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Items: 1 to 50 of 135

1.

Mathematical modelling of telomere length dynamics.

Wattis JAD, Qi Q, Byrne HM.

J Math Biol. 2019 Nov 14. doi: 10.1007/s00285-019-01448-y. [Epub ahead of print]

PMID:
31728621
2.

Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments.

Ardaševa A, Gatenby RA, Anderson ARA, Byrne HM, Maini PK, Lorenzi T.

J Math Biol. 2019 Oct 22. doi: 10.1007/s00285-019-01441-5. [Epub ahead of print]

PMID:
31641842
3.

A lipid-structured model for macrophage populations in atherosclerotic plaques.

Ford HZ, Byrne HM, Myerscough MR.

J Theor Biol. 2019 Oct 21;479:48-63. doi: 10.1016/j.jtbi.2019.07.003. Epub 2019 Jul 15.

PMID:
31319051
4.

Age Structure Can Account for Delayed Logistic Proliferation of Scratch Assays.

Ponce Bobadilla AV, Carraro T, Byrne HM, Maini PK, Alarcón T.

Bull Math Biol. 2019 Jul;81(7):2706-2724. doi: 10.1007/s11538-019-00625-w. Epub 2019 Jun 14.

PMID:
31201661
5.

Efferocytosis perpetuates substance accumulation inside macrophage populations.

Ford HZ, Zeboudj L, Purvis GSD, Ten Bokum A, Zarebski AE, Bull JA, Byrne HM, Myerscough MR, Greaves DR.

Proc Biol Sci. 2019 Jun 12;286(1904):20190730. doi: 10.1098/rspb.2019.0730. Epub 2019 Jun 5.

6.

Identifying chondrogenesis strategies for tissue engineering of articular cartilage.

Chen MJ, Whiteley JP, Please CP, Ehlicke F, Waters SL, Byrne HM.

J Tissue Eng. 2019 Apr 22;10:2041731419842431. doi: 10.1177/2041731419842431. eCollection 2019 Jan-Dec.

7.

A Biomechanical Model of Tumor-Induced Intracranial Pressure and Edema in Brain Tissue.

Sorribes IC, Moore MNJ, Byrne HM, Jain HV.

Biophys J. 2019 Apr 23;116(8):1560-1574. doi: 10.1016/j.bpj.2019.02.030. Epub 2019 Mar 23.

PMID:
30979548
8.

In vitro cell migration quantification method for scratch assays.

Bobadilla AVP, Arévalo J, Sarró E, Byrne HM, Maini PK, Carraro T, Balocco S, Meseguer A, Alarcón T.

J R Soc Interface. 2019 Feb 28;16(151):20180709. doi: 10.1098/rsif.2018.0709.

PMID:
30958186
9.

Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation.

Parker A, Vaux L, Patterson AM, Modasia A, Muraro D, Fletcher AG, Byrne HM, Maini PK, Watson AJM, Pin C.

Cell Death Dis. 2019 Feb 6;10(2):108. doi: 10.1038/s41419-018-1275-5.

10.

A mathematical model of the use of supplemental oxygen to combat surgical site infection.

Jayathilake C, Maini PK, Hopf HW, Sean McElwain DL, Byrne HM, Flegg MB, Flegg JA.

J Theor Biol. 2019 Apr 7;466:11-23. doi: 10.1016/j.jtbi.2019.01.021. Epub 2019 Jan 16.

PMID:
30659823
11.

Mathematical modelling of a hypoxia-regulated oncolytic virus delivered by tumour-associated macrophages.

Boemo MA, Byrne HM.

J Theor Biol. 2019 Jan 14;461:102-116. doi: 10.1016/j.jtbi.2018.10.044. Epub 2018 Oct 23.

12.

Thermal Sensitivity of Gypsy Moth (Lepidoptera: Erebidae) During Larval and Pupal Development.

Banahene N, Salem SK, Faske TM, Byrne HM, Glackin M, Agosta SJ, Eckert AJ, Grayson KL, Thompson LM.

Environ Entomol. 2018 Dec 7;47(6):1623-1631. doi: 10.1093/ee/nvy149.

PMID:
30272116
13.

Post-buckling behaviour of a growing elastic rod.

