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Selective depletion of metastatic stem cells as therapy for human colorectal cancer.

Céspedes MV, Unzueta U, Aviñó A, Gallardo A, Álamo P, Sala R, Sánchez-Chardi A, Casanova I, Mangues MA, Lopez-Pousa A, Eritja R, Villaverde A, Vázquez E, Mangues R.

EMBO Mol Med. 2018 Oct;10(10). pii: e8772. doi: 10.15252/emmm.201708772.


CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis.

Moreno MJ, Gallardo A, Novelli S, Mozos A, Aragó M, Pavón MÁ, Céspedes MV, Pallarès V, Falgàs A, Alcoceba M, Blanco O, Gonzalez-Díaz M, Sierra J, Mangues R, Casanova I.

PLoS One. 2018 Jun 19;13(6):e0198789. doi: 10.1371/journal.pone.0198789. eCollection 2018.


Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach.

Unzueta U, Cespedes MV, Sala R, Alamo P, Sánchez-Chardi A, Pesarrodona M, Sánchez-García L, Cano-Garrido O, Villaverde A, Vázquez E, Mangues R, Seras-Franzoso J.

J Control Release. 2018 Jun 10;279:29-39. doi: 10.1016/j.jconrel.2018.04.004. Epub 2018 Apr 8.


Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.

Sánchez-García L, Serna N, Álamo P, Sala R, Céspedes MV, Roldan M, Sánchez-Chardi A, Unzueta U, Casanova I, Mangues R, Vázquez E, Villaverde A.

J Control Release. 2018 Mar 28;274:81-92. doi: 10.1016/j.jconrel.2018.01.031. Epub 2018 Jan 31.


NEDD9, an independent good prognostic factor in intermediate-risk acute myeloid leukemia patients.

Pallarès V, Hoyos M, Chillón MC, Barragán E, Conde MIP, Llop M, Céspedes MV, Nomdedeu JF, Brunet S, Sanz MÁ, González-Díaz M, Sierra J, Casanova I, Mangues R.

Oncotarget. 2017 Jun 16;8(44):76003-76014. doi: 10.18632/oncotarget.18537. eCollection 2017 Sep 29.


Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors.

Mira A, Morello V, Céspedes MV, Perera T, Comoglio PM, Mangues R, Michieli P.

Oncotarget. 2017 Jun 13;8(24):38193-38213. doi: 10.18632/oncotarget.16942.


Engineering tumor cell targeting in nanoscale amyloidal materials.

Unzueta U, Seras-Franzoso J, Céspedes MV, Saccardo P, Cortés F, Rueda F, Garcia-Fruitós E, Ferrer-Miralles N, Mangues R, Vázquez E, Villaverde A.

Nanotechnology. 2017 Jan 6;28(1):015102. Epub 2016 Nov 28.


Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.

Céspedes MV, Guillén MJ, López-Casas PP, Sarno F, Gallardo A, Álamo P, Cuevas C, Hidalgo M, Galmarini CM, Allavena P, Avilés P, Mangues R.

Dis Model Mech. 2016 Dec 1;9(12):1461-1471. Epub 2016 Oct 20.


Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.

Céspedes MV, Fernández Y, Unzueta U, Mendoza R, Seras-Franzoso J, Sánchez-Chardi A, Álamo P, Toledo-Rubio V, Ferrer-Miralles N, Vázquez E, Schwartz S, Abasolo I, Corchero JL, Mangues R, Villaverde A.

Sci Rep. 2016 Oct 24;6:35765. doi: 10.1038/srep35765.


CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.

Cano-Garrido O, Céspedes MV, Unzueta U, Saccardo P, Roldán M, Sánchez-Chardi A, Cubarsi R, Vázquez E, Mangues R, García-Fruitós E, Villaverde A.

Nanomedicine (Lond). 2016 Sep;11(18):2387-98. doi: 10.2217/nnm-2016-0200. Epub 2016 Aug 16.


uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy.

Pavón MA, Arroyo-Solera I, Céspedes MV, Casanova I, León X, Mangues R.

Oncotarget. 2016 Aug 30;7(35):57351-57366. doi: 10.18632/oncotarget.10344. Review.


Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4+ colorectal cancer models.

Céspedes MV, Unzueta U, Álamo P, Gallardo A, Sala R, Casanova I, Pavón MA, Mangues MA, Trías M, López-Pousa A, Villaverde A, Vázquez E, Mangues R.

Nanomedicine. 2016 Oct;12(7):1987-1996. doi: 10.1016/j.nano.2016.04.003. Epub 2016 Apr 13.


Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

Rueda F, Céspedes MV, Sánchez-Chardi A, Seras-Franzoso J, Pesarrodona M, Ferrer-Miralles N, Vázquez E, Rinas U, Unzueta U, Mamat U, Mangues R, García-Fruitós E, Villaverde A.

Microb Cell Fact. 2016 Apr 8;15:59. doi: 10.1186/s12934-016-0457-z.


Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles.

Serna N, Céspedes MV, Saccardo P, Xu Z, Unzueta U, Álamo P, Pesarrodona M, Sánchez-Chardi A, Roldán M, Mangues R, Vázquez E, Villaverde A, Ferrer-Miralles N.

Nanomedicine. 2016 Jul;12(5):1241-51. doi: 10.1016/j.nano.2016.01.004. Epub 2016 Mar 4.


CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma.

Pavón MA, Parreño M, Téllez-Gabriel M, León X, Arroyo-Solera I, López M, Céspedes MV, Casanova I, Gallardo A, López-Pousa A, Mangues MA, Quer M, Barnadas A, Mangues R.

Head Neck. 2016 Apr;38 Suppl 1:E1392-403. doi: 10.1002/hed.24232. Epub 2015 Oct 30.


Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials.

Rueda F, Céspedes MV, Conchillo-Solé O, Sánchez-Chardi A, Seras-Franzoso J, Cubarsi R, Gallardo A, Pesarrodona M, Ferrer-Miralles N, Daura X, Vázquez E, García-Fruitós E, Mangues R, Unzueta U, Villaverde A.

Adv Mater. 2015 Dec 16;27(47):7816-22. doi: 10.1002/adma.201503676. Epub 2015 Oct 28.


Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients.

Pavón MA, Arroyo-Solera I, Téllez-Gabriel M, León X, Virós D, López M, Gallardo A, Céspedes MV, Casanova I, López-Pousa A, Mangues MA, Quer M, Barnadas A, Mangues R.

Oncotarget. 2015 Oct 6;6(30):29016-33. doi: 10.18632/oncotarget.5032.


Towards protein-based viral mimetics for cancer therapies.

Unzueta U, Céspedes MV, Vázquez E, Ferrer-Miralles N, Mangues R, Villaverde A.

Trends Biotechnol. 2015 May;33(5):253-8. doi: 10.1016/j.tibtech.2015.02.007. Epub 2015 Mar 22.


Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model.

Alamo P, Gallardo A, Di Nicolantonio F, Pavón MA, Casanova I, Trias M, Mangues MA, Lopez-Pousa A, Villaverde A, Vázquez E, Bardelli A, Céspedes MV, Mangues R.

FASEB J. 2015 Feb;29(2):464-76. doi: 10.1096/fj.14-262303. Epub 2014 Oct 30.


CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival.

Moreno MJ, Bosch R, Dieguez-Gonzalez R, Novelli S, Mozos A, Gallardo A, Pavón MÁ, Céspedes MV, Grañena A, Alcoceba M, Blanco O, Gonzalez-Díaz M, Sierra J, Mangues R, Casanova I.

J Pathol. 2015 Feb;235(3):445-55. doi: 10.1002/path.4446. Epub 2014 Dec 11.


Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.

Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR, Gomis RR.

Nat Cell Biol. 2014 Jul;16(7):685-94. doi: 10.1038/ncb2977. Epub 2014 Jun 1.


Immunostaining Protocol: P-Stat3 (Xenograft and Mice).

Calon A, Espinet E, Palomo-Ponce S, Tauriello DVF, Iglesias M, Céspedes MV, Sevillano M, Nadal C, Jung P, Zhang XH, Byrom D, Riera A, Rossell D, Mangues R, Massague J, Sancho E, Batlle E.

Bio Protoc. 2014 May 5;4(9). pii: e1120. doi: 10.21769/BioProtoc.1120.


In vivo architectonic stability of fully de novo designed protein-only nanoparticles.

Céspedes MV, Unzueta U, Tatkiewicz W, Sánchez-Chardi A, Conchillo-Solé O, Álamo P, Xu Z, Casanova I, Corchero JL, Pesarrodona M, Cedano J, Daura X, Ratera I, Veciana J, Ferrer-Miralles N, Vazquez E, Villaverde A, Mangues R.

ACS Nano. 2014 May 27;8(5):4166-76. doi: 10.1021/nn4055732. Epub 2014 Apr 14.


Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models.

Alamo P, Gallardo A, Pavón MA, Casanova I, Trias M, Mangues MA, Vázquez E, Villaverde A, Mangues R, Céspedes MV.

