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Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.

Sammak S, Hamdani N, Gorrec F, Allen MD, Freund SMV, Bycroft M, Zinzalla G.

Biochemistry. 2019 Jul 23;58(29):3144-3154. doi: 10.1021/acs.biochem.9b00296. Epub 2019 Jul 11.


The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex.

Sammak S, Allen MD, Hamdani N, Bycroft M, Zinzalla G.

FEBS J. 2018 Nov;285(22):4165-4180. doi: 10.1111/febs.14660. Epub 2018 Oct 1.


Iatrochemistry and the Evaluation of Mineral Waters in France, 1600-1750.

Bycroft M.

Bull Hist Med. 2017;91(2):303-330. doi: 10.1353/bhm.2017.0028.


Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy.

Thurston TL, Boyle KB, Allen M, Ravenhill BJ, Karpiyevich M, Bloor S, Kaul A, Noad J, Foeglein A, Matthews SA, Komander D, Bycroft M, Randow F.

EMBO J. 2016 Aug 15;35(16):1779-92. doi: 10.15252/embj.201694491. Epub 2016 Jul 1.


High-resolution NMR structures of the domains of Saccharomyces cerevisiae Tho1.

Jacobsen JO, Allen MD, Freund SM, Bycroft M.

Acta Crystallogr F Struct Biol Commun. 2016 Jun;72(Pt 6):500-6. doi: 10.1107/S2053230X16007597. Epub 2016 May 23.


Correction: The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.

Tumbarello DA, Manna PT, Allen M, Bycroft M, Arden SD, Kendrick-Jones J, Buss F.

PLoS Pathog. 2016 Jan 28;12(1):e1005433. doi: 10.1371/journal.ppat.1005433. eCollection 2016 Jan.


The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.

Tumbarello DA, Manna PT, Allen M, Bycroft M, Arden SD, Kendrick-Jones J, Buss F.

PLoS Pathog. 2015 Oct 9;11(10):e1005174. doi: 10.1371/journal.ppat.1005174. eCollection 2015 Oct. Erratum in: PLoS Pathog. 2016 Jan;12(1):e1005433.


The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.

Allen MD, Freund SM, Zinzalla G, Bycroft M.

Structure. 2015 Jul 7;23(7):1344-9. doi: 10.1016/j.str.2015.04.021. Epub 2015 Jun 11.


Solution structure of a soluble fragment derived from a membrane protein by shotgun proteolysis.

Allen MD, Christie M, Jones P, Porebski BT, Roome B, Freund SM, Buckle AM, Bycroft M, Christ D.

Protein Eng Des Sel. 2015 Oct;28(10):445-50. doi: 10.1093/protein/gzv021. Epub 2015 Apr 15.


A high-resolution structure of the EF-hand domain of human polycystin-2.

Allen MD, Qamar S, Vadivelu MK, Sandford RN, Bycroft M.

Protein Sci. 2014 Sep;23(9):1301-8. doi: 10.1002/pro.2513. Epub 2014 Jul 22.


An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma.

Gossage L, Pires DE, Olivera-Nappa Á, Asenjo J, Bycroft M, Blundell TL, Eisen T.

Hum Mol Genet. 2014 Nov 15;23(22):5976-88. doi: 10.1093/hmg/ddu321. Epub 2014 Jun 26.


Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.

Wolf J, Valkov E, Allen MD, Meineke B, Gordiyenko Y, McLaughlin SH, Olsen TM, Robinson CV, Bycroft M, Stewart M, Passmore LA.

EMBO J. 2014 Jul 17;33(14):1514-26. doi: 10.15252/embj.201488373. Epub 2014 May 28.


The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.

Agromayor M, Soler N, Caballe A, Kueck T, Freund SM, Allen MD, Bycroft M, Perisic O, Ye Y, McDonald B, Scheel H, Hofmann K, Neil SJ, Martin-Serrano J, Williams RL.

Structure. 2012 Mar 7;20(3):414-28. doi: 10.1016/j.str.2011.12.013.


Recognition of non-methyl histone marks.

Bycroft M.

Curr Opin Struct Biol. 2011 Dec;21(6):761-6. doi: 10.1016/ Epub 2011 Oct 24. Review.


