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Items: 1 to 50 of 127

1.

Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation.

Parker A, Vaux L, Patterson AM, Modasia A, Muraro D, Fletcher AG, Byrne HM, Maini PK, Watson AJM, Pin C.

Cell Death Dis. 2019 Feb 6;10(2):108. doi: 10.1038/s41419-018-1275-5.

2.

A mathematical model of the use of supplemental oxygen to combat surgical site infection.

Jayathilake C, Maini PK, Hopf HW, Sean McElwain DL, Byrne HM, Flegg MB, Flegg JA.

J Theor Biol. 2019 Apr 7;466:11-23. doi: 10.1016/j.jtbi.2019.01.021. Epub 2019 Jan 16.

PMID:
30659823
3.

Mathematical modelling of a hypoxia-regulated oncolytic virus delivered by tumour-associated macrophages.

Boemo MA, Byrne HM.

J Theor Biol. 2019 Jan 14;461:102-116. doi: 10.1016/j.jtbi.2018.10.044. Epub 2018 Oct 23.

4.

Thermal Sensitivity of Gypsy Moth (Lepidoptera: Erebidae) During Larval and Pupal Development.

Banahene N, Salem SK, Faske TM, Byrne HM, Glackin M, Agosta SJ, Eckert AJ, Grayson KL, Thompson LM.

Environ Entomol. 2018 Dec 7;47(6):1623-1631. doi: 10.1093/ee/nvy149.

PMID:
30272116
5.

Post-buckling behaviour of a growing elastic rod.

Almet AA, Byrne HM, Maini PK, Moulton DE.

J Math Biol. 2019 Feb;78(3):777-814. doi: 10.1007/s00285-018-1292-0. Epub 2018 Sep 11.

PMID:
30206650
6.

A two-phase model of early fibrous cap formation in atherosclerosis.

Watson MG, Byrne HM, Macaskill C, Myerscough MR.

J Theor Biol. 2018 Nov 7;456:123-136. doi: 10.1016/j.jtbi.2018.08.010. Epub 2018 Aug 8.

PMID:
30098319
7.

Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium.

Muraro D, Parker A, Vaux L, Filippi S, Almet AA, Fletcher AG, Watson AJM, Pin C, Maini PK, Byrne HM.

J R Soc Interface. 2018 Aug;15(145). pii: 20180037. doi: 10.1098/rsif.2018.0037.

8.

Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model.

Hutton-Smith LA, Gaffney EA, Byrne HM, Caruso A, Maini PK, Mazer NA.

Mol Pharm. 2018 Jul 2;15(7):2770-2784. doi: 10.1021/acs.molpharmaceut.8b00280. Epub 2018 May 29.

PMID:
29734810
9.

Predictive Mathematical Models for the Spread and Treatment of Hyperoxia-induced Photoreceptor Degeneration in Retinitis Pigmentosa.

Roberts PA, Gaffney EA, Whiteley JP, Luthert PJ, Foss AJE, Byrne HM.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1238-1249. doi: 10.1167/iovs.17-23177.

PMID:
29625444
10.

The importance of geometry in the corneal micropocket angiogenesis assay.

Grogan JA, Connor AJ, Pitt-Francis JM, Maini PK, Byrne HM.

PLoS Comput Biol. 2018 Mar 9;14(3):e1006049. doi: 10.1371/journal.pcbi.1006049. eCollection 2018 Mar.

11.

The impact of exclusion processes on angiogenesis models.

Pillay S, Byrne HM, Maini PK.

J Math Biol. 2018 Dec;77(6-7):1721-1759. doi: 10.1007/s00285-018-1214-1. Epub 2018 Mar 6.

12.

The Evolution of Tumour Composition During Fractionated Radiotherapy: Implications for Outcome.

Lewin TD, Maini PK, Moros EG, Enderling H, Byrne HM.

Bull Math Biol. 2018 May;80(5):1207-1235. doi: 10.1007/s11538-018-0391-9. Epub 2018 Feb 27.

PMID:
29488054
13.

Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis.

Lambert B, MacLean AL, Fletcher AG, Combes AN, Little MH, Byrne HM.

