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Items: 1 to 50 of 87

1.

Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii.

Shukla A, Olszewski KL, Llinás M, Rommereim LM, Fox BA, Bzik DJ, Xia D, Wastling J, Beiting D, Roos DS, Shanmugam D.

Int J Parasitol. 2018 Oct;48(12):955-968. doi: 10.1016/j.ijpara.2018.05.013. Epub 2018 Aug 31.

PMID:
30176233
2.

Cancer therapy in a microbial bottle: Uncorking the novel biology of the protozoan Toxoplasma gondii.

Fox BA, Butler KL, Guevara RB, Bzik DJ.

PLoS Pathog. 2017 Sep 14;13(9):e1006523. doi: 10.1371/journal.ppat.1006523. eCollection 2017 Sep. Review. No abstract available.

3.

Lactate dehydrogenase in Toxoplasma gondii controls virulence, bradyzoite differentiation, and chronic infection.

Abdelbaset AE, Fox BA, Karram MH, Abd Ellah MR, Bzik DJ, Igarashi M.

PLoS One. 2017 Mar 21;12(3):e0173745. doi: 10.1371/journal.pone.0173745. eCollection 2017.

4.

Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system.

Konradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA.

Nat Microbiol. 2016 Feb 15;1:16001. doi: 10.1038/nmicrobiol.2016.1.

5.

Pyrimidine Pathway-Dependent and -Independent Functions of the Toxoplasma gondii Mitochondrial Dihydroorotate Dehydrogenase.

Hortua Triana MA, Cajiao Herrera D, Zimmermann BH, Fox BA, Bzik DJ.

Infect Immun. 2016 Sep 19;84(10):2974-81. doi: 10.1128/IAI.00187-16. Print 2016 Oct.

6.

Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii.

Rommereim LM, Bellini V, Fox BA, Pètre G, Rak C, Touquet B, Aldebert D, Dubremetz JF, Cesbron-Delauw MF, Mercier C, Bzik DJ.

PLoS One. 2016 Jul 26;11(7):e0159306. doi: 10.1371/journal.pone.0159306. eCollection 2016.

7.

Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity.

Fox BA, Sanders KL, Rommereim LM, Guevara RB, Bzik DJ.

PLoS Genet. 2016 Jul 22;12(7):e1006189. doi: 10.1371/journal.pgen.1006189. eCollection 2016 Jul.

8.

The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection.

Fox BA, Rommereim LM, Guevara RB, Falla A, Hortua Triana MA, Sun Y, Bzik DJ.

MBio. 2016 May 10;7(3). pii: e00193-16. doi: 10.1128/mBio.00193-16.

9.

Attenuated Toxoplasma gondii therapy of disseminated pancreatic cancer generates long-lasting immunity to pancreatic cancer.

Sanders KL, Fox BA, Bzik DJ.

Oncoimmunology. 2015 Oct 29;5(4):e1104447. eCollection 2016 Apr.

10.

Serial Dissection of Parasite Gene Families.

Bzik DJ.

Infect Immun. 2016 Apr 22;84(5):1252-1254. doi: 10.1128/IAI.00175-16. Print 2016 May.

11.

Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen.

Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, Mercier C, Cesbron-Delauw MF, Blanchard N.

Cell Rep. 2015 Dec 15;13(10):2273-86. doi: 10.1016/j.celrep.2015.11.001. Epub 2015 Nov 25.

12.

Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection.

Leroux LP, Nishi M, El-Hage S, Fox BA, Bzik DJ, Dzierszinski FS.

Infect Immun. 2015 Oct;83(10):3865-80. doi: 10.1128/IAI.00415-15. Epub 2015 Jul 20.

13.

Attenuated Toxoplasma gondii Stimulates Immunity to Pancreatic Cancer by Manipulation of Myeloid Cell Populations.

Sanders KL, Fox BA, Bzik DJ.

Cancer Immunol Res. 2015 Aug;3(8):891-901. doi: 10.1158/2326-6066.CIR-14-0235. Epub 2015 Mar 24.

14.

Nonreplicating, cyst-defective type II Toxoplasma gondii vaccine strains stimulate protective immunity against acute and chronic infection.

Fox BA, Bzik DJ.

Infect Immun. 2015 May;83(5):2148-55. doi: 10.1128/IAI.02756-14. Epub 2015 Mar 16.

15.

