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Structure of a Wbl protein and implications for NO sensing by M. tuberculosis.

Kudhair BK, Hounslow AM, Rolfe MD, Crack JC, Hunt DM, Buxton RS, Smith LJ, Le Brun NE, Williamson MP, Green J.

Nat Commun. 2017 Dec 22;8(1):2280. doi: 10.1038/s41467-017-02418-y.


Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence.

Smith LJ, Bochkareva A, Rolfe MD, Hunt DM, Kahramanoglou C, Braun Y, Rodgers A, Blockley A, Coade S, Lougheed KEA, Hafneh NA, Glenn SM, Crack JC, Le Brun NE, Saldanha JW, Makarov V, Nobeli I, Arnvig K, Mukamolova GV, Buxton RS, Green J.

Nucleic Acids Res. 2017 Jun 20;45(11):6600-6612. doi: 10.1093/nar/gkx406.


Novel regulatory roles of cAMP receptor proteins in fast-growing environmental mycobacteria.

Aung HL, Dixon LL, Smith LJ, Sweeney NP, Robson JR, Berney M, Buxton RS, Green J, Cook GM.

Microbiology. 2015 Mar;161(Pt 3):648-61. doi: 10.1099/mic.0.000015. Epub 2014 Dec 18.


Genomic mapping of cAMP receptor protein (CRP Mt) in Mycobacterium tuberculosis: relation to transcriptional start sites and the role of CRPMt as a transcription factor.

Kahramanoglou C, Cortes T, Matange N, Hunt DM, Visweswariah SS, Young DB, Buxton RS.

Nucleic Acids Res. 2014 Jul;42(13):8320-9. doi: 10.1093/nar/gku548. Epub 2014 Jun 23.


Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches.

Green J, Stapleton MR, Smith LJ, Artymiuk PJ, Kahramanoglou C, Hunt DM, Buxton RS.

Curr Opin Microbiol. 2014 Apr;18:1-7. doi: 10.1016/j.mib.2014.01.003. Epub 2014 Feb 7. Review.


Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA.

Schuessler DL, Cortes T, Fivian-Hughes AS, Lougheed KE, Harvey E, Buxton RS, Davis EO, Young DB.

Mol Microbiol. 2013 Oct;90(1):195-207. doi: 10.1111/mmi.12358. Epub 2013 Aug 23.


An attenuated mutant of the Rv1747 ATP-binding cassette transporter of Mycobacterium tuberculosis and a mutant of its cognate kinase, PknF, show increased expression of the efflux pump-related iniBAC operon.

Spivey VL, Whalan RH, Hirst EM, Smerdon SJ, Buxton RS.

FEMS Microbiol Lett. 2013 Oct;347(2):107-15. doi: 10.1111/1574-6968.12230. Epub 2013 Aug 23.


Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response.

Matange N, Hunt DM, Buxton RS, Visweswariah SS.

Tuberculosis (Edinb). 2013 Sep;93(5):492-500. doi: 10.1016/ Epub 2013 Jul 6.


Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1.

Smith LJ, Stapleton MR, Buxton RS, Green J.

PLoS One. 2012;7(7):e40407. doi: 10.1371/journal.pone.0040407. Epub 2012 Jul 5.


Long range transcriptional control of virulence critical genes in Mycobacterium tuberculosis by nucleoid-associated proteins?

Buxton RS, Green J, Hunt DM, Kahramanoglou C, Stapleton MR, Sweeney NP.

Virulence. 2012 Jul 1;3(4):408-10. doi: 10.1128/JB.00142-12. Epub 2012 Jun 22. Review. No abstract available.


Global analysis of the regulon of the transcriptional repressor LexA, a key component of SOS response in Mycobacterium tuberculosis.

Smollett KL, Smith KM, Kahramanoglou C, Arnvig KB, Buxton RS, Davis EO.

J Biol Chem. 2012 Jun 22;287(26):22004-14. doi: 10.1074/jbc.M112.357715. Epub 2012 Apr 23.


Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis.

Chapman TM, Bouloc N, Buxton RS, Chugh J, Lougheed KE, Osborne SA, Saxty B, Smerdon SJ, Taylor DL, Whalley D.

Bioorg Med Chem Lett. 2012 May 1;22(9):3349-53. doi: 10.1016/j.bmcl.2012.02.107. Epub 2012 Mar 14.


Mycobacterium tuberculosis WhiB1 represses transcription of the essential chaperonin GroEL2.

Stapleton MR, Smith LJ, Hunt DM, Buxton RS, Green J.

Tuberculosis (Edinb). 2012 Jul;92(4):328-32. doi: 10.1016/ Epub 2012 Mar 29.


Long-range transcriptional control of an operon necessary for virulence-critical ESX-1 secretion in Mycobacterium tuberculosis.

Hunt DM, Sweeney NP, Mori L, Whalan RH, Comas I, Norman L, Cortes T, Arnvig KB, Davis EO, Stapleton MR, Green J, Buxton RS.

J Bacteriol. 2012 May;194(9):2307-20. doi: 10.1128/JB.00142-12. Epub 2012 Mar 2.


EspD is critical for the virulence-mediating ESX-1 secretion system in Mycobacterium tuberculosis.

Chen JM, Boy-Röttger S, Dhar N, Sweeney N, Buxton RS, Pojer F, Rosenkrands I, Cole ST.

J Bacteriol. 2012 Feb;194(4):884-93. doi: 10.1128/JB.06417-11. Epub 2011 Dec 9.


Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis.

Spivey VL, Molle V, Whalan RH, Rodgers A, Leiba J, Stach L, Walker KB, Smerdon SJ, Buxton RS.

J Biol Chem. 2011 Jul 22;286(29):26198-209. doi: 10.1074/jbc.M111.246132. Epub 2011 May 26.


Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.

Lougheed KE, Osborne SA, Saxty B, Whalley D, Chapman T, Bouloc N, Chugh J, Nott TJ, Patel D, Spivey VL, Kettleborough CA, Bryans JS, Taylor DL, Smerdon SJ, Buxton RS.

Tuberculosis (Edinb). 2011 Jul;91(4):277-86. doi: 10.1016/ Epub 2011 Apr 11.


Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins.

Crack JC, Smith LJ, Stapleton MR, Peck J, Watmough NJ, Buttner MJ, Buxton RS, Green J, Oganesyan VS, Thomson AJ, Le Brun NE.

J Am Chem Soc. 2011 Feb 2;133(4):1112-21. doi: 10.1021/ja109581t. Epub 2010 Dec 23.


Structural and functional analysis of phosphothreonine-dependent FHA domain interactions.

Pennell S, Westcott S, Ortiz-Lombardía M, Patel D, Li J, Nott TJ, Mohammed D, Buxton RS, Yaffe MB, Verma C, Smerdon SJ.

Structure. 2010 Dec 8;18(12):1587-95. doi: 10.1016/j.str.2010.09.014.


Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster.

Smith LJ, Stapleton MR, Fullstone GJ, Crack JC, Thomson AJ, Le Brun NE, Hunt DM, Harvey E, Adinolfi S, Buxton RS, Green J.

Biochem J. 2010 Dec 15;432(3):417-27. doi: 10.1042/BJ20101440.


Mycobacterium tuberculosis cAMP receptor protein (Rv3676) differs from the Escherichia coli paradigm in its cAMP binding and DNA binding properties and transcription activation properties.

Stapleton M, Haq I, Hunt DM, Arnvig KB, Artymiuk PJ, Buxton RS, Green J.

J Biol Chem. 2010 Mar 5;285(10):7016-27. doi: 10.1074/jbc.M109.047720. Epub 2009 Dec 22.


New anti-tuberculosis agents amongst known drugs.

Lougheed KE, Taylor DL, Osborne SA, Bryans JS, Buxton RS.

