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Items: 1 to 50 of 120

1.

Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition.

Hossan MS, Chan ZY, Collins HM, Shipton FN, Butler MS, Rahmatullah M, Lee JB, Gershkovich P, Kagan L, Khoo TJ, Wiart C, Bradshaw TD.

Cancer Lett. 2019 Jul 1;453:57-73. doi: 10.1016/j.canlet.2019.03.034. Epub 2019 Mar 28.

PMID:
30930233
2.

Structure-Function Studies of Polymyxin B Lipononapeptides.

Gallardo-Godoy A, Hansford KA, Muldoon C, Becker B, Elliott AG, Huang JX, Pelingon R, Butler MS, Blaskovich MAT, Cooper MA.

Molecules. 2019 Feb 2;24(3). pii: E553. doi: 10.3390/molecules24030553.

3.

Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection.

Chitty JL, Edwards DJ, Robertson AAB, Butler MS, Duley JA, Cooper MA, Fraser JA.

Mycopathologia. 2019 Apr;184(2):273-281. doi: 10.1007/s11046-018-0315-0. Epub 2019 Feb 1.

PMID:
30707338
4.

Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity.

Jarrad AM, Ang CW, Debnath A, Hahn HJ, Woods K, Tan L, Sykes ML, Jones AJ, Pelingon R, Butler MS, Avery VM, West NP, Karoli T, Blaskovich MAT, Cooper MA.

J Med Chem. 2018 Dec 27;61(24):11349-11371. doi: 10.1021/acs.jmedchem.8b01578. Epub 2018 Dec 11.

5.

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2019 Jan 1;36(1):248-249. doi: 10.1039/c8np90041h. Epub 2018 Nov 23.

6.

Octapeptin C4 and polymyxin resistance occur via distinct pathways in an epidemic XDR Klebsiella pneumoniae ST258 isolate.

Pitt ME, Cao MD, Butler MS, Ramu S, Ganesamoorthy D, Blaskovich MAT, Coin LJM, Cooper MA.

J Antimicrob Chemother. 2019 Mar 1;74(3):582-593. doi: 10.1093/jac/dky458.

PMID:
30445429
7.

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.

Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar V, Mantovani S, Robertson AAB, Butler MS, Rowe DB, O'Neill LA, Kanthasamy AG, Schroder K, Cooper MA, Woodruff TM.

Sci Transl Med. 2018 Oct 31;10(465). pii: eaah4066. doi: 10.1126/scitranslmed.aah4066.

PMID:
30381407
8.

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.

Kummari LK, Butler MS, Furlong E, Blundell R, Nouwens A, Silva AB, Kappler U, Fraser JA, Kobe B, Cooper MA, Robertson AAB.

Bioorg Med Chem. 2018 Nov 1;26(20):5408-5419. doi: 10.1016/j.bmc.2018.09.004. Epub 2018 Sep 5.

PMID:
30322754
9.

Anti-infective activities of 11 plants species used in traditional medicine in Malaysia.

Nor Azman NS, Hossan MS, Nissapatorn V, Uthaipibull C, Prommana P, Jin KT, Rahmatullah M, Mahboob T, Raju CS, Jindal HM, Hazra B, Mohd Abd Razak MR, Prajapati VK, Pandey RK, Aminudin N, Shaari K, Ismail NH, Butler MS, Zarubaev VV, Wiart C.

Exp Parasitol. 2018 Nov;194:67-78. doi: 10.1016/j.exppara.2018.09.020. Epub 2018 Sep 27.

PMID:
30268422
10.

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2019 Jan 1;36(1):35-107. doi: 10.1039/c7np00064b. Epub 2018 Jul 13. Erratum in: Nat Prod Rep. 2018 Nov 23;:.

11.

Perception Versus Reality in the Cost of Orthopedic Trauma Implants.

Ayoub M, Paul Bassett W, Seuffert P, Matijakovich D, O Hara DA, Butler MS.

J Surg Educ. 2018 Sep - Oct;75(5):1333-1341. doi: 10.1016/j.jsurg.2018.02.015. Epub 2018 Mar 14.

PMID:
29548909
12.

Evidence against a role for NLRP3-driven islet inflammation in db/db mice.

Kammoun HL, Allen TL, Henstridge DC, Barre S, Coll RC, Lancaster GI, Cron L, Reibe S, Chan JY, Bensellam M, Laybutt DR, Butler MS, Robertson AAB, O'Neill LA, Cooper MA, Febbraio MA.

Mol Metab. 2018 Apr;10:66-73. doi: 10.1016/j.molmet.2018.02.001. Epub 2018 Feb 7.

13.

Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance.

Stone MRL, Butler MS, Phetsang W, Cooper MA, Blaskovich MAT.