Almet AA, Byrne HM, Maini PK, Moulton DE.

J Math Biol. 2019 Feb;78(3):777-814. doi: 10.1007/s00285-018-1292-0. Epub 2018 Sep 11.

14.

A two-phase model of early fibrous cap formation in atherosclerosis.

Watson MG, Byrne HM, Macaskill C, Myerscough MR.

J Theor Biol. 2018 Nov 7;456:123-136. doi: 10.1016/j.jtbi.2018.08.010. Epub 2018 Aug 8.

PMID:
30098319
15.

Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium.

Muraro D, Parker A, Vaux L, Filippi S, Almet AA, Fletcher AG, Watson AJM, Pin C, Maini PK, Byrne HM.

J R Soc Interface. 2018 Aug;15(145). pii: 20180037. doi: 10.1098/rsif.2018.0037.

16.

Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model.

Hutton-Smith LA, Gaffney EA, Byrne HM, Caruso A, Maini PK, Mazer NA.

Mol Pharm. 2018 Jul 2;15(7):2770-2784. doi: 10.1021/acs.molpharmaceut.8b00280. Epub 2018 May 29.

PMID:
29734810
17.

Predictive Mathematical Models for the Spread and Treatment of Hyperoxia-induced Photoreceptor Degeneration in Retinitis Pigmentosa.

Roberts PA, Gaffney EA, Whiteley JP, Luthert PJ, Foss AJE, Byrne HM.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1238-1249. doi: 10.1167/iovs.17-23177.

PMID:
29625444
18.

The importance of geometry in the corneal micropocket angiogenesis assay.

Grogan JA, Connor AJ, Pitt-Francis JM, Maini PK, Byrne HM.

PLoS Comput Biol. 2018 Mar 9;14(3):e1006049. doi: 10.1371/journal.pcbi.1006049. eCollection 2018 Mar.

19.

The impact of exclusion processes on angiogenesis models.

Pillay S, Byrne HM, Maini PK.

J Math Biol. 2018 Dec;77(6-7):1721-1759. doi: 10.1007/s00285-018-1214-1. Epub 2018 Mar 6.

20.

The Evolution of Tumour Composition During Fractionated Radiotherapy: Implications for Outcome.

Lewin TD, Maini PK, Moros EG, Enderling H, Byrne HM.

Bull Math Biol. 2018 May;80(5):1207-1235. doi: 10.1007/s11538-018-0391-9. Epub 2018 Feb 27.

PMID:
29488054
21.

Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis.

Lambert B, MacLean AL, Fletcher AG, Combes AN, Little MH, Byrne HM.

J Math Biol. 2018 Jun;76(7):1673-1697. doi: 10.1007/s00285-018-1208-z. Epub 2018 Feb 1.

22.

Inducing chondrogenesis in MSC/chondrocyte co-cultures using exogenous TGF-β: a mathematical model.

Chen MJ, Whiteley JP, Please CP, Schwab A, Ehlicke F, Waters SL, Byrne HM.

J Theor Biol. 2018 Feb 14;439:1-13. doi: 10.1016/j.jtbi.2017.11.024. Epub 2017 Dec 5.

PMID:
29203122
23.

A mathematical model of antibody-dependent cellular cytotoxicity (ADCC).

Hoffman F, Gavaghan D, Osborne J, Barrett IP, You T, Ghadially H, Sainson R, Wilkinson RW, Byrne HM.

J Theor Biol. 2018 Jan 7;436:39-50. doi: 10.1016/j.jtbi.2017.09.031. Epub 2017 Sep 29.

PMID:
28970093
24.

A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium.

Maclaren OJ, Parker A, Pin C, Carding SR, Watson AJM, Fletcher AG, Byrne HM, Maini PK.

PLoS Comput Biol. 2017 Jul 28;13(7):e1005688. doi: 10.1371/journal.pcbi.1005688. eCollection 2017 Jul.

25.

A mathematical model for cell infiltration and proliferation in a chondral defect.

Kimpton LS, Schwab A, Ehlicke F, Waters SL, Please CP, Whiteley JP, Byrne HM.

Math Biosci. 2017 Oct;292:46-56. doi: 10.1016/j.mbs.2017.07.008. Epub 2017 Jul 21.

PMID:
28735871
26.

Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model.

Hutton-Smith LA, Gaffney EA, Byrne HM, Maini PK, Gadkar K, Mazer NA.

Mol Pharm. 2017 Aug 7;14(8):2690-2696. doi: 10.1021/acs.molpharmaceut.7b00164. Epub 2017 Jul 3.

PMID:
28631484
27.

Pattern formation in multiphase models of chemotactic cell aggregation.

Green JEF, Whiteley JP, Oliver JM, Byrne HM, Waters SL.

Math Med Biol. 2018 Sep 11;35(3):319-346. doi: 10.1093/imammb/dqx005.

PMID:
28520976
28.

Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues.

Grogan JA, Connor AJ, Markelc B, Muschel RJ, Maini PK, Byrne HM, Pitt-Francis JM.

Biophys J. 2017 May 9;112(9):1767-1772. doi: 10.1016/j.bpj.2017.03.036.

29.

Mathematical models of retinitis pigmentosa: The oxygen toxicity hypothesis.

Roberts PA, Gaffney EA, Luthert PJ, Foss AJE, Byrne HM.

J Theor Biol. 2017 Jul 21;425:53-71. doi: 10.1016/j.jtbi.2017.05.006. Epub 2017 May 6.

PMID:
28483568
30.

Bayesian Calibration, Validation and Uncertainty Quantification for Predictive Modelling of Tumour Growth: A Tutorial.

Collis J, Connor AJ, Paczkowski M, Kannan P, Pitt-Francis J, Byrne HM, Hubbard ME.

Bull Math Biol. 2017 Apr;79(4):939-974. doi: 10.1007/s11538-017-0258-5. Epub 2017 Mar 13.

PMID:
28290010
31.

The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.

Kay SK, Harrington HA, Shepherd S, Brennan K, Dale T, Osborne JM, Gavaghan DJ, Byrne HM.

PLoS Comput Biol. 2017 Feb 28;13(2):e1005400. doi: 10.1371/journal.pcbi.1005400. eCollection 2017 Feb.

32.

Modeling angiogenesis: A discrete to continuum description.

Pillay S, Byrne HM, Maini PK.

Phys Rev E. 2017 Jan;95(1-1):012410. doi: 10.1103/PhysRevE.95.012410. Epub 2017 Jan 25.

PMID:
28208423
33.

Mathematical modelling of cell layer growth in a hollow fibre bioreactor.

Chapman LAC, Whiteley JP, Byrne HM, Waters SL, Shipley RJ.

J Theor Biol. 2017 Apr 7;418:36-56. doi: 10.1016/j.jtbi.2017.01.016. Epub 2017 Jan 12.

34.

3D hybrid modelling of vascular network formation.

Perfahl H, Hughes BD, Alarcón T, Maini PK, Lloyd MC, Reuss M, Byrne HM.

J Theor Biol. 2017 Feb 7;414:254-268. doi: 10.1016/j.jtbi.2016.11.013. Epub 2016 Nov 24.

35.

Modeling Longitudinal Preclinical Tumor Size Data to Identify Transient Dynamics in Tumor Response to Antiangiogenic Drugs.

Hutchinson LG, Mueller HJ, Gaffney EA, Maini PK, Wagg J, Phipps A, Boetsch C, Byrne HM, Ribba B.

CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):636-645. doi: 10.1002/psp4.12142. Epub 2016 Nov 14.

36.

Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi.

Parker A, Maclaren OJ, Fletcher AG, Muraro D, Kreuzaler PA, Byrne HM, Maini PK, Watson AJ, Pin C.

FASEB J. 2017 Feb;31(2):636-649. doi: 10.1096/fj.201601002. Epub 2016 Oct 20.

37.

Predicting the Influence of Microvascular Structure On Tumor Response to Radiotherapy.

Grogan JA, Markelc B, Connor AJ, Muschel RJ, Pitt-Francis JM, Maini PK, Byrne HM.

IEEE Trans Biomed Eng. 2017 Mar;64(3):504-511. doi: 10.1109/TBME.2016.2606563. Epub 2016 Sep 8.

PMID:
27623567
38.

Mathematical modelling of stretch-induced membrane traffic in bladder umbrella cells.

