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Items: 39

1.

Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.

Fortin S, Charest-Morin X, Turcotte V, Lauvaux C, Lacroix J, Côté MF, Gobeil S, C-Gaudreault R.

J Med Chem. 2017 Jun 22;60(12):4963-4982. doi: 10.1021/acs.jmedchem.7b00343. Epub 2017 Jun 1.

PMID:
28535350
2.

Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity.

Lefebvre CA, Forcellini E, Boutin S, Côté MF, C-Gaudreault R, Mathieu P, Lagüe P, Paquin JF.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):299-302. doi: 10.1016/j.bmcl.2016.11.052. Epub 2016 Nov 19.

PMID:
27903409
3.

Synthesis of novel C2-symmetric testosterone dimers and evaluation of antiproliferative activity on androgen-dependent and -independent prostate cancer cell lines.

Vesper AR, Lacroix J, C-Gaudreault R, Tajmir-Rihai HA, Bérubé G.

Steroids. 2016 Nov;115:98-104. doi: 10.1016/j.steroids.2016.08.012. Epub 2016 Aug 21.

PMID:
27553724
4.

Discovery of ethyl urea derivatives as inhibitors of islet amyloid polypeptide fibrillization and cytotoxicity.

Fortin JS, Benoit-Biancamano MO, C-Gaudreault R.

Can J Physiol Pharmacol. 2016 Mar;94(3):341-6. doi: 10.1139/cjpp-2015-0204. Epub 2015 Sep 11.

PMID:
26679837
5.

Styryl-N-phenyl-N'-(2-chloroethyl)ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model.

Gagné-Boulet M, Fortin S, Lacroix J, Lefebvre CA, Côté MF, C-Gaudreault R.

Eur J Med Chem. 2015 Jul 15;100:34-43. doi: 10.1016/j.ejmech.2015.05.034. Epub 2015 May 28.

PMID:
26069928
6.

Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.

Turcotte V, Fortin S, Vevey F, Coulombe Y, Lacroix J, Côté MF, Masson JY, C-Gaudreault R.

J Med Chem. 2012 Jul 12;55(13):6194-208. doi: 10.1021/jm3006492. Epub 2012 Jun 21.

7.

Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.

Fortin S, Wei L, Moreau E, Lacroix J, Côté MF, Petitclerc E, Kotra LP, C-Gaudreault R.

J Med Chem. 2011 Jul 14;54(13):4559-80. doi: 10.1021/jm200488a. Epub 2011 Jun 13.

8.

Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40.

Trzeciakiewicz A, Fortin S, Moreau E, C-Gaudreault R, Lacroix J, Chambon C, Communal Y, Chezal JM, Miot-Noirault E, Bouchon B, Degoul F.

Biochem Pharmacol. 2011 May 1;81(9):1116-23. doi: 10.1016/j.bcp.2011.02.014. Epub 2011 Mar 1.

PMID:
21371445
9.

Chloroethyl urea derivatives block tumour growth and thioredoxin-1 nuclear translocation.

Patenaude A, Fortin JS, Deschenes R, Côté MF, Lacroix J, C-Gaudreault R, Petitclerc E.

Can J Physiol Pharmacol. 2010 Nov;88(11):1102-14. doi: 10.1139/y10-084.

PMID:
21076498
10.

Characterization of the covalent binding of N-phenyl-N'-(2-chloroethyl)ureas to {beta}-tubulin: importance of Glu198 in microtubule stability.

Fortin S, Bouchon B, Chambon C, Lacroix J, Moreau E, Chezal JM, Degoul F, C-Gaudreault R.

J Pharmacol Exp Ther. 2011 Feb;336(2):460-7. doi: 10.1124/jpet.110.171082. Epub 2010 Oct 26.

PMID:
20978170
11.

ASK1-P38 pathway is important for anoikis induced by microtubule-targeting aryl chloroethylureas.

Fortin J, Patenaude A, Deschesnes RG, Côté MF, Petitclerc E, C-Gaudreault R.

J Pharm Pharm Sci. 2010;13(2):175-90.

12.

Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas.

Fortin S, Moreau E, Lacroix J, Côté MF, Petitclerc E, C-Gaudreault R.

