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Advancing Biologics Development Programs with Legacy Cell Lines: Advantages and Limitations of Genetic Testing for Addressing Clonality Concerns Prior to Availability of Late Stage Process and Product Consistency Data.

Wu P, Hartman T, Almond L, Stevens J, Thrift J, OJha J, Alves C, Shaw D, Laird MW, Emmins R, Zhu Y, Liu R, Du Z, Koehler R, Jostock T, Anderson K, Campbell C, Clarke H.

PDA J Pharm Sci Technol. 2019 Sep 13. pii: pdajpst.2018.009316. doi: 10.5731/pdajpst.2018.009316. [Epub ahead of print]


Canada's hidden opioid crisis: the health care system's inability to manage high-dose opioid patients: Fallout from the 2017 Canadian opioid guidelines.

Clarke H, Bao J, Weinrib A, Dubin RE, Kahan M.

Can Fam Physician. 2019 Sep;65(9):612-614. No abstract available.


A Systematic Review of Behavioral Interventions to Decrease Opioid Prescribing After Surgery.

Zhang DDQ, Sussman J, Dossa F, Jivraj N, Ladha K, Brar S, Urbach D, Tricco AC, Wijeysundera DN, Clarke HA, Baxter NN.

Ann Surg. 2019 Jul 25. doi: 10.1097/SLA.0000000000003483. [Epub ahead of print]


Accuracy of a New Robotically Assisted Technique for Total Knee Arthroplasty: A Cadaveric Study.

Parratte S, Price AJ, Jeys LM, Jackson WF, Clarke HD.

J Arthroplasty. 2019 Jun 26. pii: S0883-5403(19)30631-X. doi: 10.1016/j.arth.2019.06.040. [Epub ahead of print]


Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

Santangelo AM, Sawiak SJ, Fryer T, Hong Y, Shiba Y, Clarke HF, Riss PJ, Ferrari V, Tait R, Suckling J, Aigbirhio FI, Roberts AC.

Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14761-14768. doi: 10.1073/pnas.1902087116. Epub 2019 Jul 2.


Evaluation of a new hybrid VMAT-IMRT multi-criteria optimization plan generation algorithm.

Spalding M BSc, Walsh A MSc, Clarke H BSc, Aland T MSc.

Med Dosim. 2019 Jun 10. pii: S0958-3947(19)30061-5. doi: 10.1016/j.meddos.2019.05.002. [Epub ahead of print]


A Systematic Review of the Relative Frequency and Risk Factors for Prolonged Opioid Prescription Following Surgery and Trauma Among Adults.

Pagé MG, Kudrina I, Zomahoun HTV, Croteau J, Ziegler D, Ngangue P, Martin E, Fortier M, Boisvert EE, Beaulieu P, Charbonneau C, Cogan J, Daoust R, Martel MO, Néron A, Richebé P, Clarke H.

Ann Surg. 2019 Jun 10. doi: 10.1097/SLA.0000000000003403. [Epub ahead of print]


Predictors of Post-operative Pain and Opioid Consumption in Patients Undergoing Liver Surgery.

Behman R, Cleary S, McHardy P, Kiss A, Sawyer J, Ladak SSJ, McCluskey SA, Srinivas C, Katz J, Coburn N, Law C, Wei AC, Greig P, Hallet J, Clarke H, Karanicolas PJ.

World J Surg. 2019 Oct;43(10):2579-2586. doi: 10.1007/s00268-019-05050-7.


UK guidelines for the medical and laboratory procurement and use of sperm, oocyte and embryo donors (2019).

Clarke H, Harrison S, Perez MJ, Kirkman-Brown J.

Hum Fertil (Camb). 2019 Jun 6:1-13. doi: 10.1080/14647273.2019.1622040. [Epub ahead of print]


A Focus on the Functions of Area 25.

Alexander L, Clarke HF, Roberts AC.

Brain Sci. 2019 Jun 3;9(6). pii: E129. doi: 10.3390/brainsci9060129. Review.


Perioperative Pain and Addiction Interdisciplinary Network (PAIN) clinical practice advisory for perioperative management of buprenorphine: results of a modified Delphi process.

