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Items: 1 to 50 of 80

1.

Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain.

Wall MJ, Subasinghe NL, Winters MP, Lubin ML, Finley MFA, Qin N, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3780-3783. doi: 10.1016/j.bmcl.2018.10.007. Epub 2018 Oct 12.

PMID:
30337231
2.

The antibody rHIgM22 facilitates hippocampal remyelination and ameliorates memory deficits in the cuprizone mouse model of demyelination.

Cui C, Wang J, Mullin AP, Caggiano AO, Parry TJ, Colburn RW, Pavlopoulos E.

Brain Res. 2018 Sep 1;1694:73-86. doi: 10.1016/j.brainres.2018.05.013. Epub 2018 May 15.

3.

rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination.

Mullin AP, Cui C, Wang Y, Wang J, Troy E, Caggiano AO, Parry TJ, Colburn RW, Pavlopoulos E.

Neurobiol Dis. 2017 Sep;105:142-155. doi: 10.1016/j.nbd.2017.05.015. Epub 2017 May 30.

4.

Recovery of sensorimotor function following sciatic nerve injury across multiple rat strains.

Ganguly A, McEwen C, Troy EL, Colburn RW, Caggiano AO, Schallert TJ, Parry TJ.

J Neurosci Methods. 2017 Jan 1;275:25-32. doi: 10.1016/j.jneumeth.2016.10.018. Epub 2016 Oct 29.

PMID:
27984099
5.

AC105 Increases Extracellular Magnesium Delivery and Reduces Excitotoxic Glutamate Exposure within Injured Spinal Cords in Rats.

Huang Z, Filipovic Z, Mp N, Ung C, Troy EL, Colburn RW, Iaci JF, Hackett C, Button DC, Caggiano AO, Parry TJ.

J Neurotrauma. 2017 Feb;34(3):685-694. doi: 10.1089/neu.2016.4607. Epub 2016 Sep 14.

PMID:
27503053
6.

Large animal and primate models of spinal cord injury for the testing of novel therapies.

Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W.

Exp Neurol. 2015 Jul;269:154-68. doi: 10.1016/j.expneurol.2015.04.008. Epub 2015 Apr 19.

PMID:
25902036
7.

Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.

Zhu B, Xia M, Xu X, Ludovici DW, Tennakoon M, Youngman MA, Matthews JM, Dax SL, Colburn RW, Qin N, Hutchinson TL, Lubin ML, Brandt MR, Stone DJ, Flores CM, Macielag MJ.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2234-7. doi: 10.1016/j.bmcl.2013.01.062. Epub 2013 Feb 4.

PMID:
23411075
8.

A novel series of pyrazolylpiperidine N-type calcium channel blockers.

Subasinghe NL, Wall MJ, Winters MP, Qin N, Lubin ML, Finley MF, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4080-3. doi: 10.1016/j.bmcl.2012.04.075. Epub 2012 May 2.

PMID:
22608964
9.

The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists.

Matthews JM, Qin N, Colburn RW, Dax SL, Hawkins M, McNally JJ, Reany L, Youngman MA, Baker J, Hutchinson T, Liu Y, Lubin ML, Neeper M, Brandt MR, Stone DJ, Flores CM.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2922-6. doi: 10.1016/j.bmcl.2012.02.060. Epub 2012 Feb 27.

PMID:
22421018
10.

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia.

Calvo RR, Meegalla SK, Parks DJ, Parsons WH, Ballentine SK, Lubin ML, Schneider C, Colburn RW, Flores CM, Player MR.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1903-7. doi: 10.1016/j.bmcl.2012.01.060. Epub 2012 Jan 28.

PMID:
22330635
11.

Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.

Parks DJ, Parsons WH, Colburn RW, Meegalla SK, Ballentine SK, Illig CR, Qin N, Liu Y, Hutchinson TL, Lubin ML, Stone DJ Jr, Baker JF, Schneider CR, Ma J, Damiano BP, Flores CM, Player MR.

J Med Chem. 2011 Jan 13;54(1):233-47. doi: 10.1021/jm101075v. Epub 2010 Dec 3.

PMID:
21128593
12.

Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine.

Codd EE, Baker J, Brandt MR, Bryant S, Cai C, Carson JR, Chevalier KM, Colburn RW, Coogan TP, Dax SL, Decorte B, Kemmerer M, Legrand EK, Lenhard JM, Leone AM, Lin L, Mabus JR, McDonnell ME, McMillian MK, McNally JJ, Stone DJ Jr, Wang CY, Zhang SP, Flores CM.

Toxicol Sci. 2010 Oct;117(2):493-504. doi: 10.1093/toxsci/kfq200. Epub 2010 Jul 8.

PMID:
20616206
13.

Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range.

