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Analysis of 1- and 3-Phosphohistidine (pHis) Protein Modification Using Model Enzymes Expressed in Bacteria.

Clubbs Coldron AKM, Byrne DP, Eyers PA.

Methods Mol Biol. 2020;2077:63-81. doi: 10.1007/978-1-4939-9884-5_5.


Covalent Aurora A regulation by the metabolic integrator coenzyme A.

Tsuchiya Y, Byrne DP, Burgess SG, Bormann J, Baković J, Huang Y, Zhyvoloup A, Yu BYK, Peak-Chew S, Tran T, Bellany F, Tabor AB, Chan AE, Guruprasad L, Garifulin O, Filonenko V, Vonderach M, Ferries S, Eyers CE, Carroll J, Skehel M, Bayliss R, Eyers PA, Gout I.

Redox Biol. 2020 Jan;28:101318. doi: 10.1016/j.redox.2019.101318. Epub 2019 Sep 5.


Strong anion exchange-mediated phosphoproteomics reveals extensive human non-canonical phosphorylation.

Hardman G, Perkins S, Brownridge PJ, Clarke CJ, Byrne DP, Campbell AE, Kalyuzhnyy A, Myall A, Eyers PA, Jones AR, Eyers CE.

EMBO J. 2019 Oct 4;38(21):e100847. doi: 10.15252/embj.2018100847. Epub 2019 Aug 21.


Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.

Walden M, Tian L, Ross RL, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel J, George R, Ault JR, El Oualid F, Pawłowski K, Salvino JM, Eyers PA, Ranson NA, Del Galdo F, Greenberg RA, Zeqiraj E.

Nature. 2019 Jun;570(7760):194-199. doi: 10.1038/s41586-019-1232-1. Epub 2019 May 29.


Towards 20,20-difluorinated bryostatin: synthesis and biological evaluation of C17,C27-fragments.

Mears PR, Hoekman S, Rye CE, Bailey FP, Byrne DP, Eyers PA, Thomas EJ.

Org Biomol Chem. 2019 Feb 6;17(6):1487-1505. doi: 10.1039/c8ob03152e.


Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.

Foulkes DM, Byrne DP, Yeung W, Shrestha S, Bailey FP, Ferries S, Eyers CE, Keeshan K, Wells C, Drewry DH, Zuercher WJ, Kannan N, Eyers PA.

Sci Signal. 2018 Sep 25;11(549). pii: eaat7951. doi: 10.1126/scisignal.aat7951.


BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL.

Greaves G, Milani M, Butterworth M, Carter RJ, Byrne DP, Eyers PA, Luo X, Cohen GM, Varadarajan S.

Cell Death Differ. 2019 Jun;26(6):1037-1047. doi: 10.1038/s41418-018-0183-7. Epub 2018 Sep 5.


Circannual variability in adrenocorticotropic hormone responses to administration of thyrotropin-releasing hormone in clinically normal horses in Australia.

Byrne DP, Secombe CJ, Tan RHH, Perera DI, Watts SP, Wearn JG.

Vet J. 2018 Aug;238:58-62. doi: 10.1016/j.tvjl.2018.07.008. Epub 2018 Jul 19.


New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors.

Byrne DP, Li Y, Ramakrishnan K, Barsukov IL, Yates EA, Eyers CE, Papy-Garcia D, Chantepie S, Pagadala V, Liu J, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA.

Biochem J. 2018 Aug 14;475(15):2417-2433. doi: 10.1042/BCJ20180265.


New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors.

Byrne DP, Li Y, Ngamlert P, Ramakrishnan K, Eyers CE, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA.

Biochem J. 2018 Aug 14;475(15):2435-2455. doi: 10.1042/BCJ20180266.


DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor.

Vonderach M, Byrne DP, Barran PE, Eyers PA, Eyers CE.

J Am Soc Mass Spectrom. 2019 Jan;30(1):128-138. doi: 10.1007/s13361-018-1984-0. Epub 2018 Jun 5. Erratum in: J Am Soc Mass Spectrom. 2019 Feb 11;:. J Am Soc Mass Spectrom. 2019 Mar 1;30(3):561.