Dis Model Mech. 2014 Mar;7(3):387-96. doi: 10.1242/dmm.013995. Epub 2014 Jan 30.


Focal adhesion protein expression in human diffuse large B-cell lymphoma.

Bosch R, Dieguez-Gonzalez R, Moreno MJ, Gallardo A, Novelli S, Espinosa I, Céspedes MV, Pavón MÁ, Briones J, Grañena A, Sierra J, Mangues R, Casanova I.

Histopathology. 2014 Jul;65(1):119-31. doi: 10.1111/his.12381. Epub 2014 Apr 3.


High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma.

Téllez-Gabriel M, Arroyo-Solera I, León X, Gallardo A, López M, Céspedes MV, Casanova I, López-Pousa A, Quer M, Mangues MA, Barnadas A, Mangues R, Pavón MA.

Cancer Med. 2013 Dec;2(6):950-63. doi: 10.1002/cam4.153. Epub 2013 Oct 31.


Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery.

Unzueta U, Saccardo P, Domingo-Espín J, Cedano J, Conchillo-Solé O, García-Fruitós E, Céspedes MV, Corchero JL, Daura X, Mangues R, Ferrer-Miralles N, Villaverde A, Vázquez E.

Nanomedicine. 2014 Apr;10(3):535-41. doi: 10.1016/j.nano.2013.11.006. Epub 2013 Nov 21.


A novel orally available inhibitor of focal adhesion signaling increases survival in a xenograft model of diffuse large B-cell lymphoma with central nervous system involvement.

Bosch R, Moreno MJ, Dieguez-Gonzalez R, Céspedes MV, Gallardo A, Trias M, Grañena A, Sierra J, Casanova I, Mangues R.

Haematologica. 2013 Aug;98(8):1242-9. doi: 10.3324/haematol.2012.071811. Epub 2013 May 28.


STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer.

Peña C, Céspedes MV, Lindh MB, Kiflemariam S, Mezheyeuski A, Edqvist PH, Hägglöf C, Birgisson H, Bojmar L, Jirström K, Sandström P, Olsson E, Veerla S, Gallardo A, Sjöblom T, Chang AC, Reddel RR, Mangues R, Augsten M, Ostman A.

Cancer Res. 2013 Feb 15;73(4):1287-97. doi: 10.1158/0008-5472.CAN-12-1875. Epub 2012 Dec 14.


Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation.

Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Céspedes MV, Sevillano M, Nadal C, Jung P, Zhang XH, Byrom D, Riera A, Rossell D, Mangues R, Massagué J, Sancho E, Batlle E.

Cancer Cell. 2012 Nov 13;22(5):571-84. doi: 10.1016/j.ccr.2012.08.013.


Intracellular CXCR4⁺ cell targeting with T22-empowered protein-only nanoparticles.

Unzueta U, Céspedes MV, Ferrer-Miralles N, Casanova I, Cedano J, Corchero JL, Domingo-Espín J, Villaverde A, Mangues R, Vázquez E.

Int J Nanomedicine. 2012;7:4533-44. doi: 10.2147/IJN.S34450. Epub 2012 Aug 15.


Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma.

Pavón MA, Parreño M, Téllez-Gabriel M, Sancho FJ, López M, Céspedes MV, Casanova I, Lopez-Pousa A, Mangues MA, Quer M, Barnadas A, León X, Mangues R.

Carcinogenesis. 2012 Sep;33(9):1707-16. doi: 10.1093/carcin/bgs207. Epub 2012 Jun 13.


Subcutaneous passage increases cell aggressiveness in a xenograft model of diffuse large B cell lymphoma.

Bosch R, Moreno MJ, Dieguez-Gonzalez R, Céspedes MV, Gallardo A, Nomdedeu J, Pavón MA, Espinosa I, Mangues MA, Sierra J, Casanova I, Mangues R.

Clin Exp Metastasis. 2012 Apr;29(4):339-47. doi: 10.1007/s10585-012-9454-8. Epub 2012 Jan 20.


A novel inhibitor of focal adhesion signaling induces caspase-independent cell death in diffuse large B-cell lymphoma.

Bosch R, Dieguez-Gonzalez R, Céspedes MV, Parreño M, Pavón MÁ, Grañena A, Sierra J, Mangues R, Casanova I.

Blood. 2011 Oct 20;118(16):4411-20. doi: 10.1182/blood-2011-04-345181. Epub 2011 Aug 25.


The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse.

Merlos-Suárez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, Rossell D, Sevillano M, Hernando-Momblona X, da Silva-Diz V, Muñoz P, Clevers H, Sancho E, Mangues R, Batlle E.

