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Items: 1 to 50 of 284

1.

Reinventing the Wheel: Synthetic Circular RNAs for Mammalian Cell Engineering.

Costello A, Lao NT, Barron N, Clynes M.

Trends Biotechnol. 2019 Aug 14. pii: S0167-7799(19)30177-5. doi: 10.1016/j.tibtech.2019.07.008. [Epub ahead of print] Review.

PMID:
31421856
2.

Zinc supplementation increases protein titer of recombinant CHO cells.

Capella Roca B, Alarcón Miguez A, Keenan J, Suda S, Barron N, O'Gorman D, Doolan P, Clynes M.

Cytotechnology. 2019 Aug 8. doi: 10.1007/s10616-019-00334-1. [Epub ahead of print]

PMID:
31396753
3.

Why we need good mentoring.

Clynes M, Corbett A, Overbaugh J.

Nat Rev Cancer. 2019 Jul 29. doi: 10.1038/s41568-019-0173-1. [Epub ahead of print] Review.

PMID:
31358894
4.

A diagnosis of knee osteoarthritis does not predict physical activity 2 years later in older adults: findings from the Hertfordshire Cohort Study.

Clynes MA, Parsons C, Edwards MH, Tobias JH, Deere K, Cooper C, Dennison EM.

Rheumatol Int. 2019 Aug;39(8):1405-1411. doi: 10.1007/s00296-019-04309-5. Epub 2019 Apr 29.

PMID:
31037363
5.

Improvements in single-use bioreactor film material composition leads to robust and reliable Chinese hamster ovary cell performance.

Kelly PS, Dorival-García N, Paré S, Carillo S, Ta C, Alarcon Miguez A, Coleman O, Harper E, Shannon M, Henry M, Connolly L, Clynes M, Meleady P, Bones J, Barron N.

Biotechnol Prog. 2019 Jul;35(4):e2824. doi: 10.1002/btpr.2824. Epub 2019 May 6.

PMID:
31017345
6.

Impact of osteoarthritis on activities of daily living: does joint site matter?

Clynes MA, Jameson KA, Edwards MH, Cooper C, Dennison EM.

Aging Clin Exp Res. 2019 Aug;31(8):1049-1056. doi: 10.1007/s40520-019-01163-0. Epub 2019 Mar 21.

7.

Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq.

Clarke C, Gallagher C, Kelly RM, Henry M, Meleady P, Frye CC, Osborne MD, Brady CP, Barron N, Clynes M.

Biotechnol Bioeng. 2019 Jun;116(6):1556-1562. doi: 10.1002/bit.26958. Epub 2019 Mar 21.

PMID:
30802296
8.

Copper-induced non-monotonic dose response in Caco-2 cells.

O'Doherty C, Keenan J, Horgan K, Murphy R, O'Sullivan F, Clynes M.

In Vitro Cell Dev Biol Anim. 2019 Apr;55(4):221-225. doi: 10.1007/s11626-019-00333-8. Epub 2019 Feb 23.

PMID:
30798514
9.

A proteomic profiling dataset of recombinant Chinese hamster ovary cells showing enhanced cellular growth following miR-378 depletion.

Coleman O, Costello A, Henry M, Lao NT, Barron N, Clynes M, Meleady P.

Data Brief. 2018 Nov 27;21:2679-2688. doi: 10.1016/j.dib.2018.11.115. eCollection 2018 Dec.

10.

Increased growth rate and productivity following stable depletion of miR-7 in a mAb producing CHO cell line causes an increase in proteins associated with the Akt pathway and ribosome biogenesis.

Coleman O, Suda S, Meiller J, Henry M, Riedl M, Barron N, Clynes M, Meleady P.

J Proteomics. 2019 Mar 20;195:23-32. doi: 10.1016/j.jprot.2019.01.003. Epub 2019 Jan 11.

PMID:
30641232
11.

Continuous translation of circularized mRNA improves recombinant protein titer.

Costello A, Lao NT, Barron N, Clynes M.

Metab Eng. 2019 Mar;52:284-292. doi: 10.1016/j.ymben.2019.01.002. Epub 2019 Jan 4.

PMID:
30615942
12.

Improved yield of rhEPO in CHO cells with synthetic 5' UTR.

Costello A, Lao NT, Barron N, Clynes M.

Biotechnol Lett. 2019 Feb;41(2):231-239. doi: 10.1007/s10529-018-2632-2. Epub 2018 Nov 30.

PMID:
30506229
13.

Acute exposure to organic and inorganic sources of copper: Differential response in intestinal cell lines.

Keenan J, O'Sullivan F, Henry M, Breen L, Doolan P, Sinkunaite I, Meleady P, Clynes M, Horgan K, Murphy R.

