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Items: 15


Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.

Aiyar RS, Bohnert M, Duvezin-Caubet S, Voisset C, Gagneur J, Fritsch ES, Couplan E, von der Malsburg K, Funaya C, Soubigou F, Courtin F, Suresh S, Kucharczyk R, Evrard J, Antony C, St Onge RP, Blondel M, di Rago JP, van der Laan M, Steinmetz LM.

Nat Commun. 2014 Dec 18;5:5585. doi: 10.1038/ncomms6585.


A yeast-based assay identifies drugs active against human mitochondrial disorders.

Couplan E, Aiyar RS, Kucharczyk R, Kabala A, Ezkurdia N, Gagneur J, St Onge RP, Salin B, Soubigou F, Le Cann M, Steinmetz LM, di Rago JP, Blondel M.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11989-94. doi: 10.1073/pnas.1101478108. Epub 2011 Jun 29.


Consequences of the pathogenic T9176C mutation of human mitochondrial DNA on yeast mitochondrial ATP synthase.

Kucharczyk R, Ezkurdia N, Couplan E, Procaccio V, Ackerman SH, Blondel M, di Rago JP.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1105-12. doi: 10.1016/j.bbabio.2009.12.022. Epub 2010 Jan 4.


Polyunsaturated fatty acids inhibit PI3K activity in a yeast-based model system.

Couplan E, Le Cann M, Le Foll C, Corporeau C, Blondel M, Delarue J.

Biotechnol J. 2009 Aug;4(8):1190-7. doi: 10.1002/biot.200800229.


Mitochondrial ATP synthase disorders: molecular mechanisms and the quest for curative therapeutic approaches.

Kucharczyk R, Zick M, Bietenhader M, Rak M, Couplan E, Blondel M, Caubet SD, di Rago JP.

Biochim Biophys Acta. 2009 Jan;1793(1):186-99. doi: 10.1016/j.bbamcr.2008.06.012. Epub 2008 Jun 20. Review.


Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide.

Leschelle X, Goubern M, Andriamihaja M, Blottière HM, Couplan E, Gonzalez-Barroso MD, Petit C, Pagniez A, Chaumontet C, Mignotte B, Bouillaud F, Blachier F.

Biochim Biophys Acta. 2005 Sep 15;1725(2):201-12.


The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity.

Kim S, Ohkuni K, Couplan E, Jazwinski SM.

Biogerontology. 2004;5(5):305-16.


Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage.

Hoerter J, Gonzalez-Barroso MD, Couplan E, Mateo P, Gelly C, Cassard-Doulcier AM, Diolez P, Bouillaud F.

Circulation. 2004 Aug 3;110(5):528-33. Epub 2004 Jul 19.


High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content.

Couplan E, Gelly C, Goubern M, Fleury C, Quesson B, Silberberg M, Thiaudiere E, Mateo P, Lonchampt M, Levens N, De Montrion C, Ortmann S, Klaus S, Gonzalez-Barroso MD, Cassard-Doulcier AM, Ricquier D, Bigard AX, Diolez P, Bouillaud F.

J Biol Chem. 2002 Nov 8;277(45):43079-88. Epub 2002 Sep 6.


No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria.

Couplan E, del Mar Gonzalez-Barroso M, Alves-Guerra MC, Ricquier D, Goubern M, Bouillaud F.

J Biol Chem. 2002 Jul 19;277(29):26268-75. Epub 2002 May 14.


Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis.

Pecqueur C, Couplan E, Bouillaud F, Ricquier D.

J Mol Med (Berl). 2001;79(1):48-56. Review.


Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4.

Bouillaud F, Couplan E, Pecqueur C, Ricquier D.

Biochim Biophys Acta. 2001 Mar 1;1504(1):107-19. Review. No abstract available.


An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds.

Raimbault S, Dridi S, Denjean F, Lachuer J, Couplan E, Bouillaud F, Bordas A, Duchamp C, Taouis M, Ricquier D.

Biochem J. 2001 Feb 1;353(Pt 3):441-4.


Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation.

Pecqueur C, Alves-Guerra MC, Gelly C, Levi-Meyrueis C, Couplan E, Collins S, Ricquier D, Bouillaud F, Miroux B.

J Biol Chem. 2001 Mar 23;276(12):8705-12. Epub 2000 Nov 29.


Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production.

Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, Couplan E, Alves-Guerra MC, Goubern M, Surwit R, Bouillaud F, Richard D, Collins S, Ricquier D.

Nat Genet. 2000 Dec;26(4):435-9.


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