Tuberculosis (Edinb). 2009 Sep;89(5):364-70. doi: 10.1016/ Epub 2009 Aug 20.


An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis.

Nott TJ, Kelly G, Stach L, Li J, Westcott S, Patel D, Hunt DM, Howell S, Buxton RS, O'Hare HM, Smerdon SJ.

Sci Signal. 2009 Mar 24;2(63):ra12. doi: 10.1126/scisignal.2000212.


Single nucleotide polymorphisms that cause structural changes in the cyclic AMP receptor protein transcriptional regulator of the tuberculosis vaccine strain Mycobacterium bovis BCG alter global gene expression without attenuating growth.

Hunt DM, Saldanha JW, Brennan JF, Benjamin P, Strom M, Cole JA, Spreadbury CL, Buxton RS.

Infect Immun. 2008 May;76(5):2227-34. doi: 10.1128/IAI.01410-07. Epub 2008 Mar 10.


Genome analysis shows a common evolutionary origin for the dominant strains of Mycobacterium tuberculosis in a UK South Asian community.

Menéndez MC, Buxton RS, Evans JT, Gascoyne-Binzi D, Barlow RE, Hinds J, Hawkey PM, Colston MJ.

Tuberculosis (Edinb). 2007 Sep;87(5):426-36. Epub 2007 Aug 23. Erratum in: Tuberculosis (Edinb). 2008 Sep;88(5):503.


Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives.

Stadthagen G, Jackson M, Charles P, Boudou F, Barilone N, Huerre M, Constant P, Liav A, Bottova I, Nigou J, Brando T, Puzo G, Daffé M, Benjamin P, Coade S, Buxton RS, Tascon RE, Rae A, Robertson BD, Lowrie DB, Young DB, Gicquel B, Griffin R.

Microbes Infect. 2006 Jul;8(8):2245-53. Epub 2006 May 30.


An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice.

Curry JM, Whalan R, Hunt DM, Gohil K, Strom M, Rickman L, Colston MJ, Smerdon SJ, Buxton RS.

Infect Immun. 2005 Aug;73(8):4471-7.


A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor.

Rickman L, Scott C, Hunt DM, Hutchinson T, Menéndez MC, Whalan R, Hinds J, Colston MJ, Green J, Buxton RS.

Mol Microbiol. 2005 Jun;56(5):1274-86. Erratum in: Mol Microbiol. 2005 Aug;57(3):869.


Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family: towards an understanding of the rules governing complex formation and thereby functional flexibility.

Lightbody KL, Renshaw PS, Collins ML, Wright RL, Hunt DM, Gordon SV, Hewinson RG, Buxton RS, Williamson RA, Carr MD.

FEMS Microbiol Lett. 2004 Sep 1;238(1):255-62.


Striate palmoplantar keratoderma arising from desmoplakin and desmoglein 1 mutations is associated with contrasting perturbations of desmosomes and the keratin filament network.

Wan H, Dopping-Hepenstal PJ, Gratian MJ, Stone MG, Zhu G, Purkis PE, South AP, Keane F, Armstrong DK, Buxton RS, McGrath JA, Eady RA.

Br J Dermatol. 2004 May;150(5):878-91.


Genome structure in the vole bacillus, Mycobacterium microti, a member of the Mycobacterium tuberculosis complex with a low virulence for humans.

Frota CC, Hunt DM, Buxton RS, Rickman L, Hinds J, Kremer K, van Soolingen D, Colston MJ.

Microbiology. 2004 May;150(Pt 5):1519-27.


A two-component signal transduction system with a PAS domain-containing sensor is required for virulence of Mycobacterium tuberculosis in mice.

Rickman L, Saldanha JW, Hunt DM, Hoar DN, Colston MJ, Millar JB, Buxton RS.

Biochem Biophys Res Commun. 2004 Jan 30;314(1):259-67.


The majority of inducible DNA repair genes in Mycobacterium tuberculosis are induced independently of RecA.