Secreted Toxoplasma gondii molecules interfere with expression of MHC-II in interferon gamma-activated macrophages.

Leroux LP, Dasanayake D, Rommereim LM, Fox BA, Bzik DJ, Jardim A, Dzierszinski FS.

Int J Parasitol. 2015 Apr;45(5):319-32. doi: 10.1016/j.ijpara.2015.01.003. Epub 2015 Feb 24.

PMID:
25720921
16.

Nuclear glycolytic enzyme enolase of Toxoplasma gondii functions as a transcriptional regulator.

Mouveaux T, Oria G, Werkmeister E, Slomianny C, Fox BA, Bzik DJ, Tomavo S.

PLoS One. 2014 Aug 25;9(8):e105820. doi: 10.1371/journal.pone.0105820. eCollection 2014.

17.

Avirulent strains of Toxoplasma gondii infect macrophages by active invasion from the phagosome.

Zhao Y, Marple AH, Ferguson DJ, Bzik DJ, Yap GS.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6437-42. doi: 10.1073/pnas.1316841111. Epub 2014 Apr 14.

18.

The Toxoplasma gondii cyst wall protein CST1 is critical for cyst wall integrity and promotes bradyzoite persistence.

Tomita T, Bzik DJ, Ma YF, Fox BA, Markillie LM, Taylor RC, Kim K, Weiss LM.

PLoS Pathog. 2013;9(12):e1003823. doi: 10.1371/journal.ppat.1003823. Epub 2013 Dec 26.

19.

Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression.

Fox BA, Sanders KL, Bzik DJ.

Oncoimmunology. 2013 Nov 1;2(11):e26296. Epub 2013 Oct 9.

20.

Co-existence of classical and alternative activation programs in macrophages responding to Toxoplasma gondii.

Patil V, Zhao Y, Shah S, Fox BA, Rommereim LM, Bzik DJ, Yap GS.

Int J Parasitol. 2014 Feb;44(2):161-4. doi: 10.1016/j.ijpara.2013.08.003. Epub 2013 Sep 29.

21.

Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines.

Fox BA, Sanders KL, Chen S, Bzik DJ.

Trends Parasitol. 2013 Sep;29(9):431-7. doi: 10.1016/j.pt.2013.07.001. Epub 2013 Aug 5. Review.

22.

Genetic manipulation in Δku80 strains for functional genomic analysis of Toxoplasma gondii.

Rommereim LM, Hortua Triana MA, Falla A, Sanders KL, Guevara RB, Bzik DJ, Fox BA.

J Vis Exp. 2013 Jul 12;(77):e50598. doi: 10.3791/50598.

23.

Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.

Baird JR, Fox BA, Sanders KL, Lizotte PH, Cubillos-Ruiz JR, Scarlett UK, Rutkowski MR, Conejo-Garcia JR, Fiering S, Bzik DJ.

Cancer Res. 2013 Jul 1;73(13):3842-51. doi: 10.1158/0008-5472.CAN-12-1974. Epub 2013 May 23.

24.

Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge.

Baird JR, Byrne KT, Lizotte PH, Toraya-Brown S, Scarlett UK, Alexander MP, Sheen MR, Fox BA, Bzik DJ, Bosenberg M, Mullins DW, Turk MJ, Fiering S.

J Immunol. 2013 Jan 1;190(1):469-78. doi: 10.4049/jimmunol.1201209. Epub 2012 Dec 7.

25.

Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii.

Hortua Triana MA, Huynh MH, Garavito MF, Fox BA, Bzik DJ, Carruthers VB, Löffler M, Zimmermann BH.

Mol Biochem Parasitol. 2012 Aug;184(2):71-81. doi: 10.1016/j.molbiopara.2012.04.009. Epub 2012 May 8.

26.

An inside job: hacking into Janus kinase/signal transducer and activator of transcription signaling cascades by the intracellular protozoan Toxoplasma gondii.

Denkers EY, Bzik DJ, Fox BA, Butcher BA.

Infect Immun. 2012 Feb;80(2):476-82. doi: 10.1128/IAI.05974-11. Epub 2011 Nov 21. Review.

27.

Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.

Butcher BA, Fox BA, Rommereim LM, Kim SG, Maurer KJ, Yarovinsky F, Herbert DR, Bzik DJ, Denkers EY.

PLoS Pathog. 2011 Sep;7(9):e1002236. doi: 10.1371/journal.ppat.1002236. Epub 2011 Sep 8.

