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Items: 41

1.

Hexons from adenovirus serotypes 5 and 48 differentially protect adenovirus vectors from neutralization by mouse and human serum.

Harmon AW, Moitra R, Xu Z, Byrnes AP.

PLoS One. 2018 Feb 5;13(2):e0192353. doi: 10.1371/journal.pone.0192353. eCollection 2018.

2.

Evaluating the Impact of Natural IgM on Adenovirus Type 5 Gene Therapy Vectors.

Xu Z, Tian J, Harmon AW, Byrnes AP.

Methods Mol Biol. 2017;1643:187-196. doi: 10.1007/978-1-4939-7180-0_15.

PMID:
28667539
3.

Substitution of blood coagulation factor X-binding to Ad5 by position-specific PEGylation: Preventing vector clearance and preserving infectivity.

Krutzke L, Prill JM, Engler T, Schmidt CQ, Xu Z, Byrnes AP, Simmet T, Kreppel F.

J Control Release. 2016 Aug 10;235:379-392. doi: 10.1016/j.jconrel.2016.06.022. Epub 2016 Jun 11.

4.

Impact of natural IgM concentration on gene therapy with adenovirus type 5 vectors.

Qiu Q, Xu Z, Tian J, Moitra R, Gunti S, Notkins AL, Byrnes AP.

J Virol. 2015 Mar;89(6):3412-6. doi: 10.1128/JVI.03217-14. Epub 2014 Dec 31.

5.

Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement.

Xu Z, Qiu Q, Tian J, Smith JS, Conenello GM, Morita T, Byrnes AP.

Nat Med. 2013 Apr;19(4):452-7. doi: 10.1038/nm.3107. Epub 2013 Mar 24.

PMID:
23524342
6.

Circulating antibodies and macrophages as modulators of adenovirus pharmacology.

Khare R, Hillestad ML, Xu Z, Byrnes AP, Barry MA.

J Virol. 2013 Apr;87(7):3678-86. doi: 10.1128/JVI.01392-12. Epub 2013 Jan 16.

7.

Breakout session C summary: current virus detection methods.

Byrnes AP, Willkommen H.

PDA J Pharm Sci Technol. 2011 Nov-Dec;65(6):660-2. doi: 10.5731/pdajpst.2011.00835.

PMID:
22294593
8.

The role of endosomal escape and mitogen-activated protein kinases in adenoviral activation of the innate immune response.

Smith JS, Xu Z, Tian J, Palmer DJ, Ng P, Byrnes AP.

PLoS One. 2011;6(10):e26755. doi: 10.1371/journal.pone.0026755. Epub 2011 Oct 27.

9.

Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor.

Xu Z, Smith JS, Tian J, Byrnes AP.

Mol Ther. 2010 Mar;18(3):609-16. doi: 10.1038/mt.2009.279. Epub 2009 Dec 1.

10.

Adenovirus activates complement by distinctly different mechanisms in vitro and in vivo: indirect complement activation by virions in vivo.

Tian J, Xu Z, Smith JS, Hofherr SE, Barry MA, Byrnes AP.

J Virol. 2009 Jun;83(11):5648-58. doi: 10.1128/JVI.00082-09. Epub 2009 Mar 25.

11.

Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement.

Xu Z, Tian J, Smith JS, Byrnes AP.

J Virol. 2008 Dec;82(23):11705-13. doi: 10.1128/JVI.01320-08. Epub 2008 Sep 24.

12.

Th1 cytokines are upregulated by adenoviral vectors in the brains of primed mice.

Lee MB, McMenamin MM, Byrnes AP, Charlton HM, Wood MJ.

Neuroreport. 2008 Aug 6;19(12):1187-92. doi: 10.1097/WNR.0b013e3283088e3d.

PMID:
18628662
13.

Interaction of systemically delivered adenovirus vectors with Kupffer cells in mouse liver.

Smith JS, Xu Z, Tian J, Stevenson SC, Byrnes AP.

Hum Gene Ther. 2008 May;19(5):547-54. doi: 10.1089/hum.2008.004.

PMID:
18447633
14.

A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells.

Smith JS, Xu Z, Byrnes AP.

J Virol Methods. 2008 Jan;147(1):54-60. Epub 2007 Sep 11.

PMID:
17850893
15.

Quality prediction of cell substrate using gene expression profiling.

Han J, Farnsworth RL, Tiwari JL, Tian J, Lee H, Ikonomi P, Byrnes AP, Goodman JL, Puri RK.

Genomics. 2006 Apr;87(4):552-9. Epub 2006 Jan 18.

16.

Heparin-binding and patterns of virulence for two recombinant strains of Sindbis virus.

Bear JS, Byrnes AP, Griffin DE.

Virology. 2006 Mar 30;347(1):183-90. Epub 2005 Dec 27.

17.

Challenges and future prospects in gene therapy.

Byrnes AP.

IDrugs. 2005 Dec;8(12):993-6.

PMID:
16320132
18.

Rapid Kupffer cell death after intravenous injection of adenovirus vectors.

Manickan E, Smith JS, Tian J, Eggerman TL, Lozier JN, Muller J, Byrnes AP.

