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Items: 6

1.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00012-18. doi: 10.1128/AAC.00012-18. Print 2018 Sep. Erratum in: Antimicrob Agents Chemother. 2018 Oct 24;62(11):.

2.

Plasmodial Kinase Inhibitors: License to Cure?

Cabrera DG, Horatscheck A, Wilson CR, Basarab G, Eyermann CJ, Chibale K.

J Med Chem. 2018 Sep 27;61(18):8061-8077. doi: 10.1021/acs.jmedchem.8b00329. Epub 2018 Jun 4.

3.

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ, Bantscheff M, Ruecker A, Blagborough AM, Zakutansky SE, Zeeman AM, White KL, Shackleford DM, Mannila J, Morizzi J, Scheurer C, Angulo-Barturen I, Martínez MS, Ferrer S, Sanz LM, Gamo FJ, Reader J, Botha M, Dechering KJ, Sauerwein RW, Tungtaeng A, Vanachayangkul P, Lim CS, Burrows J, Witty MJ, Marsh KC, Bodenreider C, Rochford R, Solapure SM, Jiménez-Díaz MB, Wittlin S, Charman SA, Donini C, Campo B, Birkholtz LM, Hanson KK, Drewes G, Kocken CHM, Delves MJ, Leroy D, Fidock DA, Waterson D, Street LJ, Chibale K.

Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735. doi: 10.1126/scitranslmed.aad9735.

4.

Drought impact on forest carbon dynamics and fluxes in Amazonia.

Doughty CE, Metcalfe DB, Girardin CA, Amézquita FF, Cabrera DG, Huasco WH, Silva-Espejo JE, Araujo-Murakami A, da Costa MC, Rocha W, Feldpausch TR, Mendoza AL, da Costa AC, Meir P, Phillips OL, Malhi Y.

Nature. 2015 Mar 5;519(7541):78-82. doi: 10.1038/nature14213.

PMID:
25739631
5.

Structure-activity relationship studies of antiplasmodial aminomethylthiazoles.

Cheuka PM, Cabrera DG, Paquet T, Chibale K.

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5207-11. doi: 10.1016/j.bmcl.2014.09.071. Epub 2014 Oct 2.

PMID:
25316314
6.

Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum.

Le Manach C, Scheurer C, Sax S, Schleiferböck S, Cabrera DG, Younis Y, Paquet T, Street L, Smith P, Ding XC, Waterson D, Witty MJ, Leroy D, Chibale K, Wittlin S.

Malar J. 2013 Nov 16;12:424. doi: 10.1186/1475-2875-12-424.

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