The Effect of Geographic Location on Circannual Adrenocorticotropic Hormone Plasma Concentrations in Horses in Australia.

Secombe CJ, Tan RHH, Perara DI, Byrne DP, Watts SP, Wearn JG.

J Vet Intern Med. 2017 Sep;31(5):1533-1540. doi: 10.1111/jvim.14782. Epub 2017 Jun 29.


Local protein kinase A action proceeds through intact holoenzymes.

Smith FD, Esseltine JL, Nygren PJ, Veesler D, Byrne DP, Vonderach M, Strashnov I, Eyers CE, Eyers PA, Langeberg LK, Scott JD.

Science. 2017 Jun 23;356(6344):1288-1293. doi: 10.1126/science.aaj1669.


YouTube provides poor information regarding anterior cruciate ligament injury and reconstruction.

Cassidy JT, Fitzgerald E, Cassidy ES, Cleary M, Byrne DP, Devitt BM, Baker JF.

Knee Surg Sports Traumatol Arthrosc. 2018 Mar;26(3):840-845. doi: 10.1007/s00167-017-4514-x. Epub 2017 Mar 17.


Scoliosis and the Social Media: Facebook as a Means of Information Exchange.

Ng JP, Tarazi N, Byrne DP, Baker JF, McCabe JP.

Spine Deform. 2017 Mar;5(2):102-108. doi: 10.1016/j.jspd.2016.11.003.


Pseudokinases: update on their functions and evaluation as new drug targets.

Byrne DP, Foulkes DM, Eyers PA.

Future Med Chem. 2017 Jan;9(2):245-265. doi: 10.4155/fmc-2016-0207. Epub 2017 Jan 18. Review.


DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis.

Milani M, Byrne DP, Greaves G, Butterworth M, Cohen GM, Eyers PA, Varadarajan S.

Cell Death Dis. 2017 Jan 12;8(1):e2552. doi: 10.1038/cddis.2016.485.


Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1).

Caron D, Byrne DP, Thebault P, Soulet D, Landry CR, Eyers PA, Elowe S.

Sci Signal. 2016 Dec 13;9(458):rs14.


KinView: a visual comparative sequence analysis tool for integrated kinome research.

McSkimming DI, Dastgheib S, Baffi TR, Byrne DP, Ferries S, Scott ST, Newton AC, Eyers CE, Kochut KJ, Eyers PA, Kannan N.

Mol Biosyst. 2016 Nov 15;12(12):3651-3665.


Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N.

PLoS Genet. 2016 Aug 11;12(8):e1006265. doi: 10.1371/journal.pgen.1006265. eCollection 2016 Aug.


cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry.

Byrne DP, Vonderach M, Ferries S, Brownridge PJ, Eyers CE, Eyers PA.

Biochem J. 2016 Oct 1;473(19):3159-75. doi: 10.1042/BCJ20160648. Epub 2016 Jul 21.


Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N.

PLoS Genet. 2016 Feb 29;12(2):e1005885. doi: 10.1371/journal.pgen.1005885. eCollection 2016 Feb. Erratum in: PLoS Genet. 2016 Aug;12(8):e1006265.


Correction: Pyocycanin, a Contributory Factor in Haem Acquisition and Virulence Enhancement of Porphyromonas gingivalis in the Lung.

Benedyk M, Byrne DP, Glowczyk I, Potempa J, Olczak M, Olczak T, Smalley JW.

PLoS One. 2016 Jan 25;11(1):e0148008. doi: 10.1371/journal.pone.0148008. eCollection 2016. No abstract available.


Tribbles pseudokinases: novel targets for chemical biology and drug discovery?

Foulkes DM, Byrne DP, Bailey FP, Eyers PA.

Biochem Soc Trans. 2015 Oct;43(5):1095-103. doi: 10.1042/BST20150109. Review.


Breakdown of albumin and haemalbumin by the cysteine protease interpain A, an albuminase of Prevotella intermedia.

Byrne DP, Manandhar SP, Potempa J, Smalley JW.

BMC Microbiol. 2015 Sep 24;15:185. doi: 10.1186/s12866-015-0516-3.