Rand L, Hinds J, Springer B, Sander P, Buxton RS, Davis EO.

Mol Microbiol. 2003 Nov;50(3):1031-42.


Parasite plastids: maintenance and functions.

Wilson RJ, Rangachari K, Saldanha JW, Rickman L, Buxton RS, Eccleston JF.

Philos Trans R Soc Lond B Biol Sci. 2003 Jan 29;358(1429):155-62; discussion 162-4.


Spectrum of dominant mutations in the desmosomal cadherin desmoglein 1, causing the skin disease striate palmoplantar keratoderma.

Hunt DM, Rickman L, Whittock NV, Eady RA, Simrak D, Dopping-Hepenstal PJ, Stevens HP, Armstrong DK, Hennies HC, Küster W, Hughes AE, Arnemann J, Leigh IM, McGrath JA, Kelsell DP, Buxton RS.

Eur J Hum Genet. 2001 Mar;9(3):197-203.


The regulatory region of the human desmocollin 3 promoter forms a DNA four-way junction.

Gadhavi PL, Greenwood MD, Strom M, King IA, Buxton RS.

Biochem Biophys Res Commun. 2001 Feb 23;281(2):520-8.


Extracellularly truncated desmoglein 1 compromises desmosomes in MDCK cells.

Serpente N, Marcozzi C, Roberts GA, Bao Q, Angst BD, Hirst EM, Burdett ID, Buxton RS, Magee AI.

Mol Membr Biol. 2000 Jul-Sep;17(3):175-83.


Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3.

Whittock NV, Hunt DM, Rickman L, Malhi S, Vogazianou AP, Dawson LF, Eady RA, Buxton RS, McGrath JA.

Biochem Biophys Res Commun. 2000 Sep 24;276(2):454-60.


Clustered cadherin genes: a sequence-ready contig for the desmosomal cadherin locus on human chromosome 18.

Hunt DM, Sahota VK, Taylor K, Simrak D, Hornigold N, Arnemann J, Wolfe J, Buxton RS.

Genomics. 1999 Dec 15;62(3):445-55.


N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma.

Rickman L, Simrak D, Stevens HP, Hunt DM, King IA, Bryant SP, Eady RA, Leigh IM, Arnemann J, Magee AI, Kelsell DP, Buxton RS.

Hum Mol Genet. 1999 Jun;8(6):971-6.


Antisense expression of a desmocollin gene in MDCK cells alters desmosome plaque assembly but does not affect desmoglein expression.

Roberts GA, Burdett ID, Pidsley SC, King IA, Magee AI, Buxton RS.

Eur J Cell Biol. 1998 Jul;76(3):192-203.


Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion.

Marcozzi C, Burdett ID, Buxton RS, Magee AI.

J Cell Sci. 1998 Feb;111 ( Pt 4):495-509.


Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens.

Adams MJ, Reichel MB, King IA, Marsden MD, Greenwood MD, Thirlwell H, Arnemann J, Buxton RS, Ali RR.

Biochem J. 1998 Jan 1;329 ( Pt 1):165-74.


Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse.

King IA, Angst BD, Hunt DM, Kruger M, Arnemann J, Buxton RS.

Differentiation. 1997 Nov;62(2):83-96.


The plakophilin 1 (PKP1) and plakoglobin (JUP) genes map to human chromosomes 1q and 17, respectively.

Cowley CM, Simrak D, Spurr NK, Arnemann J, Buxton RS.

Hum Genet. 1997 Sep;100(3-4):486-8. No abstract available.


A YAC contig joining the desmocollin and desmoglein loci on human chromosome 18 and ordering of the desmocollin genes.

Cowley CM, Simrak D, Marsden MD, King IA, Arnemann J, Buxton RS.

Genomics. 1997 Jun 1;42(2):208-16.


Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2).

Marsden MD, Collins JE, Greenwood MD, Adams MJ, Fleming TP, Magee AI, Buxton RS.

Gene. 1997 Feb 28;186(2):237-47.


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