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Items: 1 to 50 of 110

1.

Characterisation of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.

Clegg RA, Bowen LC, Bicknell AV, Tabish M, Prescott MC, Rees HH, Fisher MJ.

Arch Biochem Biophys. 2012 Mar 1;519(1):38-45. doi: 10.1016/j.abb.2012.01.008. Epub 2012 Jan 20.

PMID:
22286028
2.

An E. coli over-expression system for multiply-phosphorylated proteins and its use in a study of calcium phosphate sequestration by novel recombinant phosphopeptides.

Clegg RA, Holt C.

Protein Expr Purif. 2009 Sep;67(1):23-34. doi: 10.1016/j.pep.2009.04.004. Epub 2009 Apr 11.

PMID:
19364535
3.

Role of calcium phosphate nanoclusters in the control of calcification.

Holt C, Sørensen ES, Clegg RA.

FEBS J. 2009 Apr;276(8):2308-23. doi: 10.1111/j.1742-4658.2009.06958.x. Epub 2009 Mar 9.

4.

siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans.

Murray P, Clegg RA, Rees HH, Fisher MJ.

Gene. 2008 Jan 31;408(1-2):157-63. Epub 2007 Nov 17.

PMID:
18077108
5.

Molecular characterisation of cAMP-dependent protein kinase (PK-A) catalytic subunit isoforms in the male tick, Amblyomma hebraeum.

Tabish M, Clegg RA, Turner PC, Jonczy J, Rees HH, Fisher MJ.

Mol Biochem Parasitol. 2006 Dec;150(2):330-9. Epub 2006 Oct 5.

PMID:
17049629
6.

Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.

Bowen LC, Bicknell AV, Tabish M, Clegg RA, Rees HH, Fisher MJ.

Cell Signal. 2006 Dec;18(12):2230-7. Epub 2006 May 20.

PMID:
16806821
7.

Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action.

Allan GJ, Tonner E, Szymanowska M, Shand JH, Kelly SM, Phillips K, Clegg RA, Gow IF, Beattie J, Flint DJ.

Endocrinology. 2006 Jan;147(1):338-49. Epub 2005 Sep 29.

8.

Characterisation of an N-terminal variant of acetyl-CoA carboxylase-alpha: expression in human tissues and evolutionary aspects.

Travers MT, Vallance AJ, Clegg RA, Thomson R, Price NT, Barber MC.

Biochim Biophys Acta. 2003 Nov 15;1634(3):97-106.

PMID:
14643797
9.

The inhibition of cAMP-dependent protein kinase by full-length hepatitis C virus NS3/4A complex is due to ATP hydrolysis.

Aoubala M, Holt J, Clegg RA, Rowlands DJ, Harris M.

J Gen Virol. 2001 Jul;82(Pt 7):1637-46.

PMID:
11413375
10.

Targeting of PKA in mammary epithelial cells. Mechanisms and functional consequences.

Clegg RA, Gardner RA, Sumathipala RN, Lavialle F, Boisgard R, Ollivier-Bousquet M.

Adv Exp Med Biol. 2000;480:99-105. Review.

PMID:
10959415
12.
13.

Expression of FAT, the putative fatty acid translocator protein, is developmentally regulated in rat mammary tissue.

Sumathipala RN, Travers MT, Thomas P, Munday MR, Clegg RA.

Biochem Soc Trans. 1998 Aug;26(3):S232. No abstract available.

PMID:
9765951
14.

Casein secretion in mammary tissue: tonic regulation of basal secretion by protein kinase A.

Clegg RA, Gardner RA, Lavialle F, Boisgard R, Ollivier-Bousquet M.

Mol Cell Endocrinol. 1998 Jun 25;141(1-2):163-77.

PMID:
9723897
15.

Expression of N-myristoyl transferase is developmentally regulated in mammary epithelial cells.

Clegg RA.

Biochem Soc Trans. 1997 Nov;25(4):S680. No abstract available.

PMID:
9450107
16.

Cellular uptake and metabolism of myristoylated N-terminal peptides of PKA C-subunit.

Clegg RA, Beattie J.

Biochem Soc Trans. 1997 Nov;25(4):S679. No abstract available.

PMID:
9450106
17.

Post-translational protein N-myristoylation in mammary epithelial cells.

Clegg RA.

Biochem Soc Trans. 1997 Nov;25(4):S675. No abstract available.

PMID:
9450103
18.

AKAP expression in rat mammary gland.

Clegg RA.

Biochem Soc Trans. 1997 Nov;25(4):S634. No abstract available.

PMID:
9450062
19.

N-Myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans.

Aspbury RA, Fisher MJ, Rees HH, Clegg RA.

Biochem Biophys Res Commun. 1997 Sep 18;238(2):523-7.

PMID:
9299544
20.

Lipid metabolism in the lactating mammary gland.

Barber MC, Clegg RA, Travers MT, Vernon RG.

Biochim Biophys Acta. 1997 Aug 16;1347(2-3):101-26. Review. No abstract available.

PMID:
9295156
21.

Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue.

Gordge PC, Hulme MJ, Clegg RA, Miller WR.

Eur J Cancer. 1996 Nov;32A(12):2120-6.

PMID:
9014755
22.

Protein kinase C does not acutely modulate protein kinase A activity in mammary gland acini prepared from mid-pregnant and mid-lactating rats.

Gordge PC, Withers SE, Connor K, Miller WR, Clegg RA.

Biochem Soc Trans. 1996 Aug;24(3):338S. No abstract available.

PMID:
8878882
23.

Separation of H7-resistant protein kinase C isoforms from gonadotroph-derived alpha T3-1 cells.

