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Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression.

Andreescu C, Ajilore O, Aizenstein HJ, Albert K, Butters MA, Landman BA, Karim HT, Krafty R, Taylor WD.

Am J Geriatr Psychiatry. 2019 Dec;27(12):1316-1330. doi: 10.1016/j.jagp.2019.07.016. Epub 2019 Aug 7. Review.


Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE): Protocol.

Erickson KI, Grove GA, Burns JM, Hillman CH, Kramer AF, McAuley E, Vidoni ED, Becker JT, Butters MA, Gray K, Huang H, Jakicic JM, Kamboh MI, Kang C, Klunk WE, Lee P, Marsland AL, Mettenburg J, Rogers RJ, Stillman CM, Sutton BP, Szabo-Reed A, Verstynen TD, Watt JC, Weinstein AM, Wollam ME.

Contemp Clin Trials. 2019 Oct;85:105832. doi: 10.1016/j.cct.2019.105832. Epub 2019 Aug 26.


Molecular Senescence Is Associated With White Matter Microstructural Damage in Late-Life Depression.

Mendes-Silva AP, Mwangi B, Aizenstein H, Reynolds CF 3rd, Butters MA, Diniz BS.

Am J Geriatr Psychiatry. 2019 Dec;27(12):1414-1418. doi: 10.1016/j.jagp.2019.06.006. Epub 2019 Jun 22.


Health-related quality of life in remitted psychotic depression.

Bingham KS, Whyte EM, Mulsant BH, Rothschild AJ, Rudorfer MV, Marino P, Banerjee S, Butters MA, Alexopoulos GS, Meyers BS, Flint AJ; STOP-PD Study Group.

J Affect Disord. 2019 Sep 1;256:373-379. doi: 10.1016/j.jad.2019.05.068. Epub 2019 May 28.


Preventing disability in older adults with mild cognitive impairment: A Strategy Training intervention study.

Rodakowski J, Golias KW, Reynolds CF 3rd, Butters MA, Lopez OL, Dew MA, Skidmore ER.

Contemp Clin Trials Commun. 2019 May 1;15:100368. doi: 10.1016/j.conctc.2019.100368. eCollection 2019 Sep.


An inverse relationship between cortical plasticity and cognitive inhibition in late-life depression.

Lissemore JI, Shanks HRC, Butters MA, Bhandari A, Zomorrodi R, Rajji TK, Karp JF, Reynolds CF 3rd, Lenze EJ, Daskalakis ZJ, Mulsant BH, Blumberger DM.

Neuropsychopharmacology. 2019 Aug;44(9):1659-1666. doi: 10.1038/s41386-019-0413-9. Epub 2019 May 9.


Exercise for Depression: A Feasibility Trial Exploring Neural Mechanisms.

Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Grove G, Karp JF, Erickson KI.

Am J Geriatr Psychiatry. 2019 Jun;27(6):611-616. doi: 10.1016/j.jagp.2019.01.012. Epub 2019 Jan 17.


Depression Agency-Based Collaborative: Effect of Problem-Solving Therapy on Risk of Common Mental Disorders in Older Adults With Home Care Needs.

Albert SM, King J, Anderson S, Dew MA, Zhang J, Stahl ST, Karp JF, Gildengers AG, Butters MA, Reynolds Iii CF.

Am J Geriatr Psychiatry. 2019 Jun;27(6):619-624. doi: 10.1016/j.jagp.2019.01.002. Epub 2019 Jan 10.


Examining the Link Between Cardiovascular Risk Factors and Neuropsychiatric Symptoms in Mild Cognitive Impairment and Major Depressive Disorder in Remission.

Fischer CE, Kortebi I, Karameh WK, Kumar S, Gallagher D, Golas A, Munoz D, Barfett J, Butters MA, Bowie CR, Flint A, Rajji T, Herrmann N, Pollock BG, Mulsant B, Schweizer TA, Mah L; the PACT-MD Study Group.

J Alzheimers Dis. 2019;67(4):1305-1311. doi: 10.3233/JAD-181099.


Neural correlates of perceived physical and mental fatigability in older adults: A pilot study.

