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Items: 1 to 50 of 71

1.

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype.

Malhotra R, Mauer AC, Lino Cardenas CL, Guo X, Yao J, Zhang X, Wunderer F, Smith AV, Wong Q, Pechlivanis S, Hwang SJ, Wang J, Lu L, Nicholson CJ, Shelton G, Buswell MD, Barnes HJ, Sigurslid HH, Slocum C, Rourke CO, Rhee DK, Bagchi A, Nigwekar SU, Buys ES, Campbell CY, Harris T, Budoff M, Criqui MH, Rotter JI, Johnson AD, Song C, Franceschini N, Debette S, Hoffmann U, Kälsch H, Nöthen MM, Sigurdsson S, Freedman BI, Bowden DW, Jöckel KH, Moebus S, Erbel R, Feitosa MF, Gudnason V, Thanassoulis G, Zapol WM, Lindsay ME, Bloch DB, Post WS, O'Donnell CJ.

Nat Genet. 2019 Nov;51(11):1580-1587. doi: 10.1038/s41588-019-0514-8. Epub 2019 Oct 28.

PMID:
31659325
2.

The soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end-organ damage in the Dahl model of cardiorenal failure.

Shea CM, Price GM, Liu G, Sarno R, Buys ES, Currie MG, Masferrer JL.

Am J Physiol Renal Physiol. 2019 Oct 14. doi: 10.1152/ajprenal.00247.2019. [Epub ahead of print]

3.

Blood Pressure-Associated Genetic Variants in the Natriuretic Peptide Receptor 1 Gene Modulate Guanylate Cyclase Activity.

Vandenwijngaert S, Ledsky CD, Lahrouchi N, Khan MAF, Wunderer F, Ames L, Honda T, Diener JL, Bezzina CR, Buys ES, Bloch DB, Newton-Cheh C; CHARGE+ Exome Chip Blood Pressure Consortium, the CHD Exome+ Consortium, the Exome BP Consortium, the GoT2D Consortium, the T2D-GENES Consortium and the UK Biobank CardioMetabolic Consortium BP Working Group.

Circ Genom Precis Med. 2019 Aug;12(8):e002472. doi: 10.1161/CIRCGEN.119.002472. Epub 2019 Aug 20.

PMID:
31430210
4.

cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice.

Shvedova M, Litvak MM, Roberts JD Jr, Fukumura D, Suzuki T, Şencan İ, Li G, Reventun P, Buys ES, Kim HH, Sakadžić S, Ayata C, Huang PL, Feil R, Atochin DN.

J Cereb Blood Flow Metab. 2019 Dec;39(12):2379-2391. doi: 10.1177/0271678X19870583. Epub 2019 Aug 18.

PMID:
31423931
5.

Low guanylyl cyclase activity in Weddell seals: implications for peripheral vasoconstriction and perfusion of the brain during diving.

Hindle AG, Allen KN, Batten AJ, Hückstädt LA, Turner-Maier J, Schulberg SA, Johnson J, Karlsson E, Lindblad-Toh K, Costa DP, Bloch DB, Zapol WM, Buys ES.

Am J Physiol Regul Integr Comp Physiol. 2019 Jun 1;316(6):R704-R715. doi: 10.1152/ajpregu.00283.2018. Epub 2019 Mar 20.

PMID:
30892912
6.

Identification of Candidate miRNA Biomarkers for Glaucoma.

Hindle AG, Thoonen R, Jasien JV, Grange RMH, Amin K, Wise J, Ozaki M, Ritch R, Malhotra R, Buys ES.

Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):134-146. doi: 10.1167/iovs.18-24878.

7.

Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease.

Chen X, Umeh CC, Tainsh RE, Feng DD, Maguire M, Zuo F, Rahimian M, Logan R, Wang X, Ascherio A, Macklin EA, Buys ES, Schwarzschild MA; Parkinson Study Group (PSG) The Safety of Urate Elevation in Parkinson's Disease (SURE-PD) investigators.