Codd EE, Ma J, Zhang SP, Stone DJ Jr, Colburn RW, Brandt MR, Chevalier KM, Zhu Y, Peng S, Cai C, Acton PD, Flores CM.

Pharmacol Biochem Behav. 2010 Aug;96(2):130-5. doi: 10.1016/j.pbb.2010.04.020. Epub 2010 May 12.

PMID:
20438745
14.

JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence.

Codd EE, Carson JR, Colburn RW, Stone DJ, Van Besien CR, Zhang SP, Wade PR, Gallantine EL, Meert TF, Molino L, Pullan S, Razler CM, Dax SL, Flores CM.

J Pharmacol Exp Ther. 2009 Apr;329(1):241-51. doi: 10.1124/jpet.108.146969. Epub 2009 Jan 16.

PMID:
19151246
15.

N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1).

Jetter MC, McNally JJ, Youngman MA, McDonnell ME, Dubin AE, Nasser N, Zhang SP, Codd EE, Colburn RW, Stone DR, Brandt MR, Flores CM, Dax SL.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. doi: 10.1016/j.bmcl.2008.02.075. Epub 2008 Mar 5. Erratum in: Bioorg Med Chem Lett. 2008 Jul 15;18(14):4254.

PMID:
18359227
16.

Attenuated cold sensitivity in TRPM8 null mice.

Colburn RW, Lubin ML, Stone DJ Jr, Wang Y, Lawrence D, D'Andrea MR, Brandt MR, Liu Y, Flores CM, Qin N.

Neuron. 2007 May 3;54(3):379-86.

17.

The novel, orally active, delta opioid RWJ-394674 is biotransformed to the potent mu opioid RWJ-413216.

Codd EE, Carson JR, Colburn RW, Dax SL, Desai-Krieger D, Martinez RP, McKown LA, Neilson LA, Pitis PM, Stahle PL, Stone DJ, Streeter AJ, Wu WN, Zhang SP.

J Pharmacol Exp Ther. 2006 Sep;318(3):1273-9. Epub 2006 Jun 9.

PMID:
16766719
18.

Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine.

Liu Y, Lubin ML, Reitz TL, Wang Y, Colburn RW, Flores CM, Qin N.

Eur J Pharmacol. 2006 Jan 13;530(1-2):23-32. Epub 2005 Dec 28.

PMID:
16386244
19.

Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists.

Coats SJ, Schulz MJ, Carson JR, Codd EE, Hlasta DJ, Pitis PM, Stone DJ Jr, Zhang SP, Colburn RW, Dax SL.

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5493-8.

PMID:
15482911
20.

Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.

Breslin HJ, Miskowski TA, Rafferty BM, Coutinho SV, Palmer JM, Wallace NH, Schneider CR, Kimball ES, Zhang SP, Li J, Colburn RW, Stone DJ, Martinez RP, He W.

J Med Chem. 2004 Oct 7;47(21):5009-20.

PMID:
15456245
21.

Synthesis and structure--activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists.

Youngman MA, Carson JR, Lee JS, Dax SL, Zhang SP, Colburn RW, Stone DJ, Codd EE, Jetter MC.

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1341-4.

PMID:
12657278
22.

Spinal glial activation and cytokine expression after lumbar root injury in the rat.

Hashizume H, DeLeo JA, Colburn RW, Weinstein JN.

Spine (Phila Pa 1976). 2000 May 15;25(10):1206-17.

PMID:
10806496
23.
24.

The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior.

Colburn RW, Rickman AJ, DeLeo JA.

Exp Neurol. 1999 Jun;157(2):289-304.

PMID:
10364441
25.
26.

Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain.

Arruda JL, Colburn RW, Rickman AJ, Rutkowski MD, DeLeo JA.

Brain Res Mol Brain Res. 1998 Nov 20;62(2):228-35.

PMID:
9813345
27.

Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat.

Colburn RW, DeLeo JA, Rickman AJ, Yeager MP, Kwon P, Hickey WF.

J Neuroimmunol. 1997 Nov;79(2):163-75.

PMID:
9394789
28.

Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy.

DeLeo JA, Colburn RW, Rickman AJ.

Brain Res. 1997 Jun 6;759(1):50-7.

PMID:
9219862
29.

Intrathecal catheterization alone induces neuroimmune activation in the rat.

DeLeo JA, Colburn RW, Rickman AJ, Yeager MP.

Eur J Pain. 1997;1(2):115-22.

PMID:
15102412
30.

Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model.

DeLeo JA, Colburn RW, Nichols M, Malhotra A.

J Interferon Cytokine Res. 1996 Sep;16(9):695-700.

PMID:
8887053
31.

Comparative histopathology of epidural hydrogel and silicone elastomer catheters following 30 and 180 days implant in the ewe.

