AT.

Clin Neurophysiol. 2011 Sep;122(9):1893; author reply 1893-5. doi: 10.1016/j.clinph.2011.01.052. Epub 2011 Mar 16. No abstract available.


The mitochondrial connection in auditory neuropathy.

Cacace AT, Pinheiro JM.

Audiol Neurootol. 2011;16(6):398-413. doi: 10.1159/000323276. Epub 2011 Jan 22. Review.


Advancing tinnitus research: tales from a grand meeting at Grand Island, NY.

Cacace AT.

Am J Audiol. 2008 Dec;17(2):107. doi: 10.1044/1059-0889(2008/ed-02). No abstract available.


Dissection of reverse gyrase activities: insight into the evolution of a thermostable molecular machine.

Valenti A, Perugino G, D'Amaro A, Cacace A, Napoli A, Rossi M, Ciaramella M.

Nucleic Acids Res. 2008 Aug;36(14):4587-97. doi: 10.1093/nar/gkn418. Epub 2008 Jul 9.


Characterization of the 5-HT2b receptor in evaluation of aequorin detection of calcium mobilization for miniaturized GPCR high-throughput screening.

Gilchrist MA 2nd, Cacace A, Harden DG.

J Biomol Screen. 2008 Jul;13(6):486-93. doi: 10.1177/1087057108319212. Epub 2008 Jun 19.


Electrophysiological markers of skill-related neuroplasticity.

Romero SG, McFarland DJ, Faust R, Farrell L, Cacace AT.

Biol Psychol. 2008 Jul;78(3):221-30. doi: 10.1016/j.biopsycho.2008.03.014. Epub 2008 Mar 29.


Repetitive transcranial magnetic stimulation in veterans with debilitating tinnitus: a pilot study.

Lee SL, Abraham M, Cacace AT, Silver SM.

Otolaryngol Head Neck Surg. 2008 Mar;138(3):398-9. doi: 10.1016/j.otohns.2007.11.035.


Consensus for tinnitus patient assessment and treatment outcome measurement: Tinnitus Research Initiative meeting, Regensburg, July 2006.

Langguth B, Goodey R, Azevedo A, Bjorne A, Cacace A, Crocetti A, Del Bo L, De Ridder D, Diges I, Elbert T, Flor H, Herraiz C, Ganz Sanchez T, Eichhammer P, Figueiredo R, Hajak G, Kleinjung T, Landgrebe M, Londero A, Lainez MJ, Mazzoli M, Meikle MB, Melcher J, Rauschecker JP, Sand PG, Struve M, Van de Heyning P, Van Dijk P, Vergara R.

Prog Brain Res. 2007;166:525-36.


Myocardial texture in hypertrophic cardiomyopathy.

Losi MA, Betocchi S, Chinali M, Barbati G, D'Alessandro G, Cacace A, Lombardi R, Contaldi C, de Simone G, Chiariello M.

J Am Soc Echocardiogr. 2007 Nov;20(11):1253-9. Epub 2007 Jul 12.


A simple strategy for mitigating the effect of data variability on the identification of active chemotypes from high-throughput screening data.

Johnson SR, Padmanabha R, Vaccaro W, Hermsmeier M, Cacace A, Lawrence M, Dickey J, Esposito K, Pike K, Wong V, Poss M, Loughney D, Tebben A.

J Biomol Screen. 2007 Mar;12(2):276-84. Epub 2007 Feb 1.


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