Trends Biotechnol. 2018 May;36(5):523-536. doi: 10.1016/j.tibtech.2018.01.004. Epub 2018 Feb 22. Review.

PMID:
29478675
14.

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.

Velkov T, Gallardo-Godoy A, Swarbrick JD, Blaskovich MAT, Elliott AG, Han M, Thompson PE, Roberts KD, Huang JX, Becker B, Butler MS, Lash LH, Henriques ST, Nation RL, Sivanesan S, Sani MA, Separovic F, Mertens H, Bulach D, Seemann T, Owen J, Li J, Cooper MA.

Cell Chem Biol. 2018 Apr 19;25(4):380-391.e5. doi: 10.1016/j.chembiol.2018.01.005. Epub 2018 Feb 3.

15.

Developments in Glycopeptide Antibiotics.

Blaskovich MAT, Hansford KA, Butler MS, Jia Z, Mark AE, Cooper MA.

ACS Infect Dis. 2018 May 11;4(5):715-735. doi: 10.1021/acsinfecdis.7b00258. Epub 2018 Feb 19.

16.

Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950.

Salla M, Butler MS, Massey NL, Reid JC, Cooper MA, Robertson AAB.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):793-795. doi: 10.1016/j.bmcl.2017.12.054. Epub 2017 Dec 26.

PMID:
29338910
17.

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria.

Blaskovich MAT, Hansford KA, Gong Y, Butler MS, Muldoon C, Huang JX, Ramu S, Silva AB, Cheng M, Kavanagh AM, Ziora Z, Premraj R, Lindahl F, Bradford TA, Lee JC, Karoli T, Pelingon R, Edwards DJ, Amado M, Elliott AG, Phetsang W, Daud NH, Deecke JE, Sidjabat HE, Ramaologa S, Zuegg J, Betley JR, Beevers APG, Smith RAG, Roberts JA, Paterson DL, Cooper MA.

Nat Commun. 2018 Jan 2;9(1):22. doi: 10.1038/s41467-017-02123-w.

18.

Antimicrobial Octapeptin C4 Analogues Active against Cryptococcus Species.

Chitty JL, Butler MS, Suboh A, Edwards DJ, Cooper MA, Fraser JA, Robertson AAB.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e00986-17. doi: 10.1128/AAC.00986-17. Print 2018 Feb.

19.

5,6,7,3',4',5'-Hexamethoxyflavone from the Australian plant Eremophila debilis (Myoporaceae).

Butler MS, Healy PC, Forster PI, Guymer GP, Quinn RJ.

Fitoterapia. 2018 Apr;126:90-92. doi: 10.1016/j.fitote.2017.07.014. Epub 2017 Aug 1.

PMID:
28774690
20.

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

Chitty JL, Blake KL, Blundell RD, Koh YQAE, Thompson M, Robertson AAB, Butler MS, Cooper MA, Kappler U, Williams SJ, Kobe B, Fraser JA.

J Biol Chem. 2017 Jul 14;292(28):11829-11839. doi: 10.1074/jbc.M117.787994. Epub 2017 May 30.

21.

Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer.

Butler MS, Roshan-Moniri M, Hsing M, Lau D, Kim A, Yen P, Mroczek M, Nouri M, Lien S, Axerio-Cilies P, Dalal K, Yau C, Ghaidi F, Guo Y, Yamazaki T, Lawn S, Gleave ME, Gregory-Evans CY, McIntosh LP, Cox ME, Rennie PS, Cherkasov A.

Oncotarget. 2017 Jun 27;8(26):42438-42454. doi: 10.18632/oncotarget.17124.

22.

Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria.

Becker B, Butler MS, Hansford KA, Gallardo-Godoy A, Elliott AG, Huang JX, Edwards DJ, Blaskovich MAT, Cooper MA.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2407-2409. doi: 10.1016/j.bmcl.2017.04.027. Epub 2017 Apr 12.

23.

The National Football League-225 Bench Press Test and the Size-Weight Illusion.

Luebbers PE, Buckingham G, Butler MS.

Percept Mot Skills. 2017 Jun;124(3):634-648. doi: 10.1177/0031512517697071. Epub 2017 Mar 27.

PMID:
28347219
24.

Polishing the tarnished silver bullet: the quest for new antibiotics.

Blaskovich MA, Butler MS, Cooper MA.

Essays Biochem. 2017 Mar 3;61(1):103-114. doi: 10.1042/EBC20160077. Print 2017 Feb 28. Review.

25.

Antibacterial Nerol Cinnamates from the Australian Plant Eremophila longifolia.

Galappathie S, Edwards DJ, Elliott AG, Cooper MA, Palombo EA, Butler MS, Mahon PJ.