J Math Biol. 2018 Jun;76(7):1673-1697. doi: 10.1007/s00285-018-1208-z. Epub 2018 Feb 1.

14.

Inducing chondrogenesis in MSC/chondrocyte co-cultures using exogenous TGF-β: a mathematical model.

Chen MJ, Whiteley JP, Please CP, Schwab A, Ehlicke F, Waters SL, Byrne HM.

J Theor Biol. 2018 Feb 14;439:1-13. doi: 10.1016/j.jtbi.2017.11.024. Epub 2017 Dec 5.

PMID:
29203122
15.

A mathematical model of antibody-dependent cellular cytotoxicity (ADCC).

Hoffman F, Gavaghan D, Osborne J, Barrett IP, You T, Ghadially H, Sainson R, Wilkinson RW, Byrne HM.

J Theor Biol. 2018 Jan 7;436:39-50. doi: 10.1016/j.jtbi.2017.09.031. Epub 2017 Sep 29.

PMID:
28970093
16.

A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium.

Maclaren OJ, Parker A, Pin C, Carding SR, Watson AJM, Fletcher AG, Byrne HM, Maini PK.

PLoS Comput Biol. 2017 Jul 28;13(7):e1005688. doi: 10.1371/journal.pcbi.1005688. eCollection 2017 Jul.

17.

A mathematical model for cell infiltration and proliferation in a chondral defect.

Kimpton LS, Schwab A, Ehlicke F, Waters SL, Please CP, Whiteley JP, Byrne HM.

Math Biosci. 2017 Oct;292:46-56. doi: 10.1016/j.mbs.2017.07.008. Epub 2017 Jul 21.

PMID:
28735871
18.

Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model.

Hutton-Smith LA, Gaffney EA, Byrne HM, Maini PK, Gadkar K, Mazer NA.

Mol Pharm. 2017 Aug 7;14(8):2690-2696. doi: 10.1021/acs.molpharmaceut.7b00164. Epub 2017 Jul 3.

PMID:
28631484
19.

Pattern formation in multiphase models of chemotactic cell aggregation.

Green JEF, Whiteley JP, Oliver JM, Byrne HM, Waters SL.

Math Med Biol. 2018 Sep 11;35(3):319-346. doi: 10.1093/imammb/dqx005.

PMID:
28520976
20.

Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues.

Grogan JA, Connor AJ, Markelc B, Muschel RJ, Maini PK, Byrne HM, Pitt-Francis JM.

Biophys J. 2017 May 9;112(9):1767-1772. doi: 10.1016/j.bpj.2017.03.036.

21.

Mathematical models of retinitis pigmentosa: The oxygen toxicity hypothesis.

Roberts PA, Gaffney EA, Luthert PJ, Foss AJE, Byrne HM.

J Theor Biol. 2017 Jul 21;425:53-71. doi: 10.1016/j.jtbi.2017.05.006. Epub 2017 May 6.

PMID:
28483568
22.

Bayesian Calibration, Validation and Uncertainty Quantification for Predictive Modelling of Tumour Growth: A Tutorial.

Collis J, Connor AJ, Paczkowski M, Kannan P, Pitt-Francis J, Byrne HM, Hubbard ME.

Bull Math Biol. 2017 Apr;79(4):939-974. doi: 10.1007/s11538-017-0258-5. Epub 2017 Mar 13.

PMID:
28290010
23.

The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.

Kay SK, Harrington HA, Shepherd S, Brennan K, Dale T, Osborne JM, Gavaghan DJ, Byrne HM.

PLoS Comput Biol. 2017 Feb 28;13(2):e1005400. doi: 10.1371/journal.pcbi.1005400. eCollection 2017 Feb.

24.

Modeling angiogenesis: A discrete to continuum description.

Pillay S, Byrne HM, Maini PK.

Phys Rev E. 2017 Jan;95(1-1):012410. doi: 10.1103/PhysRevE.95.012410. Epub 2017 Jan 25.

PMID:
28208423
25.

Mathematical modelling of cell layer growth in a hollow fibre bioreactor.

Chapman LAC, Whiteley JP, Byrne HM, Waters SL, Shipley RJ.

J Theor Biol. 2017 Apr 7;418:36-56. doi: 10.1016/j.jtbi.2017.01.016. Epub 2017 Jan 12.