Comparison of four chondral repair techniques in the hip joint: a biomechanical study using a physiological human cadaveric model.

Cassar-Gheiti AJ, Byrne DP, Kavanagh E, Mulhall KJ.

Osteoarthritis Cartilage. 2015 Jun;23(6):1018-25. doi: 10.1016/j.joca.2015.02.012. Epub 2015 Feb 24.


Pyocyanina contributory factor in haem acquisition and virulence enhancement of Porphyromonas gingivalis in the lung [corrected].

Benedyk M, Byrne DP, Glowczyk I, Potempa J, Olczak M, Olczak T, Smalley JW.

PLoS One. 2015 Feb 23;10(2):e0118319. doi: 10.1371/journal.pone.0118319. eCollection 2015. Erratum in: PLoS One. 2016;11(1):e0148008.


2) Going for broke: targeting the human cancer pseudokinome.

Bailey FP, Byrne DP, McSkimming D, Kannan N, Eyers PA.

Biochem J. 2015 Feb 15;466(1):201. No abstract available.


The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner.

Bailey FP, Byrne DP, Oruganty K, Eyers CE, Novotny CJ, Shokat KM, Kannan N, Eyers PA.

Biochem J. 2015 Apr 1;467(1):47-62. doi: 10.1042/BJ20141441.


Going for broke: targeting the human cancer pseudokinome.

Bailey FP, Byrne DP, McSkimming D, Kannan N, Eyers PA.

Biochem J. 2015 Jan 15;465(2):195-211. doi: 10.1042/BJ20141060. Review. Erratum in: Biochem J. 2015 Feb 15;466(1):201.


The Oswestry Spinal Risk Index (OSRI): an external validation study.

Fleming C, Baker JF, O'Neill SC, Rowan FE, Byrne DP, Synnott K.

Eur Spine J. 2016 Jan;25(1):252-6. doi: 10.1007/s00586-014-3730-z. Epub 2014 Dec 25.


A quality analysis of internet-based information on common hand pathology.

Kelly M, Seoighe DM, Baker JF, Kennedy J, Byrne DP, O'Shea K.

J Plast Reconstr Aesthet Surg. 2015 Mar;68(3):441-2. doi: 10.1016/j.bjps.2014.10.033. Epub 2014 Oct 29. No abstract available.


Clinico-pathological analysis of renal cell carcinoma demonstrates decreasing tumour grade over a 17-year period.

Nason GJ, McGuire BB, Kelly ME, Murphy TM, Looney AT, Byrne DP, Mulvin DW, Galvin DJ, Quinlan DM, Lennon GM.

Can Urol Assoc J. 2014 Mar;8(3-4):125-32. doi: 10.5489/cuaj.1721.


Assessment of the quality and content of information on anterior cruciate ligament reconstruction on the internet.

Bruce-Brand RA, Baker JF, Byrne DP, Hogan NA, McCarthy T.

Arthroscopy. 2013 Jun;29(6):1095-100. doi: 10.1016/j.arthro.2013.02.007. Epub 2013 Apr 9.


Correction: Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif?

Byrne DP, Dart C, Rigden DJ.

PLoS One. 2013 Feb 25;8(2). doi: 10.1371/annotation/2c275a1b-2d36-4492-b36a-192bddf14f78. eCollection 2013.


Evaluating caveolin interactions: do proteins interact with the caveolin scaffolding domain through a widespread aromatic residue-rich motif?

Byrne DP, Dart C, Rigden DJ.

PLoS One. 2012;7(9):e44879. doi: 10.1371/journal.pone.0044879. Epub 2012 Sep 17. Erratum in: PLoS One. 2013 Feb 25;8(2):null.


Preliminary study of the feasibility and accuracy of percutaneous peri-acetabular screw insertion in a porcine model.

Cassar-Gheiti AJ, Dodds MK, Byrne DP, Mulhall KJ.

Injury. 2013 Feb;44(2):178-82. doi: 10.1016/j.injury.2012.09.003. Epub 2012 Sep 20.


Internet use by parents of children attending a dedicated scoliosis outpatient clinic.