28.

Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection.

Fox BA, Falla A, Rommereim LM, Tomita T, Gigley JP, Mercier C, Cesbron-Delauw MF, Weiss LM, Bzik DJ.

Eukaryot Cell. 2011 Sep;10(9):1193-206. doi: 10.1128/EC.00297-10. Epub 2011 Apr 29.

29.

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.

Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD.

Cell Host Microbe. 2010 Dec 16;8(6):484-95. doi: 10.1016/j.chom.2010.11.005.

30.
31.

CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1.

Charles E, Joshi S, Ash JD, Fox BA, Farris AD, Bzik DJ, Lang ML, Blader IJ.

Infect Immun. 2010 Aug;78(8):3484-92. doi: 10.1128/IAI.00117-10. Epub 2010 May 24.

33.

Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii.

Jordan KA, Wilson EH, Tait ED, Fox BA, Roos DS, Bzik DJ, Dzierszinski F, Hunter CA.

Infect Immun. 2009 Sep;77(9):3894-901. doi: 10.1128/IAI.00024-09. Epub 2009 Jun 15.

34.

Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining.

Fox BA, Ristuccia JG, Gigley JP, Bzik DJ.

Eukaryot Cell. 2009 Apr;8(4):520-9. doi: 10.1128/EC.00357-08. Epub 2009 Feb 13.

36.

Genetic identification of essential indels and domains in carbamoyl phosphate synthetase II of Toxoplasma gondii.

Fox BA, Ristuccia JG, Bzik DJ.

Int J Parasitol. 2009 Apr;39(5):533-9. doi: 10.1016/j.ijpara.2008.09.011. Epub 2008 Oct 21.

37.
38.

NK cells enhance dendritic cell response against parasite antigens via NKG2D pathway.

Guan H, Moretto M, Bzik DJ, Gigley J, Khan IA.

J Immunol. 2007 Jul 1;179(1):590-6.

39.

Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation.

Shaw MH, Freeman GJ, Scott MF, Fox BA, Bzik DJ, Belkaid Y, Yap GS.

J Immunol. 2006 Jun 15;176(12):7263-71.

40.

Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite.

Combe CL, Moretto MM, Schwartzman JD, Gigley JP, Bzik DJ, Khan IA.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6635-40. Epub 2006 Apr 13.

41.

Toxoplasma gondii: generation of novel truncation mutations in the linker domain of dihydrofolate reductase-thymidylate synthase.

Belperron AA, Fox BA, O'Neil RH, Peaslee KA, Horii T, Anderson AC, Bzik DJ.

Exp Parasitol. 2004 Mar-Apr;106(3-4):179-82. No abstract available.

PMID:
15172226
42.

Inactivation of protozoan parasites in red blood cells using INACTINE PEN110 chemistry.

Zavizion B, Pereira M, de Melo Jorge M, Serebryanik D, Mather TN, Chapman J, Miller NJ, Alford B, Bzik DJ, Purmal A.

Transfusion. 2004 May;44(5):731-8.

PMID:
15104655
43.
44.
45.
46.

Plasmodium falciparum: fine-mapping of an epitope of the serine repeat antigen that is a target of parasite-inhibitory antibodies.

Fox BA, Horii T, Bzik DJ.

Exp Parasitol. 2002 May;101(1):69-72. No abstract available.

PMID:
12243740
47.

Toxoplasma gondii: mechanism of the parasitostatic action of 6-thioxanthine.

Pfefferkorn ER, Bzik DJ, Honsinger CP.

Exp Parasitol. 2001 Dec;99(4):235-43.

PMID:
11888251
48.

De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii.

Fox BA, Bzik DJ.

Nature. 2002 Feb 21;415(6874):926-9.

PMID:
11859373
49.

Toxoplasma gondii: genetic selection of tethered dihydrofolate reductase-thymidylate synthase fusion proteins.

Belperron AA, Fox BA, Horii T, Bzik DJ.

Exp Parasitol. 2001 Jul;98(3):167-70. No abstract available.

PMID:
11527440
50.

Negative selection of herpes simplex virus thymidine kinase in Toxoplasma gondii.

Fox BA, Belperron AA, Bzik DJ.

Mol Biochem Parasitol. 2001 Aug;116(1):85-8. No abstract available.

PMID:
11463470

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