Food Sci Nutr. 2018 Oct 20;6(8):2499-2514. doi: 10.1002/fsn3.857. eCollection 2018 Nov.

14.

A Comparative Quantitative LC-MS/MS Profiling Analysis of Human Pancreatic Adenocarcinoma, Adjacent-Normal Tissue, and Patient-Derived Tumour Xenografts.

Coleman O, Henry M, O'Neill F, Roche S, Swan N, Boyle L, Murphy J, Meiller J, Conlon NT, Geoghegan J, Conlon KC, Lynch V, Straubinger NL, Straubinger RM, McVey G, Moriarty M, Meleady P, Clynes M.

Proteomes. 2018 Nov 6;6(4). pii: E45. doi: 10.3390/proteomes6040045.

15.

Depletion of endogenous miRNA-378-3p increases peak cell density of CHO DP12 cells and is correlated with elevated levels of ubiquitin carboxyl-terminal hydrolase 14.

Costello A, Coleman O, Lao NT, Henry M, Meleady P, Barron N, Clynes M.

J Biotechnol. 2018 Dec 20;288:30-40. doi: 10.1016/j.jbiotec.2018.10.008. Epub 2018 Oct 31.

PMID:
30389639
16.
17.

Unexpected fluctuations of trace element levels in cell culture medium in vitro: caveat emptor.

Keenan J, Horgan K, Clynes M, Sinkunaite I, Ward P, Murphy R, O'Sullivan F.

In Vitro Cell Dev Biol Anim. 2018 Sep;54(8):555-558. doi: 10.1007/s11626-018-0285-z. Epub 2018 Aug 16.

PMID:
30117037
18.

The Expression Pattern of the Phosphoproteome Is Significantly Changed During the Growth Phases of Recombinant CHO Cell Culture.

Kaushik P, Henry M, Clynes M, Meleady P.

Biotechnol J. 2018 Oct;13(10):e1700221. doi: 10.1002/biot.201700221. Epub 2018 Aug 27.

PMID:
30076757
19.

Leaky Expression of the TET-On System Hinders Control of Endogenous miRNA Abundance.

Costello A, Lao NT, Gallagher C, Capella Roca B, Julius LAN, Suda S, Ducrée J, King D, Wagner R, Barron N, Clynes M.

Biotechnol J. 2019 Mar;14(3):e1800219. doi: 10.1002/biot.201800219. Epub 2018 Jul 18.

PMID:
29989353
20.

Clonal variation in productivity and proteolytic clipping of an Fc-fusion protein in CHO cells: Proteomic analysis suggests a role for defective protein folding and the UPR.

Henry M, Gallagher C, Kelly RM, Frye CC, Osborne MD, Brady CP, Barron N, Clynes M, Meleady P.

J Biotechnol. 2018 Sep 10;281:21-30. doi: 10.1016/j.jbiotec.2018.05.018. Epub 2018 May 31.

PMID:
29860056
21.

Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine.

O'Sullivan F, Keenan J, Aherne S, O'Neill F, Clarke C, Henry M, Meleady P, Breen L, Barron N, Clynes M, Horgan K, Doolan P, Murphy R.

World J Gastroenterol. 2017 Nov 7;23(41):7369-7386. doi: 10.3748/wjg.v23.i41.7369.

22.

miR-CATCH Identifies Biologically Active miRNA Regulators of the Pro-Survival Gene XIAP, in Chinese Hamster Ovary Cells.

Griffith A, Kelly PS, Vencken S, Lao NT, Greene CM, Clynes M, Barron N.

Biotechnol J. 2018 Mar;13(3):e1700299. doi: 10.1002/biot.201700299. Epub 2017 Oct 30.

PMID:
28976632
23.

A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer.

O'Sullivan D, Dowling P, Joyce H, McAuley E, McCann A, Henry M, McGovern B, Barham P, Kelleher FC, Murphy J, Kennedy S, Swan N, Moriarty M, Clynes M, Larkin A.

Br J Cancer. 2017 Oct 24;117(9):1326-1335. doi: 10.1038/bjc.2017.306. Epub 2017 Sep 7.

24.

Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease.

White MM, Geraghty P, Hayes E, Cox S, Leitch W, Alfawaz B, Lavelle GM, McElvaney OJ, Flannery R, Keenan J, Meleady P, Henry M, Clynes M, Gunaratnam C, McElvaney NG, Reeves EP.

EBioMedicine. 2017 Sep;23:173-184. doi: 10.1016/j.ebiom.2017.08.013. Epub 2017 Aug 16.

25.

Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients.