EBioMedicine. 2018 Nov;37:259-268. doi: 10.1016/j.ebiom.2018.10.039. Epub 2018 Nov 8.

8.

Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration.

Wareham LK, Dordea AC, Schleifer G, Yao V, Batten A, Fei F, Mertz J, Gregory-Ksander M, Pasquale LR, Buys ES, Sappington RM.

Neurobiol Dis. 2019 Jan;121:65-75. doi: 10.1016/j.nbd.2018.09.002. Epub 2018 Sep 10.

PMID:
30213732
9.

Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential.

Buys ES, Zimmer DP, Chickering J, Graul R, Chien YT, Profy A, Hadcock JR, Masferrer JL, Milne GT.

Nitric Oxide. 2018 Aug 1;78:72-80. doi: 10.1016/j.niox.2018.05.009. Epub 2018 May 31. Review.

10.

Intrinsic anti-inflammatory properties in the serum of two species of deep-diving seal.

Bagchi A, Batten AJ, Levin M, Allen KN, Fitzgerald ML, Hückstädt LA, Costa DP, Buys ES, Hindle AG.

J Exp Biol. 2018 Jul 9;221(Pt 13). pii: jeb178491. doi: 10.1242/jeb.178491.

11.

The nitric oxide-guanylate cyclase pathway and glaucoma.

Wareham LK, Buys ES, Sappington RM.

Nitric Oxide. 2018 Jul 1;77:75-87. doi: 10.1016/j.niox.2018.04.010. Epub 2018 May 1. Review.

12.

MicroRNA-425 and microRNA-155 cooperatively regulate atrial natriuretic peptide expression and cGMP production.

Vandenwijngaert S, Ledsky CD, Agha O, Wu C, Hu D, Bagchi A, Domian IJ, Buys ES, Newton-Cheh C, Bloch DB.

PLoS One. 2018 Apr 26;13(4):e0196697. doi: 10.1371/journal.pone.0196697. eCollection 2018.

13.

Increased Circulating FGF23 Does Not Lead to Cardiac Hypertrophy in the Male Hyp Mouse Model of XLH.

Liu ES, Thoonen R, Petit E, Yu B, Buys ES, Scherrer-Crosbie M, Demay MB.

Endocrinology. 2018 May 1;159(5):2165-2172. doi: 10.1210/en.2018-00174.

14.

The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase.

Muenster S, Lieb WS, Fabry G, Allen KN, Kamat SS, Guy AH, Dordea AC, Teixeira L, Tainsh RE, Yu B, Zhu W, Ashpole NE, Malhotra R, Brouckaert P, Bloch DB, Scherrer-Crosbie M, Stamer WD, Kuehn MH, Pasquale LR, Buys ES.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4826-4835. doi: 10.1167/iovs.17-22168.

15.

Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha.

Nagasaka Y, Wepler M, Thoonen R, Sips PY, Allen K, Graw JA, Yao V, Burns SM, Muenster S, Brouckaert P, Miller K, Solt K, Buys ES, Ichinose F, Zapol WM.

BMC Anesthesiol. 2017 Jun 14;17(1):76. doi: 10.1186/s12871-017-0368-5.

16.

Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension.

Graw JA, Yu B, Rezoagli E, Warren HS, Buys ES, Bloch DB, Zapol WM.

Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1120-H1127. doi: 10.1152/ajpheart.00851.2016. Epub 2017 Mar 17.

17.

Erectile Dysfunction in Heme-Deficient Nitric Oxide-Unresponsive Soluble Guanylate Cyclase Knock-In Mice.

Decaluwé K, Pauwels B, Boydens C, Thoonen R, Buys ES, Brouckaert P, Van de Voorde J.

J Sex Med. 2017 Feb;14(2):196-204. doi: 10.1016/j.jsxm.2016.12.007.

PMID:
28161078
18.

Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge.