Baker JF, Devitt BM, Lynch S, Green CJ, Byrne DP, Kiely PJ.

Eur Spine J. 2012 Oct;21(10):1972-7. doi: 10.1007/s00586-012-2429-2. Epub 2012 Jul 21.


Scoliosis-specific information on the internet: has the "information highway" led to better information provision?

Nason GJ, Baker JF, Byrne DP, Noel J, Moore D, Kiely PJ.

Spine (Phila Pa 1976). 2012 Oct 1;37(21):E1364-9.


Pravastatin suppresses matrix metalloproteinase expression and activity in human articular chondrocytes stimulated by interleukin-1β.

Baker JF, Walsh PM, Byrne DP, Mulhall KJ.

J Orthop Traumatol. 2012 Sep;13(3):119-23. doi: 10.1007/s10195-012-0200-4. Epub 2012 Jun 9.


Analgesic control and functional outcome after knee arthroscopy: results of a randomized double-blinded trial comparing a hyaluronic acid supplement with bupivacaine.

Baker JF, Solayar GN, Byrne DP, Moran R, Mulhall KJ.

Clin J Sport Med. 2012 Mar;22(2):109-15. doi: 10.1097/JSM.0b013e318240e123.


The 25 most cited articles in arthroscopic orthopaedic surgery.

Cassar Gheiti AJ, Downey RE, Byrne DP, Molony DC, Mulhall KJ.

Arthroscopy. 2012 Apr;28(4):548-64. doi: 10.1016/j.arthro.2011.08.312. Epub 2012 Jan 20.


Can a periarticular levobupivacaine injection reduce postoperative opiate consumption during primary hip arthroplasty?

Murphy TP, Byrne DP, Curtin P, Baker JF, Mulhall KJ.

Clin Orthop Relat Res. 2012 Apr;470(4):1151-7. doi: 10.1007/s11999-011-2108-3. Epub 2011 Sep 30.


Diagnostic accuracy of magnetic resonance imaging and magnetic resonance arthrography of the hip is dependent on specialist training of the radiologist.

McGuire CM, MacMahon P, Byrne DP, Kavanagh E, Mulhall KJ.

Skeletal Radiol. 2012 Jun;41(6):659-65. doi: 10.1007/s00256-011-1266-4. Epub 2011 Sep 14.


Analgesic control after hip arthroscopy: a randomised, double-blinded trial comparing portal with intra-articular infiltration of bupivacaine.

Baker JF, McGuire CM, Byrne DP, Hunter K, Eustace N, Mulhall KJ.

Hip Int. 2011 May-Jun;21(3):373-7. doi: 10.5301/HIP.2011.8390. Epub 2011 Jun 7.


Review article: Osteochondral reconstruction and grafting.

Magill P, Byrne DP, Baker JF, Mulhall KJ.

J Orthop Surg (Hong Kong). 2011 Apr;19(1):93-8. Review.


Simulation of fracture healing in the tibia: mechanoregulation of cell activity using a lattice modeling approach.

Byrne DP, Lacroix D, Prendergast PJ.

J Orthop Res. 2011 Oct;29(10):1496-503. doi: 10.1002/jor.21362. Epub 2011 Apr 1.


HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis.

Smalley JW, Byrne DP, Birss AJ, Wojtowicz H, Sroka A, Potempa J, Olczak T.

PLoS One. 2011 Feb 17;6(2):e17182. doi: 10.1371/journal.pone.0017182. Erratum in: PLoS One. 2011;6(3). doi: 10.1371/annotation/8658727f-cc10-47ba-9c7e-8726f1f94b91. PLoS One. 2011;6(3). doi: 10.1371/annotation/919737a1-a459-4949-87ab-9fc56023a4cc.


In vitro assessment of human chondrocyte viability after treatment with local anaesthetic, magnesium sulphate or normal saline.

Baker JF, Walsh PM, Byrne DP, Mulhall KJ.

Knee Surg Sports Traumatol Arthrosc. 2011 Jun;19(6):1043-6. doi: 10.1007/s00167-011-1437-9. Epub 2011 Feb 18.


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