Eur J Med Chem. 2010 Jul;45(7):2928-37. doi: 10.1016/j.ejmech.2010.03.018. Epub 2010 Mar 25.

PMID:
20400211
13.

Quick and simple detection technique to assess the binding of antimicrotubule agents to the colchicine-binding site.

Fortin S, Lacroix J, Côté MF, Moreau E, Petitclerc E, C-Gaudreault R.

Biol Proced Online. 2010 Apr 8;12(1):113-7. doi: 10.1007/s12575-010-9029-5.

14.

Effects of inactivation-resistant agonists on the signalling, desensitization and down-regulation of bradykinin B(2) receptors.

Bawolak MT, Fortin S, Bouthillier J, Adam A, Gera L, C-Gaudreault R, Marceau F.

Br J Pharmacol. 2009 Nov;158(5):1375-86. doi: 10.1111/j.1476-5381.2009.00409.x. Epub 2009 Sep 28.

15.

Spectroscopic characterization of DMPC/DOTAP cationic liposomes and their interactions with DNA and drugs.

Labbé JF, Cronier F, C-Gaudreault R, Auger M.

Chem Phys Lipids. 2009 Apr;158(2):91-101. doi: 10.1016/j.chemphyslip.2009.01.002. Epub 2009 Jan 22.

PMID:
19428353
16.

Mechanism of action of N-phenyl-N'-(2-chloroethyl)ureas in the colchicine-binding site at the interface between alpha- and beta-tubulin.

Fortin S, Wei L, Moreau E, Labrie P, Petitclerc E, Kotra LP, C-Gaudreault R.

Bioorg Med Chem. 2009 May 15;17(10):3690-7. doi: 10.1016/j.bmc.2009.03.056. Epub 2009 Apr 1.

PMID:
19398206
17.

Selective alkylation of beta(II)-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents.

Fortin JS, Côté MF, Lacroix J, Desjardins M, Petitclerc E, C-Gaudreault R.

Bioorg Med Chem. 2008 Aug 1;16(15):7277-90. doi: 10.1016/j.bmc.2008.06.028. Epub 2008 Jun 20.

PMID:
18617414
18.

Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression.

Fortin JS, Côté MF, Lacroix J, Petitclerc E, C-Gaudreault R.

Bioorg Med Chem. 2008 Aug 1;16(15):7477-88. doi: 10.1016/j.bmc.2008.06.006. Epub 2008 Jun 10.

PMID:
18579387
19.

Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation.

Fortin JS, Côté MF, Lacroix J, Patenaude A, Petitclerc E, C-Gaudreault R.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3526-31. doi: 10.1016/j.bmcl.2008.05.028. Epub 2008 May 10.

PMID:
18502639
20.
21.

N-Phenyl-N'-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents. Part 3: role of carbonyl groups in the covalent binding to the colchicine-binding site.

Moreau E, Fortin S, Lacroix J, Patenaude A, Rousseau JL, C-Gaudreault R.

Bioorg Med Chem. 2008 Feb 1;16(3):1206-17. Epub 2007 Nov 12.

PMID:
17998163
22.

Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site.

Fortin JS, Lacroix J, Desjardins M, Patenaude A, Petitclerc E, C-Gaudreault R.

Bioorg Med Chem. 2007 Jul 1;15(13):4456-69. Epub 2007 Apr 22.

PMID:
17498960
23.

N-(4-iodophenyl)-N'-(2-chloroethyl)urea as a microtubule disrupter: in vitro and in vivo profiling of antitumoral activity on CT-26 murine colon carcinoma cell line cultured and grafted to mice.

Borel M, Degoul F, Communal Y, Mounetou E, Bouchon B, C-Gaudreault R, Madelmont JC, Miot-Noirault E.

Br J Cancer. 2007 Jun 4;96(11):1684-91. Epub 2007 May 8.

24.

New soft alkylating agents with enhanced cytotoxicity against cancer cells resistant to chemotherapeutics and hypoxia.

Patenaude A, Deschesnes RG, Rousseau JL, Petitclerc E, Lacroix J, Côté MF, C-Gaudreault R.

Cancer Res. 2007 Mar 1;67(5):2306-16.