Simpson J, Johnson MS, Clegg RA, Mitchell R.

Biochem Biophys Res Commun. 1996 Jan 26;218(3):720-5.

PMID:
8579580
25.

Autophosphorylation of cAMP-dependent protein kinase catalytic subunit.

Thomas PH, Adie EJ, Clegg RA, Munday MR.

Biochem Soc Trans. 1995 Aug;23(3):500S. No abstract available.

PMID:
8566402
26.

Expression of PK-A catalytic and regulatory subunits in lactating rat mammary tissue: effects of litter removal.

Gardner RA, Travers MT, Barber MC, Miller WR, Clegg RA.

Biochem Soc Trans. 1995 Aug;23(3):452S. No abstract available.

PMID:
8566343
27.

Subcellular targeting of recombinant and mammalian C alpha subunits of cAMP-dependent protein kinase.

Adie EJ, Thomas PH, Munday MR, Clegg RA.

Biochem Soc Trans. 1995 Aug;23(3):451S. No abstract available.

PMID:
8566342
28.

Ca(2+)-dependent and Ca(2+)-independent protein kinase C activity in human breast biopsies.

Gordge PC, Clegg RA, Miller WR.

Biochem Soc Trans. 1995 Aug;23(3):449S. No abstract available.

PMID:
8566339
29.

Phorbol ester and diacylglycerol activation of native protein kinase C species from various tissues.

Johnson MS, Simpson J, MacEwan DJ, Ison A, Clegg RA, Connor K, Mitchell R.

Mol Cell Biochem. 1995 May 24;146(2):127-37.

PMID:
7565642
30.

The properties of protein kinase C zeta purified from alpha T3-1 cells using hydroxyapatite chromatography.

Johnson MS, Simpson J, Clegg RA, Mitchell R.

Biochem Soc Trans. 1995 Feb;23(1):147S. No abstract available.

PMID:
7758713
31.

A novel high molecular weight form of protein kinase C in anterior pituitary.

Ison AJ, Simpson J, Lutz EM, Clegg RA, Connor K, Mitchell R.

Biochem Soc Trans. 1995 Feb;23(1):146S. No abstract available.

PMID:
7758712
32.
33.

Immunoinhibition of protein kinase activity of PK-A catalytic subunit.

Gardner RA, Clegg RA.

Biochem Soc Trans. 1994 May;22(2):211S. No abstract available.

PMID:
7958273
34.

Isoprenaline-induced lipolysis in perfused mammary tissue.

Calvert DT, Connor K, Clegg RA.

Biochem Soc Trans. 1993 Nov;21(4):456S. No abstract available.

PMID:
8132024
35.

Surface-accessibility of the myristoylated N-terminus of PK-A catalytic subunit probed with anti-peptide antibodies.

Beattie J, Clegg RA.

Biochem Soc Trans. 1993 Nov;21(4):399S. No abstract available.

PMID:
8131975
36.

Expression of PK-A catalytic subunit in mammary tissue during pregnancy and lactation.

Gardner RA, Travers MT, Barber MC, Miller WR, Clegg RA.

Biochem Soc Trans. 1993 Nov;21(4):398S. No abstract available.

PMID:
8131974
37.

Biochemical characterisation of an apparently novel isoform of protein kinase C in pituitary.

Ison AJ, Johnson MS, MacEwan DJ, Simpson J, Clegg RA, Connor K, Mitchell R.

Biochem Soc Trans. 1993 Nov;21(4):386S. No abstract available.

PMID:
8131963
38.

Evidence for a distinct H7-resistant form of protein kinase C in rat anterior pituitary gland.

Ison AJ, MacEwan DJ, Johnson MS, Clegg RA, Connor K, Mitchell R.

FEBS Lett. 1993 Aug 23;329(1-2):199-204.

39.

Evidence that protein kinase C alpha has reduced affinity towards 1,2-dioctanoyl-sn-glycerol: the effects of lipid activators on phorbol ester binding and kinase activity.

MacEwan DJ, Mitchell R, Johnson MS, Thomson FJ, Lutz EM, Clegg RA, Connor K.

Eur J Pharmacol. 1993 Jun 15;246(1):9-18.

PMID:
8354345
41.
42.

N-myristoylation of the catalytic subunit of PK-A: does this covalent modification specify receptor recognition?

Clegg RA, Connor K.

Biochem Soc Trans. 1992 Nov;20(4):386S. No abstract available.

PMID:
1487045
43.
44.

Cholesterol ester hydrolysis and hormone-sensitive lipase in lactating rat mammary tissue.

Small CA, Yeaman SJ, West DW, Clegg RA.

Biochim Biophys Acta. 1991 Apr 3;1082(3):251-4.

PMID:
2029545
45.

Calcium-translocation into mammary Golgi vesicles: molecular identity of Ca(2+) -ATPases.

Clegg RA, West DW.

Biochem Soc Trans. 1991 Apr;19(2):194S. No abstract available.

PMID:
1832395
46.

Chronic control of the beta- and alpha 2-adrenergic systems of sheep adipose tissue by growth hormone and insulin.

Watt PW, Finley E, Cork S, Clegg RA, Vernon RG.

Biochem J. 1991 Jan 1;273(Pt 1):39-42.

48.

Mammary tissue lipocortins of the lactating rat.

Jamieson AM, Paschke M, Clegg RA.

Biochem Soc Trans. 1990 Dec;18(6):1116-7. No abstract available.

PMID:
2150945
50.

Characterization of rat liver beta-adrenoceptors during lactation.

Dunphy AM, Clegg RA, Snell K.

Biochem Soc Trans. 1989 Dec;17(6):1098-9. No abstract available.

PMID:
2576414

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