Coombs DW, Colburn RW, DeLeo JA, Hoopes PJ, Twitchell BB.

Acta Anaesthesiol Scand. 1994 May;38(4):388-95.

PMID:
8067228
32.

Comparative spinal neuropathology of hydromorphone and morphine after 9- and 30-day epidural administration in sheep.

Coombs DW, Colburn RW, DeLeo JA, Hoopes PJ, Twitchell BB.

Anesth Analg. 1994 Apr;78(4):674-81.

PMID:
7510936
33.

Characterization of a neuropathic pain model: sciatic cryoneurolysis in the rat.

DeLeo JA, Coombs DW, Willenbring S, Colburn RW, Fromm C, Wagner R, Twitchell BB.

Pain. 1994 Jan;56(1):9-16.

PMID:
8159445
34.

Neurotoxicology of chronic infusion of the ganglioside GM1 in the ewe: phase I. intrathecal administration.

Coombs DW, Colburn RW, McCarthy LE, DeLeo JA, Hoopes PJ, Twitchell BB.

Anesth Analg. 1993 Sep;77(3):507-15.

PMID:
7690199
35.

The ganglioside GM1 decreases autotomy but not substance P depletion in a peripheral mononeuropathy rat model.

Fromm C, DeLeo JA, Coombs DW, Colburn RW, Twitchell BB.

Anesth Analg. 1993 Sep;77(3):501-6.

PMID:
7690198
36.

Testing an implantable intraspinal drug delivery device in the ewe.

Coombs DW, Colburn RW, DeLeo JA, Twitchell BB.

Reg Anesth. 1993 Jul-Aug;18(4):230-7.

PMID:
8398957
37.

Acute toxicology of an enkephalinase inhibitor (SCH 32615) given intrathecally in the ewe.

Coombs DW, Colburn RW, DeLeo JA, Hoopes PJ, Rhodes CH, Twitchell BB.

Anesth Analg. 1993 Jan;76(1):123-30.

PMID:
8418713
38.

Intrathecal catheterization alone reduces autotomy after sciatic cryoneurolysis in the rat.

Serpell MG, DeLeo JA, Coombs DW, Colburn RW, Twitchell BB, Willenbring S, Fromm C.

Life Sci. 1993;53(25):1887-92.

PMID:
8255149
39.
40.

Toxicity of chronic spinal analgesia in a canine model: neuropathologic observations with dezocine lactate.

Coombs DW, Colburn RW, Allen CD, Deroo DB, Fratkin JD.

Reg Anesth. 1990 Mar-Apr;15(2):94-102.

PMID:
1979915
41.

The differentiation of NSAIDs and prostaglandin action using a mechanical visceral pain model in the rat.

DeLeo JA, Colburn RW, Coombs DW, Ellis MA.

Pharmacol Biochem Behav. 1989 May;33(1):253-5.

PMID:
2780782
42.

Mechanical visceral pain model: chronic intermittent intestinal distention in the rat.

Colburn RW, Coombs DW, Degnan CC, Rogers LL.

Physiol Behav. 1989 Jan;45(1):191-7.

PMID:
2727133
43.
45.

Influence of age and cold stress on plasma catecholamine levels in rats.

Avakian EV, Horvath SM, Colburn RW.

J Auton Nerv Syst. 1984 Apr;10(2):127-33.

PMID:
6747198
46.

Efficient extraction and mass spectrometric assay of serotonin in biological fluids.

Markey SP, Colburn RW, Johannessen JN.

Biomed Mass Spectrom. 1981 Jul;8(7):301-4.

PMID:
6793109
47.

Quantitative analysis of 6-hydroxymelatonin in human urine by gas chromatography--negative chemical ionization mass spectrometry.

Tetsuo M, Markey SP, Colburn RW, Kopin IJ.

Anal Biochem. 1981 Jan 1;110(1):208-15. No abstract available.

PMID:
7212264
48.

Distribution and excretion in the rat and monkey of [82Br] bromocriptine.

Markey SP, Colburn RW, Kopin IJ, Aamodt RL.

J Pharmacol Exp Ther. 1979 Oct;211(1):31-5.

PMID:
114621
49.

Identification of 6-hydroxymelatonin in normal human urine by gas chromatography-mass spectrometry.

Sisak ME, Markey SP, Colburn RW, Zavadil AP 3rd, Kopin IJ.

Life Sci. 1979 Aug 27;25(9):803-6. No abstract available.

PMID:
491859
50.

Effect of metal chelating agents on the storage of norepinephrine in vitro by cerebral synaptic vesicles.

Rajan KS, Wiehle RD, Riesen WH, Colburn RW, Davis JM.

Biochem Pharmacol. 1977 Sep 15;26(18):1703-8. No abstract available.

PMID:
901589

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