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Items: 42


Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis.

Waudby CA, Wlodarski T, Karyadi ME, Cassaignau AME, Chan SHS, Wentink AS, Schmidt-Engler JM, Camilloni C, Vendruscolo M, Cabrita LD, Christodoulou J.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9744-9749. doi: 10.1073/pnas.1716252115. Epub 2018 Sep 10.


The ribosome and its role in protein folding: looking through a magnifying glass.

Javed A, Christodoulou J, Cabrita LD, Orlova EV.

Acta Crystallogr D Struct Biol. 2017 Jun 1;73(Pt 6):509-521. doi: 10.1107/S2059798317007446. Epub 2017 May 31. Review.


A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy.

Cassaignau AM, Launay HM, Karyadi ME, Wang X, Waudby CA, Deckert A, Robertson AL, Christodoulou J, Cabrita LD.

Nat Protoc. 2016 Aug;11(8):1492-507. doi: 10.1038/nprot.2016.101. Epub 2016 Jul 28.


Two-Dimensional NMR Lineshape Analysis.

Waudby CA, Ramos A, Cabrita LD, Christodoulou J.

Sci Rep. 2016 Apr 25;6:24826. doi: 10.1038/srep24826.


Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor.

Deckert A, Waudby CA, Wlodarski T, Wentink AS, Wang X, Kirkpatrick JP, Paton JF, Camilloni C, Kukic P, Dobson CM, Vendruscolo M, Cabrita LD, Christodoulou J.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):5012-7. doi: 10.1073/pnas.1519124113. Epub 2016 Apr 18.


A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.

Cabrita LD, Cassaignau AME, Launay HMM, Waudby CA, Wlodarski T, Camilloni C, Karyadi ME, Robertson AL, Wang X, Wentink AS, Goodsell L, Woolhead CA, Vendruscolo M, Dobson CM, Christodoulou J.

Nat Struct Mol Biol. 2016 Apr;23(4):278-285. doi: 10.1038/nsmb.3182. Epub 2016 Feb 29.


Increasing the sensitivity of NMR diffusion measurements by paramagnetic longitudinal relaxation enhancement, with application to ribosome-nascent chain complexes.

Chan SHS, Waudby CA, Cassaignau AME, Cabrita LD, Christodoulou J.

J Biomol NMR. 2015 Oct;63(2):151-163. doi: 10.1007/s10858-015-9968-x. Epub 2015 Aug 8.


The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.

Porcari R, Proukakis C, Waudby CA, Bolognesi B, Mangione PP, Paton JF, Mullin S, Cabrita LD, Penco A, Relini A, Verona G, Vendruscolo M, Stoppini M, Tartaglia GG, Camilloni C, Christodoulou J, Schapira AH, Bellotti V.

J Biol Chem. 2015 Jan 23;290(4):2395-404. doi: 10.1074/jbc.M114.610527. Epub 2014 Dec 10.


Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain.

Blombach F, Launay H, Snijders AP, Zorraquino V, Wu H, de Koning B, Brouns SJ, Ettema TJ, Camilloni C, Cavalli A, Vendruscolo M, Dickman MJ, Cabrita LD, La Teana A, Benelli D, Londei P, Christodoulou J, van der Oost J.

Biochem J. 2014 Sep 1;462(2):373-84. doi: 10.1042/BJ20131474.


Solution structure of the major factor VIII binding region on von Willebrand factor.

Shiltagh N, Kirkpatrick J, Cabrita LD, McKinnon TA, Thalassinos K, Tuddenham EG, Hansen DF.

Blood. 2014 Jun 26;123(26):4143-51. doi: 10.1182/blood-2013-07-517086. Epub 2014 Apr 3.


Protein folding on the ribosome studied using NMR spectroscopy.

Waudby CA, Launay H, Cabrita LD, Christodoulou J.

Prog Nucl Magn Reson Spectrosc. 2013 Oct;74:57-75. doi: 10.1016/j.pnmrs.2013.07.003. Epub 2013 Jul 27. Review.


In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells.