Goel A, Azargive S, Weissman JS, Shanthanna H, Hanlon JG, Samman B, Dominicis M, Ladha KS, Lamba W, Duggan S, Di Renna T, Peng P, Wong C, Sinha A, Eipe N, Martell D, Intrater H, MacDougall P, Kwofie K, St-Jean M, Rashiq S, Van Camp K, Flamer D, Satok-Wolman M, Clarke H.

Br J Anaesth. 2019 Aug;123(2):e333-e342. doi: 10.1016/j.bja.2019.03.044. Epub 2019 May 29.


Perioperative Pain and Addiction Interdisciplinary Network (PAIN): protocol of a practice advisory for the perioperative management of buprenorphine using a modified Delphi process.

Goel A, Azargive S, Weissman JS, Shanthanna H, Ladha KS, Lamba W, Duggan S, Hanlon JG, Di Renna T, Peng P, Clarke H.

BMJ Open. 2019 May 22;9(5):e027374. doi: 10.1136/bmjopen-2018-027374.


Development of a headspace solid-phase microextraction gas chromatography mass spectrometry method for the quantification of volatiles associated with lipid oxidation in whole milk powder using response surface methodology.

Clarke HJ, Mannion DT, O'Sullivan MG, Kerry JP, Kilcawley KN.

Food Chem. 2019 Sep 15;292:75-80. doi: 10.1016/j.foodchem.2019.04.027. Epub 2019 Apr 6.


Prevalence and etiology of elbow flexion contractures in brachial plexus birth injury: A scoping review.

Ho ES, Kim D, Klar K, Anthony A, Davidge K, Borschel GH, Hopyan S, Clarke HM, Wright FV.

J Pediatr Rehabil Med. 2019;12(1):75-86. doi: 10.3233/PRM-180535.


Association between harm reduction strategies and healthcare utilization in patients on long-term prescribed opioid therapy presenting to acute healthcare settings: a protocol for a systematic review and meta-analysis.

Deschamps J, Gilbertson J, Straube S, Dong K, MacMaster FP, Korownyk C, Montgomery L, Mahaffey R, Downar J, Clarke H, Muscedere J, Rittenbach K, Featherstone R, Sebastianski M, Vandermeer B, Lynam D, Magnussen R, Bagshaw SM, Rewa OG.

Syst Rev. 2019 Apr 5;8(1):88. doi: 10.1186/s13643-019-0997-5.


Time for accountability and change: institutional gaps in pain care during the opioid crisis.

Clarke H, Ladha K.

Br J Anaesth. 2019 Jun;122(6):e90-e93. doi: 10.1016/j.bja.2019.02.015. Epub 2019 Mar 18. No abstract available.


Effectiveness of non-surgical and surgical interventions for elbow flexion contractures in brachial plexus birth injury: A systematic review.

Ho ES, Zuccaro J, Klar K, Anthony A, Davidge K, Borschel GH, Hopyan S, Clarke HM, Wright FV.

J Pediatr Rehabil Med. 2019;12(1):87-100. doi: 10.3233/PRM-180563.


Prevalence and etiology of elbow flexion contractures in brachial plexus birth injury: A scoping review.

Ho ES, Kim D, Zuccaro J, Klar K, Anthony A, Davidge K, Borschel GH, Hopyan S, Clarke HM, Wright FV.

J Pediatr Rehabil Med. 2019 Mar 6. doi: 10.3233/PRM-180535. [Epub ahead of print]


Two-Stage Debridement With Prosthesis Retention for Acute Periprosthetic Joint Infections.

Chung AS, Niesen MC, Graber TJ, Schwartz AJ, Beauchamp CP, Clarke HD, Spangehl MJ.

J Arthroplasty. 2019 Jun;34(6):1207-1213. doi: 10.1016/j.arth.2019.02.013. Epub 2019 Feb 16.


Perioperative Pregabalin and Intraoperative Lidocaine Infusion to Reduce Persistent Neuropathic Pain After Breast Cancer Surgery: A Multicenter, Factorial, Randomized, Controlled Pilot Trial.

