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MicroRNA High Throughput Loss-of-Function Screening Reveals an Oncogenic Role for miR-21-5p in Hodgkin Lymphoma.

Yuan Y, Niu F, Nolte IM, Koerts J, de Jong D, Rutgers B, Osinga J, Azkanaz M, Terpstra M, Bystrykh L, Diepstra A, Visser L, Dzikiewicz-Krawczyk A, Kok K, Kluiver J, van den Berg A.

Cell Physiol Biochem. 2018;49(1):144-159. doi: 10.1159/000492850. Epub 2018 Sep 5.


Left or right? Directions to stem cell engraftment.

Belderbos ME, Bystrykh L, de Haan G.

J Exp Med. 2018 Jan 2;215(1):13-15. doi: 10.1084/jem.20171904. Epub 2017 Nov 28.


Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding.

Belderbos ME, Koster T, Ausema B, Jacobs S, Sowdagar S, Zwart E, de Bont E, de Haan G, Bystrykh LV.

Blood. 2017 Jun 15;129(24):3210-3220. doi: 10.1182/blood-2016-12-758250. Epub 2017 Apr 10.


Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors.

Wojtowicz EE, Lechman ER, Hermans KG, Schoof EM, Wienholds E, Isserlin R, van Veelen PA, Broekhuis MJ, Janssen GM, Trotman-Grant A, Dobson SM, Krivdova G, Elzinga J, Kennedy J, Gan OI, Sinha A, Ignatchenko V, Kislinger T, Dethmers-Ausema B, Weersing E, Alemdehy MF, de Looper HW, Bader GD, Ritsema M, Erkeland SJ, Bystrykh LV, Dick JE, de Haan G.

Cell Stem Cell. 2016 Sep 1;19(3):383-96. doi: 10.1016/j.stem.2016.06.008. Epub 2016 Jul 14.


Clonal Analysis of Cells with Cellular Barcoding: When Numbers and Sizes Matter.

Bystrykh LV, Belderbos ME.

Methods Mol Biol. 2016;1516:57-89. doi: 10.1007/7651_2016_343.


Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus.

Brugman MH, Wiekmeijer AS, van Eggermond M, Wolvers-Tettero I, Langerak AW, de Haas EF, Bystrykh LV, van Rood JJ, de Haan G, Fibbe WE, Staal FJ.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E6020-7. doi: 10.1073/pnas.1519118112. Epub 2015 Oct 19.


Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding.

Klauke K, Broekhuis MJ, Weersing E, Dethmers-Ausema A, Ritsema M, González MV, Zwart E, Bystrykh LV, de Haan G.

Stem Cell Reports. 2015 Jan 13;4(1):74-89. doi: 10.1016/j.stemcr.2014.10.012. Epub 2014 Nov 26.


microRNAs in hematopoiesis.

Lazare SS, Wojtowicz EE, Bystrykh LV, de Haan G.

Exp Cell Res. 2014 Dec 10;329(2):234-8. doi: 10.1016/j.yexcr.2014.08.033. Epub 2014 Sep 3. Review.


CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells.

Brendel C, Goebel B, Daniela A, Brugman M, Kneissl S, Schwäble J, Kaufmann KB, Müller-Kuller U, Kunkel H, Chen-Wichmann L, Abel T, Serve H, Bystrykh L, Buchholz CJ, Grez M.

Mol Ther. 2015 Jan;23(1):63-70. doi: 10.1038/mt.2014.173. Epub 2014 Sep 5. Erratum in: Mol Ther. 2015 Apr;23(4):790.


Enhancing the detection of barcoded reads in high throughput DNA sequencing data by controlling the false discovery rate.

Buschmann T, Zhang R, Brash DE, Bystrykh LV.

BMC Bioinformatics. 2014 Aug 7;15:264. doi: 10.1186/1471-2105-15-264.


MicroRNA-125 family members exert a similar role in the regulation of murine hematopoiesis.

Wojtowicz EE, Walasek MA, Broekhuis MJ, Weersing E, Ritsema M, Ausema A, Bystrykh LV, de Haan G.

Exp Hematol. 2014 Oct;42(10):909-18.e1. doi: 10.1016/j.exphem.2014.06.010. Epub 2014 Aug 1.


Barcoded vector libraries and retroviral or lentiviral barcoding of hematopoietic stem cells.

Bystrykh LV, de Haan G, Verovskaya E.

Methods Mol Biol. 2014;1185:345-60. doi: 10.1007/978-1-4939-1133-2_23.


No monkeying around: clonal tracking of stem cells and progenitors in the macaque.

Dykstra B, Bystrykh LV.

