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c-di-GMP Arms an Anti-σ to Control Progression of Multicellular Differentiation in Streptomyces.

Gallagher KA, Schumacher MA, Bush MJ, Bibb MJ, Chandra G, Holmes NA, Zeng W, Henderson M, Zhang H, Findlay KC, Brennan RG, Buttner MJ.

Mol Cell. 2019 Nov 27. pii: S1097-2765(19)30835-4. doi: 10.1016/j.molcel.2019.11.006. [Epub ahead of print]


Discovery of the extracytoplasmic function σ factors.

Lonetto MA, Donohue TJ, Gross CA, Buttner MJ.

Mol Microbiol. 2019 Aug;112(2):348-355. doi: 10.1111/mmi.14307. Epub 2019 Jun 17. Review.


Defining the regulon of genes controlled by σE , a key regulator of the cell envelope stress response in Streptomyces coelicolor.

Tran NT, Huang X, Hong HJ, Bush MJ, Chandra G, Pinto D, Bibb MJ, Hutchings MI, Mascher T, Buttner MJ.

Mol Microbiol. 2019 Aug;112(2):461-481. doi: 10.1111/mmi.14250. Epub 2019 Apr 29.


BldC Delays Entry into Development To Produce a Sustained Period of Vegetative Growth in Streptomyces venezuelae.

Bush MJ, Chandra G, Al-Bassam MM, Findlay KC, Buttner MJ.

MBio. 2019 Feb 5;10(1). pii: e02812-18. doi: 10.1128/mBio.02812-18.


The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor.

Schumacher MA, Bush MJ, Bibb MJ, Ramos-León F, Chandra G, Zeng W, Buttner MJ.

Nucleic Acids Res. 2018 Aug 21;46(14):7467-7468. doi: 10.1093/nar/gky616. No abstract available.


The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor.

Schumacher MA, Bush MJ, Bibb MJ, Ramos-León F, Chandra G, Zeng W, Buttner MJ.

Nucleic Acids Res. 2018 Aug 21;46(14):7405-7417. doi: 10.1093/nar/gky493. Erratum in: Nucleic Acids Res. 2018 Aug 21;46(14):7467-7468.


The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.

Schumacher MA, den Hengst CD, Bush MJ, Le TBK, Tran NT, Chandra G, Zeng W, Travis B, Brennan RG, Buttner MJ.

Nat Commun. 2018 Mar 19;9(1):1139. doi: 10.1038/s41467-018-03576-3.


Structural insights into simocyclinone as an antibiotic, effector ligand and substrate.

Buttner MJ, Schäfer M, Lawson DM, Maxwell A.

FEMS Microbiol Rev. 2018 Jan 1;42(1). doi: 10.1093/femsre/fux055. Review.


Two dynamin-like proteins stabilize FtsZ rings during Streptomyces sporulation.

Schlimpert S, Wasserstrom S, Chandra G, Bibb MJ, Findlay KC, Flärdh K, Buttner MJ.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6176-E6183. doi: 10.1073/pnas.1704612114. Epub 2017 Jul 7.


Translational Control of the SigR-Directed Oxidative Stress Response in Streptomyces via IF3-Mediated Repression of a Noncanonical GTC Start Codon.

Feeney MA, Chandra G, Findlay KC, Paget MSB, Buttner MJ.

MBio. 2017 Jun 13;8(3). pii: e00815-17. doi: 10.1128/mBio.00815-17.


The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.

Schumacher MA, Zeng W, Findlay KC, Buttner MJ, Brennan RG, Tschowri N.

Nucleic Acids Res. 2017 Jun 20;45(11):6923-6933. doi: 10.1093/nar/gkx287.


Actinoplanes Swims into the Molecular Age.

Buttner MJ.

J Bacteriol. 2017 May 25;199(12). pii: e00070-17. doi: 10.1128/JB.00070-17. Print 2017 Jun 15.


Multi-layered inhibition of Streptomyces development: BldO is a dedicated repressor of whiB.

Bush MJ, Chandra G, Findlay KC, Buttner MJ.

Mol Microbiol. 2017 Jun;104(5):700-711. doi: 10.1111/mmi.13663. Epub 2017 Mar 27.


Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate.

Schäfer M, Stevenson CEM, Wilkinson B, Lawson DM, Buttner MJ.

Cell Chem Biol. 2016 Sep 22;23(9):1091-1097. doi: 10.1016/j.chembiol.2016.07.018. Epub 2016 Sep 8.


c-di-GMP signalling and the regulation of developmental transitions in streptomycetes.

Bush MJ, Tschowri N, Schlimpert S, Flärdh K, Buttner MJ.

Nat Rev Microbiol. 2015 Dec;13(12):749-60. doi: 10.1038/nrmicro3546. Epub 2015 Oct 26. Review.


SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone.

Schäfer M, Le TB, Hearnshaw SJ, Maxwell A, Challis GL, Wilkinson B, Buttner MJ.