Khan JS, Hodgson N, Choi S, Reid S, Paul JE, Hong NJL, Holloway C, Busse JW, Gilron I, Buckley DN, McGillion M, Clarke H, Katz J, Mackey S, Avram R, Pohl K, Rao-Melacini P, Devereaux PJ.

J Pain. 2019 Aug;20(8):980-993. doi: 10.1016/j.jpain.2019.02.010. Epub 2019 Mar 5.


Examination of psychological risk factors for chronic pain following cardiac surgery: protocol for a prospective observational study.

McGillion MH, Henry S, Busse JW, Ouellette C, Katz J, Choinière M, Lamy A, Whitlock R, Pettit S, Hare J, Gregus K, Brady K, Dvirnik N, Yang SS, Parlow J, Dumerton-Shore D, Gilron I, Buckley DN, Shanthanna H, Carroll SL, Coyte PC, Ebrahim S, Isaranuwatchai W, Guerriere DN, Hoch J, Khan J, MacDermid J, Martorella G, Victor JC, Watt-Watson J, Howard-Quijano K, Mahajan A, Chan MTV, Clarke H, Devereaux PJ.

BMJ Open. 2019 Mar 1;9(2):e022995. doi: 10.1136/bmjopen-2018-022995.


Hippocampal Interaction With Area 25, but not Area 32, Regulates Marmoset Approach-Avoidance Behavior.

Wallis CU, Cockcroft GJ, Cardinal RN, Roberts AC, Clarke HF.

Cereb Cortex. 2019 Feb 23. pii: bhz015. doi: 10.1093/cercor/bhz015. [Epub ahead of print]


The impact of comorbid pain and depression in the United States: results from a nationally representative survey.

Dhanju S, Kennedy SH, Abbey S, Katz J, Weinrib A, Clarke H, Bhat V, Ladha K.

Scand J Pain. 2019 Apr 24;19(2):319-325. doi: 10.1515/sjpain-2018-0323.


Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.

Zeredo JL, Quah SKL, Wallis CU, Alexander L, Cockcroft GJ, Santangelo AM, Xia J, Shiba Y, Dalley JW, Cardinal RN, Roberts AC, Clarke HF.

J Neurosci. 2019 Apr 17;39(16):3094-3107. doi: 10.1523/JNEUROSCI.2451-18.2018. Epub 2019 Feb 4.


What is the optimal protocol to decontaminate a dropped custom polyethylene component?

Swenson RD, Kraemer JL, Clarke HD, Grys TE, Schwartz AJ.

Knee. 2019 Mar;26(2):444-450. doi: 10.1016/j.knee.2019.01.006. Epub 2019 Jan 30.


An Irish National Diabetes in Pregnancy Audit: aiming for best outcomes for women with diabetes.

Egan AM, Brassill MJ, Brosnan E, Carmody L, Clarke H, Coogan Kelly C, Culliney L, Durkan M, Fenlon M, Ferry P, Hanlon G, Higgins T, Hoashi S, Khamis A, Kinsley B, Kinsley T, Kirwan B, Liew A, McGurk C, McHugh C, Murphy MS, Murphy P, O'Halloran D, O'Mahony L, O'Sullivan E, Nolan M, Peter M, Roberts G, Smyth A, Todd M, Tuthill A, Wan Mahmood WA, Yousif O, P Dunne F; National Diabetes in Pregnancy Audit working group.

Diabet Med. 2019 Feb 2. doi: 10.1111/dme.13923. [Epub ahead of print]


Developing and testing models of the drivers of anthropogenic and lightning-caused wildfire ignitions in south-eastern Australia.

Clarke H, Gibson R, Cirulis B, Bradstock RA, Penman TD.

J Environ Manage. 2019 Apr 1;235:34-41. doi: 10.1016/j.jenvman.2019.01.055. Epub 2019 Jan 19.


Tranexamic acid in total joint arthroplasty: the endorsed clinical practice guides of the American Association of Hip and Knee Surgeons, American Society of Regional Anesthesia and Pain Medicine, American Academy of Orthopaedic Surgeons, Hip Society, and Knee Society.