Ting KR, Henry M, Meiller J, Larkin A, Clynes M, Meleady P, Bazou D, Dowling P, O'Gorman P.

BBA Clin. 2017 Jun 7;8:28-34. doi: 10.1016/j.bbacli.2017.05.003. eCollection 2017 Dec.

26.

Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift.

Henry M, Power M, Kaushik P, Coleman O, Clynes M, Meleady P.

J Proteome Res. 2017 Jul 7;16(7):2339-2358. doi: 10.1021/acs.jproteome.6b00868. Epub 2017 Jun 6.

PMID:
28509555
27.

Phosphopeptide Enrichment and LC-MS/MS Analysis to Study the Phosphoproteome of Recombinant Chinese Hamster Ovary Cells.

Henry M, Coleman O, Prashant, Clynes M, Meleady P.

Methods Mol Biol. 2017;1603:195-208. doi: 10.1007/978-1-4939-6972-2_13.

PMID:
28493132
28.

Filter-Aided Sample Preparation (FASP) for Improved Proteome Analysis of Recombinant Chinese Hamster Ovary Cells.

Coleman O, Henry M, Clynes M, Meleady P.

Methods Mol Biol. 2017;1603:187-194. doi: 10.1007/978-1-4939-6972-2_12.

PMID:
28493131
29.

Conditional Knockdown of Endogenous MicroRNAs in CHO Cells Using TET-ON-SanDI Sponge Vectors.

Costello A, Lao N, Clynes M, Barron N.

Methods Mol Biol. 2017;1603:87-100. doi: 10.1007/978-1-4939-6972-2_6.

PMID:
28493125
30.

Proteomic analysis of bronchoalveolar lavage fluid (BALF) from lung cancer patients using label-free mass spectrometry.

Hmmier A, O'Brien ME, Lynch V, Clynes M, Morgan R, Dowling P.

BBA Clin. 2017 Mar 6;7:97-104. doi: 10.1016/j.bbacli.2017.03.001. eCollection 2017 Jun.

31.

The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer: in-vitro discovery and in-vivo validation.

Lundon DJ, Boland A, Prencipe M, Hurley G, O'Neill A, Kay E, Aherne ST, Doolan P, Madden SF, Clynes M, Morrissey C, Fitzpatrick JM, Watson RW.

BMC Cancer. 2017 Mar 1;17(1):163. doi: 10.1186/s12885-017-3100-4.

32.

Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells.

Kelly PS, Clarke C, Costello A, Monger C, Meiller J, Dhiman H, Borth N, Betenbaugh MJ, Clynes M, Barron N.

Metab Eng. 2017 May;41:11-22. doi: 10.1016/j.ymben.2017.02.001. Epub 2017 Feb 8.

PMID:
28188893
33.

Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome.

Dowling P, Moran B, McAuley E, Meleady P, Henry M, Clynes M, McMenamin M, Leonard N, Monks M, Wynne B, Ormond P, Larkin A.

Oncol Lett. 2016 Nov;12(5):3296-3304. Epub 2016 Sep 7.

34.

Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics.

Kelly PS, McSweeney S, Coleman O, Carillo S, Henry M, Chandran D, Kellett A, Bones J, Clynes M, Meleady P, Barron N.

Biotechnol Prog. 2016 Nov;32(6):1547-1558. doi: 10.1002/btpr.2345. Epub 2016 Sep 4.

PMID:
27557043
35.

The incidence of sexually acquired reactive arthritis: a systematic literature review.

Denison HJ, Curtis EM, Clynes MA, Bromhead C, Dennison EM, Grainger R.

Clin Rheumatol. 2016 Nov;35(11):2639-2648. Epub 2016 Aug 1. Review.

36.

Elevated 12-hydroxyeicosatetraenoic acid (12-HETE) levels in serum of individuals with newly diagnosed Type 1 diabetes.

Hennessy E, Rakovac Tisdall A, Murphy N, Carroll A, O'Gorman D, Breen L, Clarke C, Clynes M, Dowling P, Sreenan S.

Diabet Med. 2017 Feb;34(2):292-294. doi: 10.1111/dme.13177. No abstract available.

PMID:
27353008
37.

Proteomic strategies in the search for novel pancreatic cancer biomarkers and drug targets: recent advances and clinical impact.

Coleman O, Henry M, McVey G, Clynes M, Moriarty M, Meleady P.

Expert Rev Proteomics. 2016;13(4):383-94. doi: 10.1586/14789450.2016.1167601. Review.

PMID:
26985644
38.

Proteomic differences in recombinant CHO cells producing two similar antibody fragments.

Sommeregger W, Mayrhofer P, Steinfellner W, Reinhart D, Henry M, Clynes M, Meleady P, Kunert R.