Waudby CA, Camilloni C, Fitzpatrick AW, Cabrita LD, Dobson CM, Vendruscolo M, Christodoulou J.

PLoS One. 2013 Aug 26;8(8):e72286. doi: 10.1371/journal.pone.0072286. eCollection 2013.


Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements.

Waudby CA, Mantle MD, Cabrita LD, Gladden LF, Dobson CM, Christodoulou J.

J Am Chem Soc. 2012 Jul 18;134(28):11312-5. doi: 10.1021/ja304912c. Epub 2012 Jul 10.


Structural dynamics associated with intermediate formation in an archetypal conformational disease.

Nyon MP, Segu L, Cabrita LD, Lévy GR, Kirkpatrick J, Roussel BD, Patschull AO, Barrett TE, Ekeowa UI, Kerr R, Waudby CA, Kalsheker N, Hill M, Thalassinos K, Lomas DA, Christodoulou J, Gooptu B.

Structure. 2012 Mar 7;20(3):504-12. doi: 10.1016/j.str.2012.01.012.


1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin.

Nyon MP, Kirkpatrick J, Cabrita LD, Christodoulou J, Gooptu B.

Biomol NMR Assign. 2012 Oct;6(2):153-6. doi: 10.1007/s12104-011-9345-y. Epub 2011 Nov 23.


Production of recombinant serpins in Escherichia coli.

Pearce MC, Cabrita LD.

Methods Enzymol. 2011;501:13-28. doi: 10.1016/B978-0-12-385950-1.00002-X.


Solution-state nuclear magnetic resonance spectroscopy and protein folding.

Cabrita LD, Waudby CA, Dobson CM, Christodoulou J.

Methods Mol Biol. 2011;752:97-120. doi: 10.1007/978-1-60327-223-0_7.


An HflX-type GTPase from Sulfolobus solfataricus binds to the 50S ribosomal subunit in all nucleotide-bound states.

Blombach F, Launay H, Zorraquino V, Swarts DC, Cabrita LD, Benelli D, Christodoulou J, Londei P, van der Oost J.

J Bacteriol. 2011 Jun;193(11):2861-7. doi: 10.1128/JB.01552-10. Epub 2011 Apr 8.


Protein folding on the ribosome.

Cabrita LD, Dobson CM, Christodoulou J.

Curr Opin Struct Biol. 2010 Feb;20(1):33-45. doi: 10.1016/ Epub 2010 Feb 9. Review.


Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy.

Cabrita LD, Hsu ST, Launay H, Dobson CM, Christodoulou J.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22239-44. doi: 10.1073/pnas.0903750106. Epub 2009 Dec 17.


Folding study of Venus reveals a strong ion dependence of its yellow fluorescence under mildly acidic conditions.

Hsu ST, Blaser G, Behrens C, Cabrita LD, Dobson CM, Jackson SE.

J Biol Chem. 2010 Feb 12;285(7):4859-69. doi: 10.1074/jbc.M109.000695. Epub 2009 Nov 9.


1H, 15N and 13C assignments of yellow fluorescent protein (YFP) Venus.

Hsu ST, Behrens C, Cabrita LD, Dobson CM.

Biomol NMR Assign. 2009 Jun;3(1):67-72. doi: 10.1007/s12104-009-9143-y. Epub 2009 Jan 13.


1H, 15N and 13C assignments of domain 5 of Dictyostelium discoideum gelation factor (ABP-120) in its native and 8M urea-denatured states.

Hsu ST, Cabrita LD, Christodoulou J, Dobson CM.

Biomol NMR Assign. 2009 Jun;3(1):29-31. doi: 10.1007/s12104-008-9134-4. Epub 2008 Dec 18.


Expression, purification and characterization of recombinant Z alpha(1)-antitrypsin--the most common cause of alpha(1)-antitrypsin deficiency.

Levina V, Dai W, Knaupp AS, Kaiserman D, Pearce MC, Cabrita LD, Bird PI, Bottomley SP.

Protein Expr Purif. 2009 Dec;68(2):226-32. doi: 10.1016/j.pep.2009.06.011. Epub 2009 Jun 23.