J Nat Prod. 2017 Apr 28;80(4):1178-1181. doi: 10.1021/acs.jnatprod.6b00888. Epub 2017 Mar 3.

PMID:
28257200
26.

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.

Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, Zuegg J, Robertson AA, Holmes K, Salim AA, Mamidyala S, Butler MS, Robinson AS, Lesieur E, Johnston W, Alexandrov K, Black BL, Hogan BM, De Val S, Capon RJ, Carroll JS, Bailey TL, Koopman P, Jauch R, Smyth MJ, Cooper MA, Gambin Y, Francois M.

Elife. 2017 Jan 31;6. pii: e21221. doi: 10.7554/eLife.21221.

27.

Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality.

Tse BWC, Volpert M, Ratther E, Stylianou N, Nouri M, McGowan K, Lehman ML, McPherson SJ, Roshan-Moniri M, Butler MS, Caradec J, Gregory-Evans CY, McGovern J, Das R, Takhar M, Erho N, Alshalafa M, Davicioni E, Schaeffer EM, Jenkins RB, Ross AE, Karnes RJ, Den RB, Fazli L, Gregory PA, Gleave ME, Williams ED, Rennie PS, Buttyan R, Gunter JH, Selth LA, Russell PJ, Nelson CC, Hollier BG.

Oncogene. 2017 Jun 15;36(24):3417-3427. doi: 10.1038/onc.2016.482. Epub 2017 Jan 16.

28.

GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.

Chitty JL, Tatzenko TL, Williams SJ, Koh YQ, Corfield EC, Butler MS, Robertson AA, Cooper MA, Kappler U, Kobe B, Fraser JA.

J Biol Chem. 2017 Feb 17;292(7):3049-3059. doi: 10.1074/jbc.M116.767533. Epub 2017 Jan 6.

29.

Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.

Salla M, Butler MS, Pelingon R, Kaeslin G, Croker DE, Reid JC, Baek JM, Bernhardt PV, Gillam EM, Cooper MA, Robertson AA.

ACS Med Chem Lett. 2016 Sep 27;7(12):1034-1038. eCollection 2016 Dec 8.

30.

Dietary Intake and Eating Behaviours of Obese New Zealand Children and Adolescents Enrolled in a Community-Based Intervention Programme.

Anderson YC, Wynter LE, Butler MS, Grant CC, Stewart JM, Cave TL, Wild CE, Derraik JG, Cutfield WS, Hofman PL.

PLoS One. 2016 Nov 23;11(11):e0166996. doi: 10.1371/journal.pone.0166996. eCollection 2016.

31.

Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.

Blundell RD, Williams SJ, Arras SD, Chitty JL, Blake KL, Ericsson DJ, Tibrewal N, Rohr J, Koh YQ, Kappler U, Robertson AA, Butler MS, Cooper MA, Kobe B, Fraser JA.

ACS Infect Dis. 2016 Sep 9;2(9):651-663. Epub 2016 Aug 17.

PMID:
27759389
32.

Old dogs and new tricks in antimicrobial discovery.

Butler MS, Blaskovich MA, Owen JG, Cooper MA.

Curr Opin Microbiol. 2016 Oct;33:25-34. doi: 10.1016/j.mib.2016.05.011. Epub 2016 Jun 2. Review.

PMID:
27262526
33.

Fluorescent Trimethoprim Conjugate Probes To Assess Drug Accumulation in Wild Type and Mutant Escherichia coli.

Phetsang W, Pelingon R, Butler MS, Kc S, Pitt ME, Kaeslin G, Cooper MA, Blaskovich MA.

ACS Infect Dis. 2016 Oct 14;2(10):688-701. Epub 2016 Aug 16.

34.

Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice.

Philp LK, Day TK, Butler MS, Laven-Law G, Jindal S, Hickey TE, Scher HI, Butler LM, Tilley WD.

Sci Rep. 2016 Jun 30;6:28950. doi: 10.1038/srep28950.

35.

Antibiotics in the clinical pipeline at the end of 2015.

Butler MS, Blaskovich MA, Cooper MA.

J Antibiot (Tokyo). 2017 Jan;70(1):3-24. doi: 10.1038/ja.2016.72. Epub 2016 Jun 29. Review.

PMID:
27353164
36.

Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis.

Jarrad AM, Debnath A, Miyamoto Y, Hansford KA, Pelingon R, Butler MS, Bains T, Karoli T, Blaskovich MA, Eckmann L, Cooper MA.

Eur J Med Chem. 2016 Sep 14;120:353-62. doi: 10.1016/j.ejmech.2016.04.064. Epub 2016 Apr 27.

37.

A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance.

