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Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease.

Butterfield DA, Mattson MP.

Neurobiol Dis. 2020 Feb 6:104795. doi: 10.1016/j.nbd.2020.104795. [Epub ahead of print] Review.


Unique Solid Phase Microextraction Sampler Reveals Distinctive Biogeochemical Profiles among Various Deep-Sea Hydrothermal Vents.

Grandy JJ, Onat B, Tunnicliffe V, Butterfield DA, Pawliszyn J.

Sci Rep. 2020 Jan 28;10(1):1360. doi: 10.1038/s41598-020-58418-4.


Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome.

Tramutola A, Lanzillotta C, Di Domenico F, Head E, Butterfield DA, Perluigi M, Barone E.

Neurobiol Dis. 2020 Jan 24;137:104772. doi: 10.1016/j.nbd.2020.104772. [Epub ahead of print]


Concentration trends of metals in ambient air in the UK: a review.

Goddard SL, Williams KR, Robins C, Butterfield DM, Brown RJC.

Environ Monit Assess. 2019 Oct 28;191(11):683. doi: 10.1007/s10661-019-7824-2. Review.


Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives.

Lanzillotta C, Di Domenico F, Perluigi M, Butterfield DA.

CNS Drugs. 2019 Oct;33(10):957-969. doi: 10.1007/s40263-019-00658-8.


Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease.

Ren X, Hinchie A, Swomley A, Powell DK, Butterfield DA.

Free Radic Biol Med. 2019 Nov 1;143:146-152. doi: 10.1016/j.freeradbiomed.2019.08.008. Epub 2019 Aug 8.


Extracellular vesicle-mediated macrophage activation: An insight into the mechanism of thioredoxin-mediated immune activation.

Yarana C, Thompson H, Chaiswing L, Butterfield DA, Weiss H, Bondada S, Alhakeem S, Sukati S, St Clair DK.

Redox Biol. 2019 Sep;26:101237. doi: 10.1016/j.redox.2019.101237. Epub 2019 Jun 5.


Phosphoproteomics of Alzheimer disease brain: Insights into altered brain protein regulation of critical neuronal functions and their contributions to subsequent cognitive loss.

Butterfield DA.

Biochim Biophys Acta Mol Basis Dis. 2019 Aug 1;1865(8):2031-2039. doi: 10.1016/j.bbadis.2018.08.035. Epub 2018 Aug 29. Review.


Active subseafloor microbial communities from Mariana back-arc venting fluids share metabolic strategies across different thermal niches and taxa.

Trembath-Reichert E, Butterfield DA, Huber JA.

ISME J. 2019 Sep;13(9):2264-2279. doi: 10.1038/s41396-019-0431-y. Epub 2019 May 9.


Modelling Environmental Impacts of Cesium-137 Under a Hypothetical Release of Radioactive Waste.

Lin Y, Couture RM, Klein H, Ytre-Eide MA, Dyve JE, Lind OC, Bartnicki J, Nizzetto L, Butterfield D, Larssen T, Salbu B.

Bull Environ Contam Toxicol. 2019 Jul;103(1):69-74. doi: 10.1007/s00128-019-02601-5. Epub 2019 Apr 1.


S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2.

Liu L, Qi L, Knifley T, Piecoro DW, Rychahou P, Liu J, Mitov MI, Martin J, Wang C, Wu J, Weiss HL, Butterfield DA, Evers BM, O'Connor KL, Chen M.

J Biol Chem. 2019 May 3;294(18):7516-7527. doi: 10.1074/jbc.RA118.004365. Epub 2019 Mar 18.


Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome.

Di Domenico F, Tramutola A, Barone E, Lanzillotta C, Defever O, Arena A, Zuliani I, Foppoli C, Iavarone F, Vincenzoni F, Castagnola M, Butterfield DA, Perluigi M.

Redox Biol. 2019 May;23:101162. doi: 10.1016/j.redox.2019.101162. Epub 2019 Mar 9.


Fluid geochemistry, local hydrology, and metabolic activity define methanogen community size and composition in deep-sea hydrothermal vents.

Stewart LC, Algar CK, Fortunato CS, Larson BI, Vallino JJ, Huber JA, Butterfield DA, Holden JF.