25.

N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?

Fortin S, Moreau E, Lacroix J, Teulade JC, Patenaude A, C-Gaudreault R.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):2000-4. Epub 2007 Jan 19.

PMID:
17291753
26.
27.

N-Phenyl-N'-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: role of omega-hydroxyl group in the covalent binding to beta-tubulin.

Fortin S, Moreau E, Patenaude A, Desjardins M, Lacroix J, Rousseau JL, C-Gaudreault R.

Bioorg Med Chem. 2007 Feb 1;15(3):1430-8. Epub 2006 Nov 10.

PMID:
17118664
28.

Microtubule-destabilizing agents induce focal adhesion structure disorganization and anoikis in cancer cells.

Deschesnes RG, Patenaude A, Rousseau JL, Fortin JS, Ricard C, Côté MF, Huot J, C-Gaudreault R, Petitclerc E.

J Pharmacol Exp Ther. 2007 Feb;320(2):853-64. Epub 2006 Nov 10.

PMID:
17099073
29.

N-substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects concerning ion trapping.

Morissette G, Moreau E, C-Gaudreault R, Marceau F.

Mol Pharmacol. 2005 Dec;68(6):1576-89. Epub 2005 Sep 23.

PMID:
16183854
30.

Optimized N-phenyl-N'-(2-chloroethyl)ureas as potential antineoplastic agents: synthesis and growth inhibition activity.

Moreau E, Fortin S, Desjardins M, Rousseau JL, Petitclerc E, C-Gaudreault R.

Bioorg Med Chem. 2005 Dec 15;13(24):6703-12. Epub 2005 Sep 13.

PMID:
16165366
31.

Synthesis of 17beta-estradiol-linked platinum(II) complexes and their cytocidal activity on estrogen-dependent and -independent breast tumor cells.

Perron V, Rabouin D, Asselin E, Parent S, C-Gaudreault R, Bérubé G.

Bioorg Chem. 2005 Feb;33(1):1-15.

PMID:
15668178
32.

Antiangiogenic and antitumoral activity of phenyl-3-(2-chloroethyl)ureas: a class of soft alkylating agents disrupting microtubules that are unaffected by cell adhesion-mediated drug resistance.

Petitclerc E, Deschesnes RG, Côté MF, Marquis C, Janvier R, Lacroix J, Miot-Noirault E, Legault J, Mounetou E, Madelmont JC, C -Gaudreault R.

Cancer Res. 2004 Jul 1;64(13):4654-63.

33.

Massive cell vacuolization induced by organic amines such as procainamide.

Morissette G, Moreau E, C-Gaudreault R, Marceau F.

J Pharmacol Exp Ther. 2004 Jul;310(1):395-406. Epub 2004 Mar 8.

PMID:
15007104
34.
35.

A facile synthesis of C(2)-symmetric 17 beta-estradiol dimers.

Rabouin D, Perron V, N'Zemba B, C-Gaudreault R, Bérubé G.

Bioorg Med Chem Lett. 2003 Feb 10;13(3):557-60.

PMID:
12565971
37.

Interaction between lipid bilayers and a new class of antineoplastic agents derived from arylchloroethylurea: a 2H solid-state NMR study.

Saint-Laurent A, Boudreau N, C-Gaudreault R, Poyet P, Auger M.

Biochem Cell Biol. 1998;76(2-3):465-71.

PMID:
9923715
38.

Do prostacyclin and thromboxane contribute to the "protective effect" of pregnancies with chronic hypertension? A preliminary prospective longitudinal study.

Moutquin JM, Lindsay C, Arial N, De Grandpré P, C-Gaudreault R, Forest JC, Massé J.

Am J Obstet Gynecol. 1997 Dec;177(6):1483-90.

PMID:
9423755
39.

Interaction of 4-tert-butyl-[3-(2-chloroethyl) ureido] benzene with phosphatidylcholine bilayers: a differential scanning calorimetry and infrared spectroscopy study.

Gicquad C, Auger M, Wong TT, Poyet P, Boudreau N, C-Gaudreault R.

Arch Biochem Biophys. 1996 Oct 15;334(2):193-9.

PMID:
8900392

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