Wasson E, Rosso AL, Santanasto AJ, Rosano C, Butters MA, Rejeski WJ, Boudreau RM, Aizenstein H, Gmelin T, Glynn NW; LIFE Study Group.

Exp Gerontol. 2019 Jan;115:139-147. doi: 10.1016/j.exger.2018.12.003. Epub 2018 Dec 4.


Cognitive Improvement in Older Adults in the Year After Hip Fracture: Implications for Brain Resilience in Advanced Aging.

Oughli HA, Chen G, Philip Miller J, Nicol G, Butters MA, Avidan M, Stark S, Lenze EJ.

Am J Geriatr Psychiatry. 2018 Nov;26(11):1119-1127. doi: 10.1016/j.jagp.2018.07.001.


Stopping Cognitive Decline in Patients With Late-Life Depression: A New Front in the Fight Against Dementia.

Lenze EJ, Voineskos AN, Butters MA, Karp JF; OPTIMUM and OPTIMUM-Neuro collaborative team.

Am J Geriatr Psychiatry. 2018 Aug;26(8):828-834. doi: 10.1016/j.jagp.2018.05.014. Epub 2018 Jun 5. No abstract available.


Statins and cognition in late-life bipolar disorder.

Rej S, Schulte SW, Rajji TK, Gildengers AG, Miranda D, Menon M, Butters MA, Mulsant BH.

Int J Geriatr Psychiatry. 2018 Oct;33(10):1355-1360. doi: 10.1002/gps.4956. Epub 2018 Jul 19.


Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression.

Karim HT, Wang M, Andreescu C, Tudorascu D, Butters MA, Karp JF, Reynolds CF 3rd, Aizenstein HJ.

Neuroimage Clin. 2018 Jun 8;19:831-839. doi: 10.1016/j.nicl.2018.06.006. eCollection 2018.


Efficacy, tolerability, and cognitive effects of deep transcranial magnetic stimulation for late-life depression: a prospective randomized controlled trial.

Kaster TS, Daskalakis ZJ, Noda Y, Knyahnytska Y, Downar J, Rajji TK, Levkovitz Y, Zangen A, Butters MA, Mulsant BH, Blumberger DM.

Neuropsychopharmacology. 2018 Oct;43(11):2231-2238. doi: 10.1038/s41386-018-0121-x. Epub 2018 Jun 18.


Executive Function Predicts Antidepressant Treatment Noncompletion in Late-Life Depression.

Cristancho P, Lenze EJ, Dixon D, Miller JP, Mulsant BH, Reynolds CF 3rd, Butters MA.

J Clin Psychiatry. 2018 May/Jun;79(3). pii: 16m11371. doi: 10.4088/JCP.16m11371.


Association of Hippocampal Substructure Resting-State Functional Connectivity with Memory Performance in Older Adults.

Smagula SF, Karim HT, Rangarajan A, Santos FP, Wood SC, Santini T, Jakicic JM, Reynolds CF 3rd, Cameron JL, Vallejo AN, Butters MA, Rosano C, Ibrahim TS, Erickson KI, Aizenstein HJ.

Am J Geriatr Psychiatry. 2018 Jun;26(6):690-699. doi: 10.1016/j.jagp.2018.03.003. Epub 2018 Mar 13.


Clinical Predictors of Engagement in Inpatient Rehabilitation Among Stroke Survivors With Cognitive Deficits: An Exploratory Study.

Kringle EA, Terhorst L, Butters MA, Skidmore ER.

J Int Neuropsychol Soc. 2018 Jul;24(6):572-583. doi: 10.1017/S1355617718000085. Epub 2018 Mar 19.


Disease severity and slower psychomotor speed in adults with sickle cell disease.

Jorgensen DR, Metti A, Butters MA, Mettenburg JM, Rosano C, Novelli EM.

Blood Adv. 2017 Sep 14;1(21):1790-1795. doi: 10.1182/bloodadvances.2017008219. eCollection 2017 Sep 26.


Allostatic load but not medical burden predicts memory performance in late-life bipolar disorder.