26.

3D hybrid modelling of vascular network formation.

Perfahl H, Hughes BD, Alarcón T, Maini PK, Lloyd MC, Reuss M, Byrne HM.

J Theor Biol. 2017 Feb 7;414:254-268. doi: 10.1016/j.jtbi.2016.11.013. Epub 2016 Nov 24.

27.

Modeling Longitudinal Preclinical Tumor Size Data to Identify Transient Dynamics in Tumor Response to Antiangiogenic Drugs.

Hutchinson LG, Mueller HJ, Gaffney EA, Maini PK, Wagg J, Phipps A, Boetsch C, Byrne HM, Ribba B.

CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):636-645. doi: 10.1002/psp4.12142. Epub 2016 Nov 14.

28.

Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi.

Parker A, Maclaren OJ, Fletcher AG, Muraro D, Kreuzaler PA, Byrne HM, Maini PK, Watson AJ, Pin C.

FASEB J. 2017 Feb;31(2):636-649. doi: 10.1096/fj.201601002. Epub 2016 Oct 20.

29.

Predicting the Influence of Microvascular Structure On Tumor Response to Radiotherapy.

Grogan JA, Markelc B, Connor AJ, Muschel RJ, Pitt-Francis JM, Maini PK, Byrne HM.

IEEE Trans Biomed Eng. 2017 Mar;64(3):504-511. doi: 10.1109/TBME.2016.2606563. Epub 2016 Sep 8.

PMID:
27623567
30.

Mathematical modelling of stretch-induced membrane traffic in bladder umbrella cells.

Moulton DE, Sulzer V, Apodaca G, Byrne HM, Waters SL.

J Theor Biol. 2016 Nov 21;409:115-132. doi: 10.1016/j.jtbi.2016.08.032. Epub 2016 Aug 31.

31.

Mathematical and computational models of the retina in health, development and disease.

Roberts PA, Gaffney EA, Luthert PJ, Foss AJE, Byrne HM.

Prog Retin Eye Res. 2016 Jul;53:48-69. doi: 10.1016/j.preteyeres.2016.04.001. Epub 2016 Apr 7. Review.

PMID:
27063291
32.

Vascular phenotype identification and anti-angiogenic treatment recommendation: A pseudo-multiscale mathematical model of angiogenesis.

Hutchinson LG, Gaffney EA, Maini PK, Wagg J, Phipps A, Byrne HM.

J Theor Biol. 2016 Jun 7;398:162-80. doi: 10.1016/j.jtbi.2016.03.002. Epub 2016 Mar 14.

PMID:
26987523
33.

Optimisation of simulations of stochastic processes by removal of opposing reactions.

Spill F, Maini PK, Byrne HM.

J Chem Phys. 2016 Feb 28;144(8):084105. doi: 10.1063/1.4942413.

PMID:
26931679
34.

Models, measurement and inference in epithelial tissue dynamics.

Maclaren OJ, Byrne HM, Fletcher AG, Maini PK.

Math Biosci Eng. 2015 Dec;12(6):1321-40. doi: 10.3934/mbe.2015.12.1321. Review.

35.

A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration.

Hutton-Smith LA, Gaffney EA, Byrne HM, Maini PK, Schwab D, Mazer NA.

Mol Pharm. 2016 Sep 6;13(9):2941-50. doi: 10.1021/acs.molpharmaceut.5b00849. Epub 2016 Jan 14.

PMID:
26726925
36.

Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway as a Case Study.

MacLean AL, Harrington HA, Stumpf MP, Byrne HM.

Methods Mol Biol. 2016;1386:405-39. doi: 10.1007/978-1-4939-3283-2_18. Review.

PMID:
26677193
37.

Retinal oxygen distribution and the role of neuroglobin.

Roberts PA, Gaffney EA, Luthert PJ, Foss AJ, Byrne HM.

J Math Biol. 2016 Jul;73(1):1-38. doi: 10.1007/s00285-015-0931-y. Epub 2015 Sep 14.

PMID:
26370669
38.

An investigation of the influence of extracellular matrix anisotropy and cell-matrix interactions on tissue architecture.