Watterson D, Robinson J, Chappell KJ, Butler MS, Edwards DJ, Fry SR, Bermingham IM, Cooper MA, Young PR.

Sci Rep. 2016 Mar 15;6:22791. doi: 10.1038/srep22791.

38.

Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.

Gallardo-Godoy A, Muldoon C, Becker B, Elliott AG, Lash LH, Huang JX, Butler MS, Pelingon R, Kavanagh AM, Ramu S, Phetsang W, Blaskovich MA, Cooper MA.

J Med Chem. 2016 Feb 11;59(3):1068-77. doi: 10.1021/acs.jmedchem.5b01593. Epub 2016 Jan 27.

39.

Flemingin-Type Prenylated Chalcones from the Sarawak Rainforest Plant Desmodium congestum.

Rees KA, Bermudez C, Edwards DJ, Elliott AG, Ripen JE, Seta C, Huang JX, Cooper MA, Fraser JA, Yeo TC, Butler MS.

J Nat Prod. 2015 Aug 28;78(8):2141-4. doi: 10.1021/acs.jnatprod.5b00410. Epub 2015 Aug 18.

PMID:
26284978
40.

Synthesis of Norbornane Bisether Antibiotics via Silver-mediated Alkylation.

Hickey SM, Ashton TD, White JM, Li J, Nation RL, Yu HY, Elliott AG, Butler MS, Huang JX, Cooper MA, Pfeffer FM.

RSC Adv. 2015;5:28582-28596.

41.

Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity.

Zuegg J, Muldoon C, Adamson G, McKeveney D, Le Thanh G, Premraj R, Becker B, Cheng M, Elliott AG, Huang JX, Butler MS, Bajaj M, Seifert J, Singh L, Galley NF, Roper DI, Lloyd AJ, Dowson CG, Cheng TJ, Cheng WC, Demon D, Meyer E, Meutermans W, Cooper MA.

Nat Commun. 2015 Jul 21;6:7719. doi: 10.1038/ncomms8719.

42.

Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells.

Huang JX, Kaeslin G, Ranall MV, Blaskovich MA, Becker B, Butler MS, Little MH, Lash LH, Cooper MA.

Pharmacol Res Perspect. 2015 Jun;3(3):e00148. doi: 10.1002/prp2.148. Epub 2015 May 15.

43.

Mucin Binding Reduces Colistin Antimicrobial Activity.

Huang JX, Blaskovich MA, Pelingon R, Ramu S, Kavanagh A, Elliott AG, Butler MS, Montgomery AB, Cooper MA.

Antimicrob Agents Chemother. 2015 Oct;59(10):5925-31. doi: 10.1128/AAC.00808-15. Epub 2015 Jul 13.

44.

Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol.

Abdul Rahim N, Cheah SE, Johnson MD, Yu H, Sidjabat HE, Boyce J, Butler MS, Cooper MA, Fu J, Paterson DL, Nation RL, Bergen PJ, Velkov T, Li J.

J Antimicrob Chemother. 2015 Sep;70(9):2589-97. doi: 10.1093/jac/dkv135. Epub 2015 May 28.

45.

Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents.

Hickey SM, Ashton TD, Khosa SK, Robson RN, White JM, Li J, Nation RL, Yu HY, Elliott AG, Butler MS, Huang JX, Cooper MA, Pfeffer FM.

Org Biomol Chem. 2015 Jun 14;13(22):6225-41. doi: 10.1039/c5ob00621j.

PMID:
25958967
46.

Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp.

Rho JR, Subramaniam G, Choi H, Kim EH, Ng SP, Yoganathan K, Ng S, Buss AD, Butler MS, Gerwick WH.

Org Lett. 2015 Mar 20;17(6):1377-80. doi: 10.1021/acs.orglett.5b00068. Epub 2015 Feb 27.

47.

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA.

Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16.

48.

Orphan nuclear receptors as drug targets for the treatment of prostate and breast cancers.

Roshan-Moniri M, Hsing M, Butler MS, Cherkasov A, Rennie PS.

Cancer Treat Rev. 2014 Dec;40(10):1137-52. doi: 10.1016/j.ctrv.2014.10.005. Review.

PMID:
25455729
49.

Natural product and natural product derived drugs in clinical trials.

Butler MS, Robertson AA, Cooper MA.

Nat Prod Rep. 2014 Nov;31(11):1612-61. doi: 10.1039/c4np00064a. Review.

PMID:
25204227
50.

Ramoplanin at bactericidal concentrations induces bacterial membrane depolarization in Staphylococcus aureus.

Cheng M, Huang JX, Ramu S, Butler MS, Cooper MA.

Antimicrob Agents Chemother. 2014 Nov;58(11):6819-27. doi: 10.1128/AAC.00061-14. Epub 2014 Sep 2.

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