Wepler M, Beloiartsev A, Buswell MD, Panigrahy D, Malhotra R, Buys ES, Radermacher P, Ichinose F, Bloch DB, Zapol WM.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1213-L1221. doi: 10.1152/ajplung.00394.2016. Epub 2016 Nov 4.

19.

Decreased Soluble Guanylate Cyclase Contributes to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice.

Vandenwijngaert S, Swinnen M, Walravens AS, Beerens M, Gillijns H, Caluwé E, Tainsh RE, Nathan DI, Allen K, Brouckaert P, Bartunek J, Scherrer-Crosbie M, Bloch KD, Bloch DB, Janssens SP, Buys ES.

Antioxid Redox Signal. 2017 Feb 1;26(4):153-164. doi: 10.1089/ars.2015.6542. Epub 2016 Sep 8.

20.

GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity.

Moon Y, Cao Y, Zhu J, Xu Y, Balkan W, Buys ES, Diaz F, Kerrick WG, Hare JM, Percival JM.

Antioxid Redox Signal. 2017 Feb 1;26(4):165-181. doi: 10.1089/ars.2015.6548. Epub 2016 Aug 19.

21.

Distinct Myocardial Mechanisms Underlie Cardiac Dysfunction in Endotoxemic Male and Female Mice.

Hobai IA, Aziz K, Buys ES, Brouckaert P, Siwik DA, Colucci WS.

Shock. 2016 Dec;46(6):713-722.

22.

Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms.

Moon Y, Balke JE, Madorma D, Siegel MP, Knowels G, Brouckaert P, Buys ES, Marcinek DJ, Percival JM.

Antioxid Redox Signal. 2017 Jun 10;26(17):966-985. doi: 10.1089/ars.2016.6630. Epub 2016 Aug 17. Review.

23.

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation.

O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R.

J Vis Exp. 2016 May 31;(111). doi: 10.3791/54017.

24.

Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE.

Dordea AC, Vandenwijngaert S, Garcia V, Tainsh RE, Nathan DI, Allen K, Raher MJ, Tainsh LT, Zhang F, Lieb WS, Mikelman S, Kirby A, Stevens C, Thoonen R, Hindle AG, Sips PY, Falck JR, Daly MJ, Brouckaert P, Bloch KD, Bloch DB, Malhotra R, Schwartzman ML, Buys ES.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1790-800. doi: 10.1152/ajpheart.00877.2015. Epub 2016 May 3.

25.

Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production.

Wu C, Arora P, Agha O, Hurst LA, Allen K, Nathan DI, Hu D, Jiramongkolchai P, Smith JG, Melander O, Trenson S, Janssens SP, Domian I, Wang TJ, Bloch KD, Buys ES, Bloch DB, Newton-Cheh C.

Mol Cell Biol. 2016 Jun 29;36(14):1977-87. doi: 10.1128/MCB.01114-15. Print 2016 Jul 15.

26.

An open-source computational tool to automatically quantify immunolabeled retinal ganglion cells.

Dordea AC, Bray MA, Allen K, Logan DJ, Fei F, Malhotra R, Gregory MS, Carpenter AE, Buys ES.

Exp Eye Res. 2016 Jun;147:50-56. doi: 10.1016/j.exer.2016.04.012. Epub 2016 Apr 24.

27.

Acute Metabolic Influences on the Natriuretic Peptide System in Humans.

Arora P, Wu C, Hamid T, Arora G, Agha O, Allen K, Tainsh RET, Hu D, Ryan RA, Domian IJ, Buys ES, Bloch DB, Prabhu SD, Bloch KD, Newton-Cheh C, Wang TJ.

J Am Coll Cardiol. 2016 Feb 23;67(7):804-812. doi: 10.1016/j.jacc.2015.11.049.

28.

BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy.

Shahid M, Spagnolli E, Ernande L, Thoonen R, Kolodziej SA, Leyton PA, Cheng J, Tainsh RE, Mayeur C, Rhee DK, Wu MX, Scherrer-Crosbie M, Buys ES, Zapol WM, Bloch KD, Bloch DB.

Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.

29.