ISME J. 2019 Jul;13(7):1711-1721. doi: 10.1038/s41396-019-0382-3. Epub 2019 Mar 6.


Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment ("chemobrain"), a condition that significantly impairs the quality of life of many cancer survivors.

Ren X, Boriero D, Chaiswing L, Bondada S, St Clair DK, Butterfield DA.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1088-1097. doi: 10.1016/j.bbadis.2019.02.007. Epub 2019 Feb 10. Review.


Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease.

Sharma N, Tramutola A, Lanzillotta C, Arena A, Blarzino C, Cassano T, Butterfield DA, Di Domenico F, Perluigi M, Barone E.

Neurobiol Dis. 2019 May;125:176-189. doi: 10.1016/j.nbd.2019.02.003. Epub 2019 Feb 6.


Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease.

Butterfield DA, Halliwell B.

Nat Rev Neurosci. 2019 Mar;20(3):148-160. doi: 10.1038/s41583-019-0132-6. Review.


The triangle of death of neurons: Oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment ("chemobrain") involving TNF-α.

Ren X, Keeney JTR, Miriyala S, Noel T, Powell DK, Chaiswing L, Bondada S, St Clair DK, Butterfield DA.

Free Radic Biol Med. 2019 Apr;134:1-8. doi: 10.1016/j.freeradbiomed.2018.12.029. Epub 2018 Dec 26.


mTOR Inhibitor Everolimus in Regulatory T Cell Expansion for Clinical Application in Transplantation.

Gedaly R, De Stefano F, Turcios L, Hill M, Hidalgo G, Mitov MI, Alstott MC, Butterfield DA, Mitchell HC, Hart J, Al-Attar A, Jennings CD, Marti F.

Transplantation. 2019 Apr;103(4):705-715. doi: 10.1097/TP.0000000000002495.


Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome.

Tramutola A, Lanzillotta C, Barone E, Arena A, Zuliani I, Mosca L, Blarzino C, Butterfield DA, Perluigi M, Di Domenico F.

Transl Neurodegener. 2018 Nov 6;7:28. doi: 10.1186/s40035-018-0133-9. eCollection 2018.


Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: Novel hints on immunosenescence and biomarker detection.

Tramutola A, Abate G, Lanzillotta C, Triani F, Barone E, Iavarone F, Vincenzoni F, Castagnola M, Marziano M, Memo M, Garrafa E, Butterfield DA, Perluigi M, Di Domenico F, Uberti D.

Free Radic Biol Med. 2018 Dec;129:430-439. doi: 10.1016/j.freeradbiomed.2018.10.414. Epub 2018 Oct 12.


Redox proteomics and amyloid β-peptide: insights into Alzheimer disease.

Butterfield DA, Boyd-Kimball D.

J Neurochem. 2019 Nov;151(4):459-487. doi: 10.1111/jnc.14589. Epub 2018 Nov 27. Review.


Microdose Lithium NP03 Diminishes Pre-Plaque Oxidative Damage and Neuroinflammation in a Rat Model of Alzheimer's-like Amyloidosis.

Wilson EN, Do Carmo S, Iulita MF, Hall H, Austin GL, Jia DT, Malcolm JC, Foret MK, Marks AR, Butterfield DA, Cuello AC.

Curr Alzheimer Res. 2018;15(13):1220-1230. doi: 10.2174/1567205015666180904154446.


Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment ("chemobrain").

Keeney JTR, Ren X, Warrier G, Noel T, Powell DK, Brelsfoard JM, Sultana R, Saatman KE, Clair DKS, Butterfield DA.

Oncotarget. 2018 Jul 13;9(54):30324-30339. doi: 10.18632/oncotarget.25718. eCollection 2018 Jul 13.


Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease.

Barone E, Tramutola A, Triani F, Calcagnini S, Di Domenico F, Ripoli C, Gaetani S, Grassi C, Butterfield DA, Cassano T, Perluigi M.

Mol Neurobiol. 2019 Apr;56(4):2922-2943. doi: 10.1007/s12035-018-1231-5. Epub 2018 Aug 2.


Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease.