Cell Stem Cell. 2014 Apr 3;14(4):419-20. doi: 10.1016/j.stem.2014.03.006.


Asymmetry in skeletal distribution of mouse hematopoietic stem cell clones and their equilibration by mobilizing cytokines.

Verovskaya E, Broekhuis MJ, Zwart E, Weersing E, Ritsema M, Bosman LJ, van Poele T, de Haan G, Bystrykh LV.

J Exp Med. 2014 Mar 10;211(3):487-97. doi: 10.1084/jem.20131804. Epub 2014 Feb 24.


Levenshtein error-correcting barcodes for multiplexed DNA sequencing.

Buschmann T, Bystrykh LV.

BMC Bioinformatics. 2013 Sep 11;14:272. doi: 10.1186/1471-2105-14-272.


A combinatorial approach to the restriction of a mouse genome.

Bystrykh LV.

BMC Res Notes. 2013 Jul 22;6:284. doi: 10.1186/1756-0500-6-284.


Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding.

Verovskaya E, Broekhuis MJ, Zwart E, Ritsema M, van Os R, de Haan G, Bystrykh LV.

Blood. 2013 Jul 25;122(4):523-32. doi: 10.1182/blood-2013-01-481135. Epub 2013 May 29.


Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation.

Klauke K, Radulović V, Broekhuis M, Weersing E, Zwart E, Olthof S, Ritsema M, Bruggeman S, Wu X, Helin K, Bystrykh L, de Haan G.

Nat Cell Biol. 2013 Apr;15(4):353-62. doi: 10.1038/ncb2701. Epub 2013 Mar 17.


Stem cell clonality -- theoretical concepts, experimental techniques, and clinical challenges.

Glauche I, Bystrykh L, Eaves C, Roeder I; other participants.

Blood Cells Mol Dis. 2013 Apr;50(4):232-40. doi: 10.1016/j.bcmd.2013.01.007. Epub 2013 Feb 19. Review.


Sca-1 is an early-response target of histone deacetylase inhibitors and marks hematopoietic cells with enhanced function.

Walasek MA, Bystrykh LV, Olthof S, de Haan G, van Os R.

Exp Hematol. 2013 Jan;41(1):113-23.e2. doi: 10.1016/j.exphem.2012.09.004. Epub 2012 Sep 16.


Counting stem cells: methodological constraints.

Bystrykh LV, Verovskaya E, Zwart E, Broekhuis M, de Haan G.

Nat Methods. 2012 May 30;9(6):567-74. doi: 10.1038/nmeth.2043.


Generalized DNA barcode design based on Hamming codes.

Bystrykh LV.

PLoS One. 2012;7(5):e36852. doi: 10.1371/journal.pone.0036852. Epub 2012 May 17.


The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation.

Walasek MA, Bystrykh L, van den Boom V, Olthof S, Ausema A, Ritsema M, Huls G, de Haan G, van Os R.

Blood. 2012 Mar 29;119(13):3050-9. doi: 10.1182/blood-2011-08-375386. Epub 2012 Feb 10.


Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells.

Gerrits A, Walasek MA, Olthof S, Weersing E, Ritsema M, Zwart E, van Os R, Bystrykh LV, de Haan G.

Blood. 2012 Jan 12;119(2):377-87. doi: 10.1182/blood-2011-01-331686. Epub 2011 Nov 28.


Cellular barcoding tool for clonal analysis in the hematopoietic system.

Gerrits A, Dykstra B, Kalmykowa OJ, Klauke K, Verovskaya E, Broekhuis MJ, de Haan G, Bystrykh LV.

Blood. 2010 Apr 1;115(13):2610-8. doi: 10.1182/blood-2009-06-229757. Epub 2010 Jan 21.


Expression quantitative trait loci are highly sensitive to cellular differentiation state.

Gerrits A, Li Y, Tesson BM, Bystrykh LV, Weersing E, Ausema A, Dontje B, Wang X, Breitling R, Jansen RC, de Haan G.

PLoS Genet. 2009 Oct;5(10):e1000692. doi: 10.1371/journal.pgen.1000692. Epub 2009 Oct 16.


Genetical genomics: spotlight on QTL hotspots.

Breitling R, Li Y, Tesson BM, Fu J, Wu C, Wiltshire T, Gerrits A, Bystrykh LV, de Haan G, Su AI, Jansen RC.

PLoS Genet. 2008 Oct;4(10):e1000232. doi: 10.1371/journal.pgen.1000232. Epub 2008 Oct 24. No abstract available.


Combining transcriptional profiling and genetic linkage analysis to uncover gene networks operating in hematopoietic stem cells and their progeny.