J Mol Biol. 2015 Jun 19;427(12):2192-204. doi: 10.1016/j.jmb.2015.03.019. Epub 2015 Apr 8.


Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.

Tschowri N, Schumacher MA, Schlimpert S, Chinnam NB, Findlay KC, Brennan RG, Buttner MJ.

Cell. 2014 Aug 28;158(5):1136-1147. doi: 10.1016/j.cell.2014.07.022.


Response regulator heterodimer formation controls a key stage in Streptomyces development.

Al-Bassam MM, Bibb MJ, Bush MJ, Chandra G, Buttner MJ.

PLoS Genet. 2014 Aug 7;10(8):e1004554. doi: 10.1371/journal.pgen.1004554. eCollection 2014 Aug.


A sporulation-specific, sigF-dependent protein, SspA, affects septum positioning in Streptomyces coelicolor.

Tzanis A, Dalton KA, Hesketh A, den Hengst CD, Buttner MJ, Thibessard A, Kelemen GH.

Mol Microbiol. 2014 Jan;91(2):363-80. doi: 10.1111/mmi.12466. Epub 2013 Dec 19.


Genes required for aerial growth, cell division, and chromosome segregation are targets of WhiA before sporulation in Streptomyces venezuelae.

Bush MJ, Bibb MJ, Chandra G, Findlay KC, Buttner MJ.

MBio. 2013 Sep 24;4(5):e00684-13. doi: 10.1128/mBio.00684-13.


Evolutionary relationships among actinophages and a putative adaptation for growth in Streptomyces spp.

Smith MC, Hendrix RW, Dedrick R, Mitchell K, Ko CC, Russell D, Bell E, Gregory M, Bibb MJ, Pethick F, Jacobs-Sera D, Herron P, Buttner MJ, Hatfull GF.

J Bacteriol. 2013 Nov;195(21):4924-35. doi: 10.1128/JB.00618-13. Epub 2013 Aug 30.


Determination of phosphorylation sites in the DivIVA cytoskeletal protein of Streptomyces coelicolor by targeted LC-MS/MS.

Saalbach G, Hempel AM, Vigouroux M, Flärdh K, Buttner MJ, Naldrett MJ.

J Proteome Res. 2013 Sep 6;12(9):4187-92. doi: 10.1021/pr400524d. Epub 2013 Aug 15.


Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster.

Jones AC, Gust B, Kulik A, Heide L, Buttner MJ, Bibb MJ.

PLoS One. 2013 Jul 11;8(7):e69319. doi: 10.1371/journal.pone.0069319. Print 2013.


Regulation of apical growth and hyphal branching in Streptomyces.

Flärdh K, Richards DM, Hempel AM, Howard M, Buttner MJ.

Curr Opin Microbiol. 2012 Dec;15(6):737-43. doi: 10.1016/j.mib.2012.10.012. Epub 2012 Nov 12. Review.


The Ser/Thr protein kinase AfsK regulates polar growth and hyphal branching in the filamentous bacteria Streptomyces.

Hempel AM, Cantlay S, Molle V, Wang SB, Naldrett MJ, Parker JL, Richards DM, Jung YG, Buttner MJ, Flärdh K.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2371-9. doi: 10.1073/pnas.1207409109. Epub 2012 Aug 6.


Expression of the chaplin and rodlin hydrophobic sheath proteins in Streptomyces venezuelae is controlled by σ(BldN) and a cognate anti-sigma factor, RsbN.

Bibb MJ, Domonkos A, Chandra G, Buttner MJ.

Mol Microbiol. 2012 Jun;84(6):1033-49. doi: 10.1111/j.1365-2958.2012.08070.x. Epub 2012 May 14.


Mechanistic basis of branch-site selection in filamentous bacteria.

Richards DM, Hempel AM, Flärdh K, Buttner MJ, Howard M.

PLoS Comput Biol. 2012;8(3):e1002423. doi: 10.1371/journal.pcbi.1002423. Epub 2012 Mar 8.


The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding.

Le TB, Schumacher MA, Lawson DM, Brennan RG, Buttner MJ.

Nucleic Acids Res. 2011 Nov;39(21):9433-47. doi: 10.1093/nar/gkr640. Epub 2011 Aug 10.


Identification and characterization of CdgB, a diguanylate cyclase involved in developmental processes in Streptomyces coelicolor.

Tran NT, Den Hengst CD, Gomez-Escribano JP, Buttner MJ.

J Bacteriol. 2011 Jun;193(12):3100-8. doi: 10.1128/JB.01460-10. Epub 2011 Apr 22.


Crystallization and preliminary X-ray analysis of the TetR-like efflux pump regulator SimR.

Le TB, Stevenson CE, Buttner MJ, Lawson DM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):307-9. doi: 10.1107/S1744309110053078. Epub 2011 Feb 18.


Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression.

Le TB, Stevenson CE, Fiedler HP, Maxwell A, Lawson DM, Buttner MJ.

J Mol Biol. 2011 Apr 22;408(1):40-56. doi: 10.1016/j.jmb.2011.02.035. Epub 2011 Feb 24.


Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins.

Crack JC, Smith LJ, Stapleton MR, Peck J, Watmough NJ, Buttner MJ, Buxton RS, Green J, Oganesyan VS, Thomson AJ, Le Brun NE.

J Am Chem Soc. 2011 Feb 2;133(4):1112-21. doi: 10.1021/ja109581t. Epub 2010 Dec 23.


Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth.

den Hengst CD, Tran NT, Bibb MJ, Chandra G, Leskiw BK, Buttner MJ.

Mol Microbiol. 2010 Oct;78(2):361-79.


A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.

Koteva K, Hong HJ, Wang XD, Nazi I, Hughes D, Naldrett MJ, Buttner MJ, Wright GD.

Nat Chem Biol. 2010 May;6(5):327-9. doi: 10.1038/nchembio.350. Epub 2010 Apr 11.


Leiomyoma of the gallbladder: a case report with review of the literature and discussion of the differential diagnosis.

Wachter DL, Büttner MJ, Grimm K, Hartmann A, Agaimy A.

J Clin Pathol. 2010 Feb;63(2):177-9. doi: 10.1136/jcp.2009.070649. Review.


A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase.

Edwards MJ, Flatman RH, Mitchenall LA, Stevenson CE, Le TB, Clarke TA, McKay AR, Fiedler HP, Buttner MJ, Lawson DM, Maxwell A.

Science. 2009 Dec 4;326(5958):1415-8. doi: 10.1126/science.1179123.


Characterization of [4Fe-4S]-containing and cluster-free forms of Streptomyces WhiD.

Crack JC, den Hengst CD, Jakimowicz P, Subramanian S, Johnson MK, Buttner MJ, Thomson AJ, Le Brun NE.

Biochemistry. 2009 Dec 29;48(51):12252-64. doi: 10.1021/bi901498v.


Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus.

Le TB, Fiedler HP, den Hengst CD, Ahn SK, Maxwell A, Buttner MJ.

Mol Microbiol. 2009 Jun;72(6):1462-74. doi: 10.1111/j.1365-2958.2009.06735.x. Epub 2009 May 15.


Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium.

Flärdh K, Buttner MJ.

Nat Rev Microbiol. 2009 Jan;7(1):36-49. doi: 10.1038/nrmicro1968. Review.


Vancomycin resistance VanS/VanR two-component systems.

Hong HJ, Hutchings MI, Buttner MJ; Biotechnology and Biological Sciences Research Council, UK.

Adv Exp Med Biol. 2008;631:200-13. Review.


The oligoribonuclease gene in Streptomyces coelicolor is not transcriptionally or translationally coupled to adpA, a key bldA target.

Sello JK, Buttner MJ.

FEMS Microbiol Lett. 2008 Sep;286(1):60-5. doi: 10.1111/j.1574-6968.2008.01260.x.


Function and redundancy of the chaplin cell surface proteins in aerial hypha formation, rodlet assembly, and viability in Streptomyces coelicolor.

Di Berardo C, Capstick DS, Bibb MJ, Findlay KC, Buttner MJ, Elliot MA.

J Bacteriol. 2008 Sep;190(17):5879-89. doi: 10.1128/JB.00685-08. Epub 2008 Jun 27.


Redox control in actinobacteria.

den Hengst CD, Buttner MJ.

Biochim Biophys Acta. 2008 Nov;1780(11):1201-16. doi: 10.1016/j.bbagen.2008.01.008. Epub 2008 Jan 18. Review.


SapB and the chaplins: connections between morphogenetic proteins in Streptomyces coelicolor.

Capstick DS, Willey JM, Buttner MJ, Elliot MA.

Mol Microbiol. 2007 May;64(3):602-13.


The sigma(E) cell envelope stress response of Streptomyces coelicolor is influenced by a novel lipoprotein, CseA.

Hutchings MI, Hong HJ, Leibovitz E, Sutcliffe IC, Buttner MJ.

J Bacteriol. 2006 Oct;188(20):7222-9. Erratum in: J Bacteriol. 2008 Sep;190(17):6037.


Assignment of the zinc ligands in RsrA, a redox-sensing ZAS protein from Streptomyces coelicolor.

Zdanowski K, Doughty P, Jakimowicz P, O'Hara L, Buttner MJ, Paget MS, Kleanthous C.

Biochemistry. 2006 Jul 11;45(27):8294-300.


DevA, a GntR-like transcriptional regulator required for development in Streptomyces coelicolor.

Hoskisson PA, Rigali S, Fowler K, Findlay KC, Buttner MJ.

J Bacteriol. 2006 Jul;188(14):5014-23.

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