Cell Stem Cell. 2011 May 6;8(5):511-24. doi: 10.1016/j.stem.2011.02.020. Epub 2011 Mar 17.


Site-dependent E-cadherin cleavage and nuclear translocation in a metastatic colorectal cancer model.

Céspedes MV, Larriba MJ, Pavón MA, Alamo P, Casanova I, Parreño M, Feliu A, Sancho FJ, Muñoz A, Mangues R.

Am J Pathol. 2010 Oct;177(4):2067-79. doi: 10.2353/ajpath.2010.100079. Epub 2010 Sep 2.


Bobel-24 and derivatives induce caspase-independent death in pancreatic cancer regardless of apoptotic resistance.

Parreño M, Casanova I, Céspedes MV, Vaqué JP, Pavón MA, Leon J, Mangues R.

Cancer Res. 2008 Aug 1;68(15):6313-23. doi: 10.1158/0008-5472.CAN-08-1054.


Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer.

Pavón MA, Parreño M, León X, Sancho FJ, Céspedes MV, Casanova I, Lopez-Pousa A, Mangues MA, Quer M, Barnadas A, Mangues R.

Int J Cancer. 2008 Sep 1;123(5):1068-79. doi: 10.1002/ijc.23635.


A celecoxib derivative inhibits focal adhesion signaling and induces caspase-8-dependent apoptosis in human acute myeloid leukemia cells.

Casanova I, Bosch R, Lasa A, Parreño M, Céspedes MV, Brunet S, Nomdedéu JF, Mangues MA, Sierra J, Mangues R.

Int J Cancer. 2008 Jul 1;123(1):217-26. doi: 10.1002/ijc.23516.


A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells.

Espina C, Céspedes MV, García-Cabezas MA, Gómez del Pulgar MT, Boluda A, Oroz LG, Benitah SA, Cejas P, Nistal M, Mangues R, Lacal JC.

Am J Pathol. 2008 Jan;172(1):156-66. doi: 10.2353/ajpath.2008.070561. Epub 2007 Dec 28. Erratum in: Am J Pathol. 2008 Apr;172(4):1153. Benitah, Salvador A [added].


Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites.

Céspedes MV, Espina C, García-Cabezas MA, Trias M, Boluda A, Gómez del Pulgar MT, Sancho FJ, Nistal M, Lacal JC, Mangues R.

Am J Pathol. 2007 Mar;170(3):1077-85.


Mouse models in oncogenesis and cancer therapy.

Céspedes MV, Casanova I, Parreño M, Mangues R.

Clin Transl Oncol. 2006 May;8(5):318-29. Review.


Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc.

Parreño M, Vaqué JP, Casanova I, Frade P, Céspedes MV, Pavón MA, Molins A, Camacho M, Vila L, Nomdedeu JF, Mangues R, León J.

Mol Cancer Ther. 2006 May;5(5):1166-75.


K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.

Céspedes MV, Sancho FJ, Guerrero S, Parreño M, Casanova I, Pavón MA, Marcuello E, Trias M, Cascante M, Capellà G, Mangues R.

Carcinogenesis. 2006 Nov;27(11):2190-200. Epub 2006 May 5.


Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas.

Casanova I, Parreño M, Farré L, Guerrero S, Céspedes MV, Pavon MA, Sancho FJ, Marcuello E, Trias M, Mangues R.

Int J Cancer. 2006 May 15;118(10):2381-9.


Day/night variations of dopamine ocular content during Xenopus laevis ontogeny.

Delgado MJ, Céspedes MV, De Pedro N, Alonso-Bedate M, Alonso-Gómez AL.

Neurosci Lett. 2001 Mar 16;300(3):129-32.


Peripheral nerve soluble esterases are spontaneously reactivated after inhibition by paraoxon: implications for a new definition of neuropathy target esterase.

Barril J, Estévez J, Escudero MA, Céspedes MV, Níguez N, Sogorb MA, Monroy A, Vilanova E.

Chem Biol Interact. 1999 May 14;119-120:541-50.


Discrimination of carboxylesterases of chicken neural tissue by inhibition with a neuropathic, non-neuropathic organophosphorus compounds and neuropathy promoter.

Céspedes MV, Escudero MA, Barril J, Sogorb MA, Vicedo JL, Vilanova E.

Chem Biol Interact. 1997 Oct 24;106(3):191-200.


Mu-opioid receptor is involved in beta-endorphin-induced feeding in goldfish.

de Pedro N, Céspedes MV, Delgado MJ, Alonso-Bedate M.

Peptides. 1996;17(3):421-4.


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