Relationship of brown adipose tissue perfusion and function: a study through β2-adrenoreceptor stimulation.

Ernande L, Stanford KI, Thoonen R, Zhang H, Clerte M, Hirshman MF, Goodyear LJ, Bloch KD, Buys ES, Scherrer-Crosbie M.

J Appl Physiol (1985). 2016 Apr 15;120(8):825-32. doi: 10.1152/japplphysiol.00634.2015. Epub 2016 Jan 28.

30.

Regulation of B-type natriuretic peptide synthesis by insulin in obesity in male mice.

Zhang H, Thoonen R, Yao V, Buys ES, Popovich J, Su YR, Wang TJ, Scherrer-Crosbie M.

Exp Physiol. 2016 Jan;101(1):113-23. doi: 10.1113/EP085091. Epub 2015 Nov 18.

31.

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.

Thoonen R, Cauwels A, Decaluwe K, Geschka S, Tainsh RE, Delanghe J, Hochepied T, De Cauwer L, Rogge E, Voet S, Sips P, Karas RH, Bloch KD, Vuylsteke M, Stasch JP, Van de Voorde J, Buys ES, Brouckaert P.

Nat Commun. 2015 Oct 7;6:8482. doi: 10.1038/ncomms9482.

32.

Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy.

Thoonen R, Ernande L, Cheng J, Nagasaka Y, Yao V, Miranda-Bezerra A, Chen C, Chao W, Panagia M, Sosnovik DE, Puppala D, Armoundas AA, Hindle A, Bloch KD, Buys ES, Scherrer-Crosbie M.

J Mol Cell Cardiol. 2015 Jul;84:202-11. doi: 10.1016/j.yjmcc.2015.05.002. Epub 2015 May 9.

33.

Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency.

Malhotra R, Burke MF, Martyn T, Shakartzi HR, Thayer TE, O'Rourke C, Li P, Derwall M, Spagnolli E, Kolodziej SA, Hoeft K, Mayeur C, Jiramongkolchai P, Kumar R, Buys ES, Yu PB, Bloch KD, Bloch DB.

PLoS One. 2015 Jan 20;10(1):e0117098. doi: 10.1371/journal.pone.0117098. eCollection 2015.

34.

Weight loss, saline loading, and the natriuretic peptide system.

Arora P, Reingold J, Baggish A, Guanaga DP, Wu C, Ghorbani A, Song Y, Chen-Tournaux A, Khan AM, Tainsh LT, Buys ES, Williams JS, Heublein DM, Burnett JC, Semigran MJ, Bloch KD, Scherrer-Crosbie M, Newton-Cheh C, Kaplan LM, Wang TJ.

J Am Heart Assoc. 2015 Jan 16;4(1):e001265. doi: 10.1161/JAHA.114.001265.

35.

Effect of phosphodiesterase inhibition on insulin resistance in obese individuals.

Ho JE, Arora P, Walford GA, Ghorbani A, Guanaga DP, Dhakal BP, Nathan DI, Buys ES, Florez JC, Newton-Cheh C, Lewis GD, Wang TJ.

J Am Heart Assoc. 2014 Sep 11;3(5):e001001. doi: 10.1161/JAHA.114.001001.

36.

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma.

Buys ES, Potter LR, Pasquale LR, Ksander BR.

Front Mol Neurosci. 2014 May 19;7:38. doi: 10.3389/fnmol.2014.00038. eCollection 2014. Review.

37.

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma.

Kang JH, Loomis SJ, Yaspan BL, Bailey JC, Weinreb RN, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Gaasterland D, Gaasterland T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Forman JP, Buys ES, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Wiggs JL, Pasquale LR.

Eye (Lond). 2014 Jun;28(6):662-71. doi: 10.1038/eye.2014.42. Epub 2014 Mar 7.

38.

Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons.

Mandal S, Stanco A, Buys ES, Enikolopov G, Rubenstein JL.

J Neurosci. 2013 Oct 23;33(43):16897-914. doi: 10.1523/JNEUROSCI.1871-13.2013.