Fillingham YA, Ramkumar DB, Jevsevar DS, Yates AJ, Bini SA, Clarke HD, Schemitsch E, Johnson RL, Memtsoudis SG, Sayeed SA, Sah AP, Della Valle CJ.

Reg Anesth Pain Med. 2019 Jan;44(1):7-11. doi: 10.1136/rapm-2018-000024. No abstract available.


Confounding pain and function: the WOMAC's failure to accurately predict lower extremity function.

Stratford P, Kennedy D, Clarke H.

Arthroplast Today. 2018 Oct 15;4(4):488-492. doi: 10.1016/j.artd.2018.09.003. eCollection 2018 Dec.


Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage.

Chanalaris A, Clarke H, Guimond SE, Vincent TL, Turnbull JE, Troeberg L.

Am J Pathol. 2019 Mar;189(3):632-647. doi: 10.1016/j.ajpath.2018.11.011. Epub 2018 Dec 14.


Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex.

Alexander L, Gaskin PLR, Sawiak SJ, Fryer TD, Hong YT, Cockcroft GJ, Clarke HF, Roberts AC.

Neuron. 2019 Jan 16;101(2):307-320.e6. doi: 10.1016/j.neuron.2018.11.021. Epub 2018 Dec 4.


The perioperative patient on buprenorphine: a systematic review of perioperative management strategies and patient outcomes.

Goel A, Azargive S, Lamba W, Bordman J, Englesakis M, Srikandarajah S, Ladha K, Di Renna T, Shanthanna H, Duggan S, Peng P, Hanlon J, Clarke H.

Can J Anaesth. 2019 Feb;66(2):201-217. doi: 10.1007/s12630-018-1255-3. Epub 2018 Nov 27.


Measuring Tibial Component Rotation Following Total Knee Arthroplasty: What Is the Best Method?

Saffi M, Spangehl MJ, Clarke HD, Young SW.

J Arthroplasty. 2019 Jul;34(7S):S355-S360. doi: 10.1016/j.arth.2018.10.022. Epub 2018 Oct 27.


Defining and Predicting Pain Volatility in Users of the Manage My Pain App: Analysis Using Data Mining and Machine Learning Methods.

Rahman QA, Janmohamed T, Pirbaglou M, Clarke H, Ritvo P, Heffernan JM, Katz J.

J Med Internet Res. 2018 Nov 15;20(11):e12001. doi: 10.2196/12001.


Establishing Priorities for the International Confederation of Plastic Surgery Societies.

Cooter RD, Brightman LA, Clarke HM, Cruz NI, Evans GRD, Koh KS, Murphy RX Jr, Perks GAB, Rakhorst HA.

Plast Reconstr Surg Glob Open. 2018 Sep 5;6(9):e1878. doi: 10.1097/GOX.0000000000001878. eCollection 2018 Sep.


Reliability and validity of various laboratory methods of body composition assessment in young adults.

Schubert MM, Seay RF, Spain KK, Clarke HE, Taylor JK.

Clin Physiol Funct Imaging. 2019 Mar;39(2):150-159. doi: 10.1111/cpf.12550. Epub 2018 Oct 16.


In-hospital opioid consumption, but not pain intensity scores, predicts 6-month levels of pain catastrophizing following hepatic resection: A trajectory analysis.

Pagé MG, Karanicolas PJ, Cleary S, Wei AC, McHardy P, Ladak SSJ, Ayach N, Sawyer J, McCluskey SA, Srinivas C, Katz J, Coburn N, Hallet J, Law C, Greig P, Clarke H.

Eur J Pain. 2019 Mar;23(3):503-514. doi: 10.1002/ejp.1324. Epub 2018 Nov 8.


Specialty Focus: Lower Extremity, Hip and Knee Issue.

Clarke HD.

J Am Acad Orthop Surg. 2018 Oct 15;26(20):707-708. doi: 10.5435/JAAOS-D-18-00490. No abstract available.


Prevalence of abnormal semen analysis and levels of adherence with fertility preservation in men undergoing therapy for newly diagnosed cancer: A retrospective study in 2906 patients.