Gerrits A, Dykstra B, Otten M, Bystrykh L, de Haan G.

Immunogenetics. 2008 Aug;60(8):411-22. doi: 10.1007/s00251-008-0305-3. Epub 2008 Jun 17. Review.


A verification protocol for the probe sequences of Affymetrix genome arrays reveals high probe accuracy for studies in mouse, human and rat.

Alberts R, Terpstra P, Hardonk M, Bystrykh LV, de Haan G, Breitling R, Nap JP, Jansen RC.

BMC Bioinformatics. 2007 Apr 20;8:132.


A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning.

van Os R, Kamminga LM, Ausema A, Bystrykh LV, Draijer DP, van Pelt K, Dontje B, de Haan G.

Stem Cells. 2007 Apr;25(4):836-43. Epub 2006 Dec 14.


Modern genome-wide genetic approaches to reveal intrinsic properties of stem cells.

de Haan G, Gerrits A, Bystrykh L.

Curr Opin Hematol. 2006 Jul;13(4):249-53. Review.


Selective expression of cholesterol metabolism genes in normal CD34+CD38- cells with a heterogeneous expression pattern in AML cells.

Peeters SD, van der Kolk DM, de Haan G, Bystrykh L, Kuipers F, de Vries EG, Vellenga E.

Exp Hematol. 2006 May;34(5):622-30.


The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion.

Kamminga LM, Bystrykh LV, de Boer A, Houwer S, Douma J, Weersing E, Dontje B, de Haan G.

Blood. 2006 Mar 1;107(5):2170-9. Epub 2005 Nov 17.


A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays.

Alberts R, Terpstra P, Bystrykh LV, de Haan G, Jansen RC.

Genetics. 2005 Nov;171(3):1437-9. Epub 2005 Aug 3.


Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'.

Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke MP, de Haan G.

Nat Genet. 2005 Mar;37(3):225-32. Epub 2005 Feb 13.


In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1.

de Haan G, Weersing E, Dontje B, van Os R, Bystrykh LV, Vellenga E, Miller G.

Dev Cell. 2003 Feb;4(2):241-51.


A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover.

de Haan G, Bystrykh LV, Weersing E, Dontje B, Geiger H, Ivanova N, Lemischka IR, Vellenga E, Van Zant G.

Blood. 2002 Sep 15;100(6):2056-62.


Properties of an NAD(H)-containing methanol dehydrogenase and its activator protein from Bacillus methanolicus.

Arfman N, Hektor HJ, Bystrykh LV, Govorukhina NI, Dijkhuizen L, Frank J.

Eur J Biochem. 1997 Mar 1;244(2):426-33.


Production of actinorhodin-related "blue pigments" by Streptomyces coelicolor A3(2).

Bystrykh LV, Fernández-Moreno MA, Herrema JK, Malpartida F, Hopwood DA, Dijkhuizen L.

J Bacteriol. 1996 Apr;178(8):2238-44.


Modification of flavin adenine dinucleotide in alcohol oxidase of the yeast Hansenula polymorpha.

Bystrykh LV, Dijkhuizen L, Harder W.

J Gen Microbiol. 1991 Oct;137(10):2381-6.


Production of metabolites by methylotrophic yeasts.

Trotsenko YA, Bystrykh LV.

Biotechnol Adv. 1990;8(1):105-19.


Dihydroxyacetone synthase from Candida boidinii KD1.

Bystrykh LV, de Koning W, Harder W.

Methods Enzymol. 1990;188:435-45. No abstract available.


Alcohol oxidase from Hansenula polymorpha CBS 4732.

van der Klei IJ, Bystrykh LV, Harder W.

Methods Enzymol. 1990;188:420-7. No abstract available.


3-Hexulose-6-phosphate synthase from thermotolerant methylotroph Bacillus C1.

Arfman N, Bystrykh L, Govorukhina NI, Dijkhuizen L.

Methods Enzymol. 1990;188:391-7. No abstract available.


Triokinase from Candida boidinii KD1.

Bystrykh LV, de Koning W, Harder W.

Methods Enzymol. 1990;188:445-51. No abstract available.


Alcohol oxidase of methylotrophic thermo- and acidotolerant yeast Hansenula sp.

Bystrykh LV, Dvoráková J, Volfová O.

Folia Microbiol (Praha). 1989;34(3):233-7.


Transformation of methylotrophic yeast Hansenula polymorpha: cloning and expression of genes.

Tikhomirova LP, Ikonomova RN, Kuznetsova EN, Fodor II, Bystrykh LV, Aminova LR, Trotsenko YuA.

J Basic Microbiol. 1988;28(5):343-51.


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