Vaccarino SR, Rajji TK, Gildengers AG, Waters SES, Butters MA, Menon M, Blumberger DM, Voineskos AN, Miranda D, Mulsant BH.

Int J Geriatr Psychiatry. 2018 Mar;33(3):546-552. doi: 10.1002/gps.4829. Epub 2017 Dec 13. Review.


Childhood Trauma Is Associated With Poorer Cognitive Performance in Older Adults.

Petkus AJ, Lenze EJ, Butters MA, Twamley EW, Wetherell JL.

J Clin Psychiatry. 2018 Jan/Feb;79(1). pii: 16m11021. doi: 10.4088/JCP.16m11021.


Exercise effects on depression: Possible neural mechanisms.

Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI.

Gen Hosp Psychiatry. 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. Review.


Subjective-Objective Sleep Discrepancy in Older Adults With MCI and Subsyndromal Depression.

DiNapoli EA, Gebara MA, Kho T, Butters MA, Gildengers AG, Albert SM, Dew MA, Erickson KI, Reynolds CF 3rd, Karp JF.

J Geriatr Psychiatry Neurol. 2017 Nov;30(6):316-323. doi: 10.1177/0891988717731827. Epub 2017 Sep 27.


In the grip of worry: cerebral blood flow changes during worry induction and reappraisal in late-life generalized anxiety disorder.

Karim HT, Tudorascu DL, Butters MA, Walker S, Aizenstein HJ, Andreescu C.

Transl Psychiatry. 2017 Sep 26;7(9):e1244. doi: 10.1038/tp.2017.215.


Association between change in brain gray matter volume, cognition, and depression severity: Pre- and post- antidepressant pharmacotherapy for late-life depression.

Droppa K, Karim HT, Tudorascu DL, Karp JF, Reynolds CF 3rd, Aizenstein HJ, Butters MA.

J Psychiatr Res. 2017 Dec;95:129-134. doi: 10.1016/j.jpsychires.2017.08.002. Epub 2017 Aug 8.


Brain structural changes in late-life generalized anxiety disorder.

Andreescu C, Tudorascu D, Sheu LK, Rangarajan A, Butters MA, Walker S, Berta R, Desmidt T, Aizenstein H.

Psychiatry Res Neuroimaging. 2017 Oct 30;268:15-21. doi: 10.1016/j.pscychresns.2017.08.004. Epub 2017 Aug 17.


In the grip of worry: cerebral blood flow changes during worry induction and reappraisal in late-life generalized anxiety disorder.

Karim HT, Tudorascu DL, Butters MA, Walker S, Aizenstein HJ, Andreescu C.

Transl Psychiatry. 2017 Aug 15;7(8):e1204. doi: 10.1038/tp.2017.180. Erratum in: Transl Psychiatry. 2017 Sep 26;7(9):e1244.


Measuring Participant Effort in a Depression Prevention Trial: Who Engages in Problem-Solving Therapy?

Stahl ST, Albert SM, Dew MA, Anderson S, Karp JF, Gildengers AG, Butters MA, Reynolds CF 3rd.

Am J Geriatr Psychiatry. 2017 Aug;25(8):909-916. doi: 10.1016/j.jagp.2017.03.005. Epub 2017 Mar 14.


Improvement in Depression is Associated with Improvement in Cognition in Late-Life Psychotic Depression.

Victoria LW, Whyte EM, Butters MA, Meyers BS, Alexopoulos GS, Mulsant BH, Rothschild AJ, Banerjee S, Flint AJ.

Am J Geriatr Psychiatry. 2017 Jun;25(6):672-679. doi: 10.1016/j.jagp.2017.02.006. Epub 2017 Feb 9.


Treatment Considerations for Depression Research in Older Married Couples: A Dyadic Case Study.

Stahl ST, Rodakowski J, Gildengers AG, Reynolds CF 3rd, Morse JQ, Rico K, Butters MA.

Am J Geriatr Psychiatry. 2017 Apr;25(4):388-395. doi: 10.1016/j.jagp.2016.12.013. Epub 2017 Jan 4.


History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis.