The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors.

Stapf C, Cartwright E, Bycroft M, Hofmann K, Buchberger A.

J Biol Chem. 2011 Nov 4;286(44):38670-8. doi: 10.1074/jbc.M111.274472. Epub 2011 Sep 6.


Structural basis of p63α SAM domain mutants involved in AEC syndrome.

Sathyamurthy A, Freund SM, Johnson CM, Allen MD, Bycroft M.

FEBS J. 2011 Aug;278(15):2680-8. doi: 10.1111/j.1742-4658.2011.08194.x. Epub 2011 Jun 20.


The structure of the FYR domain of transforming growth factor beta regulator 1.

García-Alai MM, Allen MD, Joerger AC, Bycroft M.

Protein Sci. 2010 Jul;19(7):1432-8. doi: 10.1002/pro.404.


The trials of theory: psychology and institutionalist economics, 1910-1931.

Bycroft M.

J Hist Behav Sci. 2010 Spring;46(2):144-64. doi: 10.1002/jhbs.20423.


Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.

Vezzoli A, Bonadies N, Allen MD, Freund SM, Santiveri CM, Kvinlaug BT, Huntly BJ, Göttgens B, Bycroft M.

Nat Struct Mol Biol. 2010 May;17(5):617-9. doi: 10.1038/nsmb.1797. Epub 2010 Apr 18.


Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2.

Teufel DP, Bycroft M, Fersht AR.

Oncogene. 2009 May 21;28(20):2112-8. doi: 10.1038/onc.2009.71. Epub 2009 Apr 13.


Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2.

Lechtenberg BC, Allen MD, Rutherford TJ, Freund SM, Bycroft M.

Protein Sci. 2009 Mar;18(3):657-61. doi: 10.1002/pro.51.


VHL mutations linked to type 2C von Hippel-Lindau disease cause extensive structural perturbations in pVHL.

Knauth K, Cartwright E, Freund S, Bycroft M, Buchberger A.

J Biol Chem. 2009 Apr 17;284(16):10514-22. doi: 10.1074/jbc.M809056200. Epub 2009 Feb 19.


Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation.

Burge S, Teufel DP, Townsley FM, Freund SM, Bycroft M, Fersht AR.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3142-7. doi: 10.1073/pnas.0900383106. Epub 2009 Feb 13.


The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine.

Santiveri CM, Lechtenberg BC, Allen MD, Sathyamurthy A, Jaulent AM, Freund SM, Bycroft M.

J Mol Biol. 2008 Oct 24;382(5):1107-12. doi: 10.1016/j.jmb.2008.07.081. Epub 2008 Aug 3.


Structural consequences of nucleophosmin mutations in acute myeloid leukemia.

Grummitt CG, Townsley FM, Johnson CM, Warren AJ, Bycroft M.

J Biol Chem. 2008 Aug 22;283(34):23326-32. doi: 10.1074/jbc.M801706200. Epub 2008 May 29.


The solution structure of the ZnF UBP domain of USP33/VDU1.

Allen MD, Bycroft M.

Protein Sci. 2007 Sep;16(9):2072-5.


Solution structure of the BRK domains from CHD7.

Allen MD, Religa TL, Freund SM, Bycroft M.

J Mol Biol. 2007 Aug 31;371(5):1135-40. Epub 2007 Jun 9.


Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53.

Teufel DP, Freund SM, Bycroft M, Fersht AR.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7009-14. Epub 2007 Apr 16.


The FtsK gamma domain directs oriented DNA translocation by interacting with KOPS.

Sivanathan V, Allen MD, de Bekker C, Baker R, Arciszewska LK, Freund SM, Bycroft M, Löwe J, Sherratt DJ.

Nat Struct Mol Biol. 2006 Nov;13(11):965-72. Epub 2006 Oct 22.


Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase.

Allen MD, Grummitt CG, Hilcenko C, Min SY, Tonkin LM, Johnson CM, Freund SM, Bycroft M, Warren AJ.

EMBO J. 2006 Oct 4;25(19):4503-12. Epub 2006 Sep 21.


The PUB domain functions as a p97 binding module in human peptide N-glycanase.