Probing side-chain dynamics of a ribosome-bound nascent chain using methyl NMR spectroscopy.

Hsu ST, Cabrita LD, Fucini P, Christodoulou J, Dobson CM.

J Am Chem Soc. 2009 Jun 24;131(24):8366-7. doi: 10.1021/ja902778n.


Structure, dynamics and folding of an immunoglobulin domain of the gelation factor (ABP-120) from Dictyostelium discoideum.

Hsu ST, Cabrita LD, Fucini P, Dobson CM, Christodoulou J.

J Mol Biol. 2009 May 15;388(4):865-79. doi: 10.1016/j.jmb.2009.02.063. Epub 2009 Mar 10.


Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy.

Hsu ST, Fucini P, Cabrita LD, Launay H, Dobson CM, Christodoulou J.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16516-21. Epub 2007 Oct 10.


Enhancing the stability and solubility of TEV protease using in silico design.

Cabrita LD, Gilis D, Robertson AL, Dehouck Y, Rooman M, Bottomley SP.

Protein Sci. 2007 Nov;16(11):2360-7. Epub 2007 Sep 28.


Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap.

Cabrita LD, Irving JA, Pearce MC, Whisstock JC, Bottomley SP.

J Biol Chem. 2007 Sep 14;282(37):26802-9. Epub 2007 Jul 16.


The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding.

Pearce MC, Cabrita LD, Ellisdon AM, Bottomley SP.

FEBS J. 2007 Jul;274(14):3622-3632. doi: 10.1111/j.1742-4658.2007.05897.x. Epub 2007 Jul 3.


The N terminus of the serpin, tengpin, functions to trap the metastable native state.

Zhang Q, Buckle AM, Law RH, Pearce MC, Cabrita LD, Lloyd GJ, Irving JA, Smith AI, Ruzyla K, Rossjohn J, Bottomley SP, Whisstock JC.

EMBO Rep. 2007 Jul;8(7):658-63. Epub 2007 Jun 8.


Purification of polyglutamine proteins.

Chow MK, Ellisdon AM, Cabrita LD, Bottomley SP.

Methods Enzymol. 2006;413:1-19.


The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.

Fulton KF, Buckle AM, Cabrita LD, Irving JA, Butcher RE, Smith I, Reeve S, Lesk AM, Bottomley SP, Rossjohn J, Whisstock JC.

J Biol Chem. 2005 Mar 4;280(9):8435-42. Epub 2004 Dec 7.


Protein expression and refolding--a practical guide to getting the most out of inclusion bodies.

Cabrita LD, Bottomley SP.

Biotechnol Annu Rev. 2004;10:31-50. Review.


Identification of residual structure within denatured antichymotrypsin: implications for serpin folding and misfolding.

Pearce MC, Cabrita LD, Rubin H, Gore MG, Bottomley SP.

Biochem Biophys Res Commun. 2004 Nov 12;324(2):729-35.


Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.

Chow MK, Ellisdon AM, Cabrita LD, Bottomley SP.

J Biol Chem. 2004 Nov 12;279(46):47643-51. Epub 2004 Sep 1.


How do proteins avoid becoming too stable? Biophysical studies into metastable proteins.

Cabrita LD, Bottomley SP.

Eur Biophys J. 2004 Apr;33(2):83-8. Epub 2003 Sep 19. Review.


The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment.

Irving JA, Cabrita LD, Rossjohn J, Pike RN, Bottomley SP, Whisstock JC.

Structure. 2003 Apr;11(4):387-97.


In vitro and in silico design of alpha1-antitrypsin mutants with different conformational stabilities.

Gilis D, McLennan HR, Dehouck Y, Cabrita LD, Rooman M, Bottomley SP.

J Mol Biol. 2003 Jan 17;325(3):581-9.


Probing the role of the F-helix in serpin stability through a single tryptophan substitution.

Cabrita LD, Whisstock JC, Bottomley SP.

Biochemistry. 2002 Apr 9;41(14):4575-81.


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