Diniz BS, Teixeira AL, Cao F, Gildengers A, Soares JC, Butters MA, Reynolds CF 3rd.

Am J Geriatr Psychiatry. 2017 Apr;25(4):357-362. doi: 10.1016/j.jagp.2016.11.014. Epub 2017 Jan 4. Review.


Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype.

Diniz BS, Reynolds CF 3rd, Sibille E, Lin CW, Tseng G, Lotrich F, Aizenstein HJ, Butters MA.

Am J Geriatr Psychiatry. 2017 Jan;25(1):64-72. doi: 10.1016/j.jagp.2016.08.018. Epub 2016 Aug 31.


Vascular depression consensus report - a critical update.

Aizenstein HJ, Baskys A, Boldrini M, Butters MA, Diniz BS, Jaiswal MK, Jellinger KA, Kruglov LS, Meshandin IA, Mijajlovic MD, Niklewski G, Pospos S, Raju K, Richter K, Steffens DC, Taylor WD, Tene O.

BMC Med. 2016 Nov 3;14(1):161.


Cognitive outcome after ventral capsule/ventral striatum stimulation for treatment-resistant major depression.

Kubu CS, Brelje T, Butters MA, Deckersbach T, Malloy P, Moberg P, Tröster AI, Williamson E, Baltuch GH, Bhati MT, Carpenter LL, Dougherty DD, Howland RH, Rezai AR, Malone DA Jr.

J Neurol Neurosurg Psychiatry. 2017 Mar;88(3):262-265. doi: 10.1136/jnnp-2016-313803. Epub 2016 Sep 22.


Gray matter regions statistically mediating the cross-sectional association of eotaxin and set-shifting among older adults with major depressive disorder.

Smagula SF, Karim HT, Lenze EJ, Butters MA, Wu GF, Mulsant BH, Reynolds CF, Aizenstein HJ.

Int J Geriatr Psychiatry. 2017 Dec;32(12):1226-1232. doi: 10.1002/gps.4585. Epub 2016 Sep 19.


Consequences of Anxiety in Aging and Cognitive Decline.

Lenze EJ, Butters MA.

Am J Geriatr Psychiatry. 2016 Oct;24(10):843-5. doi: 10.1016/j.jagp.2016.07.006. Epub 2016 Jul 12. No abstract available.


Circulating biosignatures of late-life depression (LLD): Towards a comprehensive, data-driven approach to understanding LLD pathophysiology.

Diniz BS, Lin CW, Sibille E, Tseng G, Lotrich F, Aizenstein HJ, Reynolds CF, Butters MA.

J Psychiatr Res. 2016 Nov;82:1-7. doi: 10.1016/j.jpsychires.2016.07.006. Epub 2016 Jul 11.


Combining moderators to identify clinical profiles of patients who will, and will not, benefit from aripiprazole augmentation for treatment resistant late-life major depressive disorder.

Smagula SF, Wallace ML, Anderson SJ, Karp JF, Lenze EJ, Mulsant BH, Butters MA, Blumberger DM, Diniz BS, Lotrich FE, Dew MA, Reynolds CF 3rd.

J Psychiatr Res. 2016 Oct;81:112-8. doi: 10.1016/j.jpsychires.2016.07.005. Epub 2016 Jul 7.


Immunological biomarkers associated with brain structure and executive function in late-life depression: exploratory pilot study.

Smagula SF, Lotrich FE, Aizenstein HJ, Diniz BS, Krystek J, Wu GF, Mulsant BH, Butters MA, Reynolds CF 3rd, Lenze EJ.

Int J Geriatr Psychiatry. 2017 Jun;32(6):692-699. doi: 10.1002/gps.4512. Epub 2016 Jun 10.


The effects of white matter disease on the accuracy of automated segmentation.

Karim HT, Andreescu C, MacCloud RL, Butters MA, Reynolds CF 3rd, Aizenstein HJ, Tudorascu DL.

Psychiatry Res Neuroimaging. 2016 Jul 30;253:7-14. doi: 10.1016/j.pscychresns.2016.05.003. Epub 2016 May 19.


Developing a Non-Pharmacological Intervention for Individuals With Mild Cognitive Impairment.