39.

Brown adipose tissue blood flow and mass in obesity: a contrast ultrasound study in mice.

Clerte M, Baron DM, Brouckaert P, Ernande L, Raher MJ, Flynn AW, Picard MH, Bloch KD, Buys ES, Scherrer-Crosbie M.

J Am Soc Echocardiogr. 2013 Dec;26(12):1465-73. doi: 10.1016/j.echo.2013.07.015. Epub 2013 Aug 28.

40.

Soluble guanylate cyclase modulates alveolarization in the newborn lung.

Bachiller PR, Cornog KH, Kato R, Buys ES, Roberts JD Jr.

Am J Physiol Lung Cell Mol Physiol. 2013 Oct 15;305(8):L569-81. doi: 10.1152/ajplung.00401.2012. Epub 2013 Aug 9.

41.

SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis.

Hobai IA, Buys ES, Morse JC, Edgecomb J, Weiss EH, Armoundas AA, Hou X, Khandelwal AR, Siwik DA, Brouckaert P, Cohen RA, Colucci WS.

Am J Physiol Heart Circ Physiol. 2013 Oct 15;305(8):H1189-200. doi: 10.1152/ajpheart.00392.2012. Epub 2013 Aug 9.

42.

Atrial natriuretic peptide is negatively regulated by microRNA-425.

Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ.

J Clin Invest. 2013 Aug;123(8):3378-82. doi: 10.1172/JCI67383. Epub 2013 Jul 15.

43.

Assessing murine resistance artery function using pressure myography.

Shahid M, Buys ES.

J Vis Exp. 2013 Jun 7;(76). doi: 10.3791/50328.

44.

Genetic modification of hypertension by sGCα1.

Sips PY, Buys ES.

Trends Cardiovasc Med. 2013 Nov;23(8):312-8. doi: 10.1016/j.tcm.2013.05.001. Epub 2013 Jun 5. Review.

45.

Heme deficiency of soluble guanylate cyclase induces gastroparesis.

Cosyns SM, Dhaese I, Thoonen R, Buys ES, Vral A, Brouckaert P, Lefebvre RA.

Neurogastroenterol Motil. 2013 May;25(5):e339-52. doi: 10.1111/nmo.12120. Epub 2013 Mar 28.

46.

Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma.

Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte' M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR.

Ann Neurosci. 2013 Apr;20(2):65-6. doi: 10.5214/ans.0972.7531.200207. No abstract available.

47.

Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma.

Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerté M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR.

PLoS One. 2013;8(3):e60156. doi: 10.1371/journal.pone.0060156. Epub 2013 Mar 20.

48.

Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling.

Thoonen R, Sips PY, Bloch KD, Buys ES.

Curr Hypertens Rep. 2013 Feb;15(1):47-58. doi: 10.1007/s11906-012-0320-5.

49.

In vivo noninvasive characterization of brown adipose tissue blood flow by contrast ultrasound in mice.

Baron DM, Clerte M, Brouckaert P, Raher MJ, Flynn AW, Zhang H, Carter EA, Picard MH, Bloch KD, Buys ES, Scherrer-Crosbie M.

Circ Cardiovasc Imaging. 2012 Sep 1;5(5):652-9. Epub 2012 Jul 9.

50.

Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice.

Buys ES, Raher MJ, Kirby A, Shahid M, Baron DM, Hayton SR, Tainsh LT, Sips PY, Rauwerdink KM, Yan Q, Tainsh RE, Shakartzi HR, Stevens C, Decaluwé K, Rodrigues-Machado Mda G, Malhotra R, Van de Voorde J, Wang T, Brouckaert P, Daly MJ, Bloch KD.

J Clin Invest. 2012 Jun;122(6):2316-25. doi: 10.1172/JCI60119. Epub 2012 May 8. Erratum in: J Clin Invest. 2012 Aug 1;122(8):3024. Mohd, Shahid [corrected to Shahid, Mohd].

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