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Nat Commun. 2019 Dec 6;10(1):5574. doi: 10.1038/s41467-019-13132-2.

Stem-cell-ubiquitous genes spatiotemporally coordinate division through regulation of stem-cell-specific gene networks.

Author information

1
Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, 27695, United States.
2
Biomathematics Graduate Program, North Carolina State University, Raleigh, NC, 27695, United States.
3
Department of Plant Pathology and Microbiology, Iowa State University, Ames, IA, 50011, United States.
4
Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, United States.
5
Department of Biology, Stanford University, Stanford, CA, 94305, United States.
6
Department of Biology, Denison University, Granville, OH, 43023, United States.
7
Howard Hughes Medical Institute (HHMI), Stanford University, Stanford, CA, 94305, United States.
8
Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, 27695, United States. ross_sozzani@ncsu.edu.
9
Biomathematics Graduate Program, North Carolina State University, Raleigh, NC, 27695, United States. ross_sozzani@ncsu.edu.

Abstract

Stem cells are responsible for generating all of the differentiated cells, tissues, and organs in a multicellular organism and, thus, play a crucial role in cell renewal, regeneration, and organization. A number of stem cell type-specific genes have a known role in stem cell maintenance, identity, and/or division. Yet, how genes expressed across different stem cell types, referred to here as stem-cell-ubiquitous genes, contribute to stem cell regulation is less understood. Here, we find that, in the Arabidopsis root, a stem-cell-ubiquitous gene, TESMIN-LIKE CXC2 (TCX2), controls stem cell division by regulating stem cell-type specific networks. Development of a mathematical model of TCX2 expression allows us to show that TCX2 orchestrates the coordinated division of different stem cell types. Our results highlight that genes expressed across different stem cell types ensure cross-communication among cells, allowing them to divide and develop harmonically together.

PMID:
31811116
PMCID:
PMC6897965
DOI:
10.1038/s41467-019-13132-2
[Indexed for MEDLINE]
Free PMC Article

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