Tramutola A, Sharma N, Barone E, Lanzillotta C, Castellani A, Iavarone F, Vincenzoni F, Castagnola M, Butterfield DA, Gaetani S, Cassano T, Perluigi M, Di Domenico F.

Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3309-3321. doi: 10.1016/j.bbadis.2018.07.017. Epub 2018 Jul 18.


Poly-ubiquitin profile in Alzheimer disease brain.

Tramutola A, Triani F, Di Domenico F, Barone E, Cai J, Klein JB, Perluigi M, Butterfield DA.

Neurobiol Dis. 2018 Oct;118:129-141. doi: 10.1016/j.nbd.2018.07.006. Epub 2018 Jul 9.


Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease.

Triani F, Tramutola A, Di Domenico F, Sharma N, Butterfield DA, Head E, Perluigi M, Barone E.

Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3181-3194. doi: 10.1016/j.bbadis.2018.07.005. Epub 2018 Jul 5.


Estimation of p,p'-DDT degradation in soil by modeling and constraining hydrological and biogeochemical controls.

Sanka O, Kalina J, Lin Y, Deutscher J, Futter M, Butterfield D, Melymuk L, Brabec K, Nizzetto L.

Environ Pollut. 2018 Aug;239:179-188. doi: 10.1016/j.envpol.2018.04.022. Epub 2018 Apr 11.


Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease.

Butterfield DA, Boyd-Kimball D.

J Alzheimers Dis. 2018;62(3):1345-1367. doi: 10.3233/JAD-170543. Review.


Perspectives on Oxidative Stress in Alzheimer's Disease and Predictions of Future Research Emphases.

Butterfield DA.

J Alzheimers Dis. 2018;64(s1):S469-S479. doi: 10.3233/JAD-179912. Review.


Spatially distinct, temporally stable microbial populations mediate biogeochemical cycling at and below the seafloor in hydrothermal vent fluids.

Fortunato CS, Larson B, Butterfield DA, Huber JA.

Environ Microbiol. 2018 Feb;20(2):769-784. doi: 10.1111/1462-2920.14011. Epub 2017 Dec 15.


Down syndrome: From development to adult life to Alzheimer disease.

Butterfield DA, Perluigi M.

Free Radic Biol Med. 2018 Jan;114:1-2. doi: 10.1016/j.freeradbiomed.2017.10.374. Epub 2017 Oct 24. No abstract available.


Extracellular Vesicles Released by Cardiomyocytes in a Doxorubicin-Induced Cardiac Injury Mouse Model Contain Protein Biomarkers of Early Cardiac Injury.

Yarana C, Carroll D, Chen J, Chaiswing L, Zhao Y, Noel T, Alstott M, Bae Y, Dressler EV, Moscow JA, Butterfield DA, Zhu H, St Clair DK.

Clin Cancer Res. 2018 Apr 1;24(7):1644-1653. doi: 10.1158/1078-0432.CCR-17-2046. Epub 2017 Oct 25.


Community Structure of Lithotrophically-Driven Hydrothermal Microbial Mats from the Mariana Arc and Back-Arc.

Hager KW, Fullerton H, Butterfield DA, Moyer CL.

Front Microbiol. 2017 Aug 28;8:1578. doi: 10.3389/fmicb.2017.01578. eCollection 2017.


Standardisation of a European measurement method for organic carbon and elemental carbon in ambient air: results of the field trial campaign and the determination of a measurement uncertainty and working range.

Brown RJC, Beccaceci S, Butterfield DM, Quincey PG, Harris PM, Maggos T, Panteliadis P, John A, Jedynska A, Kuhlbusch TAJ, Putaud JP, Karanasiou A.

Environ Sci Process Impacts. 2017 Oct 18;19(10):1249-1259. doi: 10.1039/c7em00261k.


The role of charge in the toxicity of polymer-coated cerium oxide nanomaterials to Caenorhabditis elegans.

Arndt DA, Oostveen EK, Triplett J, Butterfield DA, Tsyusko OV, Collin B, Starnes DL, Cai J, Klein JB, Nass R, Unrine JM.

Comp Biochem Physiol C Toxicol Pharmacol. 2017 Oct;201:1-10. doi: 10.1016/j.cbpc.2017.08.009. Epub 2017 Sep 6.


mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia.

Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA.

Free Radic Biol Med. 2018 Jan;114:94-101. doi: 10.1016/j.freeradbiomed.2017.08.009. Epub 2017 Aug 12. Review.


Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus.

Thomas TC, Beitchman JA, Pomerleau F, Noel T, Jungsuwadee P, Butterfield DA, Clair DKS, Vore M, Gerhardt GA.

Brain Res. 2017 Oct 1;1672:10-17. doi: 10.1016/j.brainres.2017.07.003. Epub 2017 Jul 11.


Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism.

Barone E, Arena A, Head E, Butterfield DA, Perluigi M.

Free Radic Biol Med. 2018 Jan;114:84-93. doi: 10.1016/j.freeradbiomed.2017.07.009. Epub 2017 Jul 10. Review.


Evidence of the immunomodulatory role of dual PI3K/mTOR inhibitors in transplantation: an experimental study in mice.

Vilchez V, Turcios L, Butterfield DA, Mitov MI, Coquillard CL, Brandon JA, Cornea V, Gedaly R, Marti F.

Transpl Int. 2017 Oct;30(10):1061-1074. doi: 10.1111/tri.12989. Epub 2017 Jul 31.


Oxidative stress and neurodegeneration.

Zhang J, Butterfield DA.

Brain Res Bull. 2017 Jul;133:1-3. doi: 10.1016/j.brainresbull.2017.04.018. Epub 2017 May 1. No abstract available.


Temperature induces significant changes in both glycolytic reserve and mitochondrial spare respiratory capacity in colorectal cancer cell lines.

Mitov MI, Harris JW, Alstott MC, Zaytseva YY, Evers BM, Butterfield DA.

Exp Cell Res. 2017 May 15;354(2):112-121. doi: 10.1016/j.yexcr.2017.03.046. Epub 2017 Mar 22.


Sorafenib and FH535 in combination act synergistically on hepatocellular carcinoma by targeting cell bioenergetics and mitochondrial function.

Turcios L, Vilchez V, Acosta LF, Poyil P, Butterfield DA, Mitov M, Marti F, Gedaly R.

Dig Liver Dis. 2017 Jun;49(6):697-704. doi: 10.1016/j.dld.2017.01.146. Epub 2017 Jan 19.


Dysregulation of cytokine mediated chemotherapy induced cognitive impairment.

Ren X, St Clair DK, Butterfield DA.

Pharmacol Res. 2017 Mar;117:267-273. doi: 10.1016/j.phrs.2017.01.001. Epub 2017 Jan 4. Review.


Standardisation of a European measurement method for the determination of anions and cations in PM2.5: results of field trial campaign and determination of measurement uncertainty.

Beccaceci S, Brown RJ, Butterfield DM, Harris PM, Otjes RP, van Hoek C, Makkonen U, Catrambone M, Patier RF, Houtzager MM, Putaud JP.

Environ Sci Process Impacts. 2016 Dec 8;18(12):1561-1571.


Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function.

Swomley AM, Triplett JC, Keeney JT, Warrier G, Pearson KJ, Mattison JA, de Cabo R, Cai J, Klein JB, Butterfield DA.

J Nutr Biochem. 2017 Jan;39:169-179. doi: 10.1016/j.jnutbio.2016.10.006. Epub 2016 Oct 13.


HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology.

Barone E, Head E, Butterfield DA, Perluigi M.

Free Radic Biol Med. 2017 Oct;111:262-269. doi: 10.1016/j.freeradbiomed.2016.10.508. Epub 2016 Nov 10. Review.


Redox Proteomics: A Key Tool for New Insights into Protein Modification with Relevance to Disease.

Butterfield DA, Perluigi M.

Antioxid Redox Signal. 2017 Mar 1;26(7):277-279. doi: 10.1089/ars.2016.6919. Epub 2017 Jan 6.


Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells.

Palmieri EM, Menga A, Lebrun A, Hooper DC, Butterfield DA, Mazzone M, Castegna A.

Antioxid Redox Signal. 2017 Mar 10;26(8):351-363. doi: 10.1089/ars.2016.6715. Epub 2016 Nov 2.

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