Biotechnol Bioeng. 2016 Sep;113(9):1902-12. doi: 10.1002/bit.25957. Epub 2016 Mar 16.

39.

Clinical utility of C-terminal telopeptide of type 1 collagen in multiple myeloma.

Ting KR, Brady JJ, Hameed A, Le G, Meiller J, Verburgh E, Bayers C, Benjamin D, Anderson KC, Richardson PG, Dowling P, Clynes M, Fitzgibbon MC, O'Gorman P.

Br J Haematol. 2016 Apr;173(1):82-8. doi: 10.1111/bjh.13928. Epub 2016 Jan 20.

PMID:
26787413
40.

The iron-responsive microsomal proteome of Aspergillus fumigatus.

Moloney NM, Owens RA, Meleady P, Henry M, Dolan SK, Mulvihill E, Clynes M, Doyle S.

J Proteomics. 2016 Mar 16;136:99-111. doi: 10.1016/j.jprot.2015.12.025. Epub 2015 Dec 29.

PMID:
26739764
41.

Transferrin-bound proteins as potential biomarkers for advanced breast cancer patients.

Dowling P, Palmerini V, Henry M, Meleady P, Lynch V, Ballot J, Gullo G, Crown J, Moriarty M, Clynes M.

BBA Clin. 2014 Sep 16;2:24-30. doi: 10.1016/j.bbacli.2014.08.004. eCollection 2014 Dec.

42.

Non-invasive Assessment of Lower Limb Geometry and Strength Using Hip Structural Analysis and Peripheral Quantitative Computed Tomography: A Population-Based Comparison.

Litwic AE, Clynes M, Denison HJ, Jameson KA, Edwards MH, Sayer AA, Taylor P, Cooper C, Dennison EM.

Calcif Tissue Int. 2016 Feb;98(2):158-64. doi: 10.1007/s00223-015-0081-7. Epub 2015 Nov 21.

43.

Definitions of Sarcopenia: Associations with Previous Falls and Fracture in a Population Sample.

Clynes MA, Edwards MH, Buehring B, Dennison EM, Binkley N, Cooper C.

Calcif Tissue Int. 2015 Nov;97(5):445-52. doi: 10.1007/s00223-015-0044-z. Epub 2015 Jul 30.

44.

Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype.

Kelly PS, Breen L, Gallagher C, Kelly S, Henry M, Lao NT, Meleady P, O'Gorman D, Clynes M, Barron N.

Biotechnol J. 2015 Jul;10(7):1029-40. doi: 10.1002/biot.201500101. Epub 2015 Jun 24.

PMID:
26097147
45.

Towards next generation CHO cell biology: Bioinformatics methods for RNA-Seq-based expression profiling.

Monger C, Kelly PS, Gallagher C, Clynes M, Barron N, Clarke C.

Biotechnol J. 2015 Jul;10(7):950-66. doi: 10.1002/biot.201500107. Epub 2015 Jun 9. Review.

PMID:
26058739
46.

How well do radiographic, clinical and self-reported diagnoses of knee osteoarthritis agree? Findings from the Hertfordshire cohort study.

Parsons C, Clynes M, Syddall H, Jagannath D, Litwic A, van der Pas S, Cooper C, Dennison EM, Edwards MH; EPOSA research group.

Springerplus. 2015 Apr 15;4:177. doi: 10.1186/s40064-015-0949-z. eCollection 2015.

47.

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression.

Aherne ST, Madden SF, Hughes DJ, Pardini B, Naccarati A, Levy M, Vodicka P, Neary P, Dowling P, Clynes M.

BMC Cancer. 2015 Apr 30;15:329. doi: 10.1186/s12885-015-1327-5.

48.

Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism.

Joyce H, McCann A, Clynes M, Larkin A.

Expert Opin Drug Metab Toxicol. 2015 May;11(5):795-809. doi: 10.1517/17425255.2015.1028356. Epub 2015 Apr 2. Review.

PMID:
25836015
49.

Prolonged pre-incubation increases the susceptibility of Galleria mellonella larvae to bacterial and fungal infection.

Browne N, Surlis C, Maher A, Gallagher C, Carolan JC, Clynes M, Kavanagh K.

Virulence. 2015;6(5):458-65. doi: 10.1080/21505594.2015.1021540. Epub 2015 Mar 18.

50.

Predictive biomarkers for dasatinib treatment in melanoma.

Eustace AJ, Kennedy S, Larkin AM, Mahgoub T, Tryfonopoulos D, O'Driscoll L, Clynes M, Crown J, O'Donovan N.

Oncoscience. 2014 Mar 12;1(2):158-66. eCollection 2014.

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