Jayasena CN, Luo R, Dimakopoulou A, Dearing C, Clarke H, Patel N, Stroud T, Seyani L, Ramsay J, Dhillo WS.

Clin Endocrinol (Oxf). 2018 Dec;89(6):798-804. doi: 10.1111/cen.13851. Epub 2018 Oct 10.


Oncological outcomes of abdominoperineal resection for the treatment of low rectal cancer: A retrospective review of a single UK tertiary centre experience.

Hussain A, Mahmood F, Torrance ADW, Clarke H, Howitt C, Dawson R.

Ann Med Surg (Lond). 2018 Jun 26;34:28-33. doi: 10.1016/j.amsu.2018.06.007. eCollection 2018 Oct.


Tranexamic Acid Use in Total Joint Arthroplasty: The Clinical Practice Guidelines Endorsed by the American Association of Hip and Knee Surgeons, American Society of Regional Anesthesia and Pain Medicine, American Academy of Orthopaedic Surgeons, Hip Society, and Knee Society.

Fillingham YA, Ramkumar DB, Jevsevar DS, Yates AJ, Bini SA, Clarke HD, Schemitsch E, Johnson RL, Memtsoudis SG, Sayeed SA, Sah AP, Della Valle CJ.

J Arthroplasty. 2018 Oct;33(10):3065-3069. doi: 10.1016/j.arth.2018.08.002. Epub 2018 Aug 7. No abstract available.


Perioperative pregabalin and delirium following total hip arthroplasty: a post hoc analysis of a double-blind randomized placebo-controlled trial.

Farlinger C, Clarke H, Wong CL.

Can J Anaesth. 2018 Nov;65(11):1269-1270. doi: 10.1007/s12630-018-1195-y. Epub 2018 Aug 6. No abstract available.


Overlaps in pharmacology for the treatment of chronic pain and mental health disorders.

Sutherland AM, Nicholls J, Bao J, Clarke H.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Dec 20;87(Pt B):290-297. doi: 10.1016/j.pnpbp.2018.07.017. Epub 2018 Jul 25. Review.


Sensory Outcome in Children Following Microsurgery for Brachial Plexus Birth Injury.

Ho ES, Davidge K, Curtis CG, Clarke HM.

J Hand Surg Am. 2019 Feb;44(2):159.e1-159.e8. doi: 10.1016/j.jhsa.2018.05.009. Epub 2018 Jul 2.


Chemical Profiling of Medical Cannabis Extracts.

Lewis MM, Yang Y, Wasilewski E, Clarke HA, Kotra LP.

ACS Omega. 2017 Sep 30;2(9):6091-6103. doi: 10.1021/acsomega.7b00996. Epub 2017 Sep 22.


Relative frequency and risk factors for long-term opioid therapy following surgery and trauma among adults: a systematic review protocol.

Pagé MG, Kudrina I, Zomahoun HTV, Ziegler D, Beaulieu P, Charbonneau C, Cogan J, Daoust R, Martel MO, Néron A, Richebé P, Clarke H.

Syst Rev. 2018 Jul 18;7(1):97. doi: 10.1186/s13643-018-0760-3. Review.


The Efficacy of Tranexamic Acid in Total Hip Arthroplasty: A Network Meta-analysis.

Fillingham YA, Ramkumar DB, Jevsevar DS, Yates AJ, Shores P, Mullen K, Bini SA, Clarke HD, Schemitsch E, Johnson RL, Memtsoudis SG, Sayeed SA, Sah AP, Della Valle CJ.

J Arthroplasty. 2018 Oct;33(10):3083-3089.e4. doi: 10.1016/j.arth.2018.06.023. Epub 2018 Jun 27.


Full elucidation of the transmembrane anion transport mechanism of squaramides using in silico investigations.

Marques I, Costa PMR, Q Miranda M, Busschaert N, Howe ENW, Clarke HJ, Haynes CJE, Kirby IL, Rodilla AM, Pérez-Tomás R, Gale PA, Félix V.

Phys Chem Chem Phys. 2018 Aug 15;20(32):20796-20811. doi: 10.1039/c8cp02576b.


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