Dyson RJ, Green JE, Whiteley JP, Byrne HM.

J Math Biol. 2016 Jun;72(7):1775-809. doi: 10.1007/s00285-015-0927-7. Epub 2015 Sep 2.

PMID:
26328534
39.

An integrated approach to quantitative modelling in angiogenesis research.

Connor AJ, Nowak RP, Lorenzon E, Thomas M, Herting F, Hoert S, Quaiser T, Shochat E, Pitt-Francis J, Cooper J, Maini PK, Byrne HM.

J R Soc Interface. 2015 Sep 6;12(110):0546. doi: 10.1098/rsif.2015.0546.

40.

A morphoelastic model for dermal wound closure.

Bowden LG, Byrne HM, Maini PK, Moulton DE.

Biomech Model Mechanobiol. 2016 Jun;15(3):663-81. doi: 10.1007/s10237-015-0716-7. Epub 2015 Aug 12.

PMID:
26264498
41.

Reinforcement of hydrogels using three-dimensionally printed microfibres.

Visser J, Melchels FP, Jeon JE, van Bussel EM, Kimpton LS, Byrne HM, Dhert WJ, Dalton PD, Hutmacher DW, Malda J.

Nat Commun. 2015 Apr 28;6:6933. doi: 10.1038/ncomms7933.

PMID:
25917746
42.

A spatially-averaged mathematical model of kidney branching morphogenesis.

Zubkov VS, Combes AN, Short KM, Lefevre J, Hamilton NA, Smyth IM, Little MH, Byrne HM.

J Theor Biol. 2015 Aug 21;379:24-37. doi: 10.1016/j.jtbi.2015.04.015. Epub 2015 Apr 24.

PMID:
25913880
43.

From invasion to latency: intracellular noise and cell motility as key controls of the competition between resource-limited cellular populations.

Guerrero P, Byrne HM, Maini PK, Alarcón T.

J Math Biol. 2016 Jan;72(1-2):123-56. doi: 10.1007/s00285-015-0883-2. Epub 2015 Apr 2.

PMID:
25833187
44.

Parameter-free methods distinguish Wnt pathway models and guide design of experiments.

MacLean AL, Rosen Z, Byrne HM, Harrington HA.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2652-7. doi: 10.1073/pnas.1416655112. Epub 2015 Feb 17.

45.

Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord.

Lovrics A, Gao Y, Juhász B, Bock I, Byrne HM, Dinnyés A, Kovács KA.

PLoS One. 2014 Nov 14;9(11):e111430. doi: 10.1371/journal.pone.0111430. eCollection 2014.

46.

A multiscale analysis of nutrient transport and biological tissue growth in vitro.

O'Dea RD, Nelson MR, El Haj AJ, Waters SL, Byrne HM.

Math Med Biol. 2015 Sep;32(3):345-66. doi: 10.1093/imammb/dqu015. Epub 2014 Oct 15.

PMID:
25323738
47.

Optimising cell aggregate expansion in a perfused hollow fibre bioreactor via mathematical modelling.

Chapman LA, Shipley RJ, Whiteley JP, Ellis MJ, Byrne HM, Waters SL.

PLoS One. 2014 Aug 26;9(8):e105813. doi: 10.1371/journal.pone.0105813. eCollection 2014.

48.

The resolution of inflammation: a mathematical model of neutrophil and macrophage interactions.

Dunster JL, Byrne HM, King JR.

Bull Math Biol. 2014 Aug;76(8):1953-80. doi: 10.1007/s11538-014-9987-x. Epub 2014 Jul 23.

PMID:
25053556
49.

An ordinary differential equation model for full thickness wounds and the effects of diabetes.

Bowden LG, Maini PK, Moulton DE, Tang JB, Wang XT, Liu PY, Byrne HM.

J Theor Biol. 2014 Nov 21;361:87-100. doi: 10.1016/j.jtbi.2014.07.001. Epub 2014 Jul 10.

PMID:
25017724
50.

Stochastic simulations of normal aging and Werner's syndrome.

Qi Q, Wattis JA, Byrne HM.

Bull Math Biol. 2014 Jun;76(6):1241-69. doi: 10.1007/s11538-014-9952-8. Epub 2014 Apr 26.

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