Mol Ther. 2006 Jan;13(1):108-17. Epub 2005 Sep 28.

19.

Severe pulmonary pathology after intravenous administration of vectors in cirrhotic rats.

Smith JS, Tian J, Lozier JN, Byrnes AP.

Mol Ther. 2004 Jun;9(6):932-41.

20.

Emergence and virulence of encephalitogenic arboviruses.

Griffin DE, Byrnes AP, Cook SH.

Arch Virol Suppl. 2004;(18):21-33. Review.

PMID:
15119760
21.

Unexpected pulmonary uptake of adenovirus vectors in animals with chronic liver disease.

Smith JS, Tian J, Muller J, Byrnes AP.

Gene Ther. 2004 Mar;11(5):431-8.

PMID:
14973536
22.

Control of Sindbis virus infection by antibody in interferon-deficient mice.

Byrnes AP, Durbin JE, Griffin DE.

J Virol. 2000 Apr;74(8):3905-8.

23.

Humoral immune responses to adenovirus vectors in the brain.

Kajiwara K, Byrnes AP, Ohmoto Y, Charlton HM, Wood MJ, Wood KJ.

J Neuroimmunol. 2000 Feb 1;103(1):8-15.

PMID:
10674984
26.

Co-injection of adenovirus expressing CTLA4-Ig prolongs adenovirally mediated lacZ reporter gene expression in the mouse retina.

Ali RR, Reichel MB, Byrnes AP, Stephens CJ, Thrasher AJ, Baker D, Hunt DM, Bhattacharya SS.

Gene Ther. 1998 Nov;5(11):1561-5.

27.

Local gene therapy with CTLA4-immunoglobulin fusion protein in experimental allergic encephalomyelitis.

Croxford JL, O'Neill JK, Ali RR, Browne K, Byrnes AP, Dallman MJ, Wood MJ, Fedlmann M, Baker D.

Eur J Immunol. 1998 Dec;28(12):3904-16.

28.

Potential and limitations of a gamma 34.5 mutant of herpes simplex 1 as a gene therapy vector in the CNS.

McMenamin MM, Byrnes AP, Pike FG, Charlton HM, Coffin RS, Latchman DS, Wood MJ.

Gene Ther. 1998 May;5(5):594-604.

29.

Binding of Sindbis virus to cell surface heparan sulfate.

Byrnes AP, Griffin DE.

J Virol. 1998 Sep;72(9):7349-56.

30.

A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain.

McMenamin MM, Byrnes AP, Charlton HM, Coffin RS, Latchman DS, Wood MJ.

Neuroscience. 1998 Apr;83(4):1225-37.

PMID:
9502260
31.

Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea.

Oral HB, Larkin DF, Fehervari Z, Byrnes AP, Rankin AM, Haskard DO, Wood MJ, Dallman MJ, George AJ.

Gene Ther. 1997 Jul;4(7):639-47.

32.

Immune responses to adenoviral vectors during gene transfer in the brain.

Kajiwara K, Byrnes AP, Charlton HM, Wood MJ, Wood KJ.

Hum Gene Ther. 1997 Feb 10;8(3):253-65.

PMID:
9048192
33.

Immune responses to adenovirus vectors in the nervous system.

Wood MJ, Charlton HM, Wood KJ, Kajiwara K, Byrnes AP.

Trends Neurosci. 1996 Nov;19(11):497-501. Review.

PMID:
8931276
34.

Persistent transgene expression in the hypothalamus following stereotaxic delivery of a recombinant adenovirus: suppression of the immune response with cyclosporin.

Geddes BJ, Harding TC, Hughes DS, Byrnes AP, Lightman SL, Conde G, Uney JB.

Endocrinology. 1996 Nov;137(11):5166-9.

PMID:
8895393
35.

Role of T cells in inflammation caused by adenovirus vectors in the brain.

Byrnes AP, Wood MJ, Charlton HM.

Gene Ther. 1996 Jul;3(7):644-51.

PMID:
8818653
37.

Adenovirus gene transfer causes inflammation in the brain.

Byrnes AP, Rusby JE, Wood MJ, Charlton HM.

Neuroscience. 1995 Jun;66(4):1015-24.

PMID:
7651606
38.

Specific patterns of defective HSV-1 gene transfer in the adult central nervous system: implications for gene targeting.

Wood MJ, Byrnes AP, Kaplitt MG, Pfaff DW, Rabkin SD, Charlton HM.

Exp Neurol. 1994 Nov;130(1):127-40.

PMID:
7821388
39.

Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors.

Wood MJ, Byrnes AP, Pfaff DW, Rabkin SD, Charlton HM.

Gene Ther. 1994 Sep;1(5):283-91.

PMID:
7584093
40.

Immunological consequences of HSV-1-mediated gene transfer into the CNS.

Wood MJ, Byrnes AP, Rabkin SD, Pfaff DW, Charlton HM.

Gene Ther. 1994;1 Suppl 1:S82.

PMID:
8542428
41.

Molecular cloning of a G-protein alpha i subunit from the lobster olfactory organ.

McClintock TS, Byrnes AP, Lerner MR.

Brain Res Mol Brain Res. 1992 Jul;14(3):273-6.

PMID:
1279345

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