Allen MD, Buchberger A, Bycroft M.

J Biol Chem. 2006 Sep 1;281(35):25502-8. Epub 2006 Jun 28.


Solution structure of the C4 zinc finger domain of HDM2.

Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M.

Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29.


Functional analysis of the post-transcriptional regulator RsmA reveals a novel RNA-binding site.

Heeb S, Kuehne SA, Bycroft M, Crivii S, Allen MD, Haas D, Cámara M, Williams P.

J Mol Biol. 2006 Feb 3;355(5):1026-36. Epub 2005 Dec 1.


The macro domain is an ADP-ribose binding module.

Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG.

EMBO J. 2005 Jun 1;24(11):1911-20. Epub 2005 May 19.


Comparative binding of p53 to its promoter and DNA recognition elements.

Weinberg RL, Veprintsev DB, Bycroft M, Fersht AR.

J Mol Biol. 2005 May 6;348(3):589-96.


Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins.

Seeliger MA, Spichty M, Kelly SE, Bycroft M, Freund SM, Karplus M, Itzhaki LS.

J Biol Chem. 2005 Aug 26;280(34):30448-59. Epub 2005 Mar 16.


Solution structure of the HPV-16 E2 DNA binding domain, a transcriptional regulator with a dimeric beta-barrel fold.

Nadra AD, Eliseo T, Mok YK, Almeida CL, Bycroft M, Paci M, de Prat-Gay G, Cicero DO.

J Biomol NMR. 2004 Oct;30(2):211-4. No abstract available.


Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain.

Dodd RB, Allen MD, Brown SE, Sanderson CM, Duncan LM, Lehner PJ, Bycroft M, Read RJ.

J Biol Chem. 2004 Dec 17;279(51):53840-7. Epub 2004 Sep 30.


Regulation of DNA binding of p53 by its C-terminal domain.

Weinberg RL, Freund SM, Veprintsev DB, Bycroft M, Fersht AR.

J Mol Biol. 2004 Sep 17;342(3):801-11.


Crystallization and preliminary crystallographic analysis of an acylphosphatase from the hyperthermophilic archaeon Pyrococcus horikoshii.

Cheung YY, Allen MD, Bycroft M, Wong KB.

Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1308-10. Epub 2004 Jun 22.


NMR structure of the alpha-hemoglobin stabilizing protein: insights into conformational heterogeneity and binding.

Santiveri CM, Pérez-Cañadillas JM, Vadivelu MK, Allen MD, Rutherford TJ, Watkins NA, Bycroft M.

J Biol Chem. 2004 Aug 13;279(33):34963-70. Epub 2004 Jun 3.


Application of thermophilic enzymes in commercial biotransformation processes.

Taylor IN, Brown RC, Bycroft M, King G, Littlechild JA, Lloyd MC, Praquin C, Toogood HS, Taylor SJ.

Biochem Soc Trans. 2004 Apr;32(Pt 2):290-2.


Crystallization and preliminary crystallographic analysis of a novel orange fluorescent protein from the Cnidaria tube anemone Cerianthus sp.

Ip DT, Chan SH, Allen MD, Bycroft M, Wan DC, Wong KB.

Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):340-1. Epub 2004 Jan 23.


The structure of the AXH domain of spinocerebellar ataxin-1.

Chen YW, Allen MD, Veprintsev DB, Löwe J, Bycroft M.

J Biol Chem. 2004 Jan 30;279(5):3758-65. Epub 2003 Oct 28.


Structure of the Jab1/MPN domain and its implications for proteasome function.

Tran HJ, Allen MD, Löwe J, Bycroft M.

Biochemistry. 2003 Oct 7;42(39):11460-5.


Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2).

Sathyamurthy A, Allen MD, Murzin AG, Bycroft M.

J Biol Chem. 2003 Nov 21;278(47):46968-73. Epub 2003 Sep 1.


Structural variation in PWWP domains.

Slater LM, Allen MD, Bycroft M.

J Mol Biol. 2003 Jul 11;330(3):571-6.


The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A.

Allen MD, Buckle AM, Cordell SC, Löwe J, Bycroft M.

J Mol Biol. 2003 Jul 11;330(3):503-11.


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