Rodakowski J, Reynolds CF 3rd, Lopez OL, Butters MA, Dew MA, Skidmore ER.

J Appl Gerontol. 2018 May;37(5):665-676. doi: 10.1177/0733464816645808. Epub 2016 Apr 22.


Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters.

Karim HT, Andreescu C, Tudorascu D, Smagula SF, Butters MA, Karp JF, Reynolds C, Aizenstein HJ.

Mol Psychiatry. 2017 Mar;22(3):450-457. doi: 10.1038/mp.2016.55. Epub 2016 Apr 19.


Design and Implementation of an Intervention Development Study: Retaining Cognition While Avoiding Late-Life Depression (ReCALL).

Gildengers AG, Butters MA, Albert SM, Anderson SJ, Dew MA, Erickson K, Garand L, Karp JF, Lockovich MH, Morse J, Reynolds CF 3rd.

Am J Geriatr Psychiatry. 2016 Jun;24(6):444-54. doi: 10.1016/j.jagp.2015.10.010. Epub 2015 Nov 18.


Development of a Standardized Approach to Disclosing Amyloid Imaging Research Results in Mild Cognitive Impairment.

Lingler JH, Butters MA, Gentry AL, Hu L, Hunsaker AE, Klunk WE, Mattos MK, Parker LS, Roberts JS, Schulz R.

J Alzheimers Dis. 2016 Mar 8;52(1):17-24. doi: 10.3233/JAD-150985. Erratum in: J Alzheimers Dis. 2017;56(3):1213.


Predictors and Moderators of Remission With Aripiprazole Augmentation in Treatment-Resistant Late-Life Depression: An Analysis of the IRL-GRey Randomized Clinical Trial.

Kaneriya SH, Robbins-Welty GA, Smagula SF, Karp JF, Butters MA, Lenze EJ, Mulsant BH, Blumberger D, Anderson SJ, Dew MA, Lotrich F, Aizenstein HJ, Diniz BS, Reynolds CF 3rd.

JAMA Psychiatry. 2016 Apr;73(4):329-36. doi: 10.1001/jamapsychiatry.2015.3447.


The influence of medical burden severity and cognition on functional competence in older community-dwelling individuals with schizophrenia.

Tsoutsoulas C, Mulsant BH, Kalache SM, Kumar S, Ghazala Z, Voineskos AN, Butters MA, Menon M, Rajji TK.

Schizophr Res. 2016 Feb;170(2-3):330-5. doi: 10.1016/j.schres.2015.12.009. Epub 2015 Dec 24.


Trajectories of suicidal ideation in depressed older adults undergoing antidepressant treatment.

Kasckow J, Youk A, Anderson SJ, Dew MA, Butters MA, Marron MM, Begley AE, Szanto K, Dombrovski AY, Mulsant BH, Lenze EJ, Reynolds CF 3rd.

J Psychiatr Res. 2016 Feb;73:96-101. doi: 10.1016/j.jpsychires.2015.11.004. Epub 2015 Nov 19.


Course of cognitive impairment following attempted suicide in older adults.

Gujral S, Ogbagaber S, Dombrovski AY, Butters MA, Karp JF, Szanto K.

Int J Geriatr Psychiatry. 2016 Jun;31(6):592-600. doi: 10.1002/gps.4365. Epub 2015 Oct 21.


Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial.

Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ, Dew MA, Butters MA, Stack JA, Begley AE, Reynolds CF 3rd.

Lancet. 2015 Dec 12;386(10011):2404-12. doi: 10.1016/S0140-6736(15)00308-6. Epub 2015 Sep 27. Erratum in: Lancet. 2015 Dec 12;386(10011):2394.


Inflammation, Depression, and Slow Gait: A High Mortality Phenotype in Later Life.

Brown PJ, Roose SP, Zhang J, Wall M, Rutherford BR, Ayonayon HN, Butters MA, Harris T, Newman AB, Satterfield S, Simonsick EM, Yaffe K.

J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):221-7. doi: 10.1093/gerona/glv156. Epub 2015 Sep 20.

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