Moulton DE, Sulzer V, Apodaca G, Byrne HM, Waters SL.

J Theor Biol. 2016 Nov 21;409:115-132. doi: 10.1016/j.jtbi.2016.08.032. Epub 2016 Aug 31.

39.

Mathematical and computational models of the retina in health, development and disease.

Roberts PA, Gaffney EA, Luthert PJ, Foss AJE, Byrne HM.

Prog Retin Eye Res. 2016 Jul;53:48-69. doi: 10.1016/j.preteyeres.2016.04.001. Epub 2016 Apr 7. Review.

PMID:
27063291
40.

Vascular phenotype identification and anti-angiogenic treatment recommendation: A pseudo-multiscale mathematical model of angiogenesis.

Hutchinson LG, Gaffney EA, Maini PK, Wagg J, Phipps A, Byrne HM.

J Theor Biol. 2016 Jun 7;398:162-80. doi: 10.1016/j.jtbi.2016.03.002. Epub 2016 Mar 14.

PMID:
26987523
41.

Optimisation of simulations of stochastic processes by removal of opposing reactions.

Spill F, Maini PK, Byrne HM.

J Chem Phys. 2016 Feb 28;144(8):084105. doi: 10.1063/1.4942413.

PMID:
26931679
42.

Models, measurement and inference in epithelial tissue dynamics.

Maclaren OJ, Byrne HM, Fletcher AG, Maini PK.

Math Biosci Eng. 2015 Dec;12(6):1321-40. doi: 10.3934/mbe.2015.12.1321. Review.

43.

A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration.

Hutton-Smith LA, Gaffney EA, Byrne HM, Maini PK, Schwab D, Mazer NA.

Mol Pharm. 2016 Sep 6;13(9):2941-50. doi: 10.1021/acs.molpharmaceut.5b00849. Epub 2016 Jan 14.

PMID:
26726925
44.

Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway as a Case Study.

MacLean AL, Harrington HA, Stumpf MP, Byrne HM.

Methods Mol Biol. 2016;1386:405-39. doi: 10.1007/978-1-4939-3283-2_18. Review.

PMID:
26677193
45.

Retinal oxygen distribution and the role of neuroglobin.

Roberts PA, Gaffney EA, Luthert PJ, Foss AJ, Byrne HM.

J Math Biol. 2016 Jul;73(1):1-38. doi: 10.1007/s00285-015-0931-y. Epub 2015 Sep 14.

PMID:
26370669
46.

An investigation of the influence of extracellular matrix anisotropy and cell-matrix interactions on tissue architecture.

Dyson RJ, Green JE, Whiteley JP, Byrne HM.

J Math Biol. 2016 Jun;72(7):1775-809. doi: 10.1007/s00285-015-0927-7. Epub 2015 Sep 2.

PMID:
26328534
47.

An integrated approach to quantitative modelling in angiogenesis research.

Connor AJ, Nowak RP, Lorenzon E, Thomas M, Herting F, Hoert S, Quaiser T, Shochat E, Pitt-Francis J, Cooper J, Maini PK, Byrne HM.

J R Soc Interface. 2015 Sep 6;12(110):0546. doi: 10.1098/rsif.2015.0546.

48.

A morphoelastic model for dermal wound closure.

Bowden LG, Byrne HM, Maini PK, Moulton DE.

Biomech Model Mechanobiol. 2016 Jun;15(3):663-81. doi: 10.1007/s10237-015-0716-7. Epub 2015 Aug 12.

PMID:
26264498
49.

Reinforcement of hydrogels using three-dimensionally printed microfibres.

Visser J, Melchels FP, Jeon JE, van Bussel EM, Kimpton LS, Byrne HM, Dhert WJ, Dalton PD, Hutmacher DW, Malda J.

Nat Commun. 2015 Apr 28;6:6933. doi: 10.1038/ncomms7933.

PMID:
25917746
50.

A spatially-averaged mathematical model of kidney branching morphogenesis.

Zubkov VS, Combes AN, Short KM, Lefevre J, Hamilton NA, Smyth IM, Little MH, Byrne HM.

J Theor Biol. 2015 Aug 21;379:24-37. doi: 10.1016/j.jtbi.2015.04.015. Epub 